Klaus Pechhold

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes
    Klaus Pechhold
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 58:1175-84. 2009
  2. ncbi request reprint Beta cell-specific CD80 (B7-1) expression disrupts tissue protection from autoantigen-specific CTL-mediated diabetes
    Klaus Pechhold
    NIDDK Transplantation and Autoimmunity Branch, Bethesda, MD 20889, USA
    J Autoimmun 20:1-13. 2003
  3. ncbi request reprint Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity
    Klaus Pechhold
    Diabetes Branch, NIDDK, NIH, 10 Center Drive, Bldg 10 CRC, Room 5W 5888, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1103:132-42. 2007
  4. ncbi request reprint Immunomodulation of autoimmune diabetes by dendritic cells
    Klaus Pechhold
    NIDDK Diabetes Branch, NIH, 10 Center Drive, Building 10 CRC, Room 5W 5888, Bethesda, MD 20892, USA
    Curr Diab Rep 8:107-13. 2008
  5. pmc Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice
    Klaus Pechhold
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD, USA
    PLoS ONE 4:e4827. 2009
  6. pmc Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors
    Anthony T Craig
    Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Virol J 6:61. 2009
  7. doi request reprint Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection
    Susanne Pechhold
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Biotechnol 27:1038-42. 2009
  8. pmc Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice
    H C Jennifer Shen
    Tissue Array Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 8322, USA
    Endocrinology 151:4024-30. 2010
  9. ncbi request reprint No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro
    Fouad Atouf
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, MD 20892, USA
    Diabetes 56:699-702. 2007
  10. ncbi request reprint Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice
    Wolfram Karges
    Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany
    Diabetes 51:3237-44. 2002

Collaborators

Detail Information

Publications10

  1. pmc Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes
    Klaus Pechhold
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 58:1175-84. 2009
    ..Less is known about beta-cell numbers and phenotype remaining at diabetes onset and the fate of other pancreatic endocrine cellular constituents...
  2. ncbi request reprint Beta cell-specific CD80 (B7-1) expression disrupts tissue protection from autoantigen-specific CTL-mediated diabetes
    Klaus Pechhold
    NIDDK Transplantation and Autoimmunity Branch, Bethesda, MD 20889, USA
    J Autoimmun 20:1-13. 2003
    ....
  3. ncbi request reprint Cytotoxic T cell-mediated diabetes in RIP-CD80 transgenic mice: autoantigen peptide sensitivity and fine specificity
    Klaus Pechhold
    Diabetes Branch, NIDDK, NIH, 10 Center Drive, Bldg 10 CRC, Room 5W 5888, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1103:132-42. 2007
    ....
  4. ncbi request reprint Immunomodulation of autoimmune diabetes by dendritic cells
    Klaus Pechhold
    NIDDK Diabetes Branch, NIH, 10 Center Drive, Building 10 CRC, Room 5W 5888, Bethesda, MD 20892, USA
    Curr Diab Rep 8:107-13. 2008
    ..Finally, we offer our perspective on how basic research progress in DC technology, mostly from mouse models, may translate into emerging diagnostic and therapeutic applications for human type 1 diabetes...
  5. pmc Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice
    Klaus Pechhold
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD, USA
    PLoS ONE 4:e4827. 2009
    ..Using two mouse autoimmune diabetes models, this study examined the proliferation of pancreatic islet ss-cells and other endocrine and non-endocrine subsets, and the factors regulating that proliferation...
  6. pmc Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors
    Anthony T Craig
    Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Virol J 6:61. 2009
    ..We are therefore investigating the use of adeno-associated viruses (AAVs) as gene therapy vectors to transduce rat islets with immunosuppressive genes prior to transplantation into diabetic mice...
  7. doi request reprint Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection
    Susanne Pechhold
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Biotechnol 27:1038-42. 2009
    ..Application of qNPA to intracellularly stained, FACS-sorted cells should be broadly applicable to the analysis of gene expression in subpopulations of any heterogeneous tissue, including tumors...
  8. pmc Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice
    H C Jennifer Shen
    Tissue Array Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 8322, USA
    Endocrinology 151:4024-30. 2010
    ..Together, we believed that the new model systems described here will allow future studies to decipher cellular interactions between islet alpha- and beta-cells in a physiological context...
  9. ncbi request reprint No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro
    Fouad Atouf
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, MD 20892, USA
    Diabetes 56:699-702. 2007
    ..As such, these mesenchymal "progenitors" might not represent the best possible source for generation of physiologically competent beta-cells for treatment of diabetes...
  10. ncbi request reprint Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice
    Wolfram Karges
    Division of Endocrinology, Department of Internal Medicine, University of Ulm, Ulm, Germany
    Diabetes 51:3237-44. 2002
    ..In antigen-based prevention of type 1 diabetes, diabetes acceleration should be considered as a potential adverse result...