A Pause

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
    A Pause
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:993-8. 1998
  2. pmc The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
    A Pause
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:2156-61. 1997
  3. ncbi request reprint Inhibition of transcription elongation by the VHL tumor suppressor protein
    D R Duan
    Urologic Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 269:1402-6. 1995
  4. pmc Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein
    S Lee
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 19:1486-97. 1999
  5. ncbi request reprint Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma
    J R Gnarra
    Urilogic Oncology Section, Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892 1502, USA
    Biochim Biophys Acta 1242:201-10. 1996
  6. pmc Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein
    A Pause
    Molecular Oncology Group, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 96:9533-8. 1999
  7. pmc Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function
    D Liakopoulos
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 96:5510-5. 1999
  8. pmc Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
    K Iwai
    Department of Molecular Biology, Graduate School of Biostudies, Kyoto University, Kyoto, 606 8501, Japan
    Proc Natl Acad Sci U S A 96:12436-41. 1999
  9. pmc Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E
    A Haghighat
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    EMBO J 14:5701-9. 1995
  10. ncbi request reprint The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A
    J Yoder-Hill
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106
    J Biol Chem 268:5566-73. 1993

Collaborators

  • S Lee
  • R Stearman
  • T Aso
  • J S Humphrey
  • F Latif
  • M I Lerman
  • Feng Chen
  • N Sonenberg
  • A C Gingras
  • S A Adam
  • John Lawrence
  • P Linder
  • G J Belsham
  • G Kurban
  • R D Klausner
  • Y V Svitkin
  • J R Gnarra
  • N de Paulsen
  • A Haghighat
  • A Brychzy
  • J Dostie
  • Y Sado
  • E Duplan
  • V Hudon
  • N Ramlal
  • D Liakopoulos
  • K Iwai
  • Y Ninomiya
  • D R Duan
  • S Mader
  • J W Conaway
  • R C Conaway
  • D Rousseau
  • M C Fournier
  • G Witherell
  • D Y Chen
  • S Pyronnet
  • W M Linehan
  • M Ferraiuolo
  • T Büsgen
  • N Minato
  • S Jentsch
  • K Yamanaka
  • T Kamura
  • T A Lin
  • N Methot
  • T Stackhouse
  • M H Wei
  • I Kuzmin
  • J Yoder-Hill
  • Y Weng
  • B Zbar
  • L Schmidt
  • C F Dudley
  • F M Duh
  • T Kishida
  • K P Garrett
  • H Lee
  • W H Burgess
  • X Kong
  • S Blum
  • T A Haystead
  • J W Hershey
  • W C Merrick
  • H Trachsel
  • P Buser
  • S R Schmid

Detail Information

Publications22

  1. pmc The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
    A Pause
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:993-8. 1998
    ..This is corrected by the reintroduction of wild-type VHL, implicating VHL as the first tumor suppressor involved in the regulation of cell cycle exit, which is consistent with its gatekeeper function in the kidney...
  2. pmc The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
    A Pause
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:2156-61. 1997
    ..Hence, Hs-cul-2 may be required for VHL function and, therefore, may be a candidate human tumor-suppressor gene...
  3. ncbi request reprint Inhibition of transcription elongation by the VHL tumor suppressor protein
    D R Duan
    Urologic Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 269:1402-6. 1995
    ..These findings reveal a potentially important transcriptional regulatory network in which the VHL protein may play a key role...
  4. pmc Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein
    S Lee
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 19:1486-97. 1999
    ..We suggest that VHL function requires not only nuclear or cytoplasmic localization, but also exon 2-mediated transcription-dependent trafficking between these two cellular compartments...
  5. ncbi request reprint Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma
    J R Gnarra
    Urilogic Oncology Section, Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892 1502, USA
    Biochim Biophys Acta 1242:201-10. 1996
  6. pmc Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein
    A Pause
    Molecular Oncology Group, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 96:9533-8. 1999
    ..Thus, it seems possible that pVHL/elongin BC/hCUL-2 complex will possess ubiquitin ligase activity targeting specific proteins for degradation by the proteasome...
  7. pmc Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function
    D Liakopoulos
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 96:5510-5. 1999
    ..A tumorigenic pVHL variant, however, is essentially deficient in this activity. Thus, ligation of NEDD8 to hCUL-2 is linked to pVHL activity and may be important for pVHL tumor suppressor function...
  8. pmc Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
    K Iwai
    Department of Molecular Biology, Graduate School of Biostudies, Kyoto University, Kyoto, 606 8501, Japan
    Proc Natl Acad Sci U S A 96:12436-41. 1999
    ..This is also, to our knowledge, the first example of a human tumor-suppressor protein being directly involved in the ubiquitin conjugation system which leads to the targeted degradation of substrate proteins...
  9. pmc Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E
    A Haghighat
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    EMBO J 14:5701-9. 1995
    ..Thus, translational control by growth factors, insulin and mitogens is affected by changes in the relative affinities of 4E-BP1 and p220 for eIF-4E...
  10. ncbi request reprint The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A
    J Yoder-Hill
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106
    J Biol Chem 268:5566-73. 1993
    ....
  11. pmc A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E
    J Dostie
    Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    EMBO J 19:3142-56. 2000
    ..Taken together, these results demonstrate that the novel nucleocytoplasmic shuttling protein 4E-T mediates the nuclear import of eIF4E via the importin alphabeta pathway by a piggy-back mechanism...
  12. ncbi request reprint PHAS-I as a link between mitogen-activated protein kinase and translation initiation
    T A Lin
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110
    Science 266:653-6. 1994
    ..Thus, PHAS-I may be a key mediator of the stimulation of protein synthesis by the diverse group of agents and stimuli that activate MAP kinase...
  13. ncbi request reprint Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
    A Pause
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Nature 371:762-7. 1994
    ..The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth...
  14. pmc Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
    N de Paulsen
    Department of Cellular and Molecular MedicineUniversity of Ottawa, Ottawa, ON, Canada K1H 8M5
    Proc Natl Acad Sci U S A 98:1387-92. 2001
    ....
  15. pmc The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins
    S Mader
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 15:4990-7. 1995
    ..These results shed light on the mechanisms of eIF-4F assembly and on the translational regulation by insulin and growth factors...
  16. pmc The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure
    Y V Svitkin
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    RNA 7:382-94. 2001
    ..Finally, the elF4A mutant forms a more stable complex with elF4G, as compared to the wild-type elF4A, thus explaining the mechanism by which substoichiometric amounts of mutant elF4A inhibit translation...
  17. pmc Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A
    A Pause
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    EMBO J 11:2643-54. 1992
    ..Our results suggest that the highly conserved regions in the DEAD box family are critical for RNA helicase activity...
  18. ncbi request reprint The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
    D Rousseau
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Oncogene 13:2415-20. 1996
    ..Thus, we demonstrate that the eIF4E-binding proteins act as negative regulators of cell growth. We propose that 4E-BPs are members of a class of negative regulators of cell growth acting on the translation machinery of the cell...
  19. pmc The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence
    N Methot
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 14:2307-16. 1994
    ..Our results indicate that the carboxy-terminal RNA-binding region of eIF-4B is essential for eIF-4B function and is distinct from the RNP-CS/RRM...
  20. pmc La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA
    Y V Svitkin
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Virol 68:7001-7. 1994
    ..This inhibition can be relieved by La but not by any other translation factor. The results suggest a possible involvement of the La autoantigen in HIV-1 gene expression...
  21. pmc ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae
    S Blum
    Institut fur Biochemie und Molekularbiologie, Universitat Bern, Switzerland
    Proc Natl Acad Sci U S A 89:7664-8. 1992
    ....
  22. ncbi request reprint Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2
    G Kurban
    McGill Cancer Center, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Oncogene 27:1004-12. 2008
    ..Our data suggest a HIF-alpha-independent role for the VHL-COL4A2 interaction in suppression of angiogenic tumor formation through collagen IV network assembly...