R S Paules

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs
    Cynthia L Innes
    Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Genomics 14:163. 2013
  2. ncbi Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
    Edward K Lobenhofer
    Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA
    Genome Biol 9:R100. 2008
  3. ncbi Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants
    Lingkang Huang
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Genomics 9:288. 2008
  4. ncbi Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes
    Jeff W Chou
    Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Bioinformatics 8:427. 2007
  5. ncbi Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
    Terrance P O'Hanlon
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 13:R69. 2011
  6. ncbi Toxicogenomics and environmental diseases: the search for biomarkers predictive of adverse effects
    R S Paules
    Toxicogenomics Facilitator and Director, NIEHS Microarray Group, National Center for Toxicogenomics, NIEHS, NIH, DHHS, USA
    Med Lav 97:322-3. 2006
  7. ncbi Moving forward in human cancer risk assessment
    Richard S Paules
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 119:739-43. 2011
  8. ncbi MAPS: a microarray project system for gene expression experiment information and data validation
    P R Bushel
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Bioinformatics 17:564-5. 2001
  9. ncbi Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats
    J M Seubert
    Division of Intramural Research, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Renal Physiol 289:F552-61. 2005
  10. ncbi Blood gene expression signatures predict exposure levels
    P R Bushel
    Biostatistics Branch, Environmental Stress and Cancer Group, Environmental Toxicology Program, Microarray Group, Cancer Biology Group, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 104:18211-6. 2007

Collaborators

  • P R Bushel
  • G A Boorman
  • Cynthia L Innes
  • Terrance P O'Hanlon
  • Yuxia Cui
  • Edward K Lobenhofer
  • Lingkang Huang
  • Alexandra N Heinloth
  • Jeff W Chou
  • J M Seubert
  • Barry P Sleckman
  • Jill E Hesse
  • Stela S Palii
  • Abigail J Holub
  • Beth A Helmink
  • Ruchir R Shah
  • Clarice R Weinberg
  • David M Umbach
  • Lisa G Rider
  • Mark F Gourley
  • Lu Gan
  • Rick Fannin
  • Deepak Mav
  • Frederick W Miller
  • Michael L Cunningham
  • Patrick Hurban
  • Jennifer M Fostel
  • Raymond W Tennant
  • Kevin Gerrish
  • Stella O Sieber
  • Richard D Irwin
  • Pamela E Blackshear
  • Charles J Tucker
  • J Todd Auman
  • Zhao Bang Zeng
  • David E Malarkey
  • Sandra M Ward
  • B Alex Merrick
  • Ralph E Wilson
  • Zhao-Bang Zeng
  • William K Kaufmann
  • Tong Zhou
  • D L Kroetz
  • J P Graves
  • J B Collins
  • F Xu
  • S O Sieber
  • D C Zeldin

Detail Information

Publications11

  1. ncbi DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs
    Cynthia L Innes
    Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Genomics 14:163. 2013
    ..Here we compare transcriptional responses to physiological DNA breaks with responses to genotoxic DNA damage induced by ionizing radiation...
  2. ncbi Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
    Edward K Lobenhofer
    Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA
    Genome Biol 9:R100. 2008
    ..The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data...
  3. ncbi Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants
    Lingkang Huang
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Genomics 9:288. 2008
    ....
  4. ncbi Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes
    Jeff W Chou
    Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Bioinformatics 8:427. 2007
    ..The approach utilizes the underlying structure of gene expression data to extract patterns and identify co-expressed genes that are responsive to experimental conditions...
  5. ncbi Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
    Terrance P O'Hanlon
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 13:R69. 2011
    ..The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders...
  6. ncbi Toxicogenomics and environmental diseases: the search for biomarkers predictive of adverse effects
    R S Paules
    Toxicogenomics Facilitator and Director, NIEHS Microarray Group, National Center for Toxicogenomics, NIEHS, NIH, DHHS, USA
    Med Lav 97:322-3. 2006
  7. ncbi Moving forward in human cancer risk assessment
    Richard S Paules
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 119:739-43. 2011
    ..This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited predictive value for human risks...
  8. ncbi MAPS: a microarray project system for gene expression experiment information and data validation
    P R Bushel
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Bioinformatics 17:564-5. 2001
    ....
  9. ncbi Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats
    J M Seubert
    Division of Intramural Research, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Renal Physiol 289:F552-61. 2005
    ..Together, our data highlight the complexity of hypertension and the numerous genes involved in and affected by this condition...
  10. ncbi Blood gene expression signatures predict exposure levels
    P R Bushel
    Biostatistics Branch, Environmental Stress and Cancer Group, Environmental Toxicology Program, Microarray Group, Cancer Biology Group, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 104:18211-6. 2007
    ..It also supports the potential use of genomic markers in the blood as surrogates for clinical markers of potential acute liver damage...
  11. ncbi Use of transcriptomics in understanding mechanisms of drug-induced toxicity
    Yuxia Cui
    Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, Mail Drop D2 03, PO Box 12233, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Pharmacogenomics 11:573-85. 2010
    ..Related issues have been discussed, including extrapolation of mechanistic findings from experimental model systems to humans using blood as a surrogate tissue for organ damage and comparative systems biology approaches...