R S Paules

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genome-wide small RNA sequencing and gene expression analysis reveals a microRNA profile of cancer susceptibility in ATM-deficient human mammary epithelial cells
    Jill E Hesse
    Environmental Stress and Cancer Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 8:e64779. 2013
  2. pmc Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue
    J Todd Auman
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 115:572-8. 2007
  3. pmc DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs
    Cynthia L Innes
    Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Genomics 14:163. 2013
  4. pmc Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
    Edward K Lobenhofer
    Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA
    Genome Biol 9:R100. 2008
  5. pmc Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants
    Lingkang Huang
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Genomics 9:288. 2008
  6. pmc Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes
    Jeff W Chou
    Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Bioinformatics 8:427. 2007
  7. pmc Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
    Terrance P O'Hanlon
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 13:R69. 2011
  8. ncbi request reprint Toxicogenomics and environmental diseases: the search for biomarkers predictive of adverse effects
    R S Paules
    Toxicogenomics Facilitator and Director, NIEHS Microarray Group, National Center for Toxicogenomics, NIEHS, NIH, DHHS, USA
    Med Lav 97:322-3. 2006
  9. pmc Moving forward in human cancer risk assessment
    Richard S Paules
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 119:739-43. 2011
  10. ncbi request reprint MAPS: a microarray project system for gene expression experiment information and data validation
    P R Bushel
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Bioinformatics 17:564-5. 2001

Collaborators

  • P R Bushel
  • R W Tennant
  • Qihong Huang
  • Cynthia L Innes
  • J Todd Auman
  • L Huang
  • J Li
  • D C Zeldin
  • F Xu
  • G A Boorman
  • Yuxia Cui
  • Jill E Hesse
  • Terrance P O'Hanlon
  • Edward K Lobenhofer
  • Jeff W Chou
  • J M Seubert
  • Stela S Palii
  • Liwen Liu
  • Lu Gan
  • Deepak Mav
  • Rick Fannin
  • Mark F Gourley
  • Frederick W Miller
  • Lisa G Rider
  • Clarice R Weinberg
  • Ruchir R Shah
  • David M Umbach
  • Sandra M Ward
  • B Alex Merrick
  • David E Malarkey
  • Kevin Gerrish
  • Pamela E Blackshear
  • Stella O Sieber
  • Alexandra N Heinloth
  • Ralph E Wilson
  • Michael L Cunningham
  • Patrick Hurban
  • Jennifer M Fostel
  • Charles J Tucker
  • Richard D Irwin
  • William K Kaufmann
  • Tong Zhou
  • D L Kroetz
  • S O Sieber
  • J B Collins
  • J P Graves
  • N Rhodes
  • A B Kasenally
  • R Hicks
  • F Propst

Detail Information

Publications14

  1. pmc Genome-wide small RNA sequencing and gene expression analysis reveals a microRNA profile of cancer susceptibility in ATM-deficient human mammary epithelial cells
    Jill E Hesse
    Environmental Stress and Cancer Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 8:e64779. 2013
    ....
  2. pmc Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue
    J Todd Auman
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 115:572-8. 2007
    ..Toxicogenomics experiments often reveal thousands of transcript alterations that are related to multiple processes, making it difficult to identify key gene changes that are related to the toxicity of interest...
  3. pmc DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs
    Cynthia L Innes
    Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    BMC Genomics 14:163. 2013
    ..Here we compare transcriptional responses to physiological DNA breaks with responses to genotoxic DNA damage induced by ionizing radiation...
  4. pmc Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
    Edward K Lobenhofer
    Cogenics, Division of Clinical Data, Inc, Morrisville, NC 27560, USA
    Genome Biol 9:R100. 2008
    ..The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data...
  5. pmc Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants
    Lingkang Huang
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Genomics 9:288. 2008
    ....
  6. pmc Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes
    Jeff W Chou
    Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    BMC Bioinformatics 8:427. 2007
    ..The approach utilizes the underlying structure of gene expression data to extract patterns and identify co-expressed genes that are responsive to experimental conditions...
  7. pmc Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases
    Terrance P O'Hanlon
    Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 13:R69. 2011
    ..The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders...
  8. ncbi request reprint Toxicogenomics and environmental diseases: the search for biomarkers predictive of adverse effects
    R S Paules
    Toxicogenomics Facilitator and Director, NIEHS Microarray Group, National Center for Toxicogenomics, NIEHS, NIH, DHHS, USA
    Med Lav 97:322-3. 2006
  9. pmc Moving forward in human cancer risk assessment
    Richard S Paules
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 119:739-43. 2011
    ..This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited predictive value for human risks...
  10. ncbi request reprint MAPS: a microarray project system for gene expression experiment information and data validation
    P R Bushel
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Bioinformatics 17:564-5. 2001
    ....
  11. pmc Blood gene expression signatures predict exposure levels
    P R Bushel
    Biostatistics Branch, Environmental Stress and Cancer Group, Environmental Toxicology Program, Microarray Group, Cancer Biology Group, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 104:18211-6. 2007
    ..It also supports the potential use of genomic markers in the blood as surrogates for clinical markers of potential acute liver damage...
  12. ncbi request reprint v-mos-transformed cells fail to enter quiescence but growth arrest in G1 following serum withdrawal
    N Rhodes
    Growth Control and Cancer Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Exp Cell Res 213:210-7. 1994
    ..Our results suggest that the v-mos oncoprotein transforms cells, at least in part, by preventing exit from the cell cycle into quiescence...
  13. ncbi request reprint Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats
    J M Seubert
    Division of Intramural Research, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Renal Physiol 289:F552-61. 2005
    ..Together, our data highlight the complexity of hypertension and the numerous genes involved in and affected by this condition...
  14. pmc Use of transcriptomics in understanding mechanisms of drug-induced toxicity
    Yuxia Cui
    Environmental Stress and Cancer Group, National Institute of Environmental Health Sciences, Mail Drop D2 03, PO Box 12233, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Pharmacogenomics 11:573-85. 2010
    ..Related issues have been discussed, including extrapolation of mechanistic findings from experimental model systems to humans using blood as a surrogate tissue for organ damage and comparative systems biology approaches...