J T Patton

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Rotavirus diversity and evolution in the post-vaccine world
    John T Patton
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Discov Med 13:85-97. 2012
  2. ncbi request reprint Rotavirus genome replication and morphogenesis: role of the viroplasm
    J T Patton
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, MSC 8026, Room 6314, Bethesda, MD 20892 8026, USA
    Curr Top Microbiol Immunol 309:169-87. 2006
  3. pmc Effect of intragenic rearrangement and changes in the 3' consensus sequence on NSP1 expression and rotavirus replication
    J T Patton
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 75:2076-86. 2001
  4. ncbi request reprint Open reading frame in rotavirus mRNA specifically promotes synthesis of double-stranded RNA: template size also affects replication efficiency
    J T Patton
    National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, MSC 0720, Room 117, Bethesda, Maryland 20892, USA
    Virology 264:167-80. 1999
  5. pmc RNA-binding and capping activities of proteins in rotavirus open cores
    J T Patton
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:1382-91. 1999
  6. ncbi request reprint Multimers of the bluetongue virus nonstructural protein, NS2, possess nucleotidyl phosphatase activity: similarities between NS2 and rotavirus NSP2
    Z F Taraporewala
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, Bethesda, Maryland 20892, USA
    Virology 280:221-31. 2001
  7. ncbi request reprint Rotavirus RNA replication and gene expression
    J T Patton
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, MSC 0720, Room 117, Bethesda, MD 20892, USA
    Novartis Found Symp 238:64-77; discussion 77-81. 2001
  8. ncbi request reprint Rotavirus nonstructural protein NSP2 self-assembles into octamers that undergo ligand-induced conformational changes
    P Schuck
    Division of Bioengineering and Physical Science, ORS, OD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:9679-87. 2001
  9. ncbi request reprint Features of the 3'-consensus sequence of rotavirus mRNAs critical to minus strand synthesis
    D Chen
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, MSC 0720, Room 117, Bethesda, Maryland, 20892, USA
    Virology 282:221-9. 2001
  10. pmc Identification and characterization of the helix-destabilizing activity of rotavirus nonstructural protein NSP2
    Z F Taraporewala
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 75:4519-27. 2001

Collaborators

  • Dexiang Chen
  • M Jones
  • V Chizhikov
  • V Gouvea
  • P Schuck
  • Yasutaka Hoshino
  • Z F Taraporewala
  • Michelle M Arnold
  • Kristen M Ogden
  • Jelle Matthijnssens
  • M Barro
  • A D Yang
  • J M Gilber
  • Harish N Ramanathan
  • Monica McNeal
  • Marc Van Ranst
  • Zenobia F Taraporewala
  • Lijuan Yuan
  • Peter P C Mertens
  • Gerry R Carner
  • Hongyan Yang
  • Karol Sestak
  • Shujing Rao
  • Dianjun Cao
  • M I Gorziglia
  • H B Greenberg
  • N Feng
  • P Mandiola
  • E Spencer

Detail Information

Publications17

  1. pmc Rotavirus diversity and evolution in the post-vaccine world
    John T Patton
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Discov Med 13:85-97. 2012
    ....
  2. ncbi request reprint Rotavirus genome replication and morphogenesis: role of the viroplasm
    J T Patton
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, MSC 8026, Room 6314, Bethesda, MD 20892 8026, USA
    Curr Top Microbiol Immunol 309:169-87. 2006
    ....
  3. pmc Effect of intragenic rearrangement and changes in the 3' consensus sequence on NSP1 expression and rotavirus replication
    J T Patton
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 75:2076-86. 2001
    ....
  4. ncbi request reprint Open reading frame in rotavirus mRNA specifically promotes synthesis of double-stranded RNA: template size also affects replication efficiency
    J T Patton
    National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, MSC 0720, Room 117, Bethesda, Maryland 20892, USA
    Virology 264:167-80. 1999
    ..In summary, rotavirus dsRNA synthesis is affected by many factors including cis-acting replication signals located in the 5'-UTR, 3'-UTR, and ORF of the mRNA as well as the size and possibly the AU content of the mRNA...
  5. pmc RNA-binding and capping activities of proteins in rotavirus open cores
    J T Patton
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:1382-91. 1999
    ....
  6. ncbi request reprint Multimers of the bluetongue virus nonstructural protein, NS2, possess nucleotidyl phosphatase activity: similarities between NS2 and rotavirus NSP2
    Z F Taraporewala
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, Bethesda, Maryland 20892, USA
    Virology 280:221-31. 2001
    ....
  7. ncbi request reprint Rotavirus RNA replication and gene expression
    J T Patton
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, MSC 0720, Room 117, Bethesda, MD 20892, USA
    Novartis Found Symp 238:64-77; discussion 77-81. 2001
    ..The NSP3-3'TE complex may mimic the function of complexes formed by eukaryotic poly(A)-tails and poly(A)-binding protein, thereby promoting more efficient translation of viral mRNAs...
  8. ncbi request reprint Rotavirus nonstructural protein NSP2 self-assembles into octamers that undergo ligand-induced conformational changes
    P Schuck
    Division of Bioengineering and Physical Science, ORS, OD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:9679-87. 2001
    ..Chen, D., and Patton, J. T. (1999) J. Virol. 73, 9934-9943) of its function as a molecular motor involved in the packaging of viral mRNA...
  9. ncbi request reprint Features of the 3'-consensus sequence of rotavirus mRNAs critical to minus strand synthesis
    D Chen
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, MSC 0720, Room 117, Bethesda, Maryland, 20892, USA
    Virology 282:221-9. 2001
    ..A single-stranded CC may be crucial for formation of an initiation complex for (-) strand synthesis consisting of viral RdRP, mRNA, and the dinucleotide pGpG...
  10. pmc Identification and characterization of the helix-destabilizing activity of rotavirus nonstructural protein NSP2
    Z F Taraporewala
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 75:4519-27. 2001
    ..The presence of SSB-like nonstructural proteins in two members of the family Reoviridae suggests a common mechanism of unwinding viral mRNA prior to packaging and subsequent minus-strand RNA synthesis...
  11. ncbi request reprint Reverse transcriptase adds nontemplated nucleotides to cDNAs during 5'-RACE and primer extension
    D Chen
    National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Biotechniques 30:574-80, 582. 2001
    ....
  12. ncbi request reprint Translation enhancer in the 3'-untranslated region of rotavirus gene 6 mRNA promotes expression of the major capsid protein VP6
    A D Yang
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Arch Virol 149:303-21. 2004
    ..The activity of the 3'-TEg6 is likely important for directing the efficient translation of the gene 6 mRNA at levels sufficient to provide the 780 copies of VP6 necessary for the assembly of each progeny virion...
  13. pmc Residues of the rotavirus RNA-dependent RNA polymerase template entry tunnel that mediate RNA recognition and genome replication
    Kristen M Ogden
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 85:1958-69. 2011
    ..Together, our findings suggest that distinct classes of VP1 residues interact with +RNA to mediate template recognition and dsRNA synthesis yet function in concert to promote viral RNA replication at appropriate times and rates...
  14. pmc Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains
    Michelle M Arnold
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892 8026, USA
    J Virol 85:1970-9. 2011
    ..Thus, RVs have evolved functionally distinct approaches for subverting the host antiviral response, a property consistent with the immense sequence variation noted for NSP1 proteins...
  15. pmc Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reassortment
    Jelle Matthijnssens
    Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    J Virol 84:2013-26. 2010
    ..Collectively, our data indicate that simian RVs are of diverse ancestry with genome constellations that originated largely by interspecies transmission and reassortment with nonhuman animal RVs...
  16. ncbi request reprint Identification of sequences in rotavirus mRNAs important for minus strand synthesis using antisense oligonucleotides
    M Barro
    , , Universidad de Santiago de Chile, Santiago, Chile
    Virology 288:71-80. 2001
    ....
  17. ncbi request reprint Rotavirus assembly - interaction of surface protein VP7 with middle layer protein VP6
    J M Gilber
    Stanford University School of Medicine, Department of Microbiology and Immunology and the Palo Alto V. A. Health Care System, California 9430, USA
    Arch Virol 146:1155-71. 2001
    ..VP6 IgA MAbs that have been shown to be protective in vivo, but not a nonprotective IgA MAb, can interfere with VP7 binding to VP6. This suggests that these IgA MAbs may protect against rotavirus infection by blocking rotavirus assembly...