Research Topics
Genomes and GenesSpecies | C G ParksSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotypeChristine G Parks
National Institute of Environmental Health Sciences, Durham, North Carolina, USA
Arthritis Rheum 52:1148-59. 2005..This study examined the seroprevalence of EBV in a population-based study of SLE patients from the southeastern United States, and potential interactions with CTLA-4 polymorphisms were assessed...
Occupational exposure to crystalline silica and autoimmune diseaseC G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Environ Health Perspect 107:793-802. 1999..The specific manifestation of this effect may depend on underlying differences in genetic susceptibility or other environmental exposures...
Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: a population-based, case-control study in the southeastern United StatesChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina 27709, USA
Arthritis Rheum 46:1840-50. 2002..We undertook this population-based study to examine the association between occupational silica exposure and SLE in the southeastern US...
Assessing exposure to crystalline silica from farm work: a population-based study in the Southeastern United StatesChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Ann Epidemiol 13:385-92. 2003..This study examines aspects of farm work that were used to estimate potential silica dust exposure in a population-based study conducted in the southeastern United States...
Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United StatesC G Parks
National Institute of Environmental Health Sciences, NIH, DHHS, Durham, NC, USA
Ann Rheum Dis 63:91-4. 2004..Interleukin (IL)1alpha and IL1beta, and their endogenous receptor antagonist (IL1Ra), have been related to the pathology of systemic lupus erythematosus (SLE), but the role of IL1 polymorphisms in the aetiology of SLE is unknown...
Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphismChristine G Parks
National Institute of Environmental Health Sciences, Durham, NC, USA
Hum Immunol 65:622-31. 2004..0, p < 0.00001) for the combined "HLA-DR3, TNF-alpha -308A, IL-1alpha -889C/C" genotype. These findings provide evidence of cytokine gene epistasis in SLE susceptibility...
CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United StatesC G Parks
Epidemiology Branch, A3 05, NIEHS, NIH, DHHS, PO Box 12233, Durham, North Carolina 27709 12233, USA
Lupus 13:784-91. 2004..These findings suggest allelic variation in this region of CTLA4 is not a major independent risk factor for SLE, but may contribute to risk of disease in younger African-Americans or in the presence of certain immunogenetic markers...
Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United StatesG S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
Lupus 11:161-7. 2002..The prevalence of oral or nasal ulcers and anti-DNA autoantibodies declined with age. The extent to which the differences we observed reflect genetic or environmental influences on the disease process should be investigated...
Comparing questionnaire-based methods to assess occupational silica exposureChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Epidemiology 15:433-41. 2004....
Childhood agricultural and adult occupational exposures to organic dusts in a population-based case-control study of systemic lupus erythematosusC G Parks
Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Lupus 17:711-9. 2008....
Occupational and environmental exposures as risk factors for systemic lupus erythematosusGlinda S Cooper
Epidemiology Branch MDA3 05, National Institute of Environmental Health Sciences, PO Box 12233, Durham, NC 27709, USA
Curr Rheumatol Rep 6:367-74. 2004..There are numerous avenues with respect to environmental factors in SLE that need additional research...
Telomere length, current perceived stress, and urinary stress hormones in womenChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27599, USA
Cancer Epidemiol Biomarkers Prev 18:551-60. 2009....
Occupational risk factors for the development of systemic lupus erythematosusGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
J Rheumatol 31:1928-33. 2004..We examined the association between the risk of SLE and occupational exposures (mercury, solvents, and pesticides), specific jobs (ever worked in teaching, healthcare, and cosmetology), and working night or rotating shifts...
Total serum IgE levels in systemic lupus erythematosus and associations with childhood onset allergiesC G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, NC 27599, USA
Lupus 19:1614-22. 2010..Future studies may want to explore potentially shared risk factors for development of allergy, atopy, and SLE...
Occupational and environmental associations with antinuclear antibodies in a general population sampleGlinda S Cooper
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina 27709, USA
J Toxicol Environ Health A 69:2063-9. 2006..Larger studies addressing these exposures may provide insights into the mechanisms by which various environmental factors affect the development of autoantibodies and the progression to clinical disease...
Obesity and weight gain in adulthood and telomere lengthSangmi Kim
Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, P O Box 12233, MD A3 05, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
Cancer Epidemiol Biomarkers Prev 18:816-20. 2009..33; 95% confidence interval, 1.30-1.36). These findings support the hypothesis that obesity may accelerate aging, and highlight the importance of maintaining a desirable weight in adulthood...
Employment and work schedule are related to telomere length in womenC G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, National Insititues of Health, Research Triangle Park, NC 27599, USA
Occup Environ Med 68:582-9. 2011....
Multivitamin use and telomere length in womenQun Xu
Epidemiology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Am J Clin Nutr 89:1857-63. 2009..Telomere length may be a marker of biological aging. Multivitamin supplements represent a major source of micronutrients, which may affect telomere length by modulating oxidative stress and chronic inflammation...
Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control studySusan L Hogan
UNC Kidney Center and Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7155, USA
Clin J Am Soc Nephrol 2:290-9. 2007..Exposure to silica from specific farming tasks related to harvesting may be of particular importance in the southeastern United States. Interval of time since last exposure did not influence development of ANCA-SVV...
Occupational exposures and risk of systemic lupus erythematosusChristine G Parks
Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Autoimmunity 38:497-506. 2005..g. high-titer autoantibodies) in occupational cohorts with well-characterized exposure histories may reveal occupational risk factors for autoimmunity, and may also provide baseline data for studies of determinants of progression to SLE...
Variation in the WBC differential count and other factors associated with reporting of herpes labialis: a population-based study of adultsChristine G Parks
Biostatistics and Epidemiology Branch and Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
FEMS Immunol Med Microbiol 51:336-43. 2007..Prospective studies may help to show whether such differences indicate susceptibility to loss of latency or represent a consequence of reactivated infection...
Analytical performance of the AtheNA MultiLyte ANA II assay in sera from lupus patients with multiple positive ANAsRaymond E Biagini
Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health NIOSH, Center for Disease Control and Prevention, Cincinnati, OH, 45226, USA
Anal Bioanal Chem 388:613-8. 2007..It also appears that the AtheNA assay identifies positive ANA specificities which are missed by ID techniques, suggesting that it may have greater analytical sensitivity for some ANAs...
Work, obesity, and occupational safety and healthPaul A Schulte
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
Am J Public Health 97:428-36. 2007....
