Research Topics
Genomes and Genes
| Harish C PantSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model miceVarsha Shukla
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
FASEB J 27:174-86. 2013..In addition, treated mice displayed decreased inflammation, amyloid plaques, NFTs, cell death, and an extended life by 2 mo. These results suggest TFP5 as a potential therapeutic, toxicity-free candidate for AD...
Role of protein phosphatase 2A in Alzheimer's diseaseP Rudrabhatla
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Curr Alzheimer Res 8:623-32. 2011..The role of peptidyl prolyl isomerase Pin1 in regulation of PP2A mediated neurodegeneration is further analyzed. Development of drugs for AD could be based on restoration of PP2A activity or targeting Pin1...- A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylationYa Li Zheng
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 285:34202-12. 2010..These results suggest that p5 peptide may be a unique and useful candidate for therapeutic studies of certain neurodegenerative diseases... - Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament proteinParvathi Rudrabhatla
Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 283:26737-47. 2008..Thus, Pin1 may be a potential therapeutic target for these diseases... - Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survivalYa Li Zheng
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Mol Biol Cell 18:404-13. 2007..These results suggest that survival of cortical neurons is also dependent on tight Cdk5 modulation of the mitogen-activated protein kinase signaling pathway... - Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1Sashi Kesavapany
Cytoskeletal Protein Regulation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Neurosignals 15:157-73. 2006..These data show that phosphorylation of RasGRF1 by Cdk5 tightly regulates its levels, which is essential for proper cellular organization... - p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neuronsSashi Kesavapany
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 24:4421-31. 2004.... - A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neuronsYa Li Zheng
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
EMBO J 24:209-20. 2005..These results, therefore, provide a strategy to address, and possibly ameliorate, the pathology of neurodegenerative diseases that may be a consequence of aberrant p25 activation of Cdk5, without affecting 'normal' Cdk5 activity... - Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survivalBing Sheng Li
Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4130, USA
J Biol Chem 278:35702-9. 2003..These findings suggest that Cdk5 may exert a key role in promoting neuronal survival by regulating Akt activity through the neuregulin/PI 3-kinase signaling pathway... 
Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosisNiranjana D Amin
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 28:3631-43. 2008..These data suggest that Cdk5 phosphorylation of human septin SEPT5 at S327 plays a role in modulating exocytotic secretion...- Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neuronsSashi Kesavapany
Cytoskeletal Protein Regulation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Mol Biol Cell 18:3645-55. 2007.... - Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiationYa Li Zheng
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
Mol Biol Cell 21:3601-14. 2010..Cdk5 phosphorylation of p27(Kip1), a modular molecule, may regulate the progress of neuronal differentiation from cell cycle arrest through differentiation, neurite outgrowth, and migration... - Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stressTomoshige Kino
Reproductive Biology and Medicine Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
Mol Endocrinol 21:1552-68. 2007..Thus, CDK5 exerts some of its biological activities in neuronal cells through the GR, dynamically modulating GR transcriptional activity in a target promoter-dependent fashion... - The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteinsJyotshnabala Kanungo
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurochem 106:2236-48. 2008..These results establish a link between Notch signaling and cdk5 expression regulating neuronal cytoskeletal protein dynamics... - Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteinsParvathi Rudrabhatla
Laboratory of Neurochemistry, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 29:14869-80. 2009..This study highlights a novel signaling role of PP2A by Pin1 and implicates Pin1 as a therapeutic target to reduce aberrant phosphorylation of NF proteins in neurodegenerative disorders such as AD, PD, and ALS... - Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1Tej K Pareek
Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:660-5. 2007..Thus, the present study indicates that Cdk5-mediated TRPV1 phosphorylation is important in the regulation of pain signaling... - Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35Elias Utreras
Functional Genomics Section, Laboratory of Cell and Developmental Biology, NIDCR, NIH, Bethesda, MD 20892, USA
J Biol Chem 284:2275-84. 2009..These findings suggest that TNF-alpha-mediated regulation of Cdk5 activity plays an important role in inflammation-induced pain signaling... - Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptideSashi Kesavapany
Cytoskeletal Protein Regulation Section, Laboratory of Neurochemistry, Building 36, Room 4D-28, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Biochim Biophys Acta 1697:143-53. 2004..This may well provide us with avenues of research focusing on the inhibition of pathologically damaging p25/Cdk5 species... - Phosphorylation of the head domain of neurofilament protein (NF-M): a factor regulating topographic phosphorylation of NF-M tail domain KSP sites in neuronsYa Li Zheng
Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:24026-32. 2003..This is consistent with our hypothesis that transient phosphorylation of NF-M head domains inhibits tail domain phosphorylation and suggests this as one of several mechanisms underlying topographic regulation... - Squid (Loligo pealei) giant fiber system: a model for studying neurodegeneration and dementia?Philip Grant
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Bull 210:318-33. 2006.... - Cyclin-dependent kinase 5 activity regulates pain signalingTej K Pareek
Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:791-6. 2006..In conclusion, our data demonstrate a role for Cdk5/p35 activity in primary afferent nociceptive signaling, suggesting that Cdk5/p35 may be a target for the development of analgesic drugs... - Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5Jyotshnabala Kanungo
Laboratory of Neurochemistry, National Institutes of Neurological Disorders and Stroke, Bethesda, MD 20892 4130, USA
Neurosci Lett 412:233-8. 2007..SiRNA-mediated cdk5 knockdown resulted in a reduction in primary sensory neurons of the trigeminal ganglia of the peripheral nervous system, suggesting that cdk5 plays a crucial role in the development of the peripheral nervous system... - Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neuronsAkira Futatsugi
Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Cell Cycle 11:1603-10. 2012..Most importantly, increased Cdk5 activity induces cell cycle re-entry, which is especially detrimental for survival of postmitotic neurons... - Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factorTomoshige Kino
Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
Mol Endocrinol 24:941-52. 2010.... - Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQParvathi Rudrabhatla
Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
FASEB J 24:4396-407. 2010.... - A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cellsYa Li Zheng
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda 20892, USA
Eur J Biochem 269:4427-34. 2002..The elucidation of the molecular basis of p25 activation and CIP inhibition of Cdk5 activity may provide insight into mechanisms underlying the pathology of Alzheimer's disease and contribute to therapeutic strategies... - Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTsParvathi Rudrabhatla
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
FASEB J 25:3896-905. 2011..In corresponding matched control preparations of PHF/NFTs, none of these phosphorylated neuronal cytoskeletal proteins were found. These studies independently demonstrate that NF proteins are an integral part of NFTs in AD brains... - Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivoJyotshnabala Kanungo
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
Biochem Biophys Res Commun 386:263-7. 2009..Thus, modulating cdk5 activity seems promising in inducing motor neuron development in vivo... - Phosphorylation-specific peptidyl-prolyl isomerization of neuronal cytoskeletal proteins by Pin1: implications for therapeutics in neurodegenerationParvathi Rudrabhatla
Laboratory of Neurochemistry, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
J Alzheimers Dis 19:389-403. 2010..Pin1 mediates the neural specific apoptosis machinery. The specific inhibitors of Pin1 may have potential therapeutic implications in neurodegeneration... - Cyclin-dependent kinase 5 in neurofilament function and regulationSashi Kesavapany
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md. 20892, USA
Neurosignals 12:252-64. 2003..Here we review the functions of neurofilaments and the significance of Cdk5 phosphorylation of neurofilaments... - Zebrafish Rohon-Beard neuron development: cdk5 in the midstJyotshnabala Kanungo
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
Neurochem Res 34:1129-37. 2009..Based on ours studies and others', here we discuss possible mechanisms that may be involved in cdk5's role in RB neuron development and survival... - Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defectsMotoyuki Hirasawa
Functional Genomics Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:6249-54. 2004..These results indicate that abrogation of Cdk5 expression in mature neurons results in a viable mouse model that offers further opportunities to investigate the molecular roles of Cdk5 in the adult CNS... - Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubulesSatoru Takahashi
Functional Genomics Unit, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:10506-15. 2003..Our data suggest that tau phosphorylation by Cdk5 may provide the neuronal microtubules with dynamic properties in a region-specific and developmentally regulated manner... - Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3Bing Sheng Li
Laboratory of Neurochemistry, NINDS, NIH, Bethesda, MD 20892 4130, USA
EMBO J 21:324-33. 2002..Taken together, these findings show that cdk5 may exert its role as a key element by negatively regulating the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway during neuronal apoptosis... - Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signalingSatoru Takahashi
Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:1737-42. 2005..These results support the idea that Cdk5 activity is involved in altered gene expression after chronic exposure to cocaine and hence impacts the long-lasting changes in neuronal function underlying cocaine addiction... - Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosisYa Li Zheng
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA
J Neurol Sci 299:101-7. 2010..It is consistent with the view that Alzheimer's disease and T2DM are linked metabolically and pathologically by Cdk5 in a number of ways... - Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filamentsRam K Sihag
Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Bldg 49 Room 2A28, MD 20892, USA
Exp Cell Res 313:2098-109. 2007..The role of IF phosphorylation in disease pathobiology is discussed... - Cyclin-dependent kinase 5 influences Rohon-Beard neuron survival in zebrafishJyotshnabala Kanungo
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurochem 99:251-9. 2006..In these embryos, RB neuron apoptosis was inhibited compared with the uninjected control embryos. These results suggest that in zebrafish, cdk5 influences RB neuron survival and potentially regulates early neuronal development... - Myelin-associated glycoprotein modulates expression and phosphorylation of neuronal cytoskeletal elements and their associated kinasesSuzanne M Dashiell
Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
J Neurochem 81:1263-72. 2002..We propose that interaction of MAG with an axonal receptor(s) induces a signal transduction cascade that regulates expression of cytoskeletal proteins and their phosphorylation by these proline-directed protein kinases... - Topographic regulation of kinase activity in Alzheimer's disease brainsPhilip Grant
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Alzheimers Dis 4:269-81. 2002..We believe that such differences in P13 complexes from human control and AD brain samples displaying extensive heterogeneity in age, post mortem time and clinical history, may be important... - Targeting Cdk5 activity in neuronal degeneration and regenerationJyotshnabala Kanungo
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Cell Mol Neurobiol 29:1073-80. 2009..Here, we discuss the therapeutic potential of CIP in regenerating neurons that are exposed to neurodegenerative stimuli... - Topographic regulation of phosphorylation in giant neurons of the squid, Loligo pealei: role of phosphatasesPhilip Grant
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, LNC, NINDS, Bldg. 36, Rm. 4D04, Bethesda, Maryland 20892, USA
J Neurobiol 58:514-28. 2004..The data are consistent with the hypothesis that neuronal protein phosphorylation in axons and cell bodies is modulated by different phosphatases associated with compartment-specific multimeric complexes... - Phosphoproteomic analysis of synaptosomes from human cerebral cortexJoseph A DeGiorgis
Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Proteome Res 4:306-15. 2005..The study shows that new phosphoproteomic strategies can be used to analyze subcellular fractions from small amounts of tissue for the identification of phosphorylated residues for research and potentially for diagnostic purposes... - Oxidative stress in neurodegenerationVarsha Shukla
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Adv Pharmacol Sci 2011:572634. 2011..The last part of the paper describes the role of oxidative stress causing deregulation of cyclin-dependent kinase 5 (Cdk5) hyperactivity associated with neurodegeneration... - Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35Niranjana D Amin
Laboratory of Neurochemistry, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci Res 67:354-62. 2002.... - Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathwayAbeba Demelash
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Mol Biol Cell 23:2856-66. 2012..We were also able to show that p35 was a direct target for hASH1. In conclusion, induction of Cdk5 activity is a novel mechanism through which hASH1 may regulate migration in lung carcinogenesis... - Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathwayPushkar Sharma
Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:528-34. 2002..Harada, T., Morooka, T., Ogawa, S., and Nishida, E. (2001) Nat. Cell Biol. 3, 453-459) have prompted us to propose a model for feedback down-regulation of the MAP kinase signal cascade by cdk5 inactivation of MEK1... - Deregulated Cdk5 activity is involved in inducing Alzheimer's diseaseVarsha Shukla
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Arch Med Res 43:655-62. 2012..This review briefly describes the above-mentioned aspects of involvement of Cdk5 in the pathology of AD and at the end summarizes the advances in Cdk5 as a therapeutic target...