Harish C Pant

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Oxidative stress in neurodegeneration
    Varsha Shukla
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Adv Pharmacol Sci 2011:572634. 2011
  2. pmc Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
    Mol Biol Cell 21:3601-14. 2010
  3. ncbi request reprint Role of protein phosphatase 2A in Alzheimer's disease
    P Rudrabhatla
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Alzheimer Res 8:623-32. 2011
  4. pmc A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:34202-12. 2010
  5. ncbi request reprint Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1
    Sashi Kesavapany
    Cytoskeletal Protein Regulation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neurosignals 15:157-73. 2006
  6. ncbi request reprint p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons
    Sashi Kesavapany
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:4421-31. 2004
  7. pmc Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein
    Parvathi Rudrabhatla
    Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:26737-47. 2008
  8. doi request reprint Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis
    Niranjana D Amin
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:3631-43. 2008
  9. pmc Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 18:404-13. 2007
  10. pmc Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons
    Sashi Kesavapany
    Cytoskeletal Protein Regulation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 18:3645-55. 2007

Collaborators

Detail Information

Publications52

  1. pmc Oxidative stress in neurodegeneration
    Varsha Shukla
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Adv Pharmacol Sci 2011:572634. 2011
    ..The last part of the paper describes the role of oxidative stress causing deregulation of cyclin-dependent kinase 5 (Cdk5) hyperactivity associated with neurodegeneration...
  2. pmc Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
    Mol Biol Cell 21:3601-14. 2010
    ..Cdk5 phosphorylation of p27(Kip1), a modular molecule, may regulate the progress of neuronal differentiation from cell cycle arrest through differentiation, neurite outgrowth, and migration...
  3. ncbi request reprint Role of protein phosphatase 2A in Alzheimer's disease
    P Rudrabhatla
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Alzheimer Res 8:623-32. 2011
    ..The role of peptidyl prolyl isomerase Pin1 in regulation of PP2A mediated neurodegeneration is further analyzed. Development of drugs for AD could be based on restoration of PP2A activity or targeting Pin1...
  4. pmc A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:34202-12. 2010
    ..These results suggest that p5 peptide may be a unique and useful candidate for therapeutic studies of certain neurodegenerative diseases...
  5. ncbi request reprint Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1
    Sashi Kesavapany
    Cytoskeletal Protein Regulation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neurosignals 15:157-73. 2006
    ..These data show that phosphorylation of RasGRF1 by Cdk5 tightly regulates its levels, which is essential for proper cellular organization...
  6. ncbi request reprint p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons
    Sashi Kesavapany
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:4421-31. 2004
    ....
  7. pmc Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein
    Parvathi Rudrabhatla
    Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:26737-47. 2008
    ..Thus, Pin1 may be a potential therapeutic target for these diseases...
  8. doi request reprint Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis
    Niranjana D Amin
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:3631-43. 2008
    ..These data suggest that Cdk5 phosphorylation of human septin SEPT5 at S327 plays a role in modulating exocytotic secretion...
  9. pmc Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 18:404-13. 2007
    ..These results suggest that survival of cortical neurons is also dependent on tight Cdk5 modulation of the mitogen-activated protein kinase signaling pathway...
  10. pmc Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons
    Sashi Kesavapany
    Cytoskeletal Protein Regulation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 18:3645-55. 2007
    ....
  11. pmc A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
    EMBO J 24:209-20. 2005
    ..These results, therefore, provide a strategy to address, and possibly ameliorate, the pathology of neurodegenerative diseases that may be a consequence of aberrant p25 activation of Cdk5, without affecting 'normal' Cdk5 activity...
  12. ncbi request reprint Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
    Bing Sheng Li
    Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4130, USA
    J Biol Chem 278:35702-9. 2003
    ..These findings suggest that Cdk5 may exert a key role in promoting neuronal survival by regulating Akt activity through the neuregulin/PI 3-kinase signaling pathway...
  13. ncbi request reprint Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress
    Tomoshige Kino
    Reproductive Biology and Medicine Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Mol Endocrinol 21:1552-68. 2007
    ..Thus, CDK5 exerts some of its biological activities in neuronal cells through the GR, dynamically modulating GR transcriptional activity in a target promoter-dependent fashion...
  14. pmc Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins
    Parvathi Rudrabhatla
    Laboratory of Neurochemistry, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:14869-80. 2009
    ..This study highlights a novel signaling role of PP2A by Pin1 and implicates Pin1 as a therapeutic target to reduce aberrant phosphorylation of NF proteins in neurodegenerative disorders such as AD, PD, and ALS...
  15. pmc Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1
    Tej K Pareek
    Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:660-5. 2007
    ..Thus, the present study indicates that Cdk5-mediated TRPV1 phosphorylation is important in the regulation of pain signaling...
  16. ncbi request reprint Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide
    Sashi Kesavapany
    Cytoskeletal Protein Regulation Section, Laboratory of Neurochemistry, Building 36, Room 4D 28, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1697:143-53. 2004
    ..This may well provide us with avenues of research focusing on the inhibition of pathologically damaging p25/Cdk5 species...
  17. pmc The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins
    Jyotshnabala Kanungo
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 106:2236-48. 2008
    ..These results establish a link between Notch signaling and cdk5 expression regulating neuronal cytoskeletal protein dynamics...
  18. pmc Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35
    Elias Utreras
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, NIDCR, NIH, Bethesda, MD 20892, USA
    J Biol Chem 284:2275-84. 2009
    ..These findings suggest that TNF-alpha-mediated regulation of Cdk5 activity plays an important role in inflammation-induced pain signaling...
  19. pmc Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ
    Parvathi Rudrabhatla
    Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    FASEB J 24:4396-407. 2010
    ....
  20. pmc Cyclin-dependent kinase 5 activity regulates pain signaling
    Tej K Pareek
    Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:791-6. 2006
    ..In conclusion, our data demonstrate a role for Cdk5/p35 activity in primary afferent nociceptive signaling, suggesting that Cdk5/p35 may be a target for the development of analgesic drugs...
  21. pmc A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice
    Varsha Shukla
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 27:174-86. 2013
    ..In addition, treated mice displayed decreased inflammation, amyloid plaques, NFTs, cell death, and an extended life by 2 mo. These results suggest TFP5 as a potential therapeutic, toxicity-free candidate for AD...
  22. ncbi request reprint Squid (Loligo pealei) giant fiber system: a model for studying neurodegeneration and dementia?
    Philip Grant
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Bull 210:318-33. 2006
    ....
  23. pmc Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons
    Akira Futatsugi
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 11:1603-10. 2012
    ..Most importantly, increased Cdk5 activity induces cell cycle re-entry, which is especially detrimental for survival of postmitotic neurons...
  24. pmc Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor
    Tomoshige Kino
    Unit on Molecular Hormone Action, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Mol Endocrinol 24:941-52. 2010
    ....
  25. pmc Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3
    Bing Sheng Li
    Laboratory of Neurochemistry, NINDS, NIH, Bethesda, MD 20892 4130, USA
    EMBO J 21:324-33. 2002
    ..Taken together, these findings show that cdk5 may exert its role as a key element by negatively regulating the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway during neuronal apoptosis...
  26. ncbi request reprint Phosphorylation of the head domain of neurofilament protein (NF-M): a factor regulating topographic phosphorylation of NF-M tail domain KSP sites in neurons
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:24026-32. 2003
    ..This is consistent with our hypothesis that transient phosphorylation of NF-M head domains inhibits tail domain phosphorylation and suggests this as one of several mechanisms underlying topographic regulation...
  27. ncbi request reprint A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda 20892, USA
    Eur J Biochem 269:4427-34. 2002
    ..The elucidation of the molecular basis of p25 activation and CIP inhibition of Cdk5 activity may provide insight into mechanisms underlying the pathology of Alzheimer's disease and contribute to therapeutic strategies...
  28. doi request reprint Zebrafish Rohon-Beard neuron development: cdk5 in the midst
    Jyotshnabala Kanungo
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
    Neurochem Res 34:1129-37. 2009
    ..Based on ours studies and others', here we discuss possible mechanisms that may be involved in cdk5's role in RB neuron development and survival...
  29. pmc Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5
    Jyotshnabala Kanungo
    Laboratory of Neurochemistry, National Institutes of Neurological Disorders and Stroke, Bethesda, MD 20892 4130, USA
    Neurosci Lett 412:233-8. 2007
    ..SiRNA-mediated cdk5 knockdown resulted in a reduction in primary sensory neurons of the trigeminal ganglia of the peripheral nervous system, suggesting that cdk5 plays a crucial role in the development of the peripheral nervous system...
  30. doi request reprint Topographic regulation of neuronal intermediate filaments by phosphorylation, role of peptidyl-prolyl isomerase 1: significance in neurodegeneration
    B K Binukumar
    Laboratory of Neuronal Cytoskeletal Protein Regulation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Histochem Cell Biol 140:23-32. 2013
    ..In addition, special emphasis has been given to describe the role of phosphatases and Pin1 in phosphorylation of NFs. ..
  31. doi request reprint Phosphorylation-specific peptidyl-prolyl isomerization of neuronal cytoskeletal proteins by Pin1: implications for therapeutics in neurodegeneration
    Parvathi Rudrabhatla
    Laboratory of Neurochemistry, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    J Alzheimers Dis 19:389-403. 2010
    ..Pin1 mediates the neural specific apoptosis machinery. The specific inhibitors of Pin1 may have potential therapeutic implications in neurodegeneration...
  32. pmc Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs
    Parvathi Rudrabhatla
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 25:3896-905. 2011
    ..In corresponding matched control preparations of PHF/NFTs, none of these phosphorylated neuronal cytoskeletal proteins were found. These studies independently demonstrate that NF proteins are an integral part of NFTs in AD brains...
  33. pmc Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo
    Jyotshnabala Kanungo
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4130, USA
    Biochem Biophys Res Commun 386:263-7. 2009
    ..Thus, modulating cdk5 activity seems promising in inducing motor neuron development in vivo...
  34. pmc Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway
    Abeba Demelash
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Biol Cell 23:2856-66. 2012
    ..We were also able to show that p35 was a direct target for hASH1. In conclusion, induction of Cdk5 activity is a novel mechanism through which hASH1 may regulate migration in lung carcinogenesis...
  35. ncbi request reprint Cyclin-dependent kinase 5 in neurofilament function and regulation
    Sashi Kesavapany
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neurosignals 12:252-64. 2003
    ..Here we review the functions of neurofilaments and the significance of Cdk5 phosphorylation of neurofilaments...
  36. pmc Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects
    Motoyuki Hirasawa
    Functional Genomics Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:6249-54. 2004
    ..These results indicate that abrogation of Cdk5 expression in mature neurons results in a viable mouse model that offers further opportunities to investigate the molecular roles of Cdk5 in the adult CNS...
  37. ncbi request reprint Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules
    Satoru Takahashi
    Functional Genomics Unit, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:10506-15. 2003
    ..Our data suggest that tau phosphorylation by Cdk5 may provide the neuronal microtubules with dynamic properties in a region-specific and developmentally regulated manner...
  38. pmc Impaired neurogenesis and neurite outgrowth in an HIV-gp120 transgenic model is reversed by exercise via BDNF production and Cdk5 regulation
    Myoung Hwa Lee
    Section of Infections of the Nervous System, National Institutes of Health, M D Bldg 10, Room 7C 103, 10 Center Drive, Bethesda, MD, 20892, USA
    J Neurovirol 19:418-31. 2013
    ..These results suggest that sustained exercise has trophic activity on the neuronal lineage which is mediated by Cdk5 modulation of the BDNF pathway. ..
  39. pmc Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments
    Ram K Sihag
    Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Bldg 49 Room 2A28, MD 20892, USA
    Exp Cell Res 313:2098-109. 2007
    ..The role of IF phosphorylation in disease pathobiology is discussed...
  40. pmc Deregulated Cdk5 activity is involved in inducing Alzheimer's disease
    Varsha Shukla
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Arch Med Res 43:655-62. 2012
    ..This review briefly describes the above-mentioned aspects of involvement of Cdk5 in the pathology of AD and at the end summarizes the advances in Cdk5 as a therapeutic target...
  41. pmc Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling
    Satoru Takahashi
    Functional Genomics Section, Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:1737-42. 2005
    ..These results support the idea that Cdk5 activity is involved in altered gene expression after chronic exposure to cocaine and hence impacts the long-lasting changes in neuronal function underlying cocaine addiction...
  42. ncbi request reprint Cyclin-dependent kinase 5 influences Rohon-Beard neuron survival in zebrafish
    Jyotshnabala Kanungo
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 99:251-9. 2006
    ..In these embryos, RB neuron apoptosis was inhibited compared with the uninjected control embryos. These results suggest that in zebrafish, cdk5 influences RB neuron survival and potentially regulates early neuronal development...
  43. doi request reprint Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosis
    Ya Li Zheng
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA
    J Neurol Sci 299:101-7. 2010
    ..It is consistent with the view that Alzheimer's disease and T2DM are linked metabolically and pathologically by Cdk5 in a number of ways...
  44. ncbi request reprint TFP5, a Peptide Derived from p35, a Cdk5 Neuronal Activator, Rescues Cortical Neurons from Glucose Toxicity
    Binukumar Bk
    Laboratory of Neuronal Cytoskeletal Protein Regulation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    J Alzheimers Dis 39:899-909. 2014
    ..Tau hyperphosphorylation, inflammation, and apoptosis induced by HG were also considerably reduced by pretreatment with TFP5. These results suggest that TFP5 peptide may be a novel candidate for type 2 diabetes therapy. ..
  45. ncbi request reprint Myelin-associated glycoprotein modulates expression and phosphorylation of neuronal cytoskeletal elements and their associated kinases
    Suzanne M Dashiell
    Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    J Neurochem 81:1263-72. 2002
    ..We propose that interaction of MAG with an axonal receptor(s) induces a signal transduction cascade that regulates expression of cytoskeletal proteins and their phosphorylation by these proline-directed protein kinases...
  46. ncbi request reprint Topographic regulation of kinase activity in Alzheimer's disease brains
    Philip Grant
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Alzheimers Dis 4:269-81. 2002
    ..We believe that such differences in P13 complexes from human control and AD brain samples displaying extensive heterogeneity in age, post mortem time and clinical history, may be important...
  47. doi request reprint Targeting Cdk5 activity in neuronal degeneration and regeneration
    Jyotshnabala Kanungo
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cell Mol Neurobiol 29:1073-80. 2009
    ..Here, we discuss the therapeutic potential of CIP in regenerating neurons that are exposed to neurodegenerative stimuli...
  48. pmc Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia
    Michaela Prochazkova
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Pain 9:66. 2013
    ....
  49. ncbi request reprint Topographic regulation of phosphorylation in giant neurons of the squid, Loligo pealei: role of phosphatases
    Philip Grant
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, LNC, NINDS, Bldg 36, Rm 4D04, Bethesda, Maryland 20892, USA
    J Neurobiol 58:514-28. 2004
    ..The data are consistent with the hypothesis that neuronal protein phosphorylation in axons and cell bodies is modulated by different phosphatases associated with compartment-specific multimeric complexes...
  50. ncbi request reprint Phosphoproteomic analysis of synaptosomes from human cerebral cortex
    Joseph A DeGiorgis
    Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Proteome Res 4:306-15. 2005
    ..The study shows that new phosphoproteomic strategies can be used to analyze subcellular fractions from small amounts of tissue for the identification of phosphorylated residues for research and potentially for diagnostic purposes...
  51. ncbi request reprint Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35
    Niranjana D Amin
    Laboratory of Neurochemistry, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci Res 67:354-62. 2002
    ....
  52. ncbi request reprint Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway
    Pushkar Sharma
    Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:528-34. 2002
    ..Harada, T., Morooka, T., Ogawa, S., and Nishida, E. (2001) Nat. Cell Biol. 3, 453-459) have prompted us to propose a model for feedback down-regulation of the MAP kinase signal cascade by cdk5 inactivation of MEK1...