Hesed M Padilla-Nash

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer
    Youfeng Yang
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1107, Bldg 10 CRC, Room 1 5942, Bethesda, MD 20892 1107
    Cancer Genet Cytogenet 196:45-55. 2010
  2. ncbi Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances
    Hesed M Padilla-Nash
    Genetics Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Genes Chromosomes Cancer 51:353-74. 2012
  3. ncbi A sequence-based survey of the complex structural organization of tumor genomes
    Benjamin J Raphael
    Department of Computer Science and Center for Computational Molecular Biology, Brown University, Waterman Street, Providence, RI 02912 1910, USA
    Genome Biol 9:R59. 2008
  4. ncbi Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms
    H M Padilla-Nash
    Genetics Department, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Chromosomes Cancer 30:349-63. 2001
  5. ncbi Spectral karyotyping demonstrates genetically unstable skin-homing T lymphocytes in cutaneous T-cell lymphoma
    Hesed M Padilla-Nash
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Exp Dermatol 16:98-103. 2007
  6. ncbi Spectral karyotyping analysis of human and mouse chromosomes
    Hesed M Padilla-Nash
    Genetics Branch, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, 50 South Drive MSC 8010, Bethesda, Maryland 20892, USA
    Nat Protoc 1:3129-42. 2006
  7. ncbi Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines
    Turid Knutsen
    Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 8010, USA
    Genes Chromosomes Cancer 49:204-23. 2010
  8. ncbi Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer
    Jordi Camps
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genes Chromosomes Cancer 48:1002-17. 2009
  9. ncbi Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation
    Masako Miura
    Dental Biology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 131, 30 Convent Drive MSC4320, Bethesda, Maryland 20892, USA
    Stem Cells 24:1095-103. 2006
  10. ncbi The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dubé gene pathway
    Youfeng Yang
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1W 5888, Bethesda, MD 20892, USA
    Cancer Genet Cytogenet 180:100-9. 2008

Collaborators

Detail Information

Publications11

  1. ncbi UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer
    Youfeng Yang
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1107, Bldg 10 CRC, Room 1 5942, Bethesda, MD 20892 1107
    Cancer Genet Cytogenet 196:45-55. 2010
    ..This tumor model is the embodiment of the Warburg effect. UOK 262 provides a unique in vitro and in vivo preclinical model for studying the bioenergetics of the Warburg effect in human cancer...
  2. ncbi Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances
    Hesed M Padilla-Nash
    Genetics Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Genes Chromosomes Cancer 51:353-74. 2012
    ....
  3. ncbi A sequence-based survey of the complex structural organization of tumor genomes
    Benjamin J Raphael
    Department of Computer Science and Center for Computational Molecular Biology, Brown University, Waterman Street, Providence, RI 02912 1910, USA
    Genome Biol 9:R59. 2008
    ..The genomes of many epithelial tumors exhibit extensive chromosomal rearrangements. All classes of genome rearrangements can be identified using end sequencing profiling, which relies on paired-end sequencing of cloned tumor genomes...
  4. ncbi Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms
    H M Padilla-Nash
    Genetics Department, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Chromosomes Cancer 30:349-63. 2001
    ..consequently resulting in tumor-specific genomic imbalances. Published 2001 Wiley-Liss, Inc...
  5. ncbi Spectral karyotyping demonstrates genetically unstable skin-homing T lymphocytes in cutaneous T-cell lymphoma
    Hesed M Padilla-Nash
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Exp Dermatol 16:98-103. 2007
    ..We did not see genetic instability or evidence of clones in cell lines from a patient with atopic dermatitis and one with psoriasis...
  6. ncbi Spectral karyotyping analysis of human and mouse chromosomes
    Hesed M Padilla-Nash
    Genetics Branch, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, 50 South Drive MSC 8010, Bethesda, Maryland 20892, USA
    Nat Protoc 1:3129-42. 2006
    ..SKY analysis requires approximately 6 d...
  7. ncbi Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines
    Turid Knutsen
    Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 8010, USA
    Genes Chromosomes Cancer 49:204-23. 2010
    ..The fact that chromosome abnormalities predominantly result in copy number changes rather than specific chromosome or gene fusions suggests that this may be the major mechanism leading to carcinogenesis in colorectal cancer...
  8. ncbi Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer
    Jordi Camps
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genes Chromosomes Cancer 48:1002-17. 2009
    ....
  9. ncbi Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation
    Masako Miura
    Dental Biology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 131, 30 Convent Drive MSC4320, Bethesda, Maryland 20892, USA
    Stem Cells 24:1095-103. 2006
    ..BMMSCs/fibrosarcoma transformation system may provide an ideal system to elucidate the mechanism of how stem cells become cancer cells and to screen anti-sarcoma drugs...
  10. ncbi The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dubé gene pathway
    Youfeng Yang
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1W 5888, Bethesda, MD 20892, USA
    Cancer Genet Cytogenet 180:100-9. 2008
    ..The result demonstrates that the established tumor cells consist of two cell populations, one containing four and one containing five copies of the MYC oncogene...
  11. ncbi PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer
    V Srikantan
    Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Proc Natl Acad Sci U S A 97:12216-21. 2000
    ....