Hesed M Padilla-Nash

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer
    Youfeng Yang
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1107, Bldg 10 CRC, Room 1 5942, Bethesda, MD 20892 1107
    Cancer Genet Cytogenet 196:45-55. 2010
  2. pmc Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells
    Hesed M Padilla-Nash
    Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 34:1929-39. 2013
  3. pmc Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances
    Hesed M Padilla-Nash
    Genetics Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Genes Chromosomes Cancer 51:353-74. 2012
  4. pmc A sequence-based survey of the complex structural organization of tumor genomes
    Benjamin J Raphael
    Department of Computer Science and Center for Computational Molecular Biology, Brown University, Waterman Street, Providence, RI 02912 1910, USA
    Genome Biol 9:R59. 2008
  5. ncbi request reprint Spectral karyotyping demonstrates genetically unstable skin-homing T lymphocytes in cutaneous T-cell lymphoma
    Hesed M Padilla-Nash
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Exp Dermatol 16:98-103. 2007
  6. ncbi request reprint Spectral karyotyping analysis of human and mouse chromosomes
    Hesed M Padilla-Nash
    Genetics Branch, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, 50 South Drive MSC 8010, Bethesda, Maryland 20892, USA
    Nat Protoc 1:3129-42. 2006
  7. ncbi request reprint Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms
    H M Padilla-Nash
    Genetics Department, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Chromosomes Cancer 30:349-63. 2001
  8. doi request reprint Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer
    Jordi Camps
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genes Chromosomes Cancer 48:1002-17. 2009
  9. pmc Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines
    Turid Knutsen
    Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 8010, USA
    Genes Chromosomes Cancer 49:204-23. 2010
  10. pmc Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs
    Thomas Winkler
    Hematology Branch, National Heart Lung and Blood Institute NHLBI, NIH, Bethesda, Maryland 0892 1202, USA
    J Clin Invest 123:1952-63. 2013

Collaborators

Detail Information

Publications13

  1. pmc UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer
    Youfeng Yang
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1107, Bldg 10 CRC, Room 1 5942, Bethesda, MD 20892 1107
    Cancer Genet Cytogenet 196:45-55. 2010
    ..This tumor model is the embodiment of the Warburg effect. UOK 262 provides a unique in vitro and in vivo preclinical model for studying the bioenergetics of the Warburg effect in human cancer...
  2. pmc Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells
    Hesed M Padilla-Nash
    Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 34:1929-39. 2013
    ..Therefore, our novel mouse models faithfully recapitulate the sequence of genomic and transcriptomic events that define human tumorigenesis, hence validating them for both basic and preclinical research. ..
  3. pmc Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances
    Hesed M Padilla-Nash
    Genetics Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Genes Chromosomes Cancer 51:353-74. 2012
    ....
  4. pmc A sequence-based survey of the complex structural organization of tumor genomes
    Benjamin J Raphael
    Department of Computer Science and Center for Computational Molecular Biology, Brown University, Waterman Street, Providence, RI 02912 1910, USA
    Genome Biol 9:R59. 2008
    ..The genomes of many epithelial tumors exhibit extensive chromosomal rearrangements. All classes of genome rearrangements can be identified using end sequencing profiling, which relies on paired-end sequencing of cloned tumor genomes...
  5. ncbi request reprint Spectral karyotyping demonstrates genetically unstable skin-homing T lymphocytes in cutaneous T-cell lymphoma
    Hesed M Padilla-Nash
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Exp Dermatol 16:98-103. 2007
    ..We did not see genetic instability or evidence of clones in cell lines from a patient with atopic dermatitis and one with psoriasis...
  6. ncbi request reprint Spectral karyotyping analysis of human and mouse chromosomes
    Hesed M Padilla-Nash
    Genetics Branch, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, 50 South Drive MSC 8010, Bethesda, Maryland 20892, USA
    Nat Protoc 1:3129-42. 2006
    ..SKY analysis requires approximately 6 d...
  7. ncbi request reprint Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms
    H M Padilla-Nash
    Genetics Department, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Chromosomes Cancer 30:349-63. 2001
    ..consequently resulting in tumor-specific genomic imbalances. Published 2001 Wiley-Liss, Inc...
  8. doi request reprint Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer
    Jordi Camps
    Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genes Chromosomes Cancer 48:1002-17. 2009
    ....
  9. pmc Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines
    Turid Knutsen
    Section of Cancer Genomics, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 8010, USA
    Genes Chromosomes Cancer 49:204-23. 2010
    ..The fact that chromosome abnormalities predominantly result in copy number changes rather than specific chromosome or gene fusions suggests that this may be the major mechanism leading to carcinogenesis in colorectal cancer...
  10. pmc Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs
    Thomas Winkler
    Hematology Branch, National Heart Lung and Blood Institute NHLBI, NIH, Bethesda, Maryland 0892 1202, USA
    J Clin Invest 123:1952-63. 2013
    ..Our data support the necessity of studying multiple clones when using iPSCs to model disease...
  11. ncbi request reprint Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation
    Masako Miura
    Dental Biology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 131, 30 Convent Drive MSC4320, Bethesda, Maryland 20892, USA
    Stem Cells 24:1095-103. 2006
    ..BMMSCs/fibrosarcoma transformation system may provide an ideal system to elucidate the mechanism of how stem cells become cancer cells and to screen anti-sarcoma drugs...
  12. pmc The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dubé gene pathway
    Youfeng Yang
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1W 5888, Bethesda, MD 20892, USA
    Cancer Genet Cytogenet 180:100-9. 2008
    ..The result demonstrates that the established tumor cells consist of two cell populations, one containing four and one containing five copies of the MYC oncogene...
  13. pmc PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer
    V Srikantan
    Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Proc Natl Acad Sci U S A 97:12216-21. 2000
    ....