Karel Pacak

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc The size of the primary tumor and age at initial diagnosis are independent predictors of the metastatic behavior and survival of patients with SDHB-related pheochromocytoma and paraganglioma: a retrospective cohort study
    Jan Schovanek
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Building 10, CRC, Room 1E 3140, 10 Center Drive MSC 1109, Bethesda, Maryland 20892 1109, USA
    BMC Cancer 14:523. 2014
  2. ncbi request reprint HIF signaling pathway in pheochromocytoma and other neuroendocrine tumors
    I Jochmanová
    Department of Internal Medicine, Faculty of Medicine, P J Safarik University, Kosice, Slovakia Section on Medical Neuroendocrinology, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver NICHD, NIH, Bethesda, MD, USA
    Physiol Res 63:S251-62. 2014
  3. pmc Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy
    Lucia Martiniova
    Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e14678. 2011
  4. pmc Warburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: insights from a mouse cell model applied to human tumor tissue
    Stephanie M J Fliedner
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e40949. 2012
  5. pmc Pheochromocytoma and paraganglioma: current functional and future molecular imaging
    Elise M Blanchet
    Department of Nuclear Medicine, Centre Hospitalo Universitaire d Angers Angers, France
    Front Oncol 1:58. 2011
  6. pmc New syndrome of paraganglioma and somatostatinoma associated with polycythemia
    Karel Pacak
    Section on Medical Neuroendocrinology, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver NICHD, NIH, Bethesda, MD 20892 1109, USA
    J Clin Oncol 31:1690-8. 2013
  7. pmc NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model
    Karel Pacak
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 131:2445-55. 2012
  8. pmc Pheochromocytoma: implications in tumorigenesis and the actual management
    U Shah
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Minerva Endocrinol 37:141-56. 2012
  9. pmc Staging and functional characterization of pheochromocytoma and paraganglioma by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography
    Henri J L M Timmers
    Department of Endocrinology and Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Natl Cancer Inst 104:700-8. 2012
  10. pmc Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma
    Christian A Koch
    Division of Endocrinology and Nephrology, University of Leipzig, Philipp Rosenthalstr, 27, 04103 Leipzig, Germany
    BMC Cancer 6:131. 2006

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. pmc The size of the primary tumor and age at initial diagnosis are independent predictors of the metastatic behavior and survival of patients with SDHB-related pheochromocytoma and paraganglioma: a retrospective cohort study
    Jan Schovanek
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Building 10, CRC, Room 1E 3140, 10 Center Drive MSC 1109, Bethesda, Maryland 20892 1109, USA
    BMC Cancer 14:523. 2014
    ..This study evaluated the size and age at diagnosis of primary SDHB-related PHEOs/PGLs as independent predictors of their metastatic behavior and outcome (survival)...
  2. ncbi request reprint HIF signaling pathway in pheochromocytoma and other neuroendocrine tumors
    I Jochmanová
    Department of Internal Medicine, Faculty of Medicine, P J Safarik University, Kosice, Slovakia Section on Medical Neuroendocrinology, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver NICHD, NIH, Bethesda, MD, USA
    Physiol Res 63:S251-62. 2014
    ..HIF signaling appears to be one of the crucial players in tumorigenesis, which could suggest new therapeutic approaches for treatment of neuroendocrine tumors. ..
  3. pmc Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy
    Lucia Martiniova
    Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e14678. 2011
    ..Subsequently, we evaluated the increased efficacy of chemotherapy combined with LB1...
  4. pmc Warburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: insights from a mouse cell model applied to human tumor tissue
    Stephanie M J Fliedner
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e40949. 2012
    ..This study provides new insight into pathogenic mechanisms in aggressive human PHEOs/PGLs, which may lead to identifying new diagnostic and prognostic markers in the near future...
  5. pmc Pheochromocytoma and paraganglioma: current functional and future molecular imaging
    Elise M Blanchet
    Department of Nuclear Medicine, Centre Hospitalo Universitaire d Angers Angers, France
    Front Oncol 1:58. 2011
    ....
  6. pmc New syndrome of paraganglioma and somatostatinoma associated with polycythemia
    Karel Pacak
    Section on Medical Neuroendocrinology, Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver NICHD, NIH, Bethesda, MD 20892 1109, USA
    J Clin Oncol 31:1690-8. 2013
    ..The occurrence of ≥ two distinct types of tumors, one of them paraganglioma (PGL), is unusual in an individual patient, except in hereditary cancer syndromes...
  7. pmc NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model
    Karel Pacak
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 131:2445-55. 2012
    ....
  8. pmc Pheochromocytoma: implications in tumorigenesis and the actual management
    U Shah
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Minerva Endocrinol 37:141-56. 2012
    ..Management of this disease requires a multidisciplinary team approach and will be discussed along with advances in its treatment...
  9. pmc Staging and functional characterization of pheochromocytoma and paraganglioma by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography
    Henri J L M Timmers
    Department of Endocrinology and Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Natl Cancer Inst 104:700-8. 2012
    ....
  10. pmc Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma
    Christian A Koch
    Division of Endocrinology and Nephrology, University of Leipzig, Philipp Rosenthalstr, 27, 04103 Leipzig, Germany
    BMC Cancer 6:131. 2006
    ..Somatic VHL gene alterations are implicated in the pathogenesis of MEN2 pheochromocytomas. We hypothesized that somatic VHL gene alterations are also important in the pathogenesis of MEN2-associated MTC...
  11. ncbi request reprint Changes of noradrenergic activity and lipolysis in the subcutaneous abdominal adipose tissue of hypo- and hyperthyroid patients: an in vivo microdialysis study
    Jara Nedvidkova
    Dr Sc, Building 10, Room 9D42, NICHD, NIH, 10 Center Drive, MSC 1583, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1018:541-9. 2004
    ..We suggest that thyroid hormones regulate lipolysis primarily by affecting local NE concentration and/or adrenergic postreceptor signaling...
  12. ncbi request reprint Functional imaging of endocrine tumors: role of positron emission tomography
    Karel Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892 1583, USA
    Endocr Rev 25:568-80. 2004
    ....
  13. ncbi request reprint The role of [(18)F]fluorodeoxyglucose positron emission tomography and [(111)In]-diethylenetriaminepentaacetate-D-Phe-pentetreotide scintigraphy in the localization of ectopic adrenocorticotropin-secreting tumors causing Cushing's syndrome
    Karel Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Clin Endocrinol Metab 89:2214-21. 2004
    ..As H-OCT identified a tumor in one patient with otherwise negative imaging, it should be considered only when other imaging modalities fail to localize the ACTH-secreting tumor in patients with EAS...
  14. ncbi request reprint Anatomical and functional imaging of tumors in animal models: focus on pheochromocytoma
    Lucia Martiniova
    D Sc, Building 10, Room 1E3140, National Institutes of Health, 10 Center Drive MSC 1583, Bethesda, MD 20892 1583
    Ann N Y Acad Sci 1073:392-404. 2006
    ..Here we review both anatomical and functional imaging methods that are used conjointly in order to localize and identify specific characteristics of tumors...
  15. ncbi request reprint Diagnostic localization of pheochromocytoma: the coming of age of positron emission tomography
    Karel Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:170-6. 2002
    ..In this report we provide an update regarding nuclear imaging of primary and metastatic pheochromocytoma, particularly using 6-[(18)F]fluorodopamine positron emission tomographic scanning...
  16. ncbi request reprint Preoperative management of the pheochromocytoma patient
    Karel Pacak
    Section on Medical Neuroendocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1E 3140, 10 Center Drive MSC 1109, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 92:4069-79. 2007
    ....
  17. pmc Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy
    Edwin W Lai
    Section on Medical Neuroendocrinology, Reproductive and Adult Endocrinology Program, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1109, USA
    J Clin Endocrinol Metab 94:2952-7. 2009
    ..When complete surgical resection is not an option, the treatment of pheochromocytoma is limited...
  18. pmc Phaeochromocytoma: a catecholamine and oxidative stress disorder
    K Pacak
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Regul 45:65-90. 2011
    ..Facing such a reality today will favor our chances to "beat" this disease tomorrow...
  19. ncbi request reprint Diagnostic imaging of pheochromocytoma
    Karel Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Front Horm Res 31:107-20. 2004
  20. ncbi request reprint Current approaches and new advances in endocrine hypertension
    Karel Pacak
    Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, Bethesda, MD, USA
    Trends Endocrinol Metab 13:96-7. 2002
  21. ncbi request reprint Stressor specificity of central neuroendocrine responses: implications for stress-related disorders
    K Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    Endocr Rev 22:502-48. 2001
    ..The adaptive response reflects the activation of specific central circuits and is genetically and constitutionally programmed and constantly modulated by environmental factors...
  22. ncbi request reprint Chronic hypercortisolemia inhibits dopamine synthesis and turnover in the nucleus accumbens: an in vivo microdialysis study
    Karel Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 1620, USA
    Neuroendocrinology 76:148-57. 2002
    ..Region-specific CORT-induced inhibition of DAergic activity may help to explain depressive symptoms in patients with chronic hypercortisolemia and normalization after medical or surgical correction of hypercortisolism...
  23. ncbi request reprint 6-[18F]fluorodopamine positron emission tomographic (PET) scanning for diagnostic localization of pheochromocytoma
    K Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hypertension 38:6-8. 2001
    ..These findings justify a clinical trial of 6-[(18)F]fluorodopamine PET scanning as a diagnostic tool...
  24. ncbi request reprint A "pheo" lurks: novel approaches for locating occult pheochromocytoma
    K Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Clin Endocrinol Metab 86:3641-6. 2001
    ..These novel approaches may be of value in difficult cases, where biochemical and clinical evidence of pheochromocytoma is compelling, yet conventional imaging modalities fail to locate the tumor...
  25. ncbi request reprint Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytoma
    K Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892 1583, USA
    Ann Intern Med 134:315-29. 2001
    ....
  26. ncbi request reprint Role of positron emission tomography and bone scintigraphy in the evaluation of bone involvement in metastatic pheochromocytoma and paraganglioma: specific implications for succinate dehydrogenase enzyme subunit B gene mutations
    Tomas Zelinka
    Reproductive Biology and Medicine Branch, NICHD, NINDS, NIH, Bethesda, MD 20892, USA
    Endocr Relat Cancer 15:311-23. 2008
    ..As for PET imaging, [(18)F]-FDG PET is highly recommended in SDHB mutation patients, whereas [(18)F]-FDA PET is recommended in patients without the mutation...
  27. pmc Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma
    Henri J L M Timmers
    Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 94:4757-67. 2009
    ....
  28. pmc Comparison of 6-18F-fluorodopamine PET with 123I-metaiodobenzylguanidine and 111in-pentetreotide scintigraphy in localization of nonmetastatic and metastatic pheochromocytoma
    Ioannis Ilias
    Reproductive Biology and Adult Endocrinology Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    J Nucl Med 49:1613-9. 2008
    ....
  29. pmc Increased uptake of [¹²³I]meta-iodobenzylguanidine, [¹⁸F]fluorodopamine, and [³H]norepinephrine in mouse pheochromocytoma cells and tumors after treatment with the histone deacetylase inhibitors
    Lucia Martiniova
    Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 1E 3140, 10 Center Drive MSC 1109, Bethesda, Maryland 20892 1109, USA
    Endocr Relat Cancer 18:143-57. 2011
    ..HDAC inhibitors may enhance the therapeutic efficacy of [(131)I]MIBG treatment in patients with advanced malignant pheochromocytoma and paraganglioma...
  30. pmc Noninvasive monitoring of a murine model of metastatic pheochromocytoma: a comparison of contrast-enhanced microCT and nonenhanced MRI
    Lucia Martiniova
    Reproductive and Adult Endocrinology Program, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892 1109, USA
    J Magn Reson Imaging 29:685-91. 2009
    ..However, the choice of imaging modality is still evolving...
  31. pmc Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature
    Lucia Martiniova
    Section on Medical Neuroendocrinology, Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
    Clin Exp Metastasis 26:239-50. 2009
    ..Microarray gene expression comparison and quantitative real-time PCR of these more aggressive cells to the MPC-parental cell line identified genes that may be important for the metastatic process...
  32. pmc Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene
    Henri J L M Timmers
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, CRC, Room 1 E 3140, Bethesda Maryland 20892 1109, USA
    J Clin Endocrinol Metab 93:4826-32. 2008
    ..We report four cases of biochemically silent abdominal PGL, in which metanephrines were normal despite extensive disease...
  33. ncbi request reprint The effects of carbidopa on uptake of 6-18F-Fluoro-L-DOPA in PET of pheochromocytoma and extraadrenal abdominal paraganglioma
    Henri J L M Timmers
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Nucl Med 48:1599-606. 2007
    ..The aim of this study was to investigate the sensitivity of (18)F-DOPA PET in the detection of paraganglioma and its metastatic lesions and to evaluate whether tracer uptake by the tumors is enhanced by carbidopa...
  34. ncbi request reprint Brown fat imaging with (18)F-6-fluorodopamine PET/CT, (18)F-FDG PET/CT, and (123)I-MIBG SPECT: a study of patients being evaluated for pheochromocytoma
    Mohiuddin Hadi
    Department of Nuclear Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 48:1077-83. 2007
    ..18)F-6-fluorodopamine (F-DA) is being used as a PET radiopharmaceutical to image adrenergic innervation and suspected pheochromocytoma. Past reports have suggested that BAT is increased in pheochromocytoma patients...
  35. doi request reprint Gender-related differences in the clinical presentation of malignant and benign pheochromocytoma
    Edwin W Lai
    Section on Medical Neuroendocrinology, Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Endocrine 34:96-100. 2008
    ..Clinicians should be aware of these complaints in female pheochromocytoma patients and offer adequate treatment if indicated...
  36. ncbi request reprint Usefulness of standardized uptake values for distinguishing adrenal glands with pheochromocytoma from normal adrenal glands by use of 6-18F-fluorodopamine PET
    Henri J L M Timmers
    Reproductive and Adult Endocrinology Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Nucl Med 48:1940-4. 2007
    ..6-(18)F-Fluorodopamine ((18)F-FDA) PET is a highly sensitive tool for the localization of pheochromocytoma (PHEO). The aim of this study was to establish cutoff values for pathologic and physiologic adrenal gland tracer uptake...
  37. pmc False-negative ¹²³I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease
    Jay S Fonte
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Relat Cancer 19:83-93. 2012
    ..We therefore recommend that patients with false-negative (123)I-MIBG SPECT be tested for SDHB mutations and undergo more regular and close follow-up...
  38. pmc Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas
    Uma Shankavaram
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Neoplasia 15:435-47. 2013
    ..The presented data suggest novel subclassification of pseudohypoxic PHEOs/PGLs and implies cluster-specific pathogenic mechanisms and treatment strategies...
  39. pmc Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas
    Chunzhang Yang
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20894, USA
    Blood 121:2563-6. 2013
    ....
  40. pmc G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis
    Min Chen
    Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 11:320-30. 2010
    ..In normal mice, high-fat diet raised sympathetic nerve activity in muscle, but not in BAT. Our results show that cold- and diet-induced thermogenesis may occur in separate tissues, especially when BAT function is impaired...
  41. ncbi request reprint The role of 6-[18F]fluorodopamine positron emission tomography in the localization of adrenal pheochromocytoma associated with von Hippel-Lindau syndrome
    Priya Kaji
    Reproductive Biology and Medicine Branch, Section on Medical Neuroendocrinology, National Institute of Child Health and Human Development, Building 10, CRC, 1 East, Room 1 3140, 10 Center Drive, MSC 1109, Bethesda, Maryland 20892, USA
    Eur J Endocrinol 156:483-7. 2007
    ..Therefore, we investigated whether [(18)F]DA PET is more effective than [(123/131)I]MIBG scintigraphy in the diagnostic localization of VHL-related adrenal pheochromocytoma...
  42. ncbi request reprint Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma
    Yehonatan Sharabi
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Hypertens 25:2286-95. 2007
    ..We therefore examined sympathoadrenal function in patients with pseudopheochromocytoma compared with age-matched control subjects in whom there was no suspicion of pheochromocytoma...
  43. ncbi request reprint Diagnosis and localization of pheochromocytoma
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 43:907-10. 2004
    ..It also confirms that functional imaging by 6-[18F]fluorodopamine or 123I-metaiodobenzylguanidine scanning can localize pheochromocytoma in difficult cases in which other imaging tests are not diagnostic...
  44. pmc Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions
    Sophie Gabriel
    Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix Marseille University, Marseille, France
    Clin Endocrinol (Oxf) 79:170-7. 2013
    ....
  45. pmc Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia
    Zhengping Zhuang
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 367:922-30. 2012
    ..The two mutations were associated with increased HIF-2α activity and increased protein half-life...
  46. pmc Metastatic pheochromocytoma/paraganglioma related to primary tumor development in childhood or adolescence: significant link to SDHB mutations
    Kathryn S King
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    J Clin Oncol 29:4137-42. 2011
    ..To present data on the high rate of SDHB mutations in patients with metastatic pheochromocytoma/paraganglioma whose initial tumor presentation began in childhood or adolescence...
  47. ncbi request reprint Superiority of 6-[18F]-fluorodopamine positron emission tomography versus [131I]-metaiodobenzylguanidine scintigraphy in the localization of metastatic pheochromocytoma
    Ioannis Ilias
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:4083-7. 2003
    ..Thus, [(18)F]-DA PET was found to be a superior imaging method in patients with metastatic PHEO, in which correct detection of disease extension often determines the most appropriate therapeutic plan and future follow-up...
  48. ncbi request reprint Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma
    Lucia Martiniova
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892 1109, USA
    Nucl Med Biol 39:215-26. 2012
    ..Furthermore, to compare tumor detection by micro-computed tomography (microCT) to magnetic resonance imaging (MRI) in individual mouse...
  49. ncbi request reprint Neuropeptide Y expression in phaeochromocytomas: relative absence in tumours from patients with von Hippel-Lindau syndrome
    Susannah Cleary
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    J Endocrinol 193:225-33. 2007
    ....
  50. pmc In vivo micro-CT imaging of liver lesions in small animal models
    Lucia Martiniova
    Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Methods 50:20-5. 2010
    ..This paper describes methods of current microCT imaging options for imaging of liver lesions compared to other imaging techniques in small animals...
  51. pmc Brief communication: radiographic contrast infusion and catecholamine release in patients with pheochromocytoma
    Smita K Baid
    Eunice Kennedy Shriver National Institute of Child Health and Human Development and Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Ann Intern Med 150:27-32. 2009
    ..However, in patients with suspected pheochromocytoma, CT is often canceled or not performed because of the strong belief that intravenous contrast may induce hypertensive crisis...
  52. pmc Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevance
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 148:3900-7. 2007
    ..At the same time, in light of their ability to effectively deliver and express genes in pheochromocytoma cells, they may be applicable to the gene therapy of adrenomedullary tumors...
  53. ncbi request reprint Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 51:735-44. 2005
    ..Measurements of plasma free metanephrines (normetanephrine and metanephrine) provide a useful test for diagnosis of pheochromocytoma and may provide other information about the nature of these tumors...
  54. pmc Functional imaging of SDHx-related head and neck paragangliomas: comparison of 18F-fluorodihydroxyphenylalanine, 18F-fluorodopamine, 18F-fluoro-2-deoxy-D-glucose PET, 123I-metaiodobenzylguanidine scintigraphy, and 111In-pentetreotide scintigraphy
    Kathryn S King
    Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:2779-85. 2011
    ..Accurate diagnosis of head and neck paragangliomas is often complicated by biochemical silence and lack of catecholamine-associated symptoms, making accurate anatomical and functional imaging techniques essential to the diagnostic process...
  55. ncbi request reprint Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2
    Thanh Truc Huynh
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Building 10, Room 6N252, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Ann N Y Acad Sci 1073:241-52. 2006
    ..Microarray analysis, however, did indicate differences in expression of genes involved in neural crest cell lineage and chromaffin cell development, consistent with differential survival of PNMT-expressing cells in the two syndromes...
  56. ncbi request reprint Tyrosine hydroxylase, chromogranin A, and steroidogenic acute regulator as markers for successful separation of human adrenal medulla
    Stephanie M J Fliedner
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Tissue Res 340:607-12. 2010
    ..Separation quality has been verified by quantitative reverse transcription with polymerase chain reaction for the medullary enzymes, tyrosine hydroxylase, and chromogranin A, and for the cortical enzyme, steroidogenic acute regulator...
  57. pmc Use of 6-[18F]-fluorodopamine positron emission tomography (PET) as first-line investigation for the diagnosis and localization of non-metastatic and metastatic phaeochromocytoma (PHEO)
    Henri J L M Timmers
    Reproductive and Adult Endocrinology Program, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Clin Endocrinol (Oxf) 71:11-7. 2009
    ..Our aim was to investigate the yield of (18)F-FDA PET vs. biochemical testing and other imaging techniques to establish the diagnosis and location of PHEO...
  58. ncbi request reprint Hypotension in a woman with a metastatic dopamine-secreting carotid body tumor
    Christian A Koch
    National Institute of Child Health and Human Development, Pediatric and Reproductive Endocrinology Branch National Institutes of Health, Bethesda, Maryland, USA
    Endocr Pract 9:310-4. 2003
    ..To describe a woman with metastatic carotid body tumor in whom hypotension occurred in the setting of exceedingly high plasma dopamine levels...
  59. ncbi request reprint Discordant localization of 2-[18F]-fluoro-2-deoxy-D-glucose in 6-[18F]-fluorodopamine- and [(123)I]-metaiodobenzylguanidine-negative metastatic pheochromocytoma sites
    Marcelo Mamede
    Nuclear Medicine Department, Clinical Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Nucl Med Commun 27:31-6. 2006
    ....
  60. ncbi request reprint Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas
    Timothy W A Vogel
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5D 37, Bethesda, Maryland 20892 1414, USA
    J Clin Endocrinol Metab 90:3747-51. 2005
    ..These findings suggest an alternative process of tumorigenesis in VHL- and MEN 2-associated pheochromocytomas and implicate Epo as a clinical biomarker to differentiate these tumors...
  61. pmc First report of bilateral pheochromocytoma in the clinical spectrum of HIF2A-related polycythemia-paraganglioma syndrome
    David Taieb
    Department of Nuclear Medicine, La Timone University Hospital, Centre Européen de Recherche en Imagerie Médicale, Aix Marseille University, 13005 Marseille, France
    J Clin Endocrinol Metab 98:E908-13. 2013
    ..Recently, a new syndrome characterized by multiple PGLs and somatostatinomas associated with congenital polycythemia due to somatic mutations in HIF2A has been reported...
  62. ncbi request reprint Pheochromocytoma: recommendations for clinical practice from the First International Symposium. October 2005
    Karel Pacak
    National Institute of Child Health and Development, NIH, Bethesda, MD, USA
    Nat Clin Pract Endocrinol Metab 3:92-102. 2007
    ..Inadequate methods to distinguish malignant from benign tumors and a lack of effective treatments for malignancy are important problems requiring further resolution...
  63. ncbi request reprint Gene expression profiling of benign and malignant pheochromocytoma
    Frederieke M Brouwers
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1E 1 3140, 10 Center Drive, MSC 1109, Bethesda, MD 20892 1109, USA
    Ann N Y Acad Sci 1073:541-56. 2006
    ....
  64. pmc Different expression of catecholamine transporters in phaeochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2
    Thanh Truc Huynh
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Eur J Endocrinol 153:551-63. 2005
    ....
  65. pmc Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function
    Chunzhang Yang
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    FASEB J 26:4506-16. 2012
    ....
  66. ncbi request reprint Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas
    Henri J L M Timmers
    Section on Medical Neuroendocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, 10 Center Drive, Building 10, CRC, Room 1 E 3140, MSC 1109, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 92:779-86. 2007
    ..Mutations of the gene encoding succinate dehydrogenase subunit B (SDHB) predispose to malignant paraganglioma (PGL). Recognition of the SDHB phenotype in apparently sporadic PGL directs appropriate treatment and family screening...
  67. pmc Mitochondrial localization of human recombinant adenovirus: from evolution to gene therapy
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimmunomodulation 14:221-3. 2007
    ..This finding, while opening new perspectives in viral gene therapy, may provide new insights into the pathogenesis, prevention and treatment of viral diseases. In addition, it may advance the current understanding of cell evolution...
  68. ncbi request reprint Pheochromocytoma in von hippel-lindau disease: distinct histopathologic phenotype compared to pheochromocytoma in multiple endocrine neoplasia type 2
    Christian A Koch
    Pediatric and Reporoductive ENdocinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Endocr Pathol 13:17-27. 2002
    ..Our findings of a distinct histologic phenotype of VHL pheochromocytoma may further help in subdividing patients who clinically present with multiple, bilateral pheochromocytomas...
  69. pmc Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction
    Ivana Jochmanová
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    J Natl Cancer Inst 105:1270-83. 2013
    ..HIF signaling appears to play an important role in the development and growth of PHEOs and PGLs, which could suggest new therapeutic approaches for the treatment of these tumors. ..
  70. pmc Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma
    Alessio Giubellino
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e56083. 2013
    ..Levels of Hsp70 in plasma from the xenograft studies served as a proximal biomarker of drug treatment. Our study suggests that targeting Hsp90 may benefit patients with advanced pheochromocytoma...
  71. pmc MicroCT for high-resolution imaging of ectopic pheochromocytoma tumors in the liver of nude mice
    Shoichiro Ohta
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 1109, USA
    Int J Cancer 119:2236-41. 2006
    ..35 mm as early as 4 weeks after the injection of the tumor cells. This model may be useful for in vivo studies of tumor biology and for development of new strategies to treat metastatic pheochromocytoma...
  72. ncbi request reprint Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine
    Graeme Eisenhofer
    Clinical Neurocardiology Section, Building 10, Room 6N252, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, Maryland 20892 1620, USA
    J Clin Endocrinol Metab 90:2068-75. 2005
    ....
  73. ncbi request reprint Metastasis-associated gene expression profile of liver and subcutaneous lesions derived from mouse pheochromocytoma cells
    Shoichiro Ohta
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1109, USA
    Mol Carcinog 47:245-51. 2008
    ....
  74. ncbi request reprint New insights into the genetics of familial chromaffin cell tumors
    Christian A Koch
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:11-28. 2002
    ..Many genetic alterations have been found in sporadic chromaffin cell tumors. However, at present such genetic changes are difficult to place into context with regard to tumor formation and progression...
  75. ncbi request reprint Diagnosis of pheochromocytoma with special emphasis on MEN2 syndrome
    Karel Pacak
    Reproductive and Adult Endocrinology Program, Section of Medical Neuroendocrinology, NICHD, National Institutes of Health, Bethesda, MD, USA
    Hormones (Athens) 8:111-6. 2009
    ..Whether these data reflect PHEO cell dedifferentiation (e.g. losing Norepinephrine Transporter-NET) or increased metabolic rate remains to be established...
  76. ncbi request reprint Cardiac uptake-1 inhibition by high circulating norepinephrine levels in patients with pheochromocytoma
    Basil A Eldadah
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
    Hypertension 43:1227-32. 2004
    ..The results call for caution in drawing quantitative conclusions about uptake-1 in the setting of high circulating concentrations of endogenous norepinephrine...
  77. ncbi request reprint Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:2656-66. 2003
    ..Patterns of biochemical test results and responses of plasma normetanephrine to clonidine can then help distinguish true- from false-positive results...
  78. pmc Comparison of clinical and imaging features in succinate dehydrogenase-positive versus sporadic paragangliomas
    Aradhana M Venkatesan
    Center for Interventional Oncology, Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD20892, USA
    Surgery 150:1186-93. 2011
    ..Limited data exist concerning the clinical and imaging features that distinguish sporadic from familial paragangliomas (PGLs)...
  79. ncbi request reprint High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing
    Frederieke M Brouwers
    Section of Medical Neuroendocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 91:4505-9. 2006
    ..Mutations of the gene for succinate dehydrogenase subunit B (SDHB) are associated with a high risk of malignancy, but establishing the precise contribution requires relatively large numbers of patients with well-defined malignancy...
  80. ncbi request reprint Proteomic profiling of von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 pheochromocytomas reveals different expression of chromogranin B
    Frederieke M Brouwers
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Relat Cancer 14:463-71. 2007
    ..In light of these new findings, as well as existing evidence for differences between both types of pheochromocytomas, we propose that these tumors may have different developmental origins...
  81. ncbi request reprint Diagnostic localization of malignant bladder pheochromocytoma using 6-18F fluorodopamine positron emission tomography
    Jonathan J Hwang
    Urologic Oncology Branch, National Cancer Institute NIH, Bethesda, MD, USA
    J Urol 169:274-5. 2003
  82. ncbi request reprint Emergencies caused by pheochromocytoma, neuroblastoma, or ganglioneuroma
    Frederieke M Brouwers
    Section on Medical Neuroendocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 1109, USA
    Endocrinol Metab Clin North Am 35:699-724, viii. 2006
    ..If they occur, they are often linked to catecholamine excess, paraneoplastic phenomena, or local tumor mass effect...
  83. ncbi request reprint Utility of plasma free metanephrines for detecting childhood pheochromocytoma
    Martina Weise
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 87:1955-60. 2002
    ..The findings indicate that plasma free metanephrines provide a sensitive tool for detection of pheochromocytoma in children. Age appropriate reference ranges should be used and gender differences should be considered...
  84. ncbi request reprint Local sympathetic function in human skeletal muscle and adipose tissue assessed by microdialysis
    Simon Bruce
    NINDS, NIH, Bethesda, Maryland 20892 1620, USA
    Clin Auton Res 12:13-9. 2002
    ..This study examined the validity of microdialysis and measurements of microdialysate concentrations of catechols, to assess local sympathetic function in skeletal muscle and adipose tissue in humans...
  85. ncbi request reprint Malignant pheochromocytoma: current status and initiatives for future progress
    Graeme Eisenhofer
    National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    Endocr Relat Cancer 11:423-36. 2004
    ..Again the success of this will require well-designed and coordinated multi-center studies...
  86. ncbi request reprint Survivin: a novel neuroendocrine marker for pheochromocytoma
    Christian A Koch
    National Institutes of Health NIH, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Eur J Endocrinol 146:381-8. 2002
    ..To study survivin expression in human adrenal medulla and in benign and malignant pheochromocytoma tissue as a tool to predict tumor metastatic potential and prognosis...
  87. ncbi request reprint Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm
    Alejandro R Ayala
    Pediatric Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:5729-37. 2004
    ..Taken together, these findings suggest that CRHR-1 antagonists may be a valid treatment for stress-related disorders...
  88. ncbi request reprint The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors
    Christian A Koch
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 87:5367-84. 2002
    ..In this article we review in addition to our own work the literature on molecular aspects of adrenocortical and adrenomedullary tumorigenesis...
  89. ncbi request reprint Somatic VHL gene deletion and point mutation in MEN 2A-associated pheochromocytoma
    Christian A Koch
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Disease NICHD, National Institutes of Health NIH, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:479-82. 2002
    ..The remaining tumor did show LOH but not mutation of the VHL gene. These results suggest that somatic genetic alterations of the VHL gene may play a role in the tumorigenesis of some MEN 2A-related pheochromocytomas...
  90. ncbi request reprint Anatomical and functional imaging of metastatic pheochromocytoma
    Ioannis Ilias
    D Sc, Chief, Unit on Clinical Neuroendocrinology, PREB, NICHD, NIH, Building 10, Room 9D42, 10 Center Drive, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:495-504. 2004
    ..Persistently negative evaluations should be followed by PET studies with non-specific ligands such as [18-F]-deoxyglucose or somatostatin receptor scintigraphy...
  91. ncbi request reprint Genomic medicine: exploring the basis of a new approach to endocrine hypertension
    Salvatore Alesci
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:177-92. 2002
    ..Research in this field is only in its infancy, but with the ever-increasing advances in DNA technologies, genomic therapies for endocrine hypertension may become available within the next few decades...
  92. ncbi request reprint Localization of medullary thyroid carcinoma metastasis in a multiple endocrine neoplasia type 2A patient by 6-[18F]-fluorodopamine positron emission tomography
    Loukas Gourgiotis
    Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
    J Clin Endocrinol Metab 88:637-41. 2003
    ....
  93. ncbi request reprint Biochemical diagnosis of pheochromocytoma
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Front Horm Res 31:76-106. 2004
  94. ncbi request reprint Cardiac sympathetic denervation preceding motor signs in Parkinson disease
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC 1620, Building 10, Room 6N252, Bethesda, MD 20892 1620, USA
    Cleve Clin J Med 76:S47-50. 2009
    ..The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD...
  95. doi request reprint Pheochromocytoma
    Bas Havekes
    National Institute of Child Health and Development, National Institutes of Health, Bethesda, USA
    Nat Clin Pract Cardiovasc Med 5:E1. 2008
  96. ncbi request reprint Cardiac sympathetic denervation preceding motor signs in Parkinson disease
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, Bethesda, MD 20892 1620, USA
    Clin Auton Res 17:118-21. 2007
    ..The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD...
  97. pmc Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation
    Min Chen
    Signal Transduction Section, Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 9:548-55. 2009
    ....
  98. ncbi request reprint Choice of biochemical test for diagnosis of pheochromocytoma: validation of plasma metanephrines
    Graeme Eisenhofer
    Building 10, Room 6N252, 10 Center Drive, MSC 1620, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Curr Hypertens Rep 4:250-5. 2002
    ..Measurements of plasma concentrations of free metanephrines thereby promise more reliable and efficient diagnosis of pheochromocytoma than offered by conventional biochemical tests...
  99. ncbi request reprint Plasma metanephrines in renal failure
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 1620, USA
    Kidney Int 67:668-77. 2005
    ..The metanephrines may be measured as free metabolites or after a deconjugation step where measurements reflect mainly sulfate-conjugated metabolites. The influence of renal insufficiency states on these various measurements is unclear...
  100. pmc Radiofrequency ablation of metastatic pheochromocytoma
    Aradhana M Venkatesan
    Center for Interventional Oncology, Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Maryland 20892, USA
    J Vasc Interv Radiol 20:1483-90. 2009
    ..3 months; range, 2.5-28 months). In conclusion, RF ablation may be safely performed for metastatic pheochromocytoma given careful attention to peri-procedural management...
  101. ncbi request reprint Utility of plasma free metanephrines in diagnosis of factitious pheochromocytoma
    Aaron R Chidakel
    Division of Intramural Research, National Institute of Diabetes and Digestive and Kidney Diseases, W G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocr Pract 12:568-71. 2006
    ..To report a case of epinephrine-induced factitious pheochromocytoma in a young woman with a past medical history of Conn's syndrome...