Hammou Oubrahim

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Pasteurella multocida toxin (PMT) upregulates CTGF which leads to mTORC1 activation in Swiss 3T3 cells
    Hammou Oubrahim
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Cell Signal 25:1136-48. 2013
  2. pmc Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells
    Hammou Oubrahim
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    J Biol Chem 288:2805-15. 2013
  3. pmc Molecular cloning and characterization of murine caspase-12 gene promoter
    Hammou Oubrahim
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Proc Natl Acad Sci U S A 102:2322-7. 2005
  4. pmc Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis
    Noriyuki Miyoshi
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Proc Natl Acad Sci U S A 103:1727-31. 2006
  5. ncbi request reprint Manganese(II) induces apoptotic cell death in NIH3T3 cells via a caspase-12-dependent pathway
    Hammou Oubrahim
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    J Biol Chem 277:20135-8. 2002
  6. ncbi request reprint Testis brain ribonucleic acid-binding protein/translin possesses both single-stranded and double-stranded ribonuclease activities
    Jun Wang
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    Biochemistry 43:13424-31. 2004
  7. pmc Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin
    Jun Wang
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Proc Natl Acad Sci U S A 100:5103-6. 2003
  8. pmc Inhibition of apoptosis in acute promyelocytic leukemia cells leads to increases in levels of oxidized protein and LMP2 immunoproteasome
    Mohammed A S Khan
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Proc Natl Acad Sci U S A 101:11560-5. 2004
  9. pmc Selective field effects on intracellular vacuoles and vesicle membranes with nanosecond electric pulses
    Ephrem Tekle
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    Biophys J 89:274-84. 2005
  10. pmc E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity
    Sungmin Song
    School of Biological Sciences, Seoul National University, Seoul, Korea
    J Cell Biol 182:675-84. 2008

Collaborators

Detail Information

Publications10

  1. pmc Pasteurella multocida toxin (PMT) upregulates CTGF which leads to mTORC1 activation in Swiss 3T3 cells
    Hammou Oubrahim
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Cell Signal 25:1136-48. 2013
    ..Our findings reveal that CTGF plays an important role, but there are additional factors involved in the mitogenic action of PMT...
  2. pmc Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells
    Hammou Oubrahim
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    J Biol Chem 288:2805-15. 2013
    ..The fact that PMT-induced protein synthesis and cell migration is partially inhibited by rapamycin indicates that these processes are in part mediated by the mTORC1 pathway...
  3. pmc Molecular cloning and characterization of murine caspase-12 gene promoter
    Hammou Oubrahim
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Proc Natl Acad Sci U S A 102:2322-7. 2005
    ..The transcriptional initiation site was identified by 5' RACE techniques using total RNA from NIH 3T3 cells. Our results should facilitate studies on the mechanism regulating the expression of this important gene...
  4. pmc Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis
    Noriyuki Miyoshi
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Proc Natl Acad Sci U S A 103:1727-31. 2006
    ..These results suggest that age-related decline in the ATP level reduces the capacity to induce apoptosis and promotes necrotic inflammation. This switch may trigger a number of age-dependent disorders...
  5. ncbi request reprint Manganese(II) induces apoptotic cell death in NIH3T3 cells via a caspase-12-dependent pathway
    Hammou Oubrahim
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    J Biol Chem 277:20135-8. 2002
    ..In addition, the dsRNA(i) method serves as an effective technique for knocking out caspase-12 in NIH3T3 cells without causing apoptosis...
  6. ncbi request reprint Testis brain ribonucleic acid-binding protein/translin possesses both single-stranded and double-stranded ribonuclease activities
    Jun Wang
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    Biochemistry 43:13424-31. 2004
    ..Both ssRNase and dsRNase activities are inhibited by high levels of common RNase inhibitors. Interestingly, both activities can be enhanced greatly by EDTA...
  7. pmc Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin
    Jun Wang
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Proc Natl Acad Sci U S A 100:5103-6. 2003
    ..By using these glutaredoxin knocked-out cells, we have demonstrated that actin deglutathionylation plays a key role in growth factor-mediated actin polymerization, translocalization, and reorganization near the cell periphery...
  8. pmc Inhibition of apoptosis in acute promyelocytic leukemia cells leads to increases in levels of oxidized protein and LMP2 immunoproteasome
    Mohammed A S Khan
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8012, USA
    Proc Natl Acad Sci U S A 101:11560-5. 2004
    ..Collectively, these results suggest the possibility that an age-related loss in capacity to carry out apoptosis might contribute to the observed accumulation of oxidized proteins during aging and in age-related diseases...
  9. pmc Selective field effects on intracellular vacuoles and vesicle membranes with nanosecond electric pulses
    Ephrem Tekle
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    Biophys J 89:274-84. 2005
    ..It is further shown that large endocytosed vacuoles in COS-7 cells can be selectively permeabilized with little effect on the integrity of outer cell membrane...
  10. pmc E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity
    Sungmin Song
    School of Biological Sciences, Seoul National University, Seoul, Korea
    J Cell Biol 182:675-84. 2008
    ..E2-25K/Hip-2 is thus an essential upstream regulator of the expression and activation of caspase-12 in ER stress-mediated Abeta neurotoxicity...