David E Ott
Affiliation: National Cancer Institute
Ott D, Coren L, Sowder R, Adams J, Nagashima K, Schubert U. Equine infectious anemia virus and the ubiquitin-proteasome system. J Virol. 2002;76:3038-44 pubmed
..This suggests that, although its Gag is monoubiquitinated, the requirements for EIAV release are somewhat different from those for retroviruses that are sensitive to proteasome inhibitors...
Ott D, Coren L, Chertova E, Gagliardi T, Nagashima K, Sowder R, et al
. Elimination of protease activity restores efficient virion production to a human immunodeficiency virus type 1 nucleocapsid deletion mutant. J Virol. 2003;77:5547-56 pubmed
..These results show that HIV-1 can form particles efficiently without NC. ..
Ott D, Coren L, Gagliardi T. Redundant roles for nucleocapsid and matrix RNA-binding sequences in human immunodeficiency virus type 1 assembly. J Virol. 2005;79:13839-47 pubmed
..Together, these results support an RNA-binding requirement for Gag assembly, which relies on binding of RNA by MA or NC sequences to condense, organize, and stabilize the HIV-1 Gag-Gag interactions that form the virion. ..
Ott D, Coren L, Sowder R, Adams J, Schubert U. Retroviruses have differing requirements for proteasome function in the budding process. J Virol. 2003;77:3384-93 pubmed
Ott D, Coren L, Shatzer T. The nucleocapsid region of human immunodeficiency virus type 1 Gag assists in the coordination of assembly and Gag processing: role for RNA-Gag binding in the early stages of assembly. J Virol. 2009;83:7718-27 pubmed publisher
..Therefore, NC plays an important initiating role in Gag assembly...