Elaine A Ostrander

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit
    Danielle M Karyadi
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 9:e1003409. 2013
  2. pmc Canine population structure: assessment and impact of intra-breed stratification on SNP-based association studies
    Pascale Quignon
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e1324. 2007
  3. pmc Canine morphology: hunting for genes and tracking mutations
    Abigail L Shearin
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 8:e1000310. 2010
  4. pmc Variation of BMP3 contributes to dog breed skull diversity
    Jeffrey J Schoenebeck
    Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002849. 2012
  5. pmc Leading the way: finding genes for neurologic disease in dogs using genome-wide mRNA sequencing
    Elaine A Ostrander
    NHGRI National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genet 13:56. 2012
  6. pmc Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American women
    Britton Trabert
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Fairview Ave N, Seattle, Washington 98109 1024, USA
    Breast Cancer Res 9:R84. 2007
  7. pmc No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees
    Kristina Allen Brady
    Genetic Epidemiology Group, Department of Biomedical Informatics, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 USA
    BMC Res Notes 2:94. 2009
  8. pmc Revisiting the missing protein-coding gene catalog of the domestic dog
    Thomas Derrien
    Institut de Génétique et Développement, CNRS UMR6061, Universite de Rennes 1, Léon Bernard, Rennes, France
    BMC Genomics 10:62. 2009
  9. pmc Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer
    Liesel M FitzGerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    BMC Cancer 8:230. 2008
  10. pmc The IGF1 small dog haplotype is derived from Middle Eastern grey wolves
    Melissa M Gray
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA
    BMC Biol 8:16. 2010

Detail Information

Publications109 found, 100 shown here

  1. pmc A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit
    Danielle M Karyadi
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 9:e1003409. 2013
    ..These findings highlight how studies of breed-limited diseases are useful for disentangling multigene disorders...
  2. pmc Canine population structure: assessment and impact of intra-breed stratification on SNP-based association studies
    Pascale Quignon
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e1324. 2007
    ..Little is known, however, about genetic variation among dogs of the same breed collected from different geographic regions...
  3. pmc Canine morphology: hunting for genes and tracking mutations
    Abigail L Shearin
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 8:e1000310. 2010
    ....
  4. pmc Variation of BMP3 contributes to dog breed skull diversity
    Jeffrey J Schoenebeck
    Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002849. 2012
    ..Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait...
  5. pmc Leading the way: finding genes for neurologic disease in dogs using genome-wide mRNA sequencing
    Elaine A Ostrander
    NHGRI National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genet 13:56. 2012
    ..This work sets the stage for similar studies that take advantage of recent advances in genomics while exploiting the historical background of dog breeds to identify disease-causing mutations...
  6. pmc Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case-control study of Caucasian and African-American women
    Britton Trabert
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Fairview Ave N, Seattle, Washington 98109 1024, USA
    Breast Cancer Res 9:R84. 2007
    ..The involvement of vitamin D receptor (VDR), which is a key mediator in the vitamin D pathway, in breast cancer etiology has long been of interest...
  7. pmc No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees
    Kristina Allen Brady
    Genetic Epidemiology Group, Department of Biomedical Informatics, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 USA
    BMC Res Notes 2:94. 2009
    ..CONCLUSION: In this set of high-risk prostate cancer pedigrees with at least nominal linkage evidence to BRCA2, we saw no evidence for segregating BRCA2 protein truncating mutations in heritable prostate cancer...
  8. pmc Revisiting the missing protein-coding gene catalog of the domestic dog
    Thomas Derrien
    Institut de Génétique et Développement, CNRS UMR6061, Universite de Rennes 1, Léon Bernard, Rennes, France
    BMC Genomics 10:62. 2009
    ..Of particular interest are the more than 400 of genes annotated in primates and rodent genomes, but missing in dog...
  9. pmc Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer
    Liesel M FitzGerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    BMC Cancer 8:230. 2008
    ..These associations suggest the hypothesis that the gene fusion may be used as a prognostic indicator for prostate cancer...
  10. pmc The IGF1 small dog haplotype is derived from Middle Eastern grey wolves
    Melissa M Gray
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA
    BMC Biol 8:16. 2010
    ....
  11. doi request reprint Genetics of athletic performance
    Elaine A Ostrander
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Genomics Hum Genet 10:407-29. 2009
    ..Finally, we discuss the implications of these findings on the future for competitive athletics...
  12. ncbi request reprint Genetic susceptibility to aggressive prostate cancer
    Elaine A Ostrander
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, 50 South Drive, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:1761-4. 2006
  13. ncbi request reprint The canine genome
    Elaine A Ostrander
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 15:1706-16. 2005
    ..We suggest that given these resources and the unique characteristics of breeds, that the dog is a uniquely valuable resource for studying the genetic basis of complex traits...
  14. pmc The role of the BRCA2 gene in susceptibility to prostate cancer revisited
    Elaine A Ostrander
    Cancer Genetic Branch, National Human Genome Research Institute, NIH, Room 52451, Building 50, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:1843-8. 2008
    ..In this commentary, we review the current literature and hypotheses surrounding the relationship between BRCA2 mutations and susceptibility to prostate cancer and speculate on the potential for involvement of additional genes...
  15. pmc Vitamin D pathway gene variants and prostate cancer prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 70:1448-60. 2010
    ..Increased understanding of relevant germline genetic variation with disease outcome could aid in the development of vitamin-D-based therapies...
  16. pmc CYP17 polymorphisms and prostate cancer outcomes
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Prostate 70:1094-101. 2010
    ..However, studies relating prostate cancer outcomes with CYP17 gene variants have conflicting results. In this study we analyzed Single Nucleotide Polymorphisms (SNPs) spanning the CYP17 gene for association with PCa survival...
  17. pmc Association of caveolin-1 and -2 genetic variants and post-treatment serum caveolin-1 with prostate cancer risk and outcomes
    Wendy J Langeberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 70:1020-35. 2010
    ..This study evaluated the relationship between post-treatment serum cav-1 levels and single nucleotide polymorphisms (SNPs) in the cav-1 and -2 genes with risk of PC, aggressive PC, PC recurrence or death...
  18. ncbi request reprint A high-resolution comparative map of canine Chromosome 5q14.3-q33 constructed utilizing the 1.5x canine genome sequence
    Kenine E Comstock
    Clinical and Human Biology Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, D4 100, P O Box 19024, Seattle, Washington 98109 1024, USA
    Mamm Genome 15:544-51. 2004
    ..Moreover, this study demonstrates the utility of genomic survey sequences when combined with accurate genome maps for rapid mapping of disease susceptibility loci...
  19. pmc Association of hepsin gene variants with prostate cancer risk and prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 70:1012-9. 2010
    ..We report results from a population-based case-control genetic association study for six tagging single nucleotide polymorphisms (tagSNPs) in the HPN gene...
  20. pmc Vitamin D pathway gene variants and prostate cancer risk
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 18:1929-33. 2009
    ....
  21. ncbi request reprint Germline mutations in the BRCA2 gene and susceptibility to hereditary prostate cancer
    Ilir Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, USA
    Clin Cancer Res 13:839-43. 2007
    ..However, studies of the contribution of BRCA2 mutations to the etiology of hereditary prostate cancer (HPC) have been inconsistent...
  22. doi request reprint Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 17:1203-13. 2008
    ....
  23. ncbi request reprint Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer
    Crystal N Holick
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, USA
    Cancer Epidemiol Biomarkers Prev 16:1990-9. 2007
    ..Our findings suggest that polymorphisms in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer...
  24. pmc Derived variants at six genes explain nearly half of size reduction in dog breeds
    Maud Rimbault
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 23:1985-95. 2013
    ..3% of variance in weight. This work advances our understanding of mammalian growth by describing genetic contributions to canine size determination in non-giant dog breeds. ..
  25. pmc An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 325:995-8. 2009
    ..These results illustrate the important role of a single evolutionary event in constraining and directing phenotypic diversity in the domestic dog...
  26. ncbi request reprint Vitamin D receptor gene polymorphisms and prostate cancer risk
    Mahesh B Keitheri Cheteri
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 59:409-18. 2004
    ..To further evaluate this relationship, we conducted a population-based case-control study of the VDR BsmI, FokI, and Poly-A polymorphisms, and prostate cancer...
  27. pmc Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Am J Epidemiol 172:578-90. 2010
    ..These results contribute further evidence that aspirin may have chemopreventive activity against prostate cancer and highlight the need for additional research...
  28. pmc Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11-q14
    Liesel M FitzGerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Eur J Hum Genet 18:1141-7. 2010
    ..This study shows the benefit of using a comprehensive family cancer history to create more genetically homogenous subsets of HPC families for linkage analyses...
  29. ncbi request reprint Genetic structure of the purebred domestic dog
    Heidi G Parker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Post Office Box 19024, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, USA
    Science 304:1160-4. 2004
    ..These results provide a genetic classification of dog breeds and will aid studies of the genetics of phenotypic breed differences...
  30. pmc Coat variation in the domestic dog is governed by variants in three genes
    Edouard Cadieu
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 326:150-3. 2009
    ..Thus, an array of varied and seemingly complex phenotypes can be reduced to the combinatorial effects of only a few genes...
  31. pmc Breed-specific ancestry studies and genome-wide association analysis highlight an association between the MYH9 gene and heat tolerance in Alaskan sprint racing sled dogs
    Heather J Huson
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Building 50, Room 5351, Bethesda, MD 20892, USA
    Mamm Genome 23:178-94. 2012
    ....
  32. pmc A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs
    Dana S Mosher
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 3:e79. 2007
    ..3619; p approximately 0.00028). These results highlight the utility of performance-enhancing polymorphisms, marking the first time a mutation in MSTN has been quantitatively linked to increased athletic performance...
  33. ncbi request reprint Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years
    Kathleen E Malone
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 66:8297-308. 2006
    ....
  34. pmc Clinical utility of five genetic variants for predicting prostate cancer risk and mortality
    Claudia A Salinas
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 69:363-72. 2009
    ..3 and a family history of the disease may predict risk of prostate cancer. The present study tests the performance of these factors in prediction models for prostate cancer risk and prostate cancer-specific mortality...
  35. pmc Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 18:1839-48. 2009
    ....
  36. ncbi request reprint Androgen receptor (CAG)n and (GGC)n polymorphisms and breast cancer risk in a population-based case-control study of young women
    Nicola M Suter
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:127-35. 2003
    ..In addition, these data suggest that AR repeat length may be partly responsible for the increased risk for early-onset breast cancer in women who use OCs, although these findings need replication in other populations...
  37. ncbi request reprint Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:876-81. 2003
    ..We estimate that the Ser217Leu genotype may account for approximately 14% of less aggressive prostate cancer cases and 9% of all sporadic cases in the general United States population of white men <age 65 years...
  38. ncbi request reprint Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98109 1024, USA
    Prostate 66:317-25. 2006
    ..Linkage studies attempting to map genes for hereditary prostate cancer (HPC) have proved challenging, and one potential problem contributing to this challenge is the variability in disease phenotypes...
  39. pmc Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 17:1562-71. 2007
    ..This work both establishes that the primary cea mutation arose as a single disease allele in a common ancestor of herding breeds as well as highlights the value of comparative population analysis for refining regions of linkage...
  40. pmc A single IGF1 allele is a major determinant of small size in dogs
    Nathan B Sutter
    National Human Genome Research Institute, Building 50, Room 5349, 50 South Drive MSC 8000, Bethesda, MD 20892 8000, USA
    Science 316:112-5. 2007
    ..A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs...
  41. pmc The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer
    Abigail L Shearin
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 21:1019-27. 2012
    ..Cancers that have been difficult to study in human families or populations are of particular interest. Histiocytic sarcoma is a rare and poorly understood neoplasm in humans that occurs in 15% to 25% of Bernese Mountain Dogs (BMD)...
  42. ncbi request reprint Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb
    Bo Johanneson
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Hum Genet 123:65-75. 2008
    ..Combining these results with data from the earlier ICPCG study reduces the three-recombination interval at 22q12.3 to approximately 1.36 Mb...
  43. pmc Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families
    Danielle M Friedrichsen
    Divisions of Clinical Research and Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:1939-44. 2004
    ..12 (P = 0.00007). These studies highlight the utility of analyzing defined sets of families with a common origin for reducing locus heterogeneity problems associated with studying complex traits...
  44. pmc Genome-wide association study identifies a genetic variant associated with risk for more aggressive prostate cancer
    Liesel M FitzGerald
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 20:1196-203. 2011
    ..We therefore undertook a search for genetic variants associated with risk of more aggressive disease...
  45. pmc Association of megalin genetic polymorphisms with prostate cancer risk and prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
    Clin Cancer Res 14:3823-31. 2008
    ..Genetic variation within megalin could potentially influence levels of steroid hormone uptake...
  46. pmc Extensive and breed-specific linkage disequilibrium in Canis familiaris
    Nathan B Sutter
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genome Res 14:2388-96. 2004
    ..We also report low haplotype diversity within regions of high LD, with 80% of chromosomes in a breed carrying two to four haplotypes, as well as a high degree of haplotype sharing among breeds...
  47. pmc Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women
    Danielle M Friedrichsen
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Breast Cancer Res 6:R629-35. 2004
    ..However, the 1100delC mutation has only been investigated in a few population-based studies and none from North America...
  48. pmc Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus
    Bo Johanneson
    National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Building 50, Room 5351, Bethesda, MD 20892, USA
    Hum Mol Genet 19:3852-62. 2010
    ..This study further characterizes the 22q locus in HPC risk and suggests that the role of this region in sporadic PC warrants additional studies...
  49. ncbi request reprint BRCA1 and BRCA2 mutations in women from Shanghai China
    Nicola M Suter
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:181-9. 2004
    ..Most alterations observed appear unique to the Chinese population, suggesting a resource that will be useful for assessing risk among both Chinese women and United States women of Chinese descent...
  50. pmc Population-based study of the association of variants in mismatch repair genes with prostate cancer risk and outcomes
    Wendy J Langeberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:258-64. 2010
    ..Mismatch repair (MMR) gene activity may be associated with prostate cancer risk and outcomes. This study evaluated whether single nucleotide polymorphisms (SNP) in key MMR genes are related to prostate cancer outcomes...
  51. ncbi request reprint Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer
    Brandon L Pierce
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 67:410-5. 2007
    ....
  52. pmc Statin use and risk of prostate cancer: results from a population-based epidemiologic study
    Ilir Agalliu
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 168:250-60. 2008
    ..Although statin use was not associated with overall prostate cancer risk, the finding of an increased risk associated with statin use among obese men, particularly use for extended durations, warrants further investigation...
  53. ncbi request reprint Marsupial BRCA1: conserved regions in mammals and the potential effect of missense changes
    Christina J Ramirez
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Oncogene 23:1780-8. 2004
    ....
  54. pmc AMACR polymorphisms, dietary intake of red meat and dairy and prostate cancer risk
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Prostate 71:498-506. 2011
    ..AMACR is also a tumor tissue biomarker over-expressed in PCa. In this study, we explored the potential relationship between AMACR polymorphisms, red meat/dairy intake, and PCa risk...
  55. pmc Evaluation of a variant in the transcription factor 7-like 2 (TCF7L2) gene and prostate cancer risk in a population-based study
    Ilir Agalliu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 68:740-7. 2008
    ..Specifically, the same risk allele of single nucleotide polymorphism (SNP) rs12255372 that is associated with diabetes (T allele) has recently been associated with an increased risk of breast cancer...
  56. pmc An insertion in the RSPO2 gene correlates with improper coat in the Portuguese water dog
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Hered 101:612-7. 2010
    ..The development of a genetic test that distinguishes these 2 allelic types would allow breeders to easily avoid producing PWD with ICs...
  57. pmc So many doggone traits: mapping genetics of multiple phenotypes in the domestic dog
    Maud Rimbault
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 21:R52-7. 2012
    ..It is our expectation that these results will contribute to a better understanding of mammalian developmental processes overall...
  58. pmc Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk
    Erika M Kwon
    National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Building 50, 50 South Drive, Bethesda, MD 20892, USA
    Cancer Epidemiol 36:347-53. 2012
    ..g., KLK3 and AR). Androgens are important in PC and genes involved in this pathway are therefore candidates for conferring susceptibility to PC...
  59. pmc A genetic dissection of breed composition and performance enhancement in the Alaskan sled dog
    Heather J Huson
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    BMC Genet 11:71. 2010
    ..Sled dogs were evaluated for breed composition based on a variety of performance phenotypes including speed, endurance and work ethic, and the data stratified based on population structure...
  60. ncbi request reprint Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24
    Miia Suuriniemi
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:809-14. 2007
    ..S. samples. Although the data were provocative, the U.S. samples were not population based, which precludes assessment of the potential contribution of this locus to prostate cancer incidence in the United States...
  61. pmc Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features
    Liesel M FitzGerald
    National Human Genome Research Institute, Cancer Genetics Branch, NIH, Bethesda, MD, USA
    Clin Cancer Res 15:3231-7. 2009
    ..We investigated the significance of these SNPs in a population-based study of Caucasian men, testing the effects of each SNP in relation to family history of prostate cancer and the clinicopathologic features of the disease...
  62. ncbi request reprint IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer
    Danielle M Friedrichsen
    Division of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 65:44-51. 2005
    ..Several polymorphisms within the IGF-I and IGFBP-3 coding regions have been associated with increased serum protein levels...
  63. ncbi request reprint Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study
    Joanna M Lubieniecka
    Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Prostate 59:357-9. 2004
    ..The transmembrane serine protease 2 (TMPRSS2) gene encodes a type II transmembrane protein which, due to its cell surface localization, could be a potentially useful predictive marker for PCa...
  64. ncbi request reprint Genomic scan of 254 hereditary prostate cancer families
    Marta Janer
    Institute for Systems Biology, Seattle, Washington, USA
    Prostate 57:309-19. 2003
    ..These analyses support the existence of multiple HPC loci, whose presence may be best identified by analyses of large, including pooled, datasets which consider locus heterogeneity...
  65. ncbi request reprint Suggestive genetic linkage to chromosome 11p11.2-q12.2 in hereditary prostate cancer families with primary kidney cancer
    Bo Johanneson
    Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA
    Prostate 67:732-42. 2007
    ..Towards that end, we analyzed a genome-wide scan of HPC families with primary kidney cancer...
  66. ncbi request reprint Dog star rising: the canine genetic system
    Nathan B Sutter
    National Human Genome Research Institute, National Institutes of Health, 50 South Drive, MSC8002, Building 50, Room 5222, Bethesda, Maryland 20892, USA
    Nat Rev Genet 5:900-10. 2004
    ....
  67. doi request reprint Leading the way: canine models of genomics and disease
    Abigail L Shearin
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dis Model Mech 3:27-34. 2010
    ..We discuss two approaches for localizing disease genes in the dog and provide examples of ongoing studies...
  68. pmc Genetic polymorphisms in inflammation pathway genes and prostate cancer risk
    Erika M Kwon
    National Human Genome Research Institute, Cancer Genetics Branch, NIH, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 20:923-33. 2011
    ..To better understand the potential relationship between genes in the inflammation pathway and PC risk, we evaluated variants in 16 candidate genes...
  69. ncbi request reprint Linkage mapping of the primary disease locus for collie eye anomaly
    Jennifer K Lowe
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, USA
    Genomics 82:86-95. 2003
    ..076), in a region corresponding to human chromosome 2q35. These results suggest the presence of a developmental regulatory gene important in ocular embryogenesis, with potential implications for other disorders of ocular vascularization...
  70. ncbi request reprint A polymorphism in the CYP17 gene and risk of prostate cancer
    Janet L Stanford
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:243-7. 2002
    ..It is also possible that CYP17 interacts with other genes that influence risk of familial prostate cancer...
  71. pmc Expression of SLCO transport genes in castration-resistant prostate cancer and impact of genetic variation in SLCO1B3 and SLCO2B1 on prostate cancer outcomes
    Jonathan L Wright
    Department of Urology, University of Washington, Seattle, WA, USA
    Cancer Epidemiol Biomarkers Prev 20:619-27. 2011
    ....
  72. doi request reprint Diabetes mellitus and prostate cancer risk
    Brandon L Pierce
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 68:1126-32. 2008
    ..The objective of this study was to examine the association between PCa risk and several characteristics of DM (duration, age at diagnosis, treatment) in data from two population-based, case-control studies of PCa...
  73. pmc Morphometrics within dog breeds are highly reproducible and dispute Rensch's rule
    Nathan B Sutter
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Building 50, 50 South Drive, Room 5351, Bethesda, MD 20892, USA
    Mamm Genome 19:713-23. 2008
    ....
  74. pmc An SNP within the angiotensin-converting enzyme distinguishes between sprint and distance performing Alaskan sled dogs in a candidate gene analysis
    Heather J Huson
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Hered 102:S19-27. 2011
    ..We observed 81 novel genetic variants within the ACE gene and 4 within the MSTN gene, including a polymorphism within the ACE gene that significantly (P value 2.38 × 10(-5)) distinguished the sprint versus distance populations...
  75. pmc Molecular genetics: DNA analysis of a putative dog clone
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 440:E1-2. 2006
    ..In light of recent concerns regarding the creation of cloned human cell lines from the same institution, we have undertaken an independent test to determine the validity of the claims made by Lee et al....
  76. pmc The genetics of canine skull shape variation
    Jeffrey J Schoenebeck
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genetics 193:317-25. 2013
    ..Of particular interest are those molecular genetic changes that are associated with the development of distinct breeds...
  77. pmc Canine behavioral genetics: pointing out the phenotypes and herding up the genes
    Tyrone C Spady
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 82:10-8. 2008
    ..Finally, we discuss the applicability of studies of canine behavior to human genetics...
  78. pmc Man's best friend becomes biology's best in show: genome analyses in the domestic dog
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Genet 44:309-36. 2010
    ..We also discuss the many ways in which the dog has illuminated our understanding of human disease and conclude with a discussion on where the field is likely headed in the next five years...
  79. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
    ..Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive...
  80. pmc Germline missense variants in the BTNL2 gene are associated with prostate cancer susceptibility
    Liesel M FitzGerald
    Division of Public Health Sciences, University of Washington, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 22:1520-8. 2013
    ..Rare, inherited mutations account for 5% to 10% of all prostate cancer cases. However, to date, few causative mutations have been identified...
  81. ncbi request reprint Canid genomics: mapping genes for behavior in the silver fox
    Tyrone C Spady
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 17:259-63. 2007
  82. pmc Sensitive quantification of mosaicism using high density SNP arrays and the cumulative distribution function
    Thomas C Markello
    Office of the Clinical Director, NHGRI, National Institutes of Health, Bethesda, MD 20892 1851, USA
    Mol Genet Metab 105:665-71. 2012
    ..We also demonstrate application of the method to novel diseases and mechanisms...
  83. ncbi request reprint Facilitating genome navigation: survey sequencing and dense radiation-hybrid gene mapping
    Christophe Hitte
    CNRS, UMR 6061, Genetique et Developpement, Faculte de Medecine, Rennes, France
    Nat Rev Genet 6:643-8. 2005
    ....
  84. ncbi request reprint Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Science 309:613-7. 2005
    ..We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement...
  85. ncbi request reprint Lessons learned from the dog genome
    Robert K Wayne
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 91302, USA
    Trends Genet 23:557-67. 2007
    ..The dog is finally emerging as a novel resource for studying the genetic basis of complex traits, including behavior...
  86. pmc An integrated 4249 marker FISH/RH map of the canine genome
    Matthew Breen
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    BMC Genomics 5:65. 2004
    ..Understanding the genetic basis of both phenotypic variation and disease susceptibility in the dog provides new ways in which to dissect the genetics of human health and biology...
  87. pmc Canine genomics and genetics: running with the pack
    Heidi G Parker
    PLoS Genet 1:e58. 2005
    ..We then highlight findings of interest related to disease gene mapping and population structure. Finally, we summarize novel results on the genetics of morphologic variation...
  88. ncbi request reprint Finding prostate cancer susceptibility genes
    Elaine A Ostrander
    Division of Clinical Research1, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Annu Rev Genomics Hum Genet 5:151-75. 2004
    ..To increase the ability to find disease-associated loci, much denser genome-wide scans must be undertaken in multiple ethnic groups. In addition, new ways of defining homogenous subsets of families need to be developed...
  89. ncbi request reprint Genome sequence, comparative analysis and haplotype structure of the domestic dog
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 438:803-19. 2005
    ..The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health...
  90. ncbi request reprint Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics
    Daniel J Schaid
    Harwick 7, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hum Genet 120:471-85. 2006
    ..This provides a basis for attempts to identify these genes, with potential clinical utility for men with aggressive prostate cancer and their relatives...
  91. pmc A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Hum Genet 77:219-29. 2005
    ....
  92. ncbi request reprint Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types
    Amanda Ewart-Toland
    UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Carcinogenesis 26:1368-73. 2005
    ..The data also underline the advantages of comparative association studies involving study populations from different ethnic groups for determination of disease risk...
  93. ncbi request reprint The domestic dog genome
    Elaine A Ostrander
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Curr Biol 14:R98-9. 2004
  94. ncbi request reprint Expanded repeat in canine epilepsy
    Hannes Lohi
    The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Science 307:81. 2005
    ..Clinicopathologic characterization establishes affected animals as a model for Lafora disease, the most severe teenage-onset human epilepsy...
  95. ncbi request reprint Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers
    Kimberly A Zuhlke
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0946, USA
    Clin Cancer Res 10:5975-80. 2004
    ..To examine the possibility that germ-line BRCA1 mutations were associated with hereditary prostate cancer, individuals from 93 families with evidence of linkage to chromosome 17q were screened for germ-line BRCA1 mutations...
  96. ncbi request reprint The keeshond defect in cardiac conotruncal development is oligogenic
    Petra Werner
    Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancy Street, Philadelphia, PA 19104 6010, USA
    Hum Genet 116:368-77. 2005
    ..We excluded from the linked regions in the dog, a number of genes known to have a role in the etiology of CTDs and predict that continuing studies will identify CTD-predisposing genes not previously recognized...
  97. ncbi request reprint CRH_Server: an online comparative and radiation hybrid mapping server for the canine genome
    Christophe Hitte
    UMR 6061 CNRS, Genetique et Developpement, Faculte de Medecine, Universite de Rennes1, 2 Avenue Pr Léon Bernard, 35043 Rennes Cedex, France
    Bioinformatics 20:3665-7. 2004
    ..CRH_Server allows users to compute their own RH data using the current canine RH map, and allows comparative dog/human mapping analyses. Finally, it suggests multiple options for storage and queries of the dog RH database...
  98. pmc Single-nucleotide-polymorphism-based association mapping of dog stereotypes
    Paul Jones
    The WALTHAM Centre for Pet Nutrition, Waltham on the Wolds, Leicsestershire LE14 4RT, United Kingdom
    Genetics 179:1033-44. 2008
    ..The strengths and limitations of the approach are discussed as well as its potential to identify loci regulating the within-breed incidence of specific polygenic diseases...
  99. ncbi request reprint An extended microsatellite set for linkage mapping in the domestic dog
    David R Sargan
    Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    J Hered 98:221-31. 2007
    ..74. This marker group will allow genome-wide scans in the dog to be conducted at close to 5 cM resolution...
  100. ncbi request reprint Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q
    Daniel J Schaid
    Division of Biostatistics, Mayo Clinic, Rochester, MN, USA
    Hum Genet 121:729-35. 2007
    ..001) was found on chromosomes 19q and 5q, with P-values <or= 0.01 observed on chromosomes 3q, 7q, and 16q. Our results confirm reports of Gleason score linkage to chromosome 19q and suggest new loci for further investigation...
  101. ncbi request reprint Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3
    Duska J Sidjanin
    Center for Canine Genetics and Reproduction, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Hum Mol Genet 11:1823-33. 2002
    ....