JOHN J O'SHEA

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer
    David F Stroncek
    Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, USA
    J Transl Med 10:48. 2012
  2. ncbi request reprint A new modality for immunosuppression: targeting the JAK/STAT pathway
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Drug Discov 3:555-64. 2004
  3. ncbi request reprint New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 1820, USA
    Curr Opin Rheumatol 17:305-11. 2005
  4. ncbi request reprint Cytokines and autoimmunity
    JOHN J O'SHEA
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch and Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:37-45. 2002
  5. ncbi request reprint Cytokine signaling in 2002: new surprises in the Jak/Stat pathway
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Cell 109:S121-31. 2002
  6. pmc Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Exp Med 206:35-41. 2009
  7. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
  8. ncbi request reprint Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression
    Akio Morinobu
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:40640-6. 2004
  9. pmc Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
    Lydia Durant
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Immunity 32:605-15. 2010
  10. ncbi request reprint Cytokines and their role in lymphoid development, differentiation and homeostasis
    Sigrun R Hofmann
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Allergy Clin Immunol 2:495-506. 2002

Detail Information

Publications107 found, 100 shown here

  1. pmc New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer
    David F Stroncek
    Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, USA
    J Transl Med 10:48. 2012
    ..In the future, combinations of adoptive transfer of T cells and specific vaccination against the cognate antigen can be envisaged to further enhance the effectiveness of these therapies...
  2. ncbi request reprint A new modality for immunosuppression: targeting the JAK/STAT pathway
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Drug Discov 3:555-64. 2004
  3. ncbi request reprint New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 1820, USA
    Curr Opin Rheumatol 17:305-11. 2005
    ..This review will discuss strategies to develop novel immunosuppressants that arise from advances in the understanding of cytokine signaling...
  4. ncbi request reprint Cytokines and autoimmunity
    JOHN J O'SHEA
    Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch and Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:37-45. 2002
    ..The balance between the pro-inflammatory and immunosuppressive functions of these well-known cytokines and the implications for the pathogenesis of autoimmune disease is the focus of this review...
  5. ncbi request reprint Cytokine signaling in 2002: new surprises in the Jak/Stat pathway
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Cell 109:S121-31. 2002
    ..This review focuses on recent advances in the field and highlights some of the most active areas of Jak-Stat pathway research...
  6. pmc Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Exp Med 206:35-41. 2009
    ..Thus, it appears that splenic LTi-like cells are a rapid source of IL-17 and IL-22, which might contribute to dynamic organization of secondary lymphoid organ structure or host defense...
  7. pmc Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 467:967-71. 2010
    ..These data indicate an alternative mode for T(H)17 differentiation. Consistent with genetic data linking IL23R with autoimmunity, our findings re-emphasize the importance of IL-23 and therefore may have therapeutic implications...
  8. ncbi request reprint Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression
    Akio Morinobu
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:40640-6. 2004
    ....
  9. pmc Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
    Lydia Durant
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Immunity 32:605-15. 2010
    ..Thus, STAT3 orchestrates multiple critical aspects of T cell function in inflammation and homeostasis...
  10. ncbi request reprint Cytokines and their role in lymphoid development, differentiation and homeostasis
    Sigrun R Hofmann
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Allergy Clin Immunol 2:495-506. 2002
    ..In this review, we will focus on recent advances in the understanding of molecular mechanisms that regulate lymphoid development, homeostasis and tolerance...
  11. pmc Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway
    Kevin M Elias
    Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD, USA
    Blood 111:1013-20. 2008
    ....
  12. pmc Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1
    Kiyoshi Hirahara
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 36:1017-30. 2012
    ..Thus, these data identify a suppressive activity of IL-27, by which CD4(+) T cells can restrict differentiation of Th17 cells in trans...
  13. ncbi request reprint Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling
    Ryuta Nishikomori
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Immunol 169:4388-98. 2002
    ..This implies that STAT4 is an essential element in the early events of Th1 differentiation...
  14. pmc Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation
    Wendy T Watford
    LCBS MIIB NIAMS NIH, Bldg 10, Room 9N256, MSC 1820, 10 Center Dr, Bethesda, MD 20892 1820, USA
    Mol Cell Biol 26:6623-32. 2006
    ..Previous in vitro studies using overexpression or short interfering RNA inhibition of the levels of Cybr protein appear to have overestimated its immunological role...
  15. ncbi request reprint Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    Arian Laurence
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 26:371-81. 2007
    ..We conclude that in addition to the promotion of activation-induced cell death of lymphocytes and the generation of Treg cells, inhibition of Th17 polarization appears to be an important function of IL-2...
  16. ncbi request reprint Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
    Denis Franchimont
    Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:2212-8. 2002
    ..These observations provide a mechanism by which glucocorticoids may have a positive influence on T cell survival and function...
  17. pmc Early Th1 cell differentiation is marked by a Tfh cell-like transition
    Shingo Nakayamada
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:919-31. 2011
    ..Our data argue that Tfh and Th1 cells share a transitional stage through the signal mediated by STAT4, which promotes both phenotypes. However, T-bet represses Tfh cell functionalities, promoting full Th1 cell differentiation...
  18. pmc Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
    Xiang Ping Yang
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:247-54. 2011
    ..Thus, the balance rather than the absolute magnitude of these signals determined the propensity of cells to make a key inflammatory cytokine...
  19. pmc T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription
    Takashi Usui
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Disease NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:755-66. 2006
    ..Thus, the principal function of T-bet in developing Th1 cells is to negatively regulate GATA-3 rather than to positively regulate the IFNG gene...
  20. pmc TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells
    Hayato Takahashi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:587-95. 2012
    ..We also found that miR-10a limited differentiation into the T(H)17 subset of helper T cells and therefore represents a factor that can fine-tune the plasticity and fate of helper T cells...
  21. pmc The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis
    Akiko Kimura
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 114:4721-8. 2009
    ..Finally, transcriptome analysis indicated that STAT5A/B directs GM-CSF signaling through the regulation of proliferation and survival genes...
  22. pmc Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
    Wendy T Watford
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:2803-12. 2008
    ..These data underscore the role of Tpl2 as a regulator of T helper cell lineage decisions and demonstrate that Tpl2 has an important functional role in the regulation of Th1 responses...
  23. pmc IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
    Lai Wei
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:34605-10. 2007
    ..These data argue that IL-21 serves as an autocrine factor secreted by Th17 cells that promotes or sustains Th17 lineage commitment...
  24. pmc T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
    Marko Pesu
    Molecular Immunology and Inflammation Branch, National Institute for Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 455:246-50. 2008
    ..Targeting furin has emerged as a strategy in malignant and infectious disease. Our results suggest that inhibiting furin might activate immune responses, but may result in a breakdown in peripheral tolerance...
  25. pmc Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    Nicolas Charles
    Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:533-43. 2009
    ..Our findings demonstrate that basophil-expressed Lyn kinase exerts regulatory control on Th2 cell differentiation and function...
  26. pmc The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B
    Akiko Kimura
    Laboratory of Genetics and Physiology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:32704-9. 2010
    ..ChIP assays using 32D cells revealed IL-3-induced binding of STAT5A/B to a γ-interferon-activated sequences site in the Ccn3/Nov gene promoter. This is the first report that Ccn3/Nov is directly induced by cytokines through STAT5A/B...
  27. pmc Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation
    Lai Wei
    Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda MD 20892, USA
    Immunity 32:840-51. 2010
    ..Clusters of genes negatively regulated by STATs were also identified, highlighting previously unappreciated repressive roles of STATs. Therefore, STAT4 and STAT6 play wide regulatory roles in T helper cell specification...
  28. pmc Helper T-cell differentiation and plasticity: insights from epigenetics
    Kiyoshi Hirahara
    Department of Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    Immunology 134:235-45. 2011
    ..In this review, we will discuss recent progress in the understanding of how cytokines influence gene expression and epigenetic modifications, and the impact of these findings on our views of helper cell lineage commitment and plasticity...
  29. pmc Stat5a/b are essential for normal lymphoid development and differentiation
    Zhengju Yao
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:1000-5. 2006
    ..Thus, deficiency of Stat5 results in severe combined immunodeficiency, similar in many respects to deficiency of IL-7R, gammac, and Jak3...
  30. pmc CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner
    John Andersson
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:1975-81. 2008
    ..T reg cell-mediated generation of functional CD4(+)FoxP3(+) cells via this TGF-beta-dependent pathway may represent a major mechanism as to how T reg cells maintain tolerance and expand their suppressive abilities...
  31. ncbi request reprint IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity
    Tomohiko Tamura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2573-81. 2005
    ..Together, IRF-4 and IRF-8 serve as a backbone of the molecular program regulating DC subset development and their functional diversity...
  32. ncbi request reprint CXCL12 signaling is independent of Jak2 and Jak3
    Masato Moriguchi
    Molecular Immunology and Inflammation Branch, NIAMS, Laboratory of Host Defenses, NIAID, and Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:17408-14. 2005
    ..Thus, we conclude that in contrast to previous reports, Jaks, especially Jak3, are unlikely to play an essential role in chemokine signaling...
  33. pmc New complexities in helper T cell fate determination and the implications for autoimmune diseases
    Hiroaki Takatori
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mod Rheumatol 18:533-41. 2008
    ..Selectively targeting Tregs and Th17 cells are likely to be important strategies in the treatment of inflammatory and autoimmune diseases in humans...
  34. ncbi request reprint A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2
    Jay H Bream
    Lymphocyte and Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health NIH, Bethesda, Maryland 20892 1820, USA
    J Biol Chem 279:41249-57. 2004
    ..These data led us to conclude that this distal region serves as both a target of chromatin remodeling in the IFNG locus as well as an IL-2-induced transcriptional enhancer that binds Stat5 proteins...
  35. ncbi request reprint Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4
    Wendy T Watford
    Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Immunol Rev 202:139-56. 2004
    ..In contrast, IL-23 promotes end-stage inflammation. Targeting IL-12, IL-23, and their downstream signaling elements would therefore be logical strategies for the treatment of immune-mediated diseases...
  36. ncbi request reprint Cell signaling. Stat acetylation--a key facet of cytokine signaling?
    JOHN J O'SHEA
    National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 307:217-8. 2005
  37. pmc Distinct requirements for T-bet in gut innate lymphoid cells
    Giuseppe Sciumè
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 209:2331-8. 2012
    ..Thus, T-bet has a general importance for ILC in the gut and plays a selective and critical role in the generation of NKp46+ ILC22...
  38. pmc STATs shape the active enhancer landscape of T cell populations
    Golnaz Vahedi
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    Cell 151:981-93. 2012
    ..Thus, these findings point to a critical role of STATs as environmental sensors in dynamically molding the specialized enhancer architecture of differentiating cells...
  39. pmc T helper 17 cell heterogeneity and pathogenicity in autoimmune disease
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Trends Immunol 32:395-401. 2011
    ..Ideally, better understanding of expression and action of key transcription factors and the epigenetic landscape of Th17 can help explain the flexibility and diversity of interleukin-17-producing cells...
  40. ncbi request reprint Characterization and analysis of the proximal Janus kinase 3 promoter
    Martin Aringer
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:6057-64. 2003
    ..Thus, transcription factors that bind these sites, especially Ets family members, are likely to be important regulators of Jak3 expression...
  41. pmc STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation
    Akio Morinobu
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:12281-6. 2002
    ..We conclude that phosphorylation of STAT4 on both tyrosine and serine residues is important in promoting normal T(H)1 differentiation and IFN-gamma secretion...
  42. pmc Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production
    Lisa A Mielke
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health Bethesda, MD 20892, USA
    J Immunol 183:7984-93. 2009
    ..These studies implicate Tpl2 as an important mediator for collaboration of pattern recognition receptors with danger-associated molecular patterns to induce TNF and IL-1beta production and optimal host defense...
  43. pmc Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    Gang Wei
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:155-67. 2009
    ..Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4(+) T helper cell differentiation...
  44. pmc Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma
    Marko Pesu
    MIIB NIAMS NIH, Bldg 10, Rm 9N262, 10 Center Dr, Bethesda, MD 20892, USA
    Blood 108:983-5. 2006
    ..Thus, we conclude that IL-12 induction of furin might represent a new aspect of IFN-gamma regulation and control of Th1 differentiation...
  45. ncbi request reprint Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights
    Davide Agnello
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10, Room 9N262, 10 Center Drive, MSC 1820, Bethesda, Maryland 20802 1820, USA
    J Clin Immunol 23:147-61. 2003
    ..The transcription factors Stat6, GATA-3, c-Maf, NFATs, and the cytokine IL-4 promote TH2 differentiation. These key regulators of TH differentiation are the subject of this review...
  46. ncbi request reprint Jak3 and the pathogenesis of severe combined immunodeficiency
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, MSC 1820, 10 Center Drive, Bethesda, MD 20892, USA
    Mol Immunol 41:727-37. 2004
    ..Further study of Jak3 will hopefully provide insights into the clinical treatment of patients suffering from immune-mediated diseases...
  47. pmc Helper T-cell identity and evolution of differential transcriptomes and epigenomes
    Golnaz Vahedi
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    Immunol Rev 252:24-40. 2013
    ....
  48. pmc BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis
    Rahul Roychoudhuri
    Center for Cancer Research, National Cancer Institute, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nature 498:506-10. 2013
    ..These findings identify BACH2 as a key regulator of CD4(+) T-cell differentiation that prevents inflammatory disease by controlling the balance between tolerance and immunity. ..
  49. pmc The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes
    Pushpa Pandiyan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 189:4237-46. 2012
    ..Taken together, these data indicate that IL-15 has a negative regulatory role in fine-tuning of IL-17A production and Th17-mediated inflammation...
  50. pmc Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity
    Yuka Kanno
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 30:707-31. 2012
    ..In this review, recent advances in understanding T helper lineage specification and deciphering the action of transcription factors are summarized with emphasis on comprehensive views of the dynamic T cell epigenome...
  51. pmc The Current STATus of lymphocyte signaling: new roles for old players
    Adewole S Adamson
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    Curr Opin Immunol 21:161-6. 2009
    ..Focusing on how STATs work in concert with other transcription factors will hopefully provide a better mechanistic understanding of the pathogenesis of various autoimmune diseases...
  52. pmc Nonredundant roles for Stat5a/b in directly regulating Foxp3
    Zhengju Yao
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Blood 109:4368-75. 2007
    ..Therefore, we conclude that Stat5a/b have an essential, nonredundant role in regulating Treg cells, and that Stat3 and Stat5a/b appear to have opposing roles in the regulation of Foxp3...
  53. pmc Signal transduction pathways and transcriptional regulation in Th17 cell differentiation
    Kiyoshi Hirahara
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cytokine Growth Factor Rev 21:425-34. 2010
    ..In this review, we will discuss the current understanding of the signaling pathways, molecular interactions, and transcriptional and epigenetic events that contribute to Th17 differentiation and acquisition of effector functions...
  54. pmc New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression
    Scott M Steward-Tharp
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 1183:123-48. 2010
    ..Within this context, we examine existing T cell-directed therapies, including new agents being evaluated in clinical and preclinical studies. We also use recent findings to speculate on novel targets...
  55. ncbi request reprint The biology of IL-12: coordinating innate and adaptive immune responses
    Wendy T Watford
    Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Cytokine Growth Factor Rev 14:361-8. 2003
    ..IL-12 and the recently identified cytokines, IL-23 and IL-27, define a family of related cytokines that induce IFN-gamma production and promote T cell expansion and proliferation...
  56. pmc Jak3 negatively regulates dendritic-cell cytokine production and survival
    Kunihiro Yamaoka
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bldg 10, 9N256, 10 Center Dr, Bethesda, MD 20892 1820, USA
    Blood 106:3227-33. 2005
    ..These results may be relevant clinically for patients with SCID who have undergone hematopoietic stem cell transplantation and for patients who might be treated with a Jak3 inhibitor...
  57. pmc Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene
    Adewole Adamson
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    PLoS ONE 8:e59367. 2013
    ..Finally, we demonstrate that when restricted to T cells, expression of TIMP1 promotes neuropathology in experimental allergic encephalomyelitis...
  58. pmc Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease
    Apostolos Kontzias
    Pediatric Rheumatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Curr Opin Pharmacol 12:464-70. 2012
    ..Many other Jakinibs are likely to follow and in this brief review, we will discuss the state-of-the art of this new class of pharmacological agents...
  59. pmc Helper T cell diversity and plasticity
    Shingo Nakayamada
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 24:297-302. 2012
    ..In this review, we highlight recent advances that pertain to this topic and the mechanisms that contribute to helper CD4(+) T cell differentiation and plasticity...
  60. pmc Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1616, USA
    Science 327:1098-102. 2010
    ..Herein, we review recent advances that pertain to this topic and the mechanisms that contribute to helper CD4+ T cell commitment and plasticity. The therapeutic implications of these new findings are also considered...
  61. pmc Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:4234-43. 2011
    ..Thus, CP-690,550 may improve autoimmune diseases and prevent transplant rejection by suppressing the differentiation of pathogenic Th1 and Th17 cells as well as innate immune cell signaling...
  62. pmc Genomic views of STAT function in CD4+ T helper cell differentiation
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 11:239-50. 2011
    ..Defining exactly how extrinsic signals control the specification and plasticity of T(H) cells will provide important insights and perhaps therapeutic opportunities in these diseases...
  63. pmc Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:8137-42. 2006
    ..We conclude that Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of Th17 differentiation...
  64. pmc Signal transduction and Th17 cell differentiation
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Microbes Infect 11:599-611. 2009
    ..Here we review our current understanding of the signaling pathways, molecular interactions and transcriptional events that lead to Th17 differentiation and effector function, as well as the epigenetic modifications that accompany them...
  65. pmc Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers
    Golnaz Vahedi
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, Bethesda, MD, USA
    Immunology 139:294-8. 2013
    ..These findings provide new insights into how signal transduction impinges upon the genome...
  66. pmc STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease
    Arian Laurence
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:209-22. 2012
    ....
  67. pmc Selectivity and therapeutic inhibition of kinases: to be or not to be?
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 10:356-60. 2009
    ..In this Perspective, we discuss the present status of Janus kinase inhibitors-a new class of immunosuppressive drugs-and the advantages and disadvantages of selectively inhibiting this class of kinase...
  68. pmc Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells
    Kristina T Lu
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:622-32. 2011
    ..ChIP-Seq analyses revealed positive epigenetic markings on Tbx21, Gata3, and Rorc in Tfh-like and ex vivo Tfh cells and on Bcl6 in non-Tfh cells, supporting the concept of plasticity between Tfh and other Th cell populations...
  69. ncbi request reprint Regulation of IL-17 production in human lymphocytes
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Cytokine 41:71-8. 2008
    ..Targeting the production and action of this cytokine is also likely to be beneficial therapeutically for autoinflammatory and autoimmune diseases...
  70. doi request reprint Th17 cells: a new fate for differentiating helper T cells
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Res 41:87-102. 2008
    ..Selectively targeting the Th17 lineage may be beneficial for the treatment of inflammatory and autoimmune diseases...
  71. ncbi request reprint IFN-gamma mediates the death of Th1 cells in a paracrine manner
    Kathryn E Foulds
    Cellular Immunology Section, Human Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:842-9. 2008
    ..Collectively, these data show the multiple mechanisms by which Th1 effector cells are efficiently eliminated in vivo...
  72. pmc Distinct regulation of interleukin-17 in human T helper lymphocytes
    Zhi Chen
    National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 56:2936-46. 2007
    ..The present study was undertaken to assess the effects on naive human CD4+ T cells of cytokines known to promote murine Th17 cells...
  73. doi request reprint The Transcription Factors Thpok and LRF Are Necessary and Partly Redundant for T Helper Cell Differentiation
    Andrea C Carpenter
    Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:622-33. 2012
    ..These findings identify the Thpok-LRF pair as a core node of Th cell differentiation and function...
  74. pmc JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 36:542-50. 2012
    ..Not only have genome-wide association studies demonstrated that this pathway is highly relevant to human autoimmunity, but targeting JAKs is now a reality in immune-mediated disease...
  75. pmc New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation
    Lai Wei
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Semin Cell Dev Biol 19:394-400. 2008
    ..Therefore, Stat5a/b and Stat3 are emerging to be key players in T cell differentiation and homeostasis...
  76. pmc Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
    Susannah D Brydges
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:875-87. 2009
    ..These data suggest that CAPS are true inflammasome-mediated diseases and provide insight for more common inflammatory disorders...
  77. pmc Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited
    Sigrun R Hofmann
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, 10 Center Dr, Bldg 10, Rm 9N256, Bethesda, MD 20892 1820, USA
    Mol Cell Biol 24:5039-49. 2004
    ..However, full-length Jak3 is required for normal trafficking of this cytokine receptor/Jak pair, a finding that has important structural and clinical implications...
  78. pmc Cytokine signaling modules in inflammatory responses
    JOHN J O'SHEA
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Immunity 28:477-87. 2008
    ....
  79. pmc Therapeutic targeting of Janus kinases
    Marko Pesu
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 223:132-42. 2008
    ..Thus, we are learning a great deal about the feasibility and effectiveness of targeting Janus kinases, and it appears likely that this will be a fruitful strategy in a variety of settings...
  80. ncbi request reprint Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
    Valentino Parravicini
    Molecular Inflammation Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Nat Immunol 3:741-8. 2002
    ..Fyn-deficiency impaired degranulation, whereas Lyn-mediated signaling and calcium was normal. Thus, Fc epsilon RI-dependent mast cell degranulation involves cross-talk between Fyn and Lyn kinases...
  81. pmc Janus kinases in immune cell signaling
    Kamran Ghoreschi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 228:273-87. 2009
    ..Despite the fact that Jaks were discovered only a little more than a decade ago, at the time of writing there are 20 clinical trials underway testing the safety and efficacy of Jak inhibitors...
  82. pmc STAT5 isoforms: controversies and clarifications
    Haydee L Ramos
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 404:e1-2. 2007
    ..This new evidence calls into question the physiological significance of this putative isoform and forces the general re-examination of proteolytically generated STAT isoforms...
  83. ncbi request reprint The Yersinia effector protein YpkA induces apoptosis independently of actin depolymerization
    Heiyoung Park
    Molecular Immunology and Inflammation Branch, Immunoregulation Unit, National Institute and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:6426-34. 2007
    ..A region including aa 133-262 in YpkA was sufficient for inducing apoptosis independent of localization to the plasma membrane. These data suggest that YpkA can act as a direct inducer of cell death...
  84. ncbi request reprint De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:3340-8. 2002
    ....
  85. pmc Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity
    Pingtao Tang
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:2625-9. 2002
    ..Because the binding protein modified activation of ADP ribosylation factor by cytohesin-1, we designate this cytokine-inducible protein Cybr (cytohesin binder and regulator)...
  86. pmc Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)
    Jian Kang Jiang
    NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA
    J Med Chem 51:8012-8. 2008
    ..Finally, an appraisal of the minimum energy conformation of each stereoisomer and molecular docking at Jak3 was performed in an effort to better understand each compounds selectivity and potency profiles...
  87. ncbi request reprint Jaks and STATs: biological implications
    W J Leonard
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1674, USA
    Annu Rev Immunol 16:293-322. 1998
    ..STATs then can modulate the expression of target genes. The basic biology of this system, including the range of known Jaks and STATs, is discussed, as are the defects in animals and humans lacking some of these signaling molecules...
  88. ncbi request reprint Recent advances in understanding NF-kappaB regulation
    David L Boone
    Department of Medicine, Ben May Institute for Cancer Research, IBD Research Center and Committee on Immunology, The University of Chicago, Chicago, Illinois 60637, USA
    Inflamm Bowel Dis 8:201-12. 2002
  89. ncbi request reprint Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
    Averil Ma
    Department of Medicine, Biomedical Sciences Program, University of California, San Francisco, California 94143 0451, USA
    Annu Rev Immunol 24:657-79. 2006
    ..Trans-presentation also raises several novel cell biological and cellular implications concerning how cytokines support lymphoid homeostasis...
  90. ncbi request reprint The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    David L Boone
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
    Nat Immunol 5:1052-60. 2004
    ..The critical function of this deubiquitinating enzyme in the restriction of TLR signals emphasizes the importance of the regulation of ubiquitin conjugation in innate immune cells...
  91. pmc Connecting the dots from Toll-like receptors to innate immune cells and inflammatory bowel disease
    David L Boone
    Department of Medicine, Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 111:1284-6. 2003
  92. ncbi request reprint Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells
    Magali Terme
    Institut National de la Santé et de la Recherche Médicale Unité 805, Tumor Immunology and Immunotherapy, Villejuif, France
    J Immunol 180:4679-86. 2008
    ..Therefore, the DC/T cell autoreactivity leading to NK cell triggering could potentially be controlled by the coinhibition of both IL-15Ralpha and CCR5 in autoimmune disorders in which NK cells play a deleterious role...
  93. ncbi request reprint Interleukin-15 and the regulation of lymphoid homeostasis
    James Lodolce
    Department of Medicine and the Ben May Institute for Cancer Research, University of Chicago, 5841 S Maryland Avenue MC 6084, Chicago, IL 60637, USA
    Mol Immunol 39:537-44. 2002
    ..This review will focus on recent studies that highlight some of these functions...
  94. pmc Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20
    Shannon L Werner
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 22:2093-101. 2008
    ..Our results delineate the nonredundant functions implied by the knockout phenotypes of ikappabalpha and a20, and identify the latter as a signaling cross-talk mediator controlling inflammatory and developmental responses...
  95. pmc IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway
    Jessica E Hutti
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 27:7451-61. 2007
    ..Phosphorylation of A20 by IKKbeta thus represents part of a novel feedback loop that regulates the duration of NF-kappaB signaling following activation of innate immune signaling pathways...
  96. doi request reprint Unresolved ER Stress Inflames the Intestine
    Averil Ma
    Department of Medicine, University of California at San Francisco, San Francisco, CA 94143 0451, USA
    Cell 134:724-5. 2008
    ..In this issue, Kaser et al. (2008) link a key mediator of endoplasmic reticulum stress, the protein XBP1, with survival of intestinal secretory epithelial cells and inflammatory bowel disease...
  97. ncbi request reprint Interleukin-2-deficient mice develop colitis in the absence of CD28 costimulation
    David L Boone
    Department of Medicine, Ben May Institute for Cancer Research, The University of Chicago, Illinois, USA
    Inflamm Bowel Dis 8:35-42. 2002
    ..This suggests that other costimulatory molecules or T-cell receptor ligation alone drive lymphocyte expansion in IL-2-deficient mice...
  98. pmc The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals
    Osamu Hitotsumatsu
    UCSF Colitis Center, Gastroenterology Division, Department of Medicine, Program in Biomedical Sciences, University of California at San Francisco, San Francisco, CA 94143 0538, USA
    Immunity 28:381-90. 2008
    ..These findings indicate that A20 directly restricts NOD2 induced signals in vitro and in vivo, and provide new insights into how these signals are physiologically restricted...
  99. ncbi request reprint Fas is not essential for lamina propria T lymphocyte homeostasis
    David L Boone
    Department of Medicine, Inflammatory Bowel Disease Research Center, Committee on Immunology, The University of Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 285:G382-8. 2003
    ..Thus our studies reveal that Fas is dispensable for LP T cell homeostasis and suggest that the intestinal inflammation observed in IL2Ralpha-/- mice is independent of defective Fas-induced cell death...
  100. ncbi request reprint Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells
    Keishi Kojima
    Department of Medicine, The MArtin Boyer Laboratory, The University of Chicago, Illinois 60637, USA
    Gastroenterology 124:1395-407. 2003
    ..This study is aimed at determining if enteric bacteria and/or immune signals regulate their physiologic expression...
  101. ncbi request reprint Generation, maintenance, and function of memory T cells
    Patrick R Burkett
    Department of Medicine and the Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA
    Adv Immunol 83:191-231. 2004