D Orlic

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Adult bone marrow stem cells regenerate myocardium in ischemic heart disease
    Donald Orlic
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 996:152-7. 2003
  2. ncbi request reprint Transplanted adult bone marrow cells repair myocardial infarcts in mice
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Building 49, Room 3W16, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 938:221-9; discussion 229-30. 2001
  3. ncbi request reprint Bone marrow stem cells regenerate infarcted myocardium
    Donald Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute NIH, Building 49, Room 3W16, 49 Convent Drive, Bethesda, MD 20892, USA
    Pediatr Transplant 7:86-8. 2003
  4. ncbi request reprint Stem cells for myocardial regeneration
    Donald Orlic
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892 4442, USA
    Circ Res 91:1092-102. 2002
  5. ncbi request reprint The strength of plasticity: stem cells for cardiac repair
    Donald Orlic
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Int J Cardiol 95:S16-9. 2004
  6. ncbi request reprint Bone marrow cells regenerate infarcted myocardium
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, NIH, Bethesda, MD 20892, USA
    Nature 410:701-5. 2001
  7. ncbi request reprint Biological properties of subpopulations of pluripotent hematopoietic stem cells enriched by elutriation and flow cytometry
    D Orlic
    Clinical Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Blood Cells 20:107-17; discussion 118-20. 1994
  8. pmc Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7
    D Orlic
    Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:4601-5. 1995
  9. ncbi request reprint Pluripotent hematopoietic stem cells of low and high density can repopulate W/Wv mice
    D Orlic
    Clinical Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Exp Hematol 20:1291-5. 1992
  10. pmc The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction
    D Orlic
    Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892 4442, USA
    Proc Natl Acad Sci U S A 93:11097-102. 1996

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Adult bone marrow stem cells regenerate myocardium in ischemic heart disease
    Donald Orlic
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 996:152-7. 2003
    ..When considerations such as these are addressed, cell therapy may become a new modality in the treatment of heart patients...
  2. ncbi request reprint Transplanted adult bone marrow cells repair myocardial infarcts in mice
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Building 49, Room 3W16, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 938:221-9; discussion 229-30. 2001
    ..These in vivo findings demonstrate the capacity of highly enriched Lin- c-kit+ adult bone marrow cells to acutely regenerate functional myocardium within an infarcted region...
  3. ncbi request reprint Bone marrow stem cells regenerate infarcted myocardium
    Donald Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute NIH, Building 49, Room 3W16, 49 Convent Drive, Bethesda, MD 20892, USA
    Pediatr Transplant 7:86-8. 2003
    ..In both experimental protocols, the BMSC gave rise to new cardiac myocytes and coronary blood vessels. This BMSC-derived myocardial regeneration resulted in improved cardiac function and survival...
  4. ncbi request reprint Stem cells for myocardial regeneration
    Donald Orlic
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892 4442, USA
    Circ Res 91:1092-102. 2002
    ..Only then will we be able to regulate this process and begin to realize the full potential of stem cells in regenerative medicine...
  5. ncbi request reprint The strength of plasticity: stem cells for cardiac repair
    Donald Orlic
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Int J Cardiol 95:S16-9. 2004
  6. ncbi request reprint Bone marrow cells regenerate infarcted myocardium
    D Orlic
    Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI, NIH, Bethesda, MD 20892, USA
    Nature 410:701-5. 2001
    ..The developing tissue comprised proliferating myocytes and vascular structures. Our studies indicate that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease...
  7. ncbi request reprint Biological properties of subpopulations of pluripotent hematopoietic stem cells enriched by elutriation and flow cytometry
    D Orlic
    Clinical Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Blood Cells 20:107-17; discussion 118-20. 1994
    ..We consider the cells in FR25 Lin- c-kitBR to be the most primitive set of hematopoietic stem cells...
  8. pmc Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7
    D Orlic
    Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:4601-5. 1995
    ..These findings also indicate that GATA-2, p45 NF-E2, and c-myb activities may be involved in PHSC maintenance or proliferation...
  9. ncbi request reprint Pluripotent hematopoietic stem cells of low and high density can repopulate W/Wv mice
    D Orlic
    Clinical Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Exp Hematol 20:1291-5. 1992
    ..We conclude that PHSC are heterogeneous for cell size and density and that the highest concentration of PHSC resides in the subset of intermediate density present in the FR29/30 fraction...
  10. pmc The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction
    D Orlic
    Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892 4442, USA
    Proc Natl Acad Sci U S A 93:11097-102. 1996
    ..We conclude that the amphoR mRNA level in HSC correlates with amphotropic retrovirus transduction efficiency...
  11. ncbi request reprint Interleukin-7R alpha mRNA expression increases as stem cells differentiate into T and B lymphocyte progenitors
    D Orlic
    Hematopoiesis Section, NHGRI, NIH, Bethesda, MD 20892 4442, USA
    Exp Hematol 25:217-22. 1997
    ..Our findings are consistent with the hypothesis that the absence of an intact IL-7R (IL-7R alpha and gamma c) may be a critical loss that interrupts lymphopoiesis...
  12. ncbi request reprint Adult BM stem cells regenerate mouse myocardium
    D Orlic
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Cytotherapy 4:521-5. 2002
  13. ncbi request reprint BM stem cells and cardiac repair: where do we stand in 2004?
    D Orlic
    Cardiovascular Branch, National Heart Lung and Blood Institute, NIH, Bethesda, Maryland 20892 1454, USA
    Cytotherapy 7:3-15. 2005
    ..Only then will it be possible to determine if, and to what extent, BM stem cells are involved in myocardial regeneration and to begin to regulate precisely tissue repair...
  14. ncbi request reprint Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell lines
    D E Sabatino
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4442, USA
    Blood Cells Mol Dis 23:422-33. 1997
    ..We conclude that the improved transduction was a direct effect of the increased levels of receptor mRNA and unrelated to changes in the cell cycle status...
  15. ncbi request reprint Transplantation of transduced nonhuman primate CD34+ cells using a gibbon ape leukemia virus vector: restricted expression of the gibbon ape leukemia virus receptor to a subset of CD34+ cells
    B A Bunnell
    Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Gene Ther 6:48-56. 1999
    ..Our findings suggest that, in rhesus macaques, PG13-derived retroviral vectors may only be able to transduce a subset of CD34+ cells as only CD34+ Thy-1+ cells express the GaLV receptor...
  16. ncbi request reprint Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA
    M E Horwitz
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Exp Hematol 27:1160-7. 1999
    ....
  17. ncbi request reprint Stem cell factor increases colony-forming unit-spleen number in vitro in synergy with interleukin-6, and in vivo in Sl/Sld mice as a single factor
    D M Bodine
    Clinical Hematology Branch NHLBI, Bethesda, MD 20892
    Blood 79:913-9. 1992
    ..These results show that SCF alone can increase CFU-S number in vivo, and in combination with other growth factors increases CFU-S numbers in vitro...
  18. ncbi request reprint Meeting summary: International Symposium and Workshop on Hematopoietic Stem Cells IV, University of Tübingen, Germany, September 19-21, 2002
    Tim H Brummendorf
    Department of Hematology, Oncology and Immunology, University Medical Center II, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    Exp Hematol 31:475-82. 2003
  19. ncbi request reprint Stem cell repair in ischemic heart disease: an experimental model
    Donald Orlic
    National Human Genome Research Institute NIH, Bethesda, MD, USA
    Int J Hematol 76:144-5. 2002
    ..We conclude that adult BMSC have the potential for repair in acute, ischemic heart disease...
  20. ncbi request reprint Meeting summary: International Symposium and Workshop on Hematopoietic Stem Cells V, University of Tübingen, Germany, September 16-18, 2004
    Katja C Weisel
    Department of Hematology, Oncology and Immunology, University Medical Center II, Tubingen, Germany
    Exp Hematol 33:513-22. 2005
  21. pmc AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates
    Andre Larochelle
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10 CRC, Rm 4E 5132, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 107:3772-8. 2006
    ..Thus, AMD3100-mobilized CD34(+) cells represent an alternative source of hematopoietic stem cells for clinical stem cell transplantation and genetic manipulation with integrating retroviral vectors...