J J Oppenheim

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi Autoantigens act as tissue-specific chemoattractants
    Joost J Oppenheim
    National Cancer Institute Frederick, Center for Cancer Research, Laboratory of Molecular Immunoregulation, MD 21702 1201, USA
    J Leukoc Biol 77:854-61. 2005
  2. ncbi Alarmins initiate host defense
    Joost J Oppenheim
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, Frederick, MD, USA
    Adv Exp Med Biol 601:185-94. 2007
  3. ncbi IL-2: more than a T cell growth factor
    Joost J Oppenheim
    Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, National Cancer Institute, Frederick, MD 21701-1201, USA
    J Immunol 179:1413-4. 2007
  4. ncbi Alarmins: chemotactic activators of immune responses
    Joost J Oppenheim
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, Scientific Application and International Cooperation, Inc SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Curr Opin Immunol 17:359-65. 2005
  5. ncbi Roles of antimicrobial peptides such as defensins in innate and adaptive immunity
    J J Oppenheim
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Ann Rheum Dis 62:ii17-21. 2003
  6. ncbi Chemokine receptors on dendritic cells promote autoimmune reactions
    Joost J Oppenheim
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Arthritis Res 4:S183-8. 2002
  7. ncbi Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1
    Y Le
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, International Corporation Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Neurosci 21:RC123. 2001
  8. ncbi Down-regulation of the chemokine receptor CCR5 by activation of chemotactic formyl peptide receptor in human monocytes
    W Shen
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick, MD 21702 1201, USA
    Blood 96:2887-94. 2000
  9. ncbi Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702 1201, USA
    Science 286:525-8. 1999
  10. ncbi Differential regulation of formyl peptide receptor-like 1 expression during the differentiation of monocytes to dendritic cells and macrophages
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    J Immunol 166:4092-8. 2001

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi Autoantigens act as tissue-specific chemoattractants
    Joost J Oppenheim
    National Cancer Institute Frederick, Center for Cancer Research, Laboratory of Molecular Immunoregulation, MD 21702 1201, USA
    J Leukoc Biol 77:854-61. 2005
    ....
  2. ncbi Alarmins initiate host defense
    Joost J Oppenheim
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, Frederick, MD, USA
    Adv Exp Med Biol 601:185-94. 2007
    ..Here, we discuss the characteristics of several alarmins, a variety of potential alarmin candidates and potential implications of alarmins...
  3. ncbi IL-2: more than a T cell growth factor
    Joost J Oppenheim
    Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, National Cancer Institute, Frederick, MD 21701-1201, USA
    J Immunol 179:1413-4. 2007
  4. ncbi Alarmins: chemotactic activators of immune responses
    Joost J Oppenheim
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, Scientific Application and International Cooperation, Inc SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Curr Opin Immunol 17:359-65. 2005
    ..We propose to highlight these proteins' unique activities by grouping them under the novel term 'alarmins', in recognition of their role in mobilizing the immune system...
  5. ncbi Roles of antimicrobial peptides such as defensins in innate and adaptive immunity
    J J Oppenheim
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    Ann Rheum Dis 62:ii17-21. 2003
    ..Linkage of defensins to weak tumour antigens potentiates their immunoadjuvant effects. Defensins use multiple cellular receptors, which endows them with the capacity to marshall adaptive host defences against microbial invaders...
  6. ncbi Chemokine receptors on dendritic cells promote autoimmune reactions
    Joost J Oppenheim
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Arthritis Res 4:S183-8. 2002
    ..These observations suggest the hypothesis that antigens delivered to receptors on iDCs are potent immunogens capable of breaking self-tolerance to tumor antigens to induce autoimmune diseases...
  7. ncbi Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1
    Y Le
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, International Corporation Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Neurosci 21:RC123. 2001
    ..Moreover, FPRL1 is expressed at high levels by inflammatory cells infiltrating senile plaques in brain tissues from AD patients. Thus, FPRL1 may mediate inflammation seen in AD and is a potential target for developing therapeutic agents...
  8. ncbi Down-regulation of the chemokine receptor CCR5 by activation of chemotactic formyl peptide receptor in human monocytes
    W Shen
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick, MD 21702 1201, USA
    Blood 96:2887-94. 2000
    ..The finding that the expression and function of CCR5 can be regulated by peptides that use an unrelated receptor may provide a novel approach to the design of anti-inflamatory and antiretroviral agents. (Blood. 2000;96:2887-2894)..
  9. ncbi Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702 1201, USA
    Science 286:525-8. 1999
    ..Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6...
  10. ncbi Differential regulation of formyl peptide receptor-like 1 expression during the differentiation of monocytes to dendritic cells and macrophages
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    J Immunol 166:4092-8. 2001
    ..The fact that macrophages rather than myeloid DC express functional FPRL1 suggests that this chemotactic receptor may be more involved in inflammatory reactions and innate host defense than in adaptive immune responses...
  11. ncbi LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells
    - De Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Frederick, MD, USA
    J Exp Med 192:1069-74. 2000
    ..Our results suggest that, in addition to its microbicidal activity, LL-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1...
  12. ncbi HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation
    J M Wang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702 1201, USA
    J Immunol 161:4309-17. 1998
    ..Thus, gp120 may be used by HIV-1 to disarm the monocyte response to inflammatory stimulation...
  13. ncbi Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells
    S B Su
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, SAIC Frederick National Cancer Institute, MD 21702, USA
    J Immunol 162:7128-32. 1999
    ..Thus, a CD4-associated signaling molecule(s) including p56lck is activated by gp120 and is required for the down-regulation of CXCR4...
  14. ncbi Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils
    O Chertov
    Laboratory of Molecular Immunoregulation, Biological Response Modifiers Program, Division of Cancer Treatment, NCI, National Institutes of Health, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 271:2935-40. 1996
    ..These proteins represent primordial antimicrobial peptides which may have evolved into acute inflammatory cell-derived signals that mobilize immunocompetent T-cells and other inflammatory cells...
  15. ncbi Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cells
    R Salcedo
    Laboratory of Molecular Immunoregulation, ABL BRP Data Management Sevices, Inc Frederick, Maryland 21702, USA
    FASEB J 14:2055-64. 2000
    ..Whether this heterogeneity in receptor expression by ECs reflects distinct differentiation pathways remains to be established...
  16. ncbi Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens
    A Biragyn
    Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 167:6644-53. 2001
    ....
  17. ncbi HIV-1 envelope gp41 is a potent inhibitor of chemoattractant receptor expression and function in monocytes
    H Ueda
    The Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research, Frederick, Maryland 21702 1201, USA
    J Clin Invest 102:804-12. 1998
    ..Thus, gp41, which had not previously been implicated as interacting with HIV-1 fusion cofactors, downregulates chemoattractant receptors on monocytes by a CD4-dependent pathway...
  18. ncbi A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells
    S B Su
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    J Exp Med 189:395-402. 1999
    ..In contrast, SAA was not a ligand or agonist for FPR, the high affinity fMLP receptor. Thus, SAA is the first chemotactic ligand identified for FPRL1. Our results suggest that FPRL1 mediates phagocyte migration in response to SAA...
  19. ncbi Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death
    Xin Chen
    Basic Research Program, SAIC-Frederick, Inc, Frederick, MD, USA
    Eur J Immunol 34:859-69. 2004
    ..Our data also suggest that selective protection of CD4+CD25+ T cell from apoptosis may constitute a role in immune tolerance for IL-2...
  20. ncbi Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37)
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA
    J Leukoc Biol 69:691-7. 2001
    ....
  21. ncbi Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function
    O M Howard
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 274:16228-34. 1999
    ....
  22. ncbi Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens
    K Tani
    Laboratory of Molecular Immunoregulation, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Int Immunol 12:691-700. 2000
    ..Thus, defensins appear to function as neutrophil-derived signals that promote adaptive immune responses...
  23. ncbi Chemokines regulate T cell adherence to recombinant adhesion molecules and extracellular matrix proteins
    A R Lloyd
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 156:932-8. 1996
    ..Our findings provide in vitro evidence of a critical role for chemokines in T cell adhesion to endothelial adhesion molecules and ECM proteins, thereby promoting haptotactic migration of T cells to sites of inflammation in vivo...
  24. ncbi The neutrophil granule protein cathepsin G activates murine T lymphocytes and upregulates antigen-specific IG production in mice
    K Tani
    Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Biochem Biophys Res Commun 282:971-6. 2001
    ..Thus, neutrophil granule cathepsin G, in addition to its capacity to kill microbes and to enhance leukocyte motility, activates T lymphocytes and modulates humoral immunity...
  25. ncbi Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells
    R Salcedo
    Laboratory of Molecular Immunoregulation, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    J Immunol 166:7571-8. 2001
    ..This suggests that CCL11 may contribute to angiogenesis in conditions characterized by increased CCL11 production and eosinophil infiltration such as Hodgkin's lymphoma, nasal polyposis, endometriosis, and allergic diathesis...
  26. ncbi Opiates transdeactivate chemokine receptors: delta and mu opiate receptor-mediated heterologous desensitization
    M C Grimm
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Science Applications International Corp Frederick, Frederick, Maryland 21702, USA
    J Exp Med 188:317-25. 1998
    ..This may contribute to the defects in host defense seen with opiate abuse and has important implications for immunomodulation induced by several endogenous neuropeptides which act through G protein-coupled receptors...
  27. ncbi Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages
    H Yazawa
    Laboratory of Molecular Immunoregulation, SAIC Frederick, Center for Cancer Research, National Cancer Institute at Frederick, Maryland 21702, USA
    FASEB J 15:2454-62. 2001
    ..These results suggest that besides mediating the proinflammatory activity of Abeta42, FPRL1 is also involved in the internalization of Abeta42, which culminates in the formation of fibrils only in macrophages...
  28. ncbi A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion
    L Xu
    Biological Carcinogenesis and Development Program, Program Resources Inc DynCorp, Frederick Cancer Research and Development Center, MD 21702, USA
    J Immunol 155:1184-90. 1995
    ..These results suggest that SAA may play an important role in recruiting T lymphocytes, as well as neutrophils and monocytes into inflammatory lesions...
  29. ncbi Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway
    R Badolato
    Biologic Carcinogenesis and Development Program, Program Resources, Inc DynCorp, Frederick, MD, USA
    J Immunol 155:4004-10. 1995
    ..The chemoattractants FMLP, RANTES, MIP-1 alpha, and MCAF/MCP-1, all failed to desensitize rSAA-induced Ca2+ influx and chemotaxis in monocytes. This suggests that SAA uses a distinct receptor that is coupled to PTx-sensitive G proteins...
  30. ncbi Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines
    T Yoshimura
    Laboratory of Immunobiology, National Cancer Institute, Frederick, MD 21701
    Proc Natl Acad Sci U S A 84:9233-7. 1987
    ..Potency and efficacy are comparable to that of fMet-Leu-Phe, which is often used as a reference. In contrast to many attractants, the protein was not chemotactic for human monocytes...
  31. ncbi Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha
    R Salcedo
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Frederick Cancer Research and Development Center, Frederick, MD 21702 1202, USA
    Am J Pathol 154:1125-35. 1999
    ..Taken together, our data indicate that SDF-1alpha acts as a potent chemoattractant for endothelial cells of different origins bearing CXCR4 and is a participant in angiogenesis that is regulated at the receptor level by VEGF and bFGF...
  32. ncbi Opiate inhibition of chemokine-induced chemotaxis
    M C Grimm
    Laboratory of Molecular Immunoregulation, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Ann N Y Acad Sci 840:9-20. 1998
    ..Since MIP-1 alpha and IL-8, unlike NAP-2, have the capacity to desensitize leukocytes, it is possible that opiates, by desensitizing some chemokine responses, can suppress inflammatory reactions...
  33. ncbi Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation
    Xin Chen
    Basic Research Program, SAIC-Frederick, Inc, National Cancer Institute-Frederick, Frederick, MD 21702-1201, USA
    J Altern Complement Med 10:519-26. 2004
    ..Our experimental results pave the way for identification of active component(s) and/or analysis of synergistic/additive effect of a YZH ingredient in future studies...
  34. ncbi The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity
    D Yang
    Laboratory of Molecular Immunoregulation, National Cancer Institute at Frederick, Maryland 21702-1201, USA
    Cell Mol Life Sci 58:978-89. 2001
    ..Consequently, all these ligand-receptor interactions in addition to mediating chemotaxis also activate receptor-expressing cells to produce other mediators of inflammation...
  35. ncbi Pleiotropic roles of formyl peptide receptors
    Y Le
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cytokine Growth Factor Rev 12:91-105. 2001
    ..These new findings have greatly expanded the functional scope of the formyl peptide receptors and call for more in-depth investigation of the role of these receptors in pathophysiological conditions...
  36. ncbi Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds
    O M Howard
    Laboratory of Molecular Immunoregulation, National Cancer Istitute Frederick Cancer Research and Development Center, MD 21702, USA
    Bioorg Med Chem Lett 11:59-62. 2001
    ..Acetylation of the reactive amino groups of RANTES abrogated the inhibitory activity of cosalane. The data suggest that cosalane and its structural analogues may interfere with the RANTES/CCR1 interaction by binding to RANTES...
  37. ncbi Cytokines: past, present, and future
    J J Oppenheim
    Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Int J Hematol 74:3-8. 2001
    ..The explosion in cytokine information over the past 40 years has been enormous and full of surprises. If past be prologue, with the advent of genomics and proteomics the future should witness even greater progress...
  38. ncbi Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant
    Kahori Kurosaka
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    J Immunol 174:6257-65. 2005
    ..Thus, CRAMP functions as both a chemoattractant for phagocytic leukocytes and an enhancer of adaptive immune response...
  39. ncbi Immunization with DNA topoisomerase I induces autoimmune responses but not scleroderma-like pathologies in mice
    Paul Q Hu
    Laboratory of Molecular Immunoregulation, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702, USA
    J Rheumatol 34:2243-52. 2007
    ..However, its pathogenic role in SSc remains unclear. We investigated whether induction of an autoreactive antibody response is directly pathogenic in mice...
  40. ncbi LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8
    O M Howard
    Intramural Research Support Program, Laboratory of Molecular Immunoregulation, Division of Basic Science, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD, USA
    Blood 96:840-5. 2000
    ..This study suggests that LEC may be a more effective inducer of cell adhesion than cell migration...
  41. ncbi Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation
    De Yang
    Basic Research Program, Science Applications International Corporation SAIC Frederick, MD 21702, USA
    J Immunol 173:6134-42. 2004
    ..We therefore propose these mediators be considered as endogenous multifunctional immune alarmins...
  42. ncbi Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation
    De Yang
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Maryland 21702 1201, USA
    J Leukoc Biol 72:598-607. 2002
    ....
  43. ncbi Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses
    Gonzalo de la Rosa
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Fredrick, MD 21702, USA
    J Immunol 180:6868-76. 2008
    ..These results suggest that lactoferrin contributes to the activation of both the innate and adaptive immune responses by promoting the recruitment of leukocytes and activation of dendritic cells...
  44. ncbi Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Science Applications International Corp Frederick Cancer Research and Develeopment Center, National Cancer Institute, MD 21702, USA
    J Immunol 163:1737-41. 1999
    ....
  45. ncbi Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3
    A Ben-Baruch
    Laboratory of Molecular Immunoregulation, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Biol Chem 270:22123-8. 1995
    ..Since MCP3 has been reported to use MCP1 receptor(s), our results with transfected 293 cells expressing only C-C CKR1 clearly establish that C-C CKR1 is also a functional receptor for MCP3...
  46. ncbi Purification and identification of chemokines potentially involved in kidney-specific metastasis by a murine lymphoma variant: induction of migration and NFkappaB activation
    J M Wang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute Frederick Cancer Research and Development Center, MD 21702, USA
    Int J Cancer 75:900-7. 1998
    ..Thus, locally produced chemokines, MCP-1(JE) and RANTES in particular, may contribute to the preferential metastasis of ESb-MP cells to the kidneys...
  47. ncbi Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1
    Xin Chen
    Basic Research Program, SAIC-Frederick, Inc, National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, USA
    Antimicrob Agents Chemother 47:2810-6. 2003
    ..Therefore, shikonin, as a naturally occurring, low-molecular-weight pan-chemokine receptor inhibitor, constitutes a basis for the development of novel anti-HIV therapeutic agents...
  48. ncbi Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells
    Xin Chen
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Immunol 178:6123-9. 2007
    ..Thus, in addition to inhibiting the development of Treg, the immunoadjuvant activity of PTx can be attributable to the generation of IL-6-dependent IL-17-producing CD4 cells...
  49. ncbi Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2
    Johann Röhrl
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Division of Basic Science, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 184:6688-94. 2010
    ..Our data indicate that hBD2 and hBD3, together with their mouse orthologs (beta-defensin 4 and 14), are chemotactic for a broad spectrum of leukocytes in a CCR6- and CCR2-dependent manner...
  50. ncbi Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor
    K Matsushima
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, Maryland 21701
    J Exp Med 167:1883-93. 1988
    ..Furthermore, we also determined that LPS, IL-1, and TNF stimulated the mononuclear cells to produce biologically active MDNCF. This observation may account for the in vivo capacity of IL-1 and TNF to induce netrophil infiltrates...
  51. ncbi Regulatory effects of deoxycholic acid, a component of the anti-inflammatory traditional Chinese medicine Niuhuang, on human leukocyte response to chemoattractants
    Xin Chen
    The Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute-Frederick, Bldg. 560, Rm. 31-19, Frederick, MD 21702-1201, USA
    Biochem Pharmacol 63:533-41. 2002
    ..Taken together, our experimental results suggest that blockade of fMLP receptors may contribute to the anti-inflammatory effects of traditional medicine containing DCA...
  52. ncbi Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication
    W Gong
    Intramural Research Support Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 273:4289-92. 1998
    ..Furthermore, MCP-2 inhibited the entry/replication of HIV-1ADA in CCR5/293 cells coexpressing CD4. These results indicated that MCP-2 uses CCR5 as one of its functional receptors and is an additional potent natural inhibitor of HIV-1...
  53. ncbi Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function
    O M Howard
    Intramural Research Support Program, SAIC Frederick, Maryland, USA
    J Leukoc Biol 64:6-13. 1998
    ..Thus, we describe a novel compound that inhibits in vivo replication of HIV-1 by down-regulation of co-receptors. These data lead us to propose that NSC 651016 may have in vivo anti-inflammatory activity...
  54. ncbi High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin
    De Yang
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, and Basic Research Program, Rm 31 19 Bldg 560, 1050 Boyles Street, Frederick, MD 21702, USA
    J Leukoc Biol 81:59-66. 2007
    ..Based on its dual DC-attracting and -activating activities as well as its reported capacity to promote an antigen-specific immune response, we consider HMGB1 to have the properties of an immune alarmin...
  55. ncbi Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE
    Xin Chen
    Basic Research Program, SAIC Frederick, Center for Cancer Research, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Eur J Immunol 36:2139-49. 2006
    ..Therefore, the combination of glucocorticoid and IL-2, two currently used therapeutics, may provide a novel approach for the treatment of autoimmune diseases, transplant rejection and graft-vs.-host disease...
  56. ncbi T cell lines from systemic sclerosis patients and healthy controls recognize multiple epitopes on DNA topoisomerase I
    Paul Q Hu
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, PA, USA
    J Autoimmun 26:258-67. 2006
    ..These results suggest that topo-I-specific T cells can become clonally expanded in some patients and may contribute to the pathogenesis of this disease...
  57. ncbi Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells
    Xin Chen
    Basic Science Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 185:174-82. 2010
    ..However, intratumoral Tregs expressing more TNFR2 are able to overcome the greater resistance to suppression of intratumoral Tconv cells, resulting in a dominant immunosuppressive tumor environment...
  58. ncbi Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking
    Xin Chen
    Basic Research Program, Science Applications International Corporation Frederick, Inc, Laboratory of Molecular Immunoregulation, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    Blood 106:2409-16. 2005
    ..These data provide new insight into the mechanism of action of TPT and indicate that the inhibition of maturation and trafficking of DCs by TPT contributes to its immunosuppressive effects...
  59. ncbi Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, Laboratory of Molecular Immunoregulation, National Cancer Institute Frederick Frederick, MD 21702 1201, USA
    Eur J Immunol 36:671-80. 2006
    ..This study concludes that an underlying cause for the immunological adjuvanticity of PTx is down-regulation of Treg cell number and function...
  60. ncbi Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate
    O M Zack Howard
    National Cancer Institute Center for Cancer Research, Laboratory of Molecular Immunoregulation, Basic Research Program, Science Applications International Corporation, Frederick, MD, USA
    Blood 105:4207-14. 2005
    ..These studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5...
  61. ncbi Chemokines and chemokine receptors as novel therapeutic targets in rheumatoid arthritis (RA): inhibitory effects of traditional Chinese medicinal components
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, MD 21702 1201, USA
    Cell Mol Immunol 1:336-42. 2004
    ..Thus, this approach may lead to the discovery of new inhibitors of chemokines or chemokine receptors that can be used to treat diseases associated with inappropriately overactive chemokine mediated inflammatory reactions...
  62. ncbi BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57BL/6 mice
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, MD 21702, USA
    J Leukoc Biol 78:114-21. 2005
    ..Our data also suggest that differences in the CD4(+)CD25(+) Treg cell number and the susceptibility of CD4(+)CD25(-) Tres cells may, at least in part, account for the differences in immune response between B6 and BALB/c strains of mice...
  63. ncbi Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2
    Arya Biragyn
    Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Science 298:1025-9. 2002
    ..These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens...
  64. ncbi Mammalian defensins in immunity: more than just microbicidal
    De Yang
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, NCI, Frederick, MD 21702, USA
    Trends Immunol 23:291-6. 2002
    ..Although showing similarity in activity and overall tertiary structure, the evolutionary relationship between defensins and chemokines remains to be determined...
  65. ncbi The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins
    David M Hoover
    Macromolecular Crystallography Laboratory, Division of Cancer Treatment, Centers and Diagnosis Developmental Therapeutics Program, NCI Frederick, Frederick, Maryland 21702, USA
    J Biol Chem 277:37647-54. 2002
    ..7 A and compare it with the crystal structures of human beta-defensin-1 and -2. Molecules of MIP-3alpha and the beta-defensins seem to share few structural motifs that are likely associated with their common biological activities...
  66. ncbi Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function
    Xin Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Fort Detrick, MD, 21702 1201, USA
    Life Sci 70:2897-913. 2002
    ..Identification of the responsible components in these two herbal preparations may yield compounds suitable for structural modification into potent novel drugs...
  67. ncbi Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition
    Maria T Rugeles
    Universidad de Antioquia, Medellin, Colombia, The Experimental Immunology Branch, NCI, NIH, Bethesda, USA
    AIDS 17:481-6. 2003
    ..CONCLUSION: These findings indicate that the majority of the soluble HIV-1 inhibitory activity contained in the supernatants of mixed lymphocyte reactions is due to EDN or a closely related RNase...
  68. ncbi Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells
    Rosalba Salcedo
    Laboratory of Molecular Immunoregulation, Cancer Center Research, National Cancer Institute NIH, Bldg 567, Rm 210, Frederick, MD 21702, USA
    Blood 102:1966-77. 2003
    ..These findings indicate that PGE2 is a mediator of VEGF- and bFGF-induced CXCR4-dependent neovessel assembly in vivo and show that angiogenic effects of PGE2 require CXCR4 expression...
  69. ncbi Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses
    De Yang
    Basic Research Program, SAIC Frederick, Inc, MD, USA
    J Exp Med 205:79-90. 2008
    ....
  70. ncbi Defensin participation in innate and adaptive immunity
    De Yang
    Basic Research Program, SAIC Frederick, Inc, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, Maryland 21702 1201, USA
    Curr Pharm Des 13:3131-9. 2007
    ..Here we will briefly outline the classification, genes, expression, and structure of mammalian defensins and focus on their roles in innate and adaptive immune response of the host...
  71. ncbi Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells
    De Yang
    Basic Research Program, SAIC Frederick, Laboratory of Molecular Regulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 560, Rm 31 19, Frederick, MD 21702 1201, USA
    Blood 102:3396-403. 2003
    ..Thus, EDN and its mouse ortholog, mEAR2, are eosinophil granule-derived antimicrobial RNases that function as chemoattractants for DCs in vitro and in vivo...
  72. ncbi Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells
    O M Zack Howard
    National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Immunoregulation, Frederick, MD 21702, USA
    J Exp Med 196:781-91. 2002
    ..Therefore, the selection of a self-molecule as a target for an autoantibody response may be a consequence of the proinflammatory properties of the molecule itself...
  73. ncbi Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells
    Xin Chen
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 179:154-61. 2007
    ..Moreover, our study suggests that the slower response of Tregs than Teffs to TNF results in delayed immunosuppressive feedback effects...
  74. ncbi Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes
    R Badolato
    Laboratory of Molecular Immunoregulation, Program Resources, Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
    J Exp Med 180:203-9. 1994
    ..On the basis of these data, we suggest that SAA may participate in enhancing the migration of monocytes and PMN to inflamed tissues during an acute phase response...
  75. ncbi International union of pharmacology. XXII. Nomenclature for chemokine receptors
    P M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 52:145-76. 2000
    ....
  76. ncbi The structure of human beta-defensin-2 shows evidence of higher order oligomerization
    D M Hoover
    Macromolecular Crystallography Laboratory, Program in Structural Biology, NCI Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 275:32911-8. 2000
    ..The structural and electrostatic properties of the hBD2 octamer support an electrostatic charge-based mechanism of membrane permeabilization by beta-defensins, rather than a mechanism based on formation of bilayer-spanning pores...
  77. ncbi TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells
    Xin Chen
    Basic Science Program, SAIC Frederick, Inc, National Cancer Institute Frederick, MD 21702, USA
    Curr Dir Autoimmun 11:119-34. 2010
    ..The role of Tregs in the autoimmune disorders and cancer as well as the effect of anti-TNF therapy on Tregs, especially in rheumatoid arthritis, will also be considered...
  78. ncbi Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells
    Xin Chen
    Basic Research Program, SAIC Frederick Inc, National Cancer Institute NCI Frederick, Frederick, MD 21702 1201, USA
    J Immunol 180:6467-71. 2008
    ..Thus, TNFR2 identifies a unique subset of mouse Tregs with an activated/memory phenotype and maximal suppressive activity that may account for tumor-infiltrating lymphocyte-mediated immune evasion by tumors...
  79. ncbi Chemerin reveals its chimeric nature
    Teizo Yoshimura
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Exp Med 205:2187-90. 2008
    ..Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation...
  80. ncbi Adenosine A2a receptors induce heterologous desensitization of chemokine receptors
    Ning Zhang
    Laboratory of Molecular Immunoregulation, Center for Cancer Research and Basic Research Program, Science Applications International-Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Blood 108:38-44. 2006
    ....
  81. ncbi Ca2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors
    Ning Zhang
    Laboratory of Molecular Immunoregulation, Intramural Research Support Program, Frederick, Maryland 21702-1201, USA
    J Biol Chem 278:12729-36. 2003
    ..Thus, opioids achieve desensitization of chemokine receptors via a unique pathway, involving only calcium-independent PKC isotypes...
  82. ncbi Suradista NSC 651016 inhibits the angiogenic activity of CXCL12-stromal cell-derived factor 1alpha
    Gregory P Schneider
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, Intramural Research Support Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA
    Clin Cancer Res 8:3955-60. 2002
    ..c. assay. These data indicate that suradista NSC 651016 possesses in vitro and in vivo antiangiogenic activity and has the potential to interfere with neovacularization of tumors and their metastases...
  83. ncbi Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses
    Rosalba Salcedo
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA
    Microcirculation 10:359-70. 2003
    ....
  84. ncbi Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense
    De Yang
    Basic Research Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Annu Rev Immunol 22:181-215. 2004
    ..Cathelicidins act on FPRL1-expressing cells. Furthermore, several defensins have considerable immunoenhancing activity. Thus, it appears that mammalian antimicrobial proteins contribute to both innate and adaptive antimicrobial immunity...
  85. ncbi Effects of IL-7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells
    Il Yup Chung
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, Frederick, MD 21702-1201, USA
    Cell Immunol 232:57-63. 2004
    ..This combination may provide a novel means of priming CD4 T cells to respond to IL-2 and may prove useful in up-regulation of normal immune responses in immune deficient diseases...
  86. ncbi The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes
    C G Larsen
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21701
    Science 243:1464-6. 1989
    ..Intradermal injection of rNAP-1 caused dose-dependent accumulation of neutrophils and lymphocytes...
  87. ncbi A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1
    Ning Zhang
    Laboratory of Molecular Immunoregulation, Intramural Research Support Program, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 102:4536-41. 2005
    ....
  88. ncbi Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin
    Poonam Tewary
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute Frederick NIH, Frederick, MD, USA
    Blood 116:3465-74. 2010
    ..Thus, GNLY is the first identified lymphocyte-derived alarmin capable of promoting APC recruitment, activation, and antigen-specific immune response...
  89. ncbi Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood
    Xin Chen
    Basic Science Program, Laboratory of Molecular Immunoregulation, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702 1201, USA
    Eur J Immunol 40:1099-106. 2010
    ..As some non-Treg express TNFR2, the combination of CD25 and TNFR2 must be used to identify a larger population of human Treg, a population that may prove to be of diagnostic and therapeutic benefit in cancer and autoimmune diseases...
  90. ncbi Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN
    Ping Gao
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, PO Box B, Bldg 560, Rm 31 19, Frederick, MD 21702 1201, USA
    Blood 106:2619-26. 2005
    ..Our findings may account for the reported increase in metastatic activity of PTEN-null tumor cells...
  91. ncbi Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis
    Bo Chen
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, 1050 Boyles Street, Frederick, MD 21702, USA
    J Immunol 173:5914-7. 2004
    ..Thus, the results identify that Drm and Dan can interact with Slit proteins and act as inhibitors of monocyte chemotaxis, demonstrating a previously unidentified biological role for these proteins...
  92. ncbi Proinflammatory chemokines, such as C-C chemokine ligand 3, desensitize mu-opioid receptors on dorsal root ganglia neurons
    Ning Zhang
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 173:594-9. 2004
    ..Our data indicate that proinflammatory chemokines are capable of desensitizing mu-opioid receptors on peripheral sensory neurons, providing a novel potential mechanism for peripheral inflammation-induced hyperalgesia...
  93. ncbi Temporin A and related frog antimicrobial peptides use formyl peptide receptor-like 1 as a receptor to chemoattract phagocytes
    Qian Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702-1201, USA
    J Immunol 173:2652-9. 2004
    ....
  94. ncbi Alarmins and antimicrobial immunity
    D Yang
    Basic Research Program, SAIC Frederick, Inc, Center for Cancer Research, National Cancer Institute at Frederick, National Institute of Health, 1050 Boyles Street, Frederick, MD 21702 1201, USA
    Med Mycol 47:S146-53. 2009
    ..Here we provide a brief overview of various alarmins, highlight their critical roles in innate and adaptive antimicrobial immunity, and speculate on potential usage of alarmins in combating aspergillosis...
  95. ncbi Cellular pharmacology studies of shikonin derivatives
    Xin Chen
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute-Frederick, MD 21702-1201, USA
    Phytother Res 16:199-209. 2002
    ..This general inhibitory effect can account for the broad spectrum of shikonin biological and pharmacological activities...
  96. ncbi Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems
    Ning Zhang
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 21-89A, Frederick, MD 21702-1201, USA
    J Leukoc Biol 78:1210-4. 2005
    ..These observations suggest that the crosstalk between chemokine receptors and neuropeptide membrane receptors serves as a bridge between the immune and nervous systems...
  97. ncbi Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15
    Ronald Wolf
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 181:1499-506. 2008
    ..The identified S100A7 interaction with RAGE may provide a novel therapeutic target for inflammation...
  98. ncbi Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor
    Ronghua Sun
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Immunol 173:428-36. 2004
    ..Thus, our studies identify CaG as a novel, host-derived chemotactic agonist for FPR and expand the functional scope of this receptor in inflammatory and immune responses...
  99. ncbi The alarmin functions of high-mobility group proteins
    De Yang
    Basic Science Program, SAIC Frederick, Inc, Frederick, MD 21702, USA
    Biochim Biophys Acta 1799:157-63. 2010
    ....
  100. ncbi Combined administration of antibodies to human interleukin 8 and epidermal growth factor receptor results in increased antimetastatic effects on human breast carcinoma xenografts
    Rosalba Salcedo
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Frederick Cancer Research and Development Center, National Cancer Institute, Maryland 21702-1201, USA
    Clin Cancer Res 8:2655-65. 2002
    ..CONCLUSION: Combined administration of these two human antibodies using growth factor blockade in conjunction with chemokine blockade may thus provide a more effective approach for treatment of metastatic human breast carcinoma...
  101. ncbi IL-1 can act as number one
    Ana M Gamero
    Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, FCRF, Frederick, Maryland 21702, USA
    Immunity 24:16-7. 2006
    ..However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense...