O A Olivero

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys
    O A Olivero
    Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892 4255, USA
    J Natl Cancer Inst 89:1602-8. 1997
  2. ncbi request reprint Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice
    B A Diwan
    Division of Basic Sciences, SAIC Frederick, Inc, Frederick, Maryland, 21702 1201, USA
    Toxicol Appl Pharmacol 161:82-99. 1999
  3. ncbi request reprint Transplacental cisplatin exposure induces persistent fetal mitochondrial and genomic DNA damage in patas monkeys
    A J Giurgiovich
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Reprod Toxicol 11:95-100. 1997
  4. ncbi request reprint Incorporation of 3'-azido-3'-deoxythymidine (AZT) into fetal DNA and fetal tissue distribution of drug after infusion of pregnant late-term rhesus macaques with a human-equivalent AZT dose
    M C Poirier
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Acquir Immune Defic Syndr 22:477-83. 1999
  5. ncbi request reprint Chromosome site-specific immunohistochemical detection of DNA adducts in N-acetoxy-2-acetylaminofluorene--exposed Chinese hamster ovary cells
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892
    Mol Carcinog 3:37-43. 1990
  6. pmc Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity
    A Dutra
    Cytogenetics and Microscopy Core, National Human Genome Research Institute, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Cytogenet Genome Res 128:105-10. 2010
  7. ncbi request reprint Association between GSTM1*0 and squamous dysplasia of the esophagus in the high risk region of Linxian, China
    M J Roth
    The Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Cancer Lett 156:73-81. 2000
  8. ncbi request reprint Localization of DNA adducts induced by N-acetoxy-N-2-acetylaminofluorene in Chinese hamster ovary cells using electron microscopy and colloidal gold
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892
    Genes Chromosomes Cancer 2:130-6. 1990
  9. ncbi request reprint Plasma drug levels compared with DNA incorporation of 3'-azido-3'-deoxythymidine (AZT) in adult cynomolgus (Macaca fascicularis) monkeys
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA
    Exp Biol Med (Maywood) 226:446-9. 2001
  10. ncbi request reprint Preferential formation and decreased removal of cisplatin-DNA adducts in Chinese hamster ovary cell mitochondrial DNA as compared to nuclear DNA
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA
    Mutat Res 391:79-86. 1997

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys
    O A Olivero
    Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892 4255, USA
    J Natl Cancer Inst 89:1602-8. 1997
    ..In this study, we assessed the transplacental tumorigenic and genotoxic effects of AZT in the offspring of CD-1 mice and Erythrocebus patas monkeys given AZT orally during pregnancy...
  2. ncbi request reprint Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice
    B A Diwan
    Division of Basic Sciences, SAIC Frederick, Inc, Frederick, Maryland, 21702 1201, USA
    Toxicol Appl Pharmacol 161:82-99. 1999
    ..The results confirm that AZT is a moderately effective perinatal carcinogen in mice, targeting several tissue types...
  3. ncbi request reprint Transplacental cisplatin exposure induces persistent fetal mitochondrial and genomic DNA damage in patas monkeys
    A J Giurgiovich
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Reprod Toxicol 11:95-100. 1997
    ..The study demonstrates significant fetal genotoxicity in g-DNA and mt-DNA of patas monkeys exposed to cisplatin in utero, suggesting that similarly exposed human fetuses may also sustain drug-induced DNA damage...
  4. ncbi request reprint Incorporation of 3'-azido-3'-deoxythymidine (AZT) into fetal DNA and fetal tissue distribution of drug after infusion of pregnant late-term rhesus macaques with a human-equivalent AZT dose
    M C Poirier
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Acquir Immune Defic Syndr 22:477-83. 1999
    ..Data imply that the human fetus may also be subject to incorporation of AZT into DNA even after short-term AZT infusion to the mother just before delivery...
  5. ncbi request reprint Chromosome site-specific immunohistochemical detection of DNA adducts in N-acetoxy-2-acetylaminofluorene--exposed Chinese hamster ovary cells
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892
    Mol Carcinog 3:37-43. 1990
    ..Thus, the stage of cell cycle in which adducts are induced is an important factor in the specific location of the highest concentrations of this type of DNA lesion...
  6. pmc Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity
    A Dutra
    Cytogenetics and Microscopy Core, National Human Genome Research Institute, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Cytogenet Genome Res 128:105-10. 2010
    ..It has been hypothesized that NBs occur as a result of expulsion of amplified DNA from the main nucleus; however, this data demonstrates that NBs may contain any chromosome, suggesting that NBs do not consist of just amplified DNA...
  7. ncbi request reprint Association between GSTM1*0 and squamous dysplasia of the esophagus in the high risk region of Linxian, China
    M J Roth
    The Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Cancer Lett 156:73-81. 2000
    ..These results are consistent with the notion that exposure to environmental carcinogens that are detoxified by GSTM1, such as polycyclic aromatic hydrocarbons, may contribute to the etiology of esophageal cancer in Linxian...
  8. ncbi request reprint Localization of DNA adducts induced by N-acetoxy-N-2-acetylaminofluorene in Chinese hamster ovary cells using electron microscopy and colloidal gold
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892
    Genes Chromosomes Cancer 2:130-6. 1990
    ..15-26 in the surrounding cytoplasm. Treated cells incubated with normal rabbit serum or specific adduct-absorbed serum showed 19-34 particles for all cellular compartments...
  9. ncbi request reprint Plasma drug levels compared with DNA incorporation of 3'-azido-3'-deoxythymidine (AZT) in adult cynomolgus (Macaca fascicularis) monkeys
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA
    Exp Biol Med (Maywood) 226:446-9. 2001
    ..In addition, AZT-DNA levels in monkey organs were similar to or lower than values observed in peripheral leukocytes of adult AIDS patients...
  10. ncbi request reprint Preferential formation and decreased removal of cisplatin-DNA adducts in Chinese hamster ovary cell mitochondrial DNA as compared to nuclear DNA
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD, USA
    Mutat Res 391:79-86. 1997
    ..The final results demonstrated that both, higher initial binding and lack of removal of cisplatin-DNA adducts appear to contribute to the preferential cisplatin-mtDNA binding observed in CHO cells...
  11. ncbi request reprint 3'-azido-3'-deoxythymidine (AZT) transplacental perfusion kinetics and DNA incorporation in normal human placentas perfused with AZT
    O A Olivero
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Mutat Res 428:41-7. 1999
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