Research Topics
| Joao B OliveiraSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Evaluation of IL-2-Withdrawal-Induced Apoptosis in Human T LymphocytesJoão Bosco Oliveira
Pediatrics Department, Medical Institute Prof Fernando Figueira IMIP, Recife, PE, Brazil
Methods Mol Biol 979:25-31. 2013..We describe here how to evaluate the integrity of the intrinsic pathway of lymphocyte apoptosis triggered by starvation for IL-2 or other survival cytokines...
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International WorkshopJoao B Oliveira
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
Blood 116:e35-40. 2010..It is hoped that harmonizing the diagnosis and classification of ALPS will foster collaborative research and better understanding of the pathogenesis of autoimmune cytopenias and B-cell lymphomas...
Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasisJulie E Niemela
Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, Bethesda, MD, USA
Blood 117:2883-6. 2011..We suggest the use of the term RAS-associated autoimmune leukoproliferative disease to differentiate this disorder from autoimmune lymphoproliferative syndrome...
Molecular- and flow cytometry-based diagnosis of primary immunodeficiency disordersJoao B Oliveira
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
Curr Allergy Asthma Rep 10:460-7. 2010..We discuss here advances in flow cytometry and molecular techniques applied to the study of primary immunodeficiencies...
Critical role for BIM in T cell receptor restimulation-induced deathAndrew L Snow
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
Biol Direct 3:34. 2008....
FAS haploinsufficiency is a common disease mechanism in the human autoimmune lymphoproliferative syndromeHye Sun Kuehn
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20814, USA
J Immunol 186:6035-43. 2011..The apoptosis defect could be corrected by FAS overexpression in vitro. Our findings define haploinsufficiency as a common disease mechanism in ALPS patients with extracellular FAS mutations...
Applications of flow cytometry for the study of primary immune deficienciesJoao B Oliveira
Immunology Service, Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland 20892 1508, USA
Curr Opin Allergy Clin Immunol 8:499-509. 2008..This review focuses on the current applications of flow cytometry for the diagnosis and evaluation of primary immune deficiencies (PIDs)...
Autoimmune lymphoproliferative syndromeJoao B Oliveira
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA
Curr Opin Allergy Clin Immunol 4:497-503. 2004..In this review we summarize current information regarding the diagnosis, management and underlying molecular basis of the syndrome...
Laboratory evaluation of primary immunodeficienciesJoao B Oliveira
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, USA
J Allergy Clin Immunol 125:S297-305. 2010..In this article the authors describe a general approach for the investigation of the most common primary immunodeficiencies, outlining the typical clinical symptoms and most appropriate laboratory investigations...
Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humansHye Sun Kuehn
Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD
Blood 121:3117-25. 2013..In summary, homozygous PRKCD mutation results in B-cell hyperproliferation and defective apoptosis with consequent lymphocyte accumulation and autoantibody production in humans, and disrupts natural killer cell function...
Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasiaPeter D Burbelo
Neurobiology and Pain Therapeutics, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
Blood 116:4848-58. 2010..This study was registered at http://clinicaltrials.gov as NCT00001355...
TNF receptor-associated periodic syndrome (TRAPS): description of a novel TNFRSF1A mutation and response to etanerceptAdriana A Jesus
Pediatric Rheumatology Unit, Pediatrics Department, University of Sao Paulo, Av Dr Eneas de Carvalho Aguiar, 647, 05403 900, Sao Paulo, SP, Brazil
Eur J Pediatr 167:1421-5. 2008....
CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndromeXiying Fan
Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
Clin Immunol 143:152-61. 2012..This study demonstrates that CP-870,893 suppressed oocysts shedding in XHM patients with biliary cryptosporidiosis. The continued study of CD40 agonists in XHM is warranted...
ALPS-ten lessons from an international workshop on a genetic disease of apoptosisMichael J Lenardo
Molecular Development Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 32:291-5. 2010..Their discussions yielded ten broad messages applicable to genetic and immunological investigations of human disease...
NRAS mutation causes a human autoimmune lymphoproliferative syndromeJoao B Oliveira
Department of Laboratory Medicine, Clinical Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:8953-8. 2007..Our observations on the effects of NRAS activation indicate that RAS-inactivating drugs, such as farnesyltransferase inhibitors should be examined in human autoimmune and lymphocyte homeostasis disorders...
Autoimmunity in hyper-IgM syndromeAdriana A Jesus
Pediatric Rheumatology Unit, Pediatrics Department, Universidade de Sao Paulo, Av Dr Enéas Carvalho de Aguiar 500 IMT Bldg II 3rd floor, Sao Paulo, Sao Paulo 054030 000, Brazil
J Clin Immunol 28:S62-6. 2008..HIGM can thus be associated with an impairment of both B-cell and T-cell activation...
