Research Topics
Genomes and Genes | Terrance P O'HanlonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Genetic risk and protective factors for the idiopathic inflammatory myopathiesTerrance P O'Hanlon
National Institute of Environmental Health Sciences, National Institutes of Health, Room 1W101, Bethesda, MD 20892, USA
Curr Rheumatol Rep 11:287-94. 2009....
Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseasesTerrance P O'Hanlon
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arthritis Res Ther 13:R69. 2011..The objective of this study is to determine if multiple systemic autoimmune diseases (SAID) share gene expression pathways that could provide insights into pathogenic mechanisms common to these disorders...- HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodiesTerrance P O'Hanlon
National Institute of Environmental Health Sciences, Bethesda, Maryland 20892, USA
Arthritis Rheum 54:3670-81. 2006..To investigate possible associations of HLA polymorphisms with idiopathic inflammatory myopathy (IIM) in African Americans, and to compare this with HLA associations in European American IIM patients with IIM... - Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathiesTerrance P O'Hanlon
National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 58:3239-46. 2008..To investigate possible associations of GM and KM markers with adult and juvenile forms of the idiopathic inflammatory myopathies (IIMs) in Caucasian and African American patients... - Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodiesTerrance P O'Hanlon
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Medicine (Baltimore) 85:111-27. 2006.... - Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasiansTerrance P O'Hanlon
National Institute of Environmental Health Sciences, Rockville, MD 20892 0958, USA
Medicine (Baltimore) 84:338-49. 2005..These variations in associated HLA polymorphisms may reflect responses to unique environmental triggers resulting in the tissue pathospecificity and distinct clinicopathologic syndromes of the IIM... - Immunogenetic risk and protective factors for juvenile dermatomyositis in CaucasiansGulnara Mamyrova
National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 54:3979-87. 2006.... - Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositisEjaz A Shamim
Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA
Arthritis Rheum 46:1885-93. 2002.... - Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositisGulnara Mamyrova
National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland 20892 1301, USA
Arthritis Rheum 58:3941-50. 2008.... - Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severityApril Bingham
From Office of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland 20892 1301, USA
Medicine (Baltimore) 87:70-86. 2008..Further study is warranted to investigate the pathogenesis of acquired LD in patients with DM... - Ultraviolet radiation intensity predicts the relative distribution of dermatomyositis and anti-Mi-2 autoantibodies in womenLori A Love
Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA
Arthritis Rheum 60:2499-504. 2009.... - Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle diseaseSatoshi Okada
Center for Biologics Evaluation and Research, Food and Drug Administration/NIH, Bethesda, MD, USA
Arthritis Rheum 48:2285-93. 2003..CONCLUSION: These data suggest that UV radiation exposure may modulate the clinical and immunologic expression of an autoimmune disease in different populations around the world... - Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseasesTerrance P O'Hanlon
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arthritis Res Ther 13:R181. 2011..We assessed plasma proteomic profiles among different SAID for evidence of common molecular pathways that could provide insights into pathogenic mechanisms shared by these diseases... - Damage extent and predictors in adult and juvenile dermatomyositis and polymyositis as determined with the myositis damage indexLisa G Rider
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD 20892 1301, USA
Arthritis Rheum 60:3425-35. 2009..We undertook this study to validate the Myositis Damage Index (MDI) in juvenile and adult myositis, to describe the degree and types of damage and to develop predictors of damage... - Validation of manual muscle testing and a subset of eight muscles for adult and juvenile idiopathic inflammatory myopathiesLisa G Rider
Environmental Autoimmunity Group, Office of Clinical Research, National Institute of Environmental Health Sciences NIH, 10 Center Drive, Bethesda, MD 20892 1301, USA
Arthritis Care Res (Hoboken) 62:465-72. 2010..To validate manual muscle testing (MMT) for strength assessment in juvenile and adult dermatomyositis (DM) and polymyositis (PM)... - Environmental factors preceding illness onset differ in phenotypes of the juvenile idiopathic inflammatory myopathiesLisa G Rider
Environmental Autoimmunity Group, National Institute of Environmental Sciences, National Institutes of Health, DHHS, Clinical Research Center Room 4 2352, 10 Center Drive, MSC 1301, Bethesda, MD 20892 1301, USA
Rheumatology (Oxford) 49:2381-90. 2010..To assess whether certain environmental factors temporally associated with the onset of juvenile idiopathic inflammatory myopathies (JIIMs) differ between phenotypes... 
Deciphering the clinical presentations, pathogenesis, and treatment of the idiopathic inflammatory myopathiesLisa G Rider
Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
JAMA 305:183-90. 2011..Knowledge of myositis phenotypes should enhance clinicians' ability to recognize and manage these rare disorders...- Seasonal influence on the onset of idiopathic inflammatory myopathies in serologically defined groupsKakali Sarkar
National Institute of Environmental Health Sciences, NIH, DHHS, Bethesda, MD 20892, USA
Arthritis Rheum 52:2433-8. 2005..To assess possible seasonal patterns in the onset of polymyositis (PM) and dermatomyositis (DM)... - Possible roles and determinants of microchimerism in autoimmune and other disordersKakali Sarkar
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, HHS, 9000 Rockville Pike, NIH 9 1W107, Bethesda, MD 20892 0958, USA
Autoimmun Rev 3:454-63. 2004.... - International consensus on preliminary definitions of improvement in adult and juvenile myositisLisa G Rider
National Institute of Environmental Health Sciences, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 50:2281-90. 2004..To use a core set of outcome measures to develop preliminary definitions of improvement for adult and juvenile myositis as composite end points for therapeutic trials... - Defining Clinical Improvement in Adult and Juvenile MyositisLisa G Rider
Enviromental Autoimmunity Group, National Institute of Enviromental Health Sciences, National Institutes of Health, Bethesda, MD 20892, USA
J Rheumatol 30:603-17. 2003..This workshop is the first of several planned to develop multidisciplinary, international consensus on the conduct and reporting of IIM clinical trials... - Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. Response Criteria Working Group reportSteven Z Pavletic
National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1203, USA
Biol Blood Marrow Transplant 12:252-66. 2006..The proposed response criteria are based on current expert consensus opinion and are intended to improve consistency in the conduct and reporting of chronic GVHD trials, but their use remains to be demonstrated in practice... - Is occupational exposure to mineral oil a risk factor for rheumatoid arthritis?Frederick W Miller
Environmental Autoimmunity Group, National Institutes of Health, DHHS, Clinical Research Center, Bethesda, MD 20892 1301, USA
Nat Clin Pract Rheumatol 2:130-1. 2006 - Mechanisms of disease: Environmental factors in the pathogenesis of rheumatic diseaseMark Gourley
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD 20892 1301, USA
Nat Clin Pract Rheumatol 3:172-80. 2007.... - Neopterin and quinolinic acid are surrogate measures of disease activity in the juvenile idiopathic inflammatory myopathiesLisa G Rider
Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Clin Chem 48:1681-8. 2002..We evaluated the utility of neopterin and quinolinic acid (QUIN) as surrogate measures of disease activity in juvenile idiopathic inflammatory myopathies (IIMs)... - Autoantibodies as predictive and diagnostic markers of idiopathic inflammatory myopathiesKakali Sarkar
NIH 9/1W107, Bethesda, MD 20892, USA
Autoimmunity 37:291-4. 2004 - Serum proteins and paraproteins in women with silicone implants and connective tissue disease: a case-control studyGyorgy Csako
Department of Laboratory Medicine, Clinical Center, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arthritis Res Ther 9:R95. 2007..The causes and clinical implications of these findings require further investigation... - Occupational exposures and autoimmune diseasesGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Int Immunopharmacol 2:303-13. 2002.... - HLA type and immune response to Borrelia burgdorferi outer surface protein a in people in whom arthritis developed after Lyme disease vaccinationRobert Ball
Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA
Arthritis Rheum 60:1179-86. 2009.... - Seasonal birth patterns in myositis subgroups suggest an etiologic role of early environmental exposuresLeora J Vegosen
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH DHHS, 10 Center Drive, Bethesda, MD 20892, USA
Arthritis Rheum 56:2719-28. 2007..To evaluate whether seasonal early environmental exposures might influence later development of autoimmune disease, by assessing distributions of birth dates in groups of patients with idiopathic inflammatory myopathies (IIMs)... - Genomic organization, transcriptional mapping, and evolutionary implications of the human bi-directional histidyl-tRNA synthetase locus (HARS/HARSL)Terrance P O'Hanlon
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD 20892, USA
Biochem Biophys Res Commun 294:609-14. 2002..Human and rodent HARS/HARSL loci are homologous and support a model of inverted gene duplication to explain the emergence of HARSL during mammalian evolution... - Late-onset gastrointestinal pain in juvenile dermatomyositis as a manifestation of ischemic ulceration from chronic endarteropathyGulnara Mamyrova
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, Bethesda, Maryland 20892-1301, USA
Arthritis Rheum 57:881-4. 2007 - Metabolic abnormalities and cardiovascular risk factors in children with myositisKathleen Coyle
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1301, USA
J Pediatr 155:882-7. 2009..To characterize the metabolic abnormalities and risk factors for future cardiovascular disease in children with myositis...