Christopher J O'Donnell

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc A systematic comparison and evaluation of high density exon arrays and RNA-seq technology used to unravel the peripheral blood transcriptome of sickle cell disease
    Nalini Raghavachari
    Genomics Core Facility, Genetics and Development Biology, NHLBI, The National Institutes of Health, 10 Center Drive, Bldg 10, 8C 103B, Bethesda, MD 20892, USA
    BMC Med Genomics 5:28. 2012
  2. pmc Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
    Christopher J O'Donnell
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 26:2769-74. 2006
  3. pmc Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction
    Christopher J O'Donnell
    MPH, NHLBI s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Circulation 124:2855-64. 2011
  4. pmc Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    Christopher J O'Donnell
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S4. 2007
  5. pmc An open access database of genome-wide association results
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 10:6. 2009
  6. ncbi request reprint Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
  7. ncbi request reprint Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
  8. ncbi request reprint Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:1473-81. 2007
  9. pmc Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium
    George Thanassoulis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 55:2491-8. 2010
  10. ncbi request reprint Association of aortic valve calcium detected by electron beam computed tomography with echocardiographic aortic valve disease and with calcium deposits in the coronary arteries and thoracic aorta
    Craig R Walsh
    National Heart, Lung and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Am J Cardiol 93:421-5. 2004

Detail Information

Publications94

  1. pmc A systematic comparison and evaluation of high density exon arrays and RNA-seq technology used to unravel the peripheral blood transcriptome of sickle cell disease
    Nalini Raghavachari
    Genomics Core Facility, Genetics and Development Biology, NHLBI, The National Institutes of Health, 10 Center Drive, Bldg 10, 8C 103B, Bethesda, MD 20892, USA
    BMC Med Genomics 5:28. 2012
    ..The field of transcriptomics is currently being revolutionized by high throughput DNA sequencing methodologies to map, characterize, and quantify the transcriptome...
  2. pmc Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
    Christopher J O'Donnell
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 26:2769-74. 2006
    ..Matrix Gla protein (MGP) is an inhibitor of calcification in vivo. However, little is known regarding the distribution of circulating MGP and its associations with CHD risk factors or with CAC in humans...
  3. pmc Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction
    Christopher J O'Donnell
    MPH, NHLBI s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Circulation 124:2855-64. 2011
    ..We sought to identify common genetic variants associated with CAC and further investigate their associations with MI...
  4. pmc Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study
    Christopher J O'Donnell
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S4. 2007
    ..We conducted a genome-wide association study (GWAS) for SCA measurements in the community-based Framingham Heart Study...
  5. pmc An open access database of genome-wide association results
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 10:6. 2009
    ..However, no database or centralized resource currently exists that contains anywhere near the full scope of GWAS results...
  6. ncbi request reprint Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
    ..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  7. ncbi request reprint Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
    ..The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting...
  8. ncbi request reprint Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:1473-81. 2007
    ..We related validated parental premature CVD with the subclinical measures of coronary artery (CAC) and abdominal aortic (AAC) calcification in the community...
  9. pmc Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium
    George Thanassoulis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 55:2491-8. 2010
    ..To determine the association of long-term exposure to atherosclerosis risk factors with valvular calcification...
  10. ncbi request reprint Association of aortic valve calcium detected by electron beam computed tomography with echocardiographic aortic valve disease and with calcium deposits in the coronary arteries and thoracic aorta
    Craig R Walsh
    National Heart, Lung and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702, USA
    Am J Cardiol 93:421-5. 2004
    ..EBCT AV calcium was associated with calcium deposits in the coronary arteries and the thoracic aorta, but these associations were confounded by age and risk factors...
  11. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  12. ncbi request reprint Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 108:572-6. 2003
    ..We hypothesized that an important mediator of the familial predisposition to CHD is subclinical atherosclerosis, which is detectable by noninvasive imaging...
  13. ncbi request reprint Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study)
    Avni H Thakore
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 99:1598-602. 2007
    ..In conclusion, there were modest associations of inflammatory markers, particularly IL-6, with carotid atherosclerosis. This association appears more pronounced in current smokers than in former smokers and nonsmokers...
  14. pmc Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality
    Wolfgang Lieb
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Arterioscler Thromb Vasc Biol 30:1849-54. 2010
    ..Experimental evidence identified the osteoprotegerin (OPG)/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand (RANKL) pathway as a candidate system modulating vascular remodeling and cardiovascular disease (CVD)...
  15. ncbi request reprint Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Arterioscler Thromb Vasc Biol 22:1662-7. 2002
    ..The objective of this study was to examine the relationship between C-reactive protein (CRP) and carotid atherosclerosis...
  16. ncbi request reprint Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    Stroke 34:397-401. 2003
    ..There is controversy regarding the proportion of variability in IMT explained by genetic factors. Thus, it is uncertain whether carotid IMT is a heritable trait that can be used in genetic studies...
  17. pmc Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study
    George Thanassoulis
    Framingham Heart Study, Boston University and the National Institutes of Health National Heart, Lung, and Blood Institute, 73 Mt Wayte Ave No 2, Framingham, MA 01702, USA
    Circ Arrhythm Electrophysiol 3:345-50. 2010
    ..We tested the hypothesis that pericardial fat, a unique fat deposit in close anatomic proximity to cardiac structures and autonomic fibers, is associated with prevalent AF...
  18. pmc Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 119:1203-10. 2009
    ..We hypothesized that this paradox is due partly to the advent of increasingly sensitive biomarkers for AMI diagnosis...
  19. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  20. pmc Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007
    ..We report the results of a community-based genomewide association study of six ECG and HRV intermediate traits...
  21. pmc Indexes of kidney function and coronary artery and abdominal aortic calcium (from the Framingham Offspring Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 102:440-3. 2008
    ..Neither cysC nor MA was significantly associated with AAC in age- and gender- or multivariable-adjusted models. In conclusion, CKD, cysC, and MA are not associated with CAC or AAC when accounting for cardiovascular disease risk factors...
  22. ncbi request reprint Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study
    Roberto Elosua
    US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 47:990-6. 2006
    ..APOA5 variants were associated with CCA IMT, particularly in obese participants. The mechanism of these associations and the effect modification by obesity are independent of fasting triglyceride levels...
  23. ncbi request reprint C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 106:1189-91. 2002
    ..It has not been established whether elevated CRP reflects an increased burden of subclinical coronary atherosclerosis...
  24. ncbi request reprint Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA 01702 5827, USA
    Arterioscler Thromb Vasc Biol 26:1405-12. 2006
    ..We undertook a linkage disequilibrium (LD)-based genetic approach to investigate the hypothesis that common sequence variants in 5 thrombosis genes influence plasma hemostatic protein levels or risk of cardiovascular disease (CVD)...
  25. pmc Prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat depots in the Framingham heart study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA, Boston, USA
    Circ Cardiovasc Imaging 3:559-66. 2010
    ..We sought to determine the prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat deposits...
  26. pmc Correlation of trabeculae and papillary muscles with clinical and cardiac characteristics and impact on CMR measures of LV anatomy and function
    Michael L Chuang
    NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    JACC Cardiovasc Imaging 5:1115-23. 2012
    ....
  27. pmc Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study
    George Thanassoulis
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 125:2836-43. 2012
    ..Although impaired vascular function is hypothesized to influence the BP response during exercise, limited data exist on the association of vascular function with exercise BP in the community...
  28. pmc Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study
    Sarah R Preis
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 18:2191-8. 2010
    ..003), where VAT had a stronger association in obese individuals. In conclusion, SAT and VAT are both correlates of insulin resistance; however, VAT is a stronger correlate of insulin resistance than SAT...
  29. pmc Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
    ..Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear...
  30. pmc Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study
    Christopher J O'Donnell
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue 2, Framingham, MA 01702 5827, USA
    Arterioscler Thromb Vasc Biol 28:1165-71. 2008
    ..The purpose of this study was to examine the link between LTL and the predisposition to atherosclerosis, as determined by carotid artery intimal medial thickness (IMT) in participants of the Framingham Offspring Study...
  31. pmc Inflammation, kidney function and albuminuria in the Framingham Offspring cohort
    Ashish Upadhyay
    Division of Nephrology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Nephrol Dial Transplant 26:920-6. 2011
    ..Whether inflammatory biomarkers are associated with kidney function and albuminuria after accounting for traditional CVD risk factors is not completely understood...
  32. pmc Visceral and subcutaneous adiposity and brachial artery vasodilator function
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 17:2054-9. 2009
    ..265), above and beyond traditional risk factors. VAT, but not SAT was associated with FMD% after adjusting for clinical covariates. Nevertheless, the differential association with VAT as compared to SAT was minimal...
  33. ncbi request reprint Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  34. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  35. ncbi request reprint Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: the Framingham Heart Study
    Craig R Walsh
    Framingham Heart Study, Framingham, Mass 01702, USA
    Am Heart J 144:733-9. 2002
    ..We sought to determine the association of aortic atherosclerosis, detected by calcific deposits in the abdominal aorta seen on lateral lumbar radiographs, with risk for congestive heart failure (CHF)...
  36. pmc Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study
    Andrew D Johnson
    National Institutes of Health National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circulation 127:799-810. 2013
    ..3 region followed by a comprehensive study of genetic associations with clinical and subclinical cardiovascular disease and its risk factors, as well as with copy number variation and gene expression, in the Framingham Heart Study (FHS)...
  37. pmc Gene expression signatures of coronary heart disease
    Roby Joehanes
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 33:1418-26. 2013
    ..To identify transcriptomic biomarkers of coronary heart disease (CHD) in 188 cases with CHD and 188 age- and sex-matched controls who were participants in the Framingham Heart Study...
  38. pmc Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study
    Connie W Tsao
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    J Am Coll Cardiol 60:2364-71. 2012
    ..This study evaluated the association of timing of lipid levels and lipid genetic risk score (GRS) with subclinical atherosclerosis...
  39. pmc Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies
    Joanne M Murabito
    Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01701, USA
    Circ Cardiovasc Genet 5:100-12. 2012
    ..To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts...
  40. ncbi request reprint Relations of inflammation and novel risk factors to valvular calcification
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 97:1502-5. 2006
    ..In conclusion, inflammatory markers were elevated in patients with valvular calcium. Our findings suggest that much of the observed association between systemic inflammatory markers and valvular calcium may be due to shared risk factors...
  41. ncbi request reprint Prediction of intermittent claudication, ischemic stroke, and other cardiovascular disease by detection of abdominal aortic calcific deposits by plain lumbar radiographs
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 101:326-31. 2008
    ..AAC appears to be useful for risk stratification in patients at intermediate CHD risk...
  42. ncbi request reprint Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample
    Christopher Newton-Cheh
    Framingham Heart Study of the National Heart Lung and Blood Institute and Boston University School of Medicine, Framingham, MA 01702 5827, USA
    Hypertension 49:846-56. 2007
    ..16; 95% CI: 1.00 to 1.33). ARR is a heritable trait influenced by clinical and genetic factors. There is a continuous gradient of increasing risk of BP progression across ARR levels in nonhypertensive individuals...
  43. pmc Eligibility of individuals with subclinical coronary artery calcium and intermediate coronary heart disease risk for reclassification (from the Framingham Heart Study)
    Sarah Rosner Preis
    Center for Population Studies, National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 103:1710-5. 2009
    ..Approximately 25% of intermediate-risk individuals have high CAC scores and may be eligible for reclassification into a higher-risk category...
  44. pmc Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 119:1586-91. 2009
    ..Whether the associations of pericardial fat and measures of cardiac structure and function are independent of the systemic effects of obesity and visceral adiposity has not been fully explored...
  45. pmc Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study
    Thomas M Tadros
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1039-45. 2010
    ..Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress...
  46. ncbi request reprint Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Circulation 112:1728-35. 2005
    ....
  47. pmc C-reactive protein, inflammatory conditions, and cardiovascular disease risk
    Ravi Dhingra
    National Heart Lung and Blood Institute s NHBLI Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Am J Med 120:1054-62. 2007
    ..It is uncertain to what extent high C-reactive protein (CRP) concentrations reflect the presence of inflammatory conditions in the community...
  48. ncbi request reprint Heritability, linkage, and genetic associations of exercise treadmill test responses
    Erik Ingelsson
    Framingham Study, Framingham, Mass, USA
    Circulation 115:2917-24. 2007
    ..The blood pressure (BP) and heart rate responses to exercise treadmill testing predict incidence of cardiovascular disease, but the genetic determinants of hemodynamic and chronotropic responses to exercise are largely unknown...
  49. pmc Periaortic adipose tissue and aortic dimensions in the Framingham Heart Study
    George Thanassoulis
    NIH NHLBI Framingham Heart Study, Framingham, MA, USA
    J Am Heart Assoc 1:e000885. 2012
    ..Periaortic fat, because of its contiguity with the aorta, may promote vascular remodeling and aortic dilatation. However, the relations between perioartic fat depots and aortic dimensions have not been previously described...
  50. pmc Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study
    Ming Huei Chen
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS ONE 7:e51589. 2012
    ..Further examination may be required to generalize this threshold to other studies...
  51. pmc Calcium intake is not associated with increased coronary artery calcification: the Framingham Study
    Elizabeth J Samelson
    Department of Medicine, Harvard Medical School and Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA
    Am J Clin Nutr 96:1274-80. 2012
    ..Adequate calcium intake is known to protect the skeleton. However, studies that have reported adverse effects of calcium supplementation on vascular events have raised widespread concern...
  52. pmc Subclinical and clinical correlates of left ventricular wall motion abnormalities in the community
    Connie W Tsao
    Harvard Thorndike Laboratory, Boston, MA, USA
    Am J Cardiol 107:949-55. 2011
    ..WMAs were associated with the clinical parameters associated with cardiovascular disease risk. Aggressive risk factor modification may be prudent for subjects with WMAs, particularly those free of clinical CHD-HF...
  53. ncbi request reprint Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study
    Roberto Elosua
    National Heart, Lung, and Blood Institute NIH, Framingham Heart Study, Framingham, MA, USA
    J Lipid Res 45:1868-75. 2004
    ..22 mm) than the APOE3 group (0.90 mm) or the APOE2 group (0.84 mm). The E2 allele was associated with lower carotid atherosclerosis in women, and the E4 allele was associated with higher internal carotid IMT in diabetic men...
  54. ncbi request reprint Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study
    Roberto Elosua
    The Department of Biostatistics, Boston University, Boston, MA, United States The USDA Human Nutrition Research Center on Aging, Tufts University, MA, USA
    Atherosclerosis 189:222-8. 2006
    ..To determine the association of well-characterized lipoprotein-related genetic variants with carotid intimal medial thickness (IMT) and stenosis...
  55. pmc Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study
    Marie France Hivert
    General Medicine Division, Massachusetts General Hospital, Boston, MA, USA
    Diabetes 57:3353-9. 2008
    ..Using comprehensive linkage disequilibrium mapping, we genotyped single nucleotide polymorphisms (SNPs) in ADIPOQ to evaluate the association of common variants with adiponectin levels and risk of diabetes...
  56. pmc Common variants at ten loci influence QT interval duration in the QTGEN Study
    Christopher Newton-Cheh
    Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Nat Genet 41:399-406. 2009
    ..5% of the variation in QT interval. These results, together with an accompanying paper, offer insights into myocardial repolarization and suggest candidate genes that could predispose to sudden cardiac death and drug-induced arrhythmias...
  57. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  58. pmc Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
    Qiong Yang
    The National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S12. 2007
    ..We sought to confirm known putative loci and identify novel loci that may influence either trait in genome-wide association and linkage analyses using the Affymetrix GeneChip 100K single nucleotide polymorphism (SNP) set...
  59. pmc Variants in the CNR1 and the FAAH genes and adiposity traits in the community
    Wolfgang Lieb
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 17:755-60. 2009
    ....
  60. pmc Distribution, determinants, and normal reference values of thoracic and abdominal aortic diameters by computed tomography (from the Framingham Heart Study)
    Ian S Rogers
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Cardiol 111:1510-6. 2013
    ....
  61. pmc Neck circumference as a novel measure of cardiometabolic risk: the Framingham Heart study
    Sarah Rosner Preis
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA
    J Clin Endocrinol Metab 95:3701-10. 2010
    ..Neck circumference, a proxy for upper-body sc fat, may be a unique fat depot that confers additional cardiovascular risk above and beyond central body fat...
  62. pmc Periaortic fat deposition is associated with peripheral arterial disease: the Framingham heart study
    Caroline S Fox
    National Heart, Lung, and Blood Institute Framingham Heart Study, Bethesda, MD, USA
    Circ Cardiovasc Imaging 3:515-9. 2010
    ..We hypothesized that persons with greater amounts of periaortic fat are more likely to have clinical PAD and a low ankle-brachial index...
  63. ncbi request reprint Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 107:1492-6. 2003
    ..Prospective data are limited on the relation of MAC with CVD morbidity and mortality...
  64. ncbi request reprint Heart rate recovery after treadmill exercise testing and risk of cardiovascular disease events (The Framingham Heart Study)
    Ali Morshedi-Meibodi
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Am J Cardiol 90:848-52. 2002
    ..A very rapid HR recovery immediately after exercise was associated with lower risk of CHD and CVD events. These findings should be confirmed in other settings...
  65. ncbi request reprint Genome scan linkage results for heart rate variability (the Framingham Heart Study)
    Jagmeet P Singh
    National Heart, Lung and Blood Institute s NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Am J Cardiol 90:1290-3. 2002
    ..Recognition of the genetic determinants of HRV may provide additional insights into the pathophysiology of the autonomic nervous system and offer clues to its modulation...
  66. pmc A systems biology framework identifies molecular underpinnings of coronary heart disease
    Tianxiao Huan
    From the National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 33:1427-34. 2013
    ..The molecular mechanisms underlying CHD gene-disease associations, however, remain unclear. We hypothesized that genetic variants with both strong and subtle effects drive gene subnetworks that in turn affect CHD...
  67. pmc Prevalence and distribution of abdominal aortic calcium by gender and age group in a community-based cohort (from the Framingham Heart Study)
    Michael L Chuang
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston University School of Public Health, Boston, MA, USA
    Am J Cardiol 110:891-6. 2012
    ..We found AAC to be widely prevalent, with the burden of AAC associated with 10-year coronary risk, in a white, free-living adult cohort...
  68. pmc Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702 5827, USA
    JAMA 302:168-78. 2009
    ..Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease...
  69. pmc Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
    Daniel Levy
    National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    BMC Genet 7:30. 2006
    ..Hundreds of statistical tests may be performed for a single SNP, thereby complicating interpretation of results and inhibiting identification of patterns of association...
  70. pmc Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists
    Andrew D Johnson
    National Heart, Lung, and Blood Institute s The Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 42:608-13. 2010
    ..05 in an additional African-American cohort (N<or=840 in the Genetic Study of Atherosclerosis Risk). These results provide insights into platelet aggregation pathways and may suggest new antiplatelet therapeutic targets...
  71. ncbi request reprint Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    J Am Soc Nephrol 17:521-7. 2006
    ..Further research is warranted to understand whether traditional and novel vascular risk factor burden, as well as metabolic derangements found in early kidney disease, can account for the CKD-MAC association...
  72. pmc Relation of subcutaneous and visceral adipose tissue to coronary and abdominal aortic calcium (from the Framingham Heart Study)
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 104:543-7. 2009
    ..However, these cross-sectional associations are attenuated by cardiovascular disease risk factors, possibly because they mediate the association between adiposity measures and subclinical cardiovascular disease...
  73. pmc Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 108:979-84. 2011
    ..These findings suggest that excess visceral adiposity and concomitant hyperinsulinemia may contribute to the natriuretic peptide "deficiency" observed in obesity...
  74. pmc Visceral fat is associated with lower brain volume in healthy middle-aged adults
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, MA, USA
    Ann Neurol 68:136-44. 2010
    ....
  75. ncbi request reprint Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study
    Christopher Newton-Cheh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:1128-36. 2007
    ..We tested common KCNH2 variants for association with continuous QT interval duration...
  76. ncbi request reprint The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination
    Greta Lee Splansky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5827, USA
    Am J Epidemiol 165:1328-35. 2007
    ....
  77. pmc Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors
    Kenneth S Cohen
    Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 121:e50-6. 2013
    ..CD34(+) frequency is highly heritable. The results of the present study have implications for therapies that use CD34(+) cell populations and support efforts to better understand the genetic mechanisms that underlie CD34(+) frequency...
  78. pmc Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation
    Jie Huang
    National Heart, Lung, and Blood Institute NHBLI Framingham Heart Study, Framingham, MA 01702, USA
    Blood 120:4873-81. 2012
    ..1. In summary, SNPs in SERPINE1 and ARNTL and an SNP associated with the expression of MUC3 were robustly associated with circulating levels of PAI-1...
  79. pmc Genome-wide association meta-analysis for total serum bilirubin levels
    Andrew D Johnson
    National Heart Lung and Blood Institute s The Framingham Heart Study, 73 Mt Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    Hum Mol Genet 18:2700-10. 2009
    ..In analyses for association with gallbladder disease or gallstones, top bilirubin SNPs in UGT1A1 and SLCO1B1 were not associated...
  80. pmc Gene expression analysis of whole blood, peripheral blood mononuclear cells, and lymphoblastoid cell lines from the Framingham Heart Study
    Roby Joehanes
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Physiol Genomics 44:59-75. 2012
    ..LCL, however, was able to detect two genes related to smoking status. PAX and PBMC identified Y-chromosome probe sets similarly and slightly better than LCL...
  81. pmc Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    Circ Cardiovasc Genet 3:523-30. 2010
    ....
  82. ncbi request reprint Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    JAMA 294:3117-23. 2005
    ..While parental cardiovascular disease (CVD) doubles the risk for CVD in offspring, the extent of increased risk associated with sibling CVD is unclear...
  83. pmc Genomewide linkage analysis for internal carotid artery intimal medial thickness: evidence for linkage to chromosome 12
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, MA 01702, USA
    Am J Hum Genet 74:253-61. 2004
    ....
  84. pmc Relations of insulin resistance and glycemic abnormalities to cardiovascular magnetic resonance measures of cardiac structure and function: the Framingham Heart Study
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute and the NHLBI Framingham Heart Study, Framingham, MA 01702, USA
    Circ Cardiovasc Imaging 3:257-63. 2010
    ..We sought to apply volumetric cardiovascular magnetic resonance (CMR) in a free-living cohort to potentially clarify these associations...
  85. ncbi request reprint Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Stroke 35:e65-7. 2004
    ..We sought to test whether carotid IMT is associated with polymorphisms in several well-characterized genes in the hemostatic factor pathways...
  86. pmc Consent for genetic research in the Framingham Heart Study
    Daniel Levy
    Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MA 01702, USA
    Am J Med Genet A 152:1250-6. 2010
    ..Published 2010 Wiley-Liss, Inc...
  87. ncbi request reprint Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community
    Sekar Kathiresan
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Circulation 112:1419-27. 2005
    ..Sequence variants at the endothelial nitric oxide synthase (NOS3) locus have been associated with endothelial function measures, but replication has been limited...
  88. pmc Usefulness of the left ventricular myocardial contraction fraction in healthy men and women to predict cardiovascular morbidity and mortality
    Michael L Chuang
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 109:1454-8. 2012
    ..In conclusion, in a cohort of adults initially without clinical CVD, lowest-quartile MCF conferred an increased hazard for hard CVD events after adjustment for traditional CVD risk factors and LV mass...
  89. ncbi request reprint Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: the Framingham Heart Study
    Caroline S Fox
    NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 66:2017-21. 2004
    ..Because the risk of coronary heart disease is increased even at moderate declines in kidney function, we sought to test whether high CAC scores are seen among those with mild reductions in kidney function...
  90. pmc CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies
    Andrew D Johnson
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Genet Med 12:355-63. 2010
    ..We set out to survey potential notifiable variants on arrays used in genome-wide association studies and in direct-to-consumer genetic services...
  91. pmc Genomics of heart failure
    Raghava S Velagaleti
    The NHLBI s Framingham Heart Study, 73 Mt Wayte Avenue, Suite 2, Framingham, MA 01702, USA
    Heart Fail Clin 6:115-24. 2010
    ..This article reviews the status of these and other important developments in genomics, in particular genome-wide sequencing, and other "omics"...
  92. ncbi request reprint A comparison of death certificate out-of-hospital coronary heart disease death with physician-adjudicated sudden cardiac death
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 95:856-9. 2005
    ..Out-of-hospital coronary heart disease deaths overestimated sudden cardiac death by 47%, suggesting that out-of-hospital coronary heart disease death rates derived from death certificates should be interpreted with caution...
  93. pmc SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
    Andrew D Johnson
    The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health, USA
    Bioinformatics 24:2938-9. 2008
    ....
  94. ncbi request reprint Genetics of ultrasonographic carotid atherosclerosis
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, MSC 7934, Bethesda, MD 20892 7934, USA
    Arterioscler Thromb Vasc Biol 24:1567-77. 2004
    ..Another, PON1 L55 mol/L, is weakly associated in subgroups only. Genetic variants reported to be associated with clinical cardiovascular disease show weak or no relationship to carotid atherosclerosis...