Research Topics
Genomes and Genes
| THOMAS R O'BRIENSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
An IL28B genotype-based clinical prediction model for treatment of chronic hepatitis CTHOMAS R O'BRIEN
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
PLoS ONE 6:e20904. 2011..Using data from the HALT-C Trial, we developed a model to predict a patient's probability of SVR based on IL28B genotype and clinical variables...- Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liverT R O'Brien
Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Genes Immun 12:428-33. 2011..We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV... - HCV RNA levels in a multiethnic cohort of injection drug users: human genetic, viral and demographic associationsLorenzo Uccellini
Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA
Hepatology 56:86-94. 2012..CONCLUSION: The level of HCV viremia is influenced by a large number of demographic, viral, and human genetic factors... 
Hepatitis B and C virus infection and the risk of biliary tract cancer: a population-based study in ChinaAnn W Hsing
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Blvd, Bethesda, MD 20852 7234, USA
Int J Cancer 122:1849-53. 2008..In Shanghai, an HBV endemic area, chronic HBV infection was associated with a 2.4-fold risk of extrahepatic bile duct cancer. These results should be confirmed in other populations with varying risks of HBV and HCV infection...- IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive associationFatma M Shebl
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
J Infect Dis 204:1843-7. 2011.... - HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couplesTania M Welzel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
AIDS 21:225-9. 2007..Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission... - Interferon-lambda and therapy for chronic hepatitis C virus infectionRaymond P Donnelly
Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Trends Immunol 32:443-50. 2011.... - Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trialTania Mara Welzel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Hepatology 49:1847-58. 2009..006). CONCLUSION: Genetic polymorphisms in the interferon-alpha pathway may affect responses to antiviral therapy of chronic hepatitis C... - Population genetics and comparative genetics of CLDN1, a gene involved in hepatitis C virus entryVincent Bekker
Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
Hum Hered 67:206-16. 2009..The pattern of linkage disequilibrium was determined for each group and there is substantial difference for common SNPS (>5%) between populations as well as genes, further supporting the absence of signatures of recent selection... - Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCVEishiro Mizukoshi
Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
J Infect Dis 198:203-12. 2008..To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years)... - Serum concentrations of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and risk of primary liver cancerKatherine A McGlynn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS 7060, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
J Natl Cancer Inst 98:1005-10. 2006..Whether DDT and DDE are associated with hepatocarcinogenesis in humans is not clear... - Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entryIndu Kohaar
Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
J Virol 84:6987-94. 2010..Genetic factors crucial for regulation of OCLN expression and susceptibility to HCV infection remain to be elucidated... - MBL2 and hepatitis C virus infection among injection drug usersElizabeth E Brown
Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
BMC Infect Dis 8:57. 2008..We examined whether MBL2 variants influence the outcome of hepatitis C virus (HCV) infection... - Genetic variations in CC chemokine receptors and hypertensionMingdong Zhang
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Rm 7082, MSC 7234, Rockville, MD 20852, USA
Am J Hypertens 19:67-72. 2006..The present study was carried out to verify these associations... - Population distribution of the functional caspase-12 alleleKritika Kachapati
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Hum Mutat 27:975. 2006..In this study, Csp 12-L allele frequency ranged from 3.6% to 60.7% among populations from sub-Saharan Africa and was also present at low frequency among North African, Middle Eastern, and South Asian populations... - Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United StatesTania M Welzel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7084, MSC 7234 6120 Executive Blvd, Bethesda, MD 20892, USA
J Natl Cancer Inst 98:873-5. 2006..001)... - Hepatocellular carcinoma: paradigm of preventive oncologyTHOMAS R O'BRIEN
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Cancer J 10:67-73. 2004..HCC prevention efforts provide a paradigm for preventive oncology in cancers of viral etiology... - A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individualsPing An
Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
J Infect Dis 188:228-31. 2003..It is possible that increased IFN-gamma production induced by TNF-alpha when -179T is present causes CD4 cell depletion by apoptosis...