THOMAS R O'BRIEN

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc An IL28B genotype-based clinical prediction model for treatment of chronic hepatitis C
    THOMAS R O'BRIEN
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e20904. 2011
  2. pmc Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver
    T R O'Brien
    Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Genes Immun 12:428-33. 2011
  3. ncbi request reprint Hepatitis B and C virus infection and the risk of biliary tract cancer: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Blvd, Bethesda, MD 20852 7234, USA
    Int J Cancer 122:1849-53. 2008
  4. pmc Hepatitis C virus infection, Linxian, China
    Mingdong Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Emerg Infect Dis 11:17-21. 2005
  5. pmc HCV RNA levels in a multiethnic cohort of injection drug users: human genetic, viral and demographic associations
    Lorenzo Uccellini
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 56:86-94. 2012
  6. pmc IFNL4-ΔG genotype is associated with slower viral clearance in hepatitis C, genotype-1 patients treated with sofosbuvir and ribavirin
    Eric G Meissner
    Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland
    J Infect Dis 209:1700-4. 2014
  7. pmc MBL2 and hepatitis C virus infection among injection drug users
    Elizabeth E Brown
    Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    BMC Infect Dis 8:57. 2008
  8. ncbi request reprint Seroprevalence of human herpesvirus 8 among injection drug users in San Francisco
    Jonnae Atkinson
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Infect Dis 187:974-81. 2003
  9. ncbi request reprint Serum concentrations of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and risk of primary liver cancer
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS 7060, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 98:1005-10. 2006
  10. pmc Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV
    Eishiro Mizukoshi
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
    J Infect Dis 198:203-12. 2008

Detail Information

Publications25

  1. pmc An IL28B genotype-based clinical prediction model for treatment of chronic hepatitis C
    THOMAS R O'BRIEN
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e20904. 2011
    ..Using data from the HALT-C Trial, we developed a model to predict a patient's probability of SVR based on IL28B genotype and clinical variables...
  2. pmc Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver
    T R O'Brien
    Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Genes Immun 12:428-33. 2011
    ..We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV...
  3. ncbi request reprint Hepatitis B and C virus infection and the risk of biliary tract cancer: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Blvd, Bethesda, MD 20852 7234, USA
    Int J Cancer 122:1849-53. 2008
    ..In Shanghai, an HBV endemic area, chronic HBV infection was associated with a 2.4-fold risk of extrahepatic bile duct cancer. These results should be confirmed in other populations with varying risks of HBV and HCV infection...
  4. pmc Hepatitis C virus infection, Linxian, China
    Mingdong Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Emerg Infect Dis 11:17-21. 2005
    ..1%) were positive for HCV. For HIV-1, 0/200 participants were positive. We conclude that HCV is now a common infection among older adults in Linxian, China...
  5. pmc HCV RNA levels in a multiethnic cohort of injection drug users: human genetic, viral and demographic associations
    Lorenzo Uccellini
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 56:86-94. 2012
    ..In an adjusted analysis, age, gender, racial ancestry, HIV-1 infection, HCV genotype, and IL28B rs12979860 genotype were all independently associated with HCV RNA...
  6. pmc IFNL4-ΔG genotype is associated with slower viral clearance in hepatitis C, genotype-1 patients treated with sofosbuvir and ribavirin
    Eric G Meissner
    Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland
    J Infect Dis 209:1700-4. 2014
    ..039) and decreased drug efficacy (P = .048), suggesting functional relevance of IFN-λ4 in IFN-α-free DAA therapies. ..
  7. pmc MBL2 and hepatitis C virus infection among injection drug users
    Elizabeth E Brown
    Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    BMC Infect Dis 8:57. 2008
    ..We examined whether MBL2 variants influence the outcome of hepatitis C virus (HCV) infection...
  8. ncbi request reprint Seroprevalence of human herpesvirus 8 among injection drug users in San Francisco
    Jonnae Atkinson
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    J Infect Dis 187:974-81. 2003
    ..These results are consistent with the occurrence of bloodborne transmission of HHV-8 among IDUs...
  9. ncbi request reprint Serum concentrations of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and risk of primary liver cancer
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS 7060, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 98:1005-10. 2006
    ..Whether DDT and DDE are associated with hepatocarcinogenesis in humans is not clear...
  10. pmc Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV
    Eishiro Mizukoshi
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA
    J Infect Dis 198:203-12. 2008
    ..To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years)...
  11. pmc IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association
    Fatma M Shebl
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    J Infect Dis 204:1843-7. 2011
    ....
  12. ncbi request reprint HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couples
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    AIDS 21:225-9. 2007
    ..Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission...
  13. ncbi request reprint Prevalence of SEN viruses among injection drug users in the San Francisco Bay area
    Ruth M Pfeiffer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    J Infect Dis 188:13-8. 2003
    ..05; 95% CI, 2.62-18.95). SENV strains are common among San Francisco Bay area IDUs, and prevalence varies demographically within this group...
  14. pmc A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
    Ludmila Prokunina-Olsson
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 45:164-71. 2013
    ..Our findings provide new insights into the genetic regulation of HCV clearance and its clinical management...
  15. pmc Interferon-lambda and therapy for chronic hepatitis C virus infection
    Raymond P Donnelly
    Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Trends Immunol 32:443-50. 2011
    ....
  16. pmc Population genetics and comparative genetics of CLDN1, a gene involved in hepatitis C virus entry
    Vincent Bekker
    Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
    Hum Hered 67:206-16. 2009
    ..The pattern of linkage disequilibrium was determined for each group and there is substantial difference for common SNPS (>5%) between populations as well as genes, further supporting the absence of signatures of recent selection...
  17. pmc Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial
    Tania Mara Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Hepatology 49:1847-58. 2009
    ..51; P = 0.05) and a strong relationship among African American patients; all 10 with SVR who were genotyped for TYK2 -2256 carried the A variant compared with 68 of 120 (57%) nonresponders (P = 0.006)...
  18. ncbi request reprint Antibodies to varicella-zoster virus in blood donors with genetic variance in CC chemokine receptor 5
    Mingdong Zhang
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7248, Rockville, MD 20852, USA
    Lancet 359:1034-6. 2002
    ..We have therefore found no evidence that the CCR5-Delta32 allele is associated with decreased seroprevalence of varicella-zoster virus infection...
  19. pmc Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry
    Indu Kohaar
    Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892 4605, USA
    J Virol 84:6987-94. 2010
    ..Genetic factors crucial for regulation of OCLN expression and susceptibility to HCV infection remain to be elucidated...
  20. ncbi request reprint Seroprevalence of hepatitis C virus and hepatitis B virus among San Francisco injection drug users, 1998 to 2000
    Fan Chen Tseng
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hepatology 46:666-71. 2007
    ..During 1987, however, 58.7% of recent initiates had shared syringes within the past 30 days compared with 33.6% during 1998-2000 (P < 0.0001)...
  21. ncbi request reprint Genetic variations in CC chemokine receptors and hypertension
    Mingdong Zhang
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Rm 7082, MSC 7234, Rockville, MD 20852, USA
    Am J Hypertens 19:67-72. 2006
    ..The present study was carried out to verify these associations...
  22. ncbi request reprint Population distribution of the functional caspase-12 allele
    Kritika Kachapati
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Hum Mutat 27:975. 2006
    ..In this study, Csp 12-L allele frequency ranged from 3.6% to 60.7% among populations from sub-Saharan Africa and was also present at low frequency among North African, Middle Eastern, and South Asian populations...
  23. ncbi request reprint A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals
    Ping An
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    J Infect Dis 188:228-31. 2003
    ..It is possible that increased IFN-gamma production induced by TNF-alpha when -179T is present causes CD4 cell depletion by apoptosis...
  24. ncbi request reprint Hepatocellular carcinoma: paradigm of preventive oncology
    THOMAS R O'BRIEN
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Cancer J 10:67-73. 2004
    ..HCC prevention efforts provide a paradigm for preventive oncology in cancers of viral etiology...
  25. ncbi request reprint Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7084, MSC 7234 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:873-5. 2006
    ..001)...