Research Topics
Genomes and Genes
Species | STEPHEN J O'BRIENSummaryAffiliation: National Cancer Institute Country: USA Publications
| Collaborators
|
Detail Information
Publications
The evolution of cats. Genomic paw prints in the DNA of the world's wild cats have clarified the cat family tree and uncovered several remarkable migrations in their pastWarren E Johnson
Laboratory of Genomic Diversity, National Cancer Institute, USA
Sci Am 297:68-75. 2007
Phylogeography and genetic ancestry of tigers (Panthera tigris)Shu-Jin Luo
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
PLoS Biol 2:e442. 2004..These results provide an explicit basis for subspecies recognition and will lead to the improved management and conservation of these recently isolated but distinct geographic populations of tigers...- Functions, structure, and read-through alternative splicing of feline APOBEC3 genesCarsten Munk
Division of Medical Biotechnology, Paul Ehrlich Institut, 63225 Langen, Germany
Genome Biol 9:R48. 2008..While primates encode seven of these genes (A3A to A3H), rodents carry only a single A3 gene... - A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese populationZheng Zeng
SAIC Laboratory of Genomic Diversity, National Cancer Institute Frederick, National Institutes of Health, Frederick, USA
BMC Infect Dis 8:1. 2008..We believe that a better understanding of these factors and interactions will lead to more effective diagnostic and therapeutic options... - The adaptive evolution of the mammalian mitochondrial genomeRute R da Fonseca
REQUIMTE, Departamento de Quimica, Faculdade de Ciencias, Universidade do Porto, Rua do Campo Alegre, 687, 4169 007 Porto, Portugal
BMC Genomics 9:119. 2008.... - Light whole genome sequence for SNP discovery across domestic cat breedsJames C Mullikin
Genome Technology Branch and NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
BMC Genomics 11:406. 2010..However, to realize this bio-medical potential, a high density single nucleotide polymorphism (SNP) map is required in order to accomplish disease and phenotype association discovery... - Genomic organization, sequence divergence, and recombination of feline immunodeficiency virus from lions in the wildJill Pecon-Slattery
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick MD 21702 USA
BMC Genomics 9:66. 2008..In African lions (Panthera leo) and other exotic felid species, disease etiology introduced by FIV infection are less clear, but recent studies indicate that FIV causes moderate to severe CD4 depletion... - Accounting for multiple comparisons in a genome-wide association study (GWAS)Randall C Johnson
Basic Research Program, SAIC Frederick, Inc NCI Frederick, Frederick, MD, USA
BMC Genomics 11:724. 2010..We consider seven implementations of these commonly used methods using data from 1514 European American participants genotyped for 700,078 SNPs in a GWAS for AIDS... - Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundaryJohannes Krause
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
BMC Evol Biol 8:220. 2008..Widely divergent topologies have been suggested based on various data sets and methods... - Polygenic and multifactorial disease gene association in man: Lessons from AIDSS J O'Brien
Laboratory of Genomic Diversity, National Cancer Institute, Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201, USA
Annu Rev Genet 34:563-591. 2000.... - Big cat genomicsSTEPHEN J O'BRIEN
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
Annu Rev Genomics Hum Genet 6:407-29. 2005..Conservation, stabilization, and management of the big cats are important areas that derive benefit from the genome resources expanded and applied to highly successful species, imperiled by an expanding human population... 
The platypus genome unraveledSTEPHEN J O'BRIEN
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
Cell 133:953-5. 2008..The genome of the platypus has been sequenced, assembled, and annotated by an international genomics team. Like the animal itself the platypus genome contains an amalgam of mammal, reptile, and bird-like features...- Human genes that limit AIDSSTEPHEN J O'BRIEN
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
Nat Genet 36:565-74. 2004..The influence and translational impact of these genes on individual and population sensitivity to AIDS is considerable... - The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDSS J O'Brien
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA 21702 1201, USA
Immunol Rev 177:99-111. 2000..The functional and therapeutic implications of these AIDS restriction genes for disease progression and intervention are explored in this review... - Comparative genomics: lessons from catsS J O'Brien
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
Trends Genet 13:393-9. 1997..We review here the remarkable extent of genome homology conservation among mammals illustrated by technology applications in the feline genome project... - State of cat genomicsSTEPHEN J O'BRIEN
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
Trends Genet 24:268-79. 2008..We review these recent advances here. As the genome resources develop, the cat is poised to make a major contribution to many areas in genetics and biology... - The Feline Genome ProjectSTEPHEN J O'BRIEN
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
Annu Rev Genet 36:657-86. 2002..Here we review the advantages, rationale, and present strategy of a feline genome project, and we describe the disease models, comparative genomics, and biological applications posed by the full resolution of the cat's genome... - Stewardship of human biospecimens, DNA, genotype, and clinical data in the GWAS eraSTEPHEN J O'BRIEN
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702 1201, USA
Annu Rev Genomics Hum Genet 10:193-209. 2009..A way forward may be to convene a colloquium of international medical and science organizations charged with developing global consensus guidance and ethical principles for access to and use of genomic biobanks... - Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDSEfe Sezgin
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
J Acquir Immune Defic Syndr 54:343-51. 2010..Clearly, further studies are warrented... - Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individualsPing An
Laboratory of Genomic Diversity, SAIC Frederick, Incorporated, National Cancer Institute, Frederick, Maryland, United States of America
PLoS Genet 3:e19. 2007.... - Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virusEfe Sezgin
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
Am J Ophthalmol 151:999-1006.e4. 2011.... - Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progressionWilliam S Modi
SAIC Frederick, Inc, Basic Research Program, Frederick, MD 21702 1201, USA
Am J Hum Genet 79:120-8. 2006..01-.02). These results reiterate the importance of chemokine gene variation in HIV-1/AIDS pathogenesis and emphasize that localized linkage disequilibrium makes the identification of causal mutations difficult... - Mitochondrial DNA haplogroups influence AIDS progressionSher L Hendrickson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702 1201, USA
AIDS 22:2429-39. 2008.... - Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcomeAnn L Truelove
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA
Int J Immunogenet 35:255-64. 2008..01-0.04). These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis... - MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmissionWilliam S Modi
SAIC Frederick and the Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
AIDS 17:2357-65. 2003..An epidemiological analysis identified genetic variants influencing HIV-1 transmission and disease progression... - The late Miocene radiation of modern Felidae: a genetic assessmentWarren E Johnson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
Science 311:73-7. 2006..The phylogenetic performance of distinct gene classes showed that Y-chromosome segments are appreciably more informative than mitochondrial DNA, X-linked, or autosomal genes in resolving the rapid Felidae species radiation... - Genomics. A dog's breakfast?STEPHEN J O'BRIEN
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
Science 301:1854-5. 2003..As they explain, even though the coverage of the dog genome (1.5x) is lower than that of mouse (8x), there are many valuable insights to be gained from comparing the sequence of dog with those of mouse and human... - Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survivalSher L Hendrickson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
J Acquir Immune Defic Syndr 48:263-71. 2008..27; P=0.01). ARG influence after HAART suggests residual HIV-1 replication, and spread continues even in patients successfully suppressing detectable viral RNA... - Development of Y chromosome intraspecific polymorphic markers in the FelidaeShu Jin Luo
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
J Hered 98:400-13. 2007.... - The effect of RANTES chemokine genetic variants on early HIV-1 plasma RNA among African American injection drug usersPriya Duggal
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 38:584-9. 2005..Because RANTES is a critical chemokine and competitively inhibits HIV-1 by binding to its receptor CCR5, treatment to enhance RANTES expression may assist in delaying the progression of AIDS by decreasing the initial viral load... - Association of Y chromosome haplogroup I with HIV progression, and HAART outcomeEfe Sezgin
NCI Frederick, MD 21702, USA
Hum Genet 125:281-94. 2009..Our results suggest that one or more loci on the Y chromosome found on haplogroup Y-I have an effect on AIDS progression and treatment responses in European Americans... - A molecular phylogeny for bats illuminates biogeography and the fossil recordEmma C Teeling
Laboratory of Genomic Diversity, Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
Science 307:580-4. 2005.... - Behavioral risk exposure and host genetics of susceptibility to HIV-1 infectionSadeep Shrestha
Laboratory of Genomic Diversity, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, USA
J Infect Dis 193:16-26. 2006..The matched case-control study design with measured risk exposures provides an avenue for discovering genes involved in susceptibility to infection... - Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDSPing An
Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, Maryland, United States of America
PLoS Pathog 3:e88. 2007..These results implicate regulatory PPIA polymorphisms as a component of genetic susceptibility to HIV-1 infection or disease progression, affirming the important role of PPIA in HIV-1 pathogenesis... - An autosomal genetic linkage map of the domestic cat, Felis silvestris catusMarilyn Menotti-Raymond
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
Genomics 93:305-13. 2009..The improved linkage map will provide an added resource for the mapping of phenotypic variation in the domestic cat and the use of this species as a model system for biological research... - A domestic cat X chromosome linkage map and the sex-linked orange locus: mapping of orange, multiple origins and epistasis over nonagoutiAnne Schmidt-Küntzel
Laboratory of Genomic Diversity, Science Applications International Corporation, Frederick, MD 21702, USA
Genetics 181:1415-25. 2009..5 Mb and suggested multiple origins for the orange phenotype in the domestic cat. Furthermore, epistasis of orange over nonagouti was demonstrated at the genetic level... - The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomicsAgostinho Antunes
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, United States of America
PLoS Genet 4:e1000251. 2008..In particular, lion and FIV(Ple) variation affirms that the large, well-studied lion population occupying the greater Serengeti Ecosystem is derived from three distinct populations that admixed recently... - Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lionsMelody E Roelke
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
Virology 390:1-12. 2009.... - A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic catYasuko Ishida
Laboratory of Genomic Diversity, National Cancer Institute, Building 560, Room 11 38, Fort Detrick, Frederick, MD 21702, USA
Genomics 88:698-705. 2006..00001). Single-nucleotide polymorphism analyses in dilute individuals identified a single haplotype in dilute cats, suggesting that a single mutation event in MLPH gave rise to dilute in domestic cats... - Examination of disease-based selection, demographic history and population structure in European Y-chromosome haplogroup IEfe Sezgin
Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
J Hum Genet 55:613-20. 2010..Clearly, further studies on Y-chromosome candidate loci sequencing to discover functional variants and discern the roles of evolutionary factors are warranted... - A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individualsPing An
Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
J Infect Dis 188:228-31. 2003..It is possible that increased IFN-gamma production induced by TNF-alpha when -179T is present causes CD4 cell depletion by apoptosis... - Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic catsJAMES S KEHLER
The Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Hered 98:555-66. 2007..In combination, these genomic approaches demonstrated that FGF5 is the major genetic determinant of hair length in the domestic cat... - Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative mapsWilliam J Murphy
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
Hum Genomics 1:30-40. 2003.... - Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progressionCheryl A Winkler
Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
J Acquir Immune Defic Syndr 37:1534-8. 2004.... - A mutation in KIR3DS1 that results in truncation and lack of cell surface expressionMaureen P Martin
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Immunogenetics 59:823-9. 2007..The data indicate that the null KIR3DS1 allele is uncommon, arose on a single haplotype, and spread across geographically distinct populations... - FIV cross-species transmission: an evolutionary prospectiveJennifer L Troyer
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, United States
Vet Immunol Immunopathol 123:159-66. 2008..These studies illustrate the utility of FIV as a model to discover the variables necessary for establishment and control of lentiviral infections in new species... - Evolution of feline immunodeficiency virus in Felidae: implications for human health and wildlife ecologyJill Pecon-Slattery
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, United States
Vet Immunol Immunopathol 123:32-44. 2008.... - Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progressionSher L Hendrickson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA
PLoS ONE 5:e12862. 2010..Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression... - HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couplesTania M Welzel
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
AIDS 21:225-9. 2007..Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission... - The Near Eastern origin of cat domesticationCarlos A Driscoll
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
Science 317:519-23. 2007..Domestic cats derive from at least five founders from across this region, whose descendants were transported across the world by human assistance... - Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumoniaPing An
Basic Research Laboratory, SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland, USA
PLoS Genet 7:e1002328. 2011..28-6.31) among four major AIDS-defining conditions. Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect PCP through immune regulation and inducing inflammation... - Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistenceChloe L Thio
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
J Virol 81:441-5. 2007.... - Genome-wide association study implicates PARD3B-based AIDS restrictionJennifer L Troyer
Laboratory of Genomic Diversity, SAIC Frederick, Inc, Frederick, MD 21702, USA
J Infect Dis 203:1491-502. 2011..Here we used clinically well-characterized subjects from 5 pretreatment HIV/AIDS cohorts for a genome-wide association study to identify gene associations with rate of AIDS progression... - Comparative genomic structure of human, dog, and cat MHC: HLA, DLA, and FLANaoya Yuhki
Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
J Hered 98:390-9. 2007.... - Mitochondrial haplogroups are associated with risk of neuroretinal disorder in HIV-positive patientsSher L Hendrickson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
J Acquir Immune Defic Syndr 53:451-5. 2010..5% vs. 8.9% in patients with vs. without haplogroup J, respectively, P = 0.05). These data suggest that mitochondrial genotype may influence propensity to develop HIV-associated NRD in patients with AIDS... - Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic catNaoya Yuhki
Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
PLoS ONE 3:e2674. 2008..84 Mbp (0.00411 SNP per bp), which is 2.4 times higher rate than average heterozygous region in the WGS (0.0017 SNP per bp genome), and slightly higher than the SNP rate observed in human MHC (0.00337 SNP per bp)... - Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infectionLeslie W Chinn
National Cancer Institute, Rockville, MD, USA
J Infect Dis 202:1836-45. 2010..Genes conferring a significant effect were termed HIV-dependency factors (HDFs)... - Diversity of MICA and linkage disequilibrium with HLA-B in two North American populationsXiaojiang Gao
Laboratory of Genomic Diversity, NCI Frederick, Basic Research Program, SAIC Frederick, Frederick, MD 21702, USA
Hum Immunol 67:152-8. 2006..The lack of evidence for an active diversification of the MICA gene after racial separation indicates an evolutionary history distinct from that of the classical HLA genes... - Genetic characterization of feline leukemia virus from Florida panthersMeredith A Brown
National Cancer Institute, Frederick, Maryland, USA
Emerg Infect Dis 14:252-9. 2008..These unique features may also account for the severity of the outbreak after cross-species transmission to the panther... - APOBEC3G genetic variants and their influence on the progression to AIDSPing An
Basic Research Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
J Virol 78:11070-6. 2004..These studies suggest that there may be a modifying role of variants of APOBEC3G on HIV-1 disease progression that warrants further investigation... - Mitochondrial introgressions into the nuclear genome of the domestic catAgostinho Antunes
Laboratory of Genomic Diversity, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702 1201, USA
J Hered 98:414-20. 2007..The catalog of cat numts provides a valuable resource for future studies in Felidae species, including its use as a tool to avoid numt contaminations that may confound population genetics and phylogenetic studies... - A population genetic database of cat breeds developed in coordination with a domestic cat STR multiplexMarilyn Menotti-Raymond
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Building 560, Room 11 38, Frederick, MD 21702, USA
J Forensic Sci 57:596-601. 2012..Heterozygosities obtained for the 10 loci range from 0.72 to 0.96. The power for genetic individualization of domestic cat samples of the multiplex is high, with a probability of match (p(m)) of 6.2E-14, using a conservative θ = 0.05... - Genetics and pathogenesis of feline infectious peritonitis virusMeredith A Brown
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
Emerg Infect Dis 15:1445-52. 2009..In addition, 5 membrane protein amino acid residues with functional potential differentiated healthy cats from cats with FIP. These findings may have potential as diagnostic markers for virulent FIP-associated FCoV... - Subspecies genetic assignments of worldwide captive tigers increase conservation value of captive populationsShu Jin Luo
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
Curr Biol 18:592-6. 2008..Assessment of verified subspecies ancestry offers a powerful tool that, if applied to tigers of uncertain background, may considerably increase the number of purebred tigers suitable for conservation management... - Haplotype diversity in the interleukin-4 gene is not associated with HIV-1 transmission and AIDS progressionWilliam S Modi
Basic Research Program, SAIC Frederick, National Cancer Institute FCRDC, Frederick, MD 21702 1201, USA
Immunogenetics 55:157-64. 2003..Present analyses failed to identify any significant associations with HIV-1 infection or progression to AIDS... - Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDSEfe Sezgin
Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702 1201, USA
J Infect Dis 202:606-13. 2010..The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway... - Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infectionMaureen P Martin
Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA
J Virol 78:14053-6. 2004..87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested... - FIV diversity: FIV Ple subtype composition may influence disease outcome in African lionsJennifer L Troyer
Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute, Frederick, MD, USA
Vet Immunol Immunopathol 143:338-46. 2011.... - Initial sequence and comparative analysis of the cat genomeJoan U Pontius
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
Genome Res 17:1675-89. 2007..9-fold) coverage mammal genome sequence... - Identifying selected regions from heterozygosity and divergence using a light-coverage genomic dataset from two human populationsTaras K Oleksyk
Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, USA
PLoS ONE 3:e1712. 2008..The main strength of our analysis method compared to others is that it does not require dense genotyping and therefore can be used with data from population-based genome SNP scans from smaller studies of humans or other species... - Mutation discovered in a feline model of human congenital retinal blinding diseaseMarilyn Menotti-Raymond
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
Invest Ophthalmol Vis Sci 51:2852-9. 2010..Disease expression in Rdy cats is comparable to that in young patients with congenital blindness (Leber congenital amaurosis [LCA] or retinitis pigmentosa [RP])... - Mammalian phylogenomics comes of ageWilliam J Murphy
Basic Research Laboratory, SAIC Frederick, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
Trends Genet 20:631-9. 2004.... - Insertional polymorphisms of endogenous feline leukemia virusesAlfred L Roca
Laboratory of Genomic Diversity, Basic Research Program, SAIC Frederick, Maryland, USA
J Virol 79:3979-86. 2005..Since endogenous FeLVs may affect the infectiousness or pathogenicity of exogenous FeLVs, genomic variation in enFeLVs represents a candidate for genetic influences on FeLV leukemogenesis in cats... - Mapping of the domestic cat "SILVER" coat color locus identifies a unique genomic location for silver in mammalsMarilyn Menotti-Raymond
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Hered 100:S8-13. 2009.... - Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: a potential mechanism for receptor dimerizationNuria Vazquez-Salat
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
Genomics 90:213-24. 2007.... - Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDSMaureen P Martin
Basic Research Program, SAIC Frederick, Frederick, Maryland 21702 1201, USA
Nat Genet 31:429-34. 2002..The strongest synergistic effect of these loci was on progression to depletion of CD4(+) T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection... - Mitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapySher L Hendrickson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201
J Acquir Immune Defic Syndr 51:111-6. 2009..05, OR = 0.52, 95% CI = 0.20 to 1.00). These data suggest that mitochondrial DNA haplogroup may influence the propensity for lipoatrophy in patients receiving nucleoside reverse transcriptase inhibitors... - Molecular evidence for species-level distinctions in clouded leopardsValerie A Buckley-Beason
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
Curr Biol 16:2371-6. 2006..n. diardi in Borneo and Sumatra, would support reclassification of N. n. diardi as a new species (Neofelis diardi)... - Evolutionary analysis of a large mtDNA translocation (numt) into the nuclear genome of the Panthera genus speciesJae-Heup Kim
Laboratory of Genomic Diversity, National Cancer Institute-Frederick Cancer Research and Development Center (NCI-FCRDC, Frederick, MD 21702-1201, USA
Gene 366:292-302. 2006..The tiger cymtDNA shared around 90% sequence identity with the homologous numt sequence, suggesting an origin for the Panthera numt at around 3.5 million years ago, prior to the radiation of the five extant Panthera species... - Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern ChinaXiuchan Guo
Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Int J Cancer 124:2942-7. 2009..7% of NPC development in NPC high risk population. These findings should have important public health implications for NPC risk reduction in endemic regions... - Genetic restoration of the Florida pantherWarren E Johnson
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
Science 329:1641-5. 2010..This intensive management program illustrates the challenges of maintaining populations of large predators worldwide... - Molecular genetics and evolution of melanism in the cat familyEduardo Eizirik
Laboratory of Genomic Diversity, NCI Frederick, National Institutes of Health, Frederick, MD 21702 1201, USA
Curr Biol 13:448-53. 2003..The inferred multiple origins and independent historical elevation in population frequency of felid melanistic mutations suggest the occurrence of adaptive evolution of this visible phenotype in a group of related free-ranging species... - Patterns of molecular genetic variation among cat breedsMarilyn Menotti-Raymond
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
Genomics 91:1-11. 2008.... - Life on the edge: the long-term persistence and contrasting spatial genetic structure of distinct brown trout life histories at their ecological limitsAgostinho Antunes
CIBIO UP, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Campus Agrário de Vairão, 4485 661 Vairão, Portugal
J Hered 97:193-205. 2006..These peripheral populations are of high conservation value and should be preserved to help conserve the future potential of the species... - Artifacts of the 1.9x feline genome assembly derived from the feline-specific satellite sequenceJoan U Pontius
Laboratory of Genomic Diversity, Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
J Hered 100:S14-8. 2009..The findings regarding the feline-specific sequence should be considered in the pending 8x assembly of the cat genome... - A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han ChinesePing An
Basic Research Laboratory, SAIC Frederick, Maryland, USA
J Infect Dis 203:943-7. 2011..We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma... - A molecular phylogeny of living primatesPolina Perelman
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland, USA
PLoS Genet 7:e1001342. 2011.... - Feline immunodeficiency virus (FIV) in wild Pallas' catsMeredith A Brown
Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
Vet Immunol Immunopathol 134:90-5. 2010..Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIV(Oma) causes immune depletion in its' native host...