REBECCA L O'BRIEN

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi request reprint Depletion of a gamma delta T cell subset can increase host resistance to a bacterial infection
    R L O'Brien
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 165:6472-9. 2000
  2. pmc Protective role of gammadelta T cells in spontaneous ocular inflammation
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, Colorado 80206, USA
    Invest Ophthalmol Vis Sci 50:3266-74. 2009
  3. ncbi request reprint gammadelta T-cell receptors: functional correlations
    REBECCA L O'BRIEN
    Integrated Deaprtment of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Rev 215:77-88. 2007
  4. pmc Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 182:2002-10. 2009
  5. pmc Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    J Immunol 182:657-65. 2009
  6. pmc Vgamma1+ T cells and tumor necrosis factor-alpha in ozone-induced airway hyperresponsiveness
    Shigeki Matsubara
    Division of Cell Biology, Department of Pediatrics, National Jewish Health and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 40:454-63. 2009
  7. pmc Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness
    Laura Cook
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:309-19. 2008
  8. pmc Antigen-specific regulation of IgE antibodies by non-antigen-specific γδ T cells
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 190:913-21. 2013
  9. pmc The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:849-55. 2009
  10. pmc αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Invest Ophthalmol Vis Sci 53:301-8. 2012

Research Grants

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Depletion of a gamma delta T cell subset can increase host resistance to a bacterial infection
    R L O'Brien
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 165:6472-9. 2000
    ..Our findings indicate that Vgamma1(+) gammadelta T cells reduce the ability of the innate immune system to destroy Listeria, even though other gammadelta T cells as a whole promote clearance of this pathogen...
  2. pmc Protective role of gammadelta T cells in spontaneous ocular inflammation
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, Colorado 80206, USA
    Invest Ophthalmol Vis Sci 50:3266-74. 2009
    ..That certain mice lacking gammadelta T cells often spontaneously develop keratitis, characterized by a progressive and destructive inflammation of the cornea is reported here...
  3. ncbi request reprint gammadelta T-cell receptors: functional correlations
    REBECCA L O'BRIEN
    Integrated Deaprtment of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Rev 215:77-88. 2007
    ..The use of recombinant soluble versions of gammadeltaTCRs appears to be a promising approach to finding new ligands, and recent results using this method are reviewed...
  4. pmc Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 182:2002-10. 2009
    ..We conclude that both the development and the cytokine potential of the AHR-enhancing gammadelta T cells differs critically from that of Th2 cells and NKT cells, despite similar influences of these cell populations on AHR...
  5. pmc Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    J Immunol 182:657-65. 2009
    ..These data are the first to demonstrate an important role for Th17-polarized CD4(+) T lymphocytes in the immune response directed against S. rectivirgula in this murine model of hypersensitivity pneumonitis and pulmonary fibrosis...
  6. pmc Vgamma1+ T cells and tumor necrosis factor-alpha in ozone-induced airway hyperresponsiveness
    Shigeki Matsubara
    Division of Cell Biology, Department of Pediatrics, National Jewish Health and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 40:454-63. 2009
    ..These results demonstrate that TNF-alpha and activation of Vgamma1+ gammadelta T cells are required for the development of AHR after O3 exposure...
  7. pmc Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness
    Laura Cook
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:309-19. 2008
    ..Our findings suggest that CD8+ DCs in the lymphoid tissues enable an early step in the development of gammadelta T cells through direct cell contact. DC-expressed CD8 might take part in this interaction...
  8. pmc Antigen-specific regulation of IgE antibodies by non-antigen-specific γδ T cells
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 190:913-21. 2013
    ..Together, our data suggest that Ag itself, when acquired by γδ T cells, directs the specificity of their IgE suppression...
  9. pmc The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:849-55. 2009
    ..Thus, airway allergen challenge differentially affects two distinct subsets of gammadelta T cells with nonoverlapping functional potentials, and the outcome is IgE suppression...
  10. pmc αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Invest Ophthalmol Vis Sci 53:301-8. 2012
    ..To investigate additional factors in the spontaneous development of keratitis previously reported in B10.TCRδ⁻/⁻ female mice...
  11. doi request reprint Balanced approach of gammadelta T cells to type 2 immunity
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Immunol Cell Biol 88:269-74. 2010
    ..However, after airway allergen exposure, suppressive gammadelta T cells become dominant. The underlying mechanisms are discussed...
  12. ncbi request reprint V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice
    Youn Soo Hahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3170-8. 2003
    ..These findings establish Vgamma4(+) gammadelta T cells as negative regulators of AHR and show that their regulatory effect bypasses much of the allergic inflammatory response coincident with AHR...
  13. ncbi request reprint Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 177:4436-43. 2006
    ..These findings indicate that chronic inhalation of B. subtilis can result in T cell accumulation in the lung and fibrosis, constituting a new model of immune-mediated pulmonary fibrosis...
  14. pmc Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin
    Jena D French
    National Jewish Health, Integrated Department of Immunology, Denver, CO 80206, USA
    J Immunol 182:1892-900. 2009
    ....
  15. pmc {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells
    Jena D French
    Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 102:14741-6. 2005
    ..Our results suggest that CD8(+) alphabeta T cells are the most potent inhibitors of gammadelta T cell homeostasis and exert their effect by competing for IL-15...
  16. pmc Macrophages express multiple ligands for gammadelta TCRs
    M Kemal Aydintug
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, United States
    Mol Immunol 45:3253-63. 2008
    ....
  17. doi request reprint Analysis of gamma delta T cell functions in the mouse
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 184:4055-61. 2010
    ..They also are revealed as a potentially useful target for immune intervention...
  18. ncbi request reprint gammadelta T lymphocytes-selectable cells within the innate system?
    Willi K Born
    Department of Immunology at National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    J Clin Immunol 27:133-44. 2007
    ....
  19. ncbi request reprint Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 179:2961-8. 2007
    ..The data suggest that lymphocytic synergism, which is key to the Ag-specific adaptive immune response, is also intrinsic to T cell-dependent innate responses...
  20. pmc IL-17-producing gammadelta T cells
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA
    Eur J Immunol 39:662-6. 2009
    ..Surprisingly, gammadelta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on...
  21. pmc gammadelta T cells: an important source of IL-17
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Curr Opin Immunol 20:353-7. 2008
    ..Interestingly, some gammadelta T cells produce IL-17 in response to IL-23 alone, even in naïve animals, suggesting they are already differentiated and may develop differently than CD4(+) alphabeta Th17 cells...
  22. doi request reprint Peptide antigens for gamma/delta T cells
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Cell Mol Life Sci 68:2335-43. 2011
    ..To settle the questions of whether peptides can be ligands for the γδ TCRs, and whether responses to small peptides might occur normally, peptide binding will have to be demonstrated, and natural peptide ligands identified...
  23. pmc Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 179:5576-83. 2007
    ..A decrease in total IgG and IgG2a anti-collagen Abs was also seen. These results suggest that Vgamma4/Vdelta4(+) gammadelta T cells exacerbate CIA through their production of IL-17...
  24. doi request reprint Antigen-restricted gammadelta T-cell receptors?
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Arch Immunol Ther Exp (Warsz) 57:129-35. 2009
    ..Here we outline this hypothetical mechanism and discuss its possible implications for thymic selection and potential for complementing known innate and adaptive mechanisms of immune defense...
  25. pmc gammadelta T cell subsets: a link between TCR and function?
    REBECCA L O'BRIEN
    Integrated Dept of Immunology, National Jewish Health, 1400 Jackson St, Denver, CO 80206, United States Univ of Colorado Denver, Aurora, CO 80045, USA
    Semin Immunol 22:193-8. 2010
    ..Here, we describe functionally distinct, TCR-defined gammadelta T cell subsets, and evidence that their functions are predetermined in the thymus...
  26. doi request reprint γδ T cells develop, respond and survive - with a little help from CD27
    Willi K Born
    Integrated Department of Immunology, National Jewish Health and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Eur J Immunol 41:26-8. 2011
    ..This new information underscores the significance of CD27 in γδ T-cell functional differentiation, and is likely to facilitate the development of γδ T-cell-based clinical immunotherapy...
  27. doi request reprint Diversity of γδ T-cell antigens
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Cell Mol Immunol 10:13-20. 2013
    ..While posing a unique challenge in the maintenance of self-tolerance, this broad reactivity pattern might enable multiple overlapping uses of γδ T-cell populations, and thus generate a more efficient immune response...
  28. pmc CD4 T cells play important roles in maintaining IL-17-producing γδ T-cell subsets in naive animals
    Jeong su Do
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Immunol Cell Biol 90:396-403. 2012
    ..Taken together, our results highlight a novel CD4 T cell-dependent mechanism that shapes the generation of IL-17+ γδ T cells in naive settings...
  29. ncbi request reprint The function of gammadelta T cells in innate immunity
    Willi K Born
    Department of Immunology, at National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Immunol 18:31-8. 2006
    ..Thus, at present, much evidence suggests that gammadelta T cells function in an innate manner, although they are arguably the most complex and advanced cellular representatives of the innate immune system...
  30. ncbi request reprint Mismatched antigen prepares gamma delta T cells for suppression of airway hyperresponsiveness
    Niyun Jin
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 174:2671-9. 2005
    ..We conclude that AHR-suppressive Vgamma4(+) gammadelta T cells require induction. They are induced by allergen stimulation, but AHR suppression by these cells does not require their restimulation with the same allergen...
  31. ncbi request reprint Different potentials of gamma delta T cell subsets in regulating airway responsiveness: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation
    Youn Soo Hahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:2894-902. 2004
    ..These findings show how gammadelta T cells can be both inhibitors and enhancers of AHR and airway inflammation, and they provide further support for the hypothesis that TCR expression and function cosegregate in gammadelta T cells...
  32. ncbi request reprint Distribution and leukocyte contacts of gammadelta T cells in the lung
    J M Wands
    Departments of Immunology, National Jewish Medical and Research Center, Denver, Colorado, USA
    J Leukoc Biol 78:1086-96. 2005
    ..The continuous interaction of gammadelta T cells with these sentinels likely is related to their protective role...

Research Grants13

  1. Identifying Ligands with Soluble Gamma/Delta TCRs
    REBECCA O BRIEN; Fiscal Year: 2006
    ..3 sTCR. The backup approach involves generation of ligand specific mAbs, identified by their ability to block sTCR/ligand binding, as reagents to affinity-purify the ligand. ..
  2. Spontaneous Corneal Inflammation in gd T cell absence
    REBECCA O BRIEN; Fiscal Year: 2005
    ..In addition, we will carryout experiments designed to examine whether the disease is autoimmune, results from bacterial infection, or stems from damage caused by a chemical released from dirty cage litter. ..
  3. MECHANISM OF A FUNCTIONAL SWITCH IN GAMMA DELTA T CELLS
    REBECCA O BRIEN; Fiscal Year: 2003
    ....
  4. The Basis of Functional Variation in Gamma/Delta T cells
    REBECCA O BRIEN; Fiscal Year: 2009
    ..We will also examine the importance to disease outcome of the ability of each subset to produce particular cytokines, induce the death of other cells, and undergo apoptosis. ..