A Nyska

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Single or group housing altered hormonal physiology and affected pituitary and interstitial cell kinetics
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Toxicol Sci 27:449-57. 2002
  2. ncbi Characterization of spontaneous and chemically induced cardiac lesions in rodent model systems: the national toxicology program experience
    Micheal P Jokinen
    Pathology Associates Division of Charles River Laboratories, 11000 Weston Parkway, Suite 110, Cary, NC 27513, USA
    Cardiovasc Toxicol 5:227-44. 2005
  3. ncbi Slowing tumorigenic progression in TRAMP mice and prostatic carcinoma cell lines using natural anti-oxidant from spinach, NAO--a comparative study of three anti-oxidants
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 31:39-51. 2003
  4. ncbi Ocular expression of vascular cell adhesion molecule (VCAM-1) in 2-butoxyethanol-induced hemolysis and thrombosis in female rats
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 9998, USA
    Exp Toxicol Pathol 55:231-6. 2003
  5. ncbi The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 184:153-64. 2002
  6. ncbi Olfactory epithelial metaplasia and hyperplasia in female Harlan Sprague-Dawley rats following chronic treatment with polychlorinated biphenyls
    Abraham Nyska
    Laboratory of Experimental Pathology National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 9998, USA
    Toxicol Pathol 33:371-7. 2005
  7. ncbi Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and caffeine
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 83:388-96. 2005
  8. ncbi Characterization of the toxicity, mutagenicity, and carcinogenicity of methacrylonitrile in F344 Rats and B6C3F1 mice
    Abraham Nyska
    Laboratory of Experimental Pathology, MD B3 06, Environmental Toxicology Program, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Arch Toxicol 77:233-42. 2003
  9. ncbi Electron microscopy of wet tissues: a case study in renal pathology
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:357-63. 2004
  10. ncbi Association of liver hemangiosarcoma and secondary iron overload in B6C3F1 mice--the National Toxicology Program experience
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 9998, USA
    Toxicol Pathol 32:222-8. 2004

Detail Information

Publications95

  1. ncbi Single or group housing altered hormonal physiology and affected pituitary and interstitial cell kinetics
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Toxicol Sci 27:449-57. 2002
    ..This study indicates that the number of animals in a cage is associated with hormonal and cellular kinetic changes in the pituitary and testes, which could influence the incidence of tumors in these organs...
  2. ncbi Characterization of spontaneous and chemically induced cardiac lesions in rodent model systems: the national toxicology program experience
    Micheal P Jokinen
    Pathology Associates Division of Charles River Laboratories, 11000 Weston Parkway, Suite 110, Cary, NC 27513, USA
    Cardiovasc Toxicol 5:227-44. 2005
    ....
  3. ncbi Slowing tumorigenic progression in TRAMP mice and prostatic carcinoma cell lines using natural anti-oxidant from spinach, NAO--a comparative study of three anti-oxidants
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 31:39-51. 2003
    ..The anti-oxidative and antiproliferative properties of NAO may explain its efficacy in slowing the spontaneous prostatic carcinogenic process in the TRAMP and its effects in the cell lines...
  4. ncbi Ocular expression of vascular cell adhesion molecule (VCAM-1) in 2-butoxyethanol-induced hemolysis and thrombosis in female rats
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 9998, USA
    Exp Toxicol Pathol 55:231-6. 2003
    ..No change in ICAM-1 or P-selectin expression was seen. This immunolabeling distribution suggests that VCAM-1 functions in the pathogenesis of BE-related thrombosis by promoting adhesion of erythrocytes to the endothelium...
  5. ncbi The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 184:153-64. 2002
    ..Endothelial proliferation may also have been promoted through endothelial arrest at S phase, which was associated with endothelial karyo- and cytomegaly, resulting in hepatocytic hypoxia, triggering VEGF induction...
  6. ncbi Olfactory epithelial metaplasia and hyperplasia in female Harlan Sprague-Dawley rats following chronic treatment with polychlorinated biphenyls
    Abraham Nyska
    Laboratory of Experimental Pathology National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 9998, USA
    Toxicol Pathol 33:371-7. 2005
    ..Variable amounts of acute inflammatory exudate appeared within the lumen of the nasal cavity, overlying the affected epithelium. Occasionally, the inflammation eroded through the skull and into the adjacent olfactory bulbs...
  7. ncbi Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and caffeine
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 83:388-96. 2005
    ..Our work shows the direct relationship between combined ephedrine and caffeine exposure and cardiac pathology...
  8. ncbi Characterization of the toxicity, mutagenicity, and carcinogenicity of methacrylonitrile in F344 Rats and B6C3F1 mice
    Abraham Nyska
    Laboratory of Experimental Pathology, MD B3 06, Environmental Toxicology Program, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Arch Toxicol 77:233-42. 2003
    ..Methacrylonitrile-related non-neoplastic lesions were seen in the nose and liver of rats...
  9. ncbi Electron microscopy of wet tissues: a case study in renal pathology
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:357-63. 2004
    ..These advantages of the wet scanning electron microscopy technique indicate its potential utility in a wide range of applications in histopathology and toxicology...
  10. ncbi Association of liver hemangiosarcoma and secondary iron overload in B6C3F1 mice--the National Toxicology Program experience
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 9998, USA
    Toxicol Pathol 32:222-8. 2004
    ..The reason for the sex-increased susceptibility for development of hemangiosarcoma is unknown but may be due to a hormone-related, reduced antioxidative defensive capacity through modulation of the activities of antioxidative enzymes...
  11. ncbi Exocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health DHHS, PO Box 12233, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 112:903-9. 2004
    ..These results indicate that the pancreatic acini are target tissues for dioxin and certain dioxin-like compounds. Key words: carcinogenesis, dioxin, furans, inflammation, pancreas, polychlorinated biphenyls...
  12. ncbi New tools in therapeutic research--prostatic cancer and models
    Abraham Nyska
    National Institute of Environmental Health Sciences, Laboratory of Experimental Pathology, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:283-7. 2002
  13. ncbi Lysosomal-storage disorder induced by elmiron following 90-days gavage administration in rats and mice
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:178-87. 2002
    ..The cytoplasmic membrane-bound structures within macrophages were lysosomes containing membranous material of cellular origin and, perhaps, remnants of the deposited test material, Elmiron...
  14. ncbi Glutathione S-transferase pi expression in forestomach carcinogenesis process induced by gavage-administered 2,4-hexadienal in the F344 rat
    A Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Arch Toxicol 75:618-24. 2001
    ....
  15. ncbi Disseminated thrombosis and bone infarction in female rats following inhalation exposure to 2-butoxyethanol
    A Nyska
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:287-94. 1999
    ..In conclusion, exposure to 500 ppm BE vapors caused acute disseminated thrombosis and bone infarction in female rats. Possible pathogenic mechanisms are discussed...
  16. ncbi The association between severe nephropathy and pheochromocytoma in the male F344 rat -- the National Toxicology Program experience
    A Nyska
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:456-62. 1999
    ..The possible correlation between the severity of CPN and the incidence of pheochromocytoma may influence interpretation of carcinogenic effects observed at this site...
  17. ncbi Effects of iodine on inducible nitric oxide synthase and cyclooxygenase-2 expression in sulfur mustard-induced skin
    A Nyska
    Laboratory of Experimental Pathology, National Institutes of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Arch Toxicol 74:768-74. 2001
    ..The results suggest that nitric oxide radicals (NO*) are involved in mediating the damage induced by the SM and that iodine-related reduction in acute epidermal inflammation is associated with reduced iNOS expression...
  18. ncbi Topical and oral administration of the natural water-soluble antioxidant from spinach reduces the multiplicity of papillomas in the Tg.AC mouse model
    A Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Lett 122:33-44. 2001
    ..According to histological criteria, papilloma multiplicity were lower in both topical-NAO and oral-NAO groups, but significantly so only in the oral-NAO mice (P<0.01). The beneficial effect of NAO in the Tg.AC mouse is reported...
  19. ncbi Hemolytic anemia, thrombosis, and infarction in male and female F344 rats following gavage exposure to 2-butoxyethanol
    B I Ghanayem
    National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Exp Toxicol Pathol 53:97-105. 2001
    ..Thrombosis may be related to intravascular hemolysis, which could be triggered by procoagulant release and/or alterations in erythrocyte morphology, as well as increased rigidity...
  20. ncbi Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies
    J R Hailey
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 26:602-11. 1998
    ..hepaticus and that hepatitis may be important in the pathogenesis. Therefore, interpretation of carcinogenic effects in the liver of B6C3F1 mice may be confounded if there is H. hepaticus-associated hepatitis...
  21. ncbi Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice
    P C Chan
    Toxicology Operation Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 82:45-53. 2008
    ..4MI is carcinogenic inducing alveolar/bronchiolar adenoma and carcinoma in male and female mice. 4MI may also induce mononuclear cell leukemia in female rats...
  22. ncbi Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice
    P C Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 82:399-412. 2008
    ..Under these experimental conditions, carcinogenic activity of 2MI was demonstrated in male and female rats and mice...
  23. ncbi A retrospective analysis of background lesions and tissue accountability for male accessory sex organs in Fischer-344 rats
    T Suwa
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 29:467-78. 2001
    ..Inflammation was also present in the ampullary glands. We suggest an optimal embedment and trimming method in rat prostate and seminal vesicle to ensure adequate, consistent sampling...
  24. ncbi Unique renal tubule changes induced in rats and mice by the peroxisome proliferators 2,4-dichlorophenoxyacetic acid (2,4-D) and WY-14643
    K Ozaki
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 29:440-50. 2001
    ..Although 2,4-D is considered a weak PP for the liver, it was the most effective at inducing renal lesions, indicating that the toxic potency of various PPs will depend on the target organ...
  25. ncbi Alteration in cell kinetics in control B6C3F1 mice infected with Helicobacter hepaticus
    A Nyska
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 25:591-6. 1997
    ..Furthermore, the absence of enhanced cell proliferation in lungs and kidneys of male and females suggests that neoplastic effects at these sites are not exacerbated by H. hepaticus infection...
  26. ncbi Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination
    Sherine S L Chan
    Laboratory of Molecular Genetics, National Institute of Environmental HealthSciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 48:190-200. 2007
    ..Our data suggest that AZT/3TC combination treatment produces greater mtDNA damage than either agent individually, and that female mice are more sensitive than males to AZT/3TC-induced mtDNA damage...
  27. ncbi A chemically induced rat model of hemolysis with disseminated thrombosis
    Nathan Ezov
    Harlan Biotech Israel Ltd, Rehovot, Israel
    Cardiovasc Toxicol 2:181-94. 2002
    ....
  28. ncbi Urethral carcinoma and hyperplasia in male and female B6C3F1 mice treated with 3,3',4,4'-tetrachloroazobenzene (TCAB)
    B P Singh
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 2233 USA
    Toxicol Pathol 38:372-81. 2010
    ....
  29. ncbi Cardiotoxicity of Ma Huang/caffeine or ephedrine/caffeine in a rodent model system
    J K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 35:657-64. 2007
    ..The combination of Ma Huang or ephedrine with caffeine enhanced the cardiotoxicity over that with the herbal medicine or the active ingredient alone...
  30. ncbi Gingival carcinogenicity in female Harlan Sprague-Dawley rats following two-year oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds
    Katsuhiko Yoshizawa
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 83:64-77. 2005
    ..These results indicate that dioxin and DLCs target the gingiva of the oral cavity, in particular the junctional epithelium of molars...
  31. ncbi Association of adrenal pheochromocytoma and lung pathology in inhalation studies with particulate compounds in the male F344 rat--the National Toxicology Program experience
    Keisuke Ozaki
    Laboratory of Experimental Pathology National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:263-70. 2002
    ..Our investigation assessed the strength of these various associations and supports the possible roles of 2 chronic pulmonary lesions-fibrosis and inflammation-and hypoxemia in the induction of pheochromocytoma in the F344 male rat...
  32. ncbi Follicular epithelial cell hypertrophy induced by chronic oral administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Harlan Sprague-Dawley rats
    Yoshiro Tani
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:41-9. 2004
    ..These results indicate that the follicular cell response was hypertrophic and reversible. This information should contribute to diagnosis of nonneoplastic thyroid follicular lesions in rats...
  33. ncbi Hemostatic activation in a chemically induced rat model of severe hemolysis and thrombosis
    Deborah A Lewis
    Hemostasis and Thrombosis Center, Department of Medicine, Duke University Medical Center, Duke University Health System, Box 3422 Durham, NC 27710, USA
    Thromb Res 118:747-53. 2006
    ....
  34. ncbi Dimethylarsinic acid: results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice
    Lora L Arnold
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Toxicology 223:82-100. 2006
    ..Female rats appear to be more sensitive to the effects of DMA(V) than male rats. DMA(V) is not carcinogenic in mice...
  35. ncbi An investigation of the effects of late-onset dietary restriction on prostate cancer development in the TRAMP mouse
    Andrew W Suttie
    Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:386-97. 2005
    ..NETs did not stain for cyclo-oxygenase-2 (COX-2) nor androgen receptor (AR). SV40 positive tubulo-acinar tumors seen occasionally in the kidney, did not stain for synaptophysin nor NSE...
  36. ncbi The role of particulate matter-associated zinc in cardiac injury in rats
    Urmila P Kodavanti
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27710, USA
    Environ Health Perspect 116:13-20. 2008
    ..Exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity; however, causative components are unknown. Zinc is a major element detected at high levels in urban air...
  37. ncbi Application of a statistical dynamic model investigating the short-term cellular kinetics induced by riddelliine, a hepatic endothelial carcinogen
    Marjo V Smith
    Constella Health Sciences, 2605 Meridian Parkway, Durham, North Carolina 27713, USA
    Toxicol Sci 80:258-67. 2004
    ..That estimated replication rates were found to be significantly higher for endothelial cells supports the supposition of induction of hemangiosarcoma by riddelliine in the liver...
  38. ncbi Increase in cardiovascular pathology in female Sprague-Dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3',4,4',5-pentachlorobiphenyl
    Micheal P Jokinen
    Pathology Associates, Durham, NC, USA
    Cardiovasc Toxicol 3:299-310. 2003
    ..The authors' investigations indicate that the rat cardiovascular system is a target for dioxin toxicity, which increases the incidence of spontaneous cardiomyopathy and arteritis...
  39. ncbi Critical pathways in heart function: bis(2-chloroethoxy)methane-induced heart gene transcript change in F344 rats
    J Dunnick
    National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 34:348-56. 2006
    ..The heart transcript changes suggest that CEM cardiotoxicity activates protective processes associated energy conservation and maintenance of heart function...
  40. ncbi The accuracy of extended histopathology to detect immunotoxic chemicals
    D R Germolec
    Laboratory of Molecular Toxicology National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 82:504-14. 2004
    ....
  41. ncbi Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years
    M D Stout
    National Toxicology Program, National Institute of Environmental Health Sciences, NIEHS, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 47:729-33. 2009
    ..In male rats, a statistically significant increase in the incidence of preputial gland adenoma at 10,000 ppm was considered an equivocal finding. CPM was not carcinogenic to female rats or to male or female mice...
  42. ncbi Epithelial-stromal tumor of the seminal vesicles in the transgenic adenocarcinoma mouse prostate model
    Y Tani
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, PO Box 12233, Mail Drop B3-06, Research Triangle Park, NC 27709, USA
    Vet Pathol 42:306-14. 2005
    ..No conclusive evidence of malignancy (invasion or metastasis) was identified. Our recommended diagnosis of this lesion in the seminal vesicles is epithelial-stromal tumor...
  43. ncbi The transduction of rat submandibular glands by an adenoviral vector carrying the human growth hormone gene is associated with limited and reversible changes at the infusion site
    S Elmore
    Otsuka Maryland Research Institute, Rockville, Maryland, 20850, USA
    Toxicol Pathol 34:385-92. 2006
    ..In order to access the full article online, you must have either an individual subscription or a member subscription accessed through www.toxpath.org.]...
  44. ncbi Extended histopathology in immunotoxicity testing: interlaboratory validation studies
    D R Germolec
    Laboratory of Molecular Toxicology National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 78:107-15. 2004
    ....
  45. ncbi 2-Butoxyethanol female-rat model of hemolysis and disseminated thrombosis: X-ray characterization of osteonecrosis and growth-plate suppression
    Danielle N Lewis
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709-9998, USA
    Toxicol Pathol 33:272-82. 2005
    ..The Faxitron proved to be an excellent noninvasive tool that can be used in future studies with this animal model to examine treatment modalities for the chronic effects of human thrombotic disorders...
  46. ncbi Gene expression profiling of rat pheochromocytoma
    Abdel G Elkahloun
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bldg 50, 50 South Drive, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1073:290-9. 2006
    ..Cross-comparison with a human pheochromocytoma database showed greater than 60% correlation. Results of this study reveal both generic and specific parallels between rat and human pheochromocytomas...
  47. ncbi Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice
    Po Chan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Arch Toxicol 80:169-80. 2006
    ..Our studies demonstrated that, in rats and mice, 2MI induces thyroid hyperplasia and hypertrophy, and both 2MI and 4MI induce anemia; 2MI induces thyroid follicular-cell adenoma in male rats...
  48. ncbi Comparison of chronic toxicity and carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 2-year bioassays in female Sprague-Dawley rats
    Nigel J Walker
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Natinal Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Nutr Food Res 50:934-44. 2006
    ..This may result from differences in the experimental protocols as well as divergence in the biological behavior of the different stocks of Sprague-Dawley rat strains used...
  49. ncbi Incidences of selected lesions in control female Harlan Sprague-Dawley rats from two-year studies performed by the National Toxicology Program
    Amy E Brix
    Experimental Pathology Laboratories, PO Box 12766, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 33:477-83. 2005
    ..2%). Squamous metaplasia is not a lesion commonly observed in NTP control Fischer rats. The Harlan SD rats had a very low incidence of mononuclear cell leukemia (0.5%), compared with an incidence of 24% in female Fischer rats...
  50. ncbi The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats
    John C Seely
    Experimental Pathology Laboratories, Inc, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:681-6. 2002
    ..This marginal association suggests that the number of RTCNs that may develop secondary to chemically exacerbated nephropathy would be few...
  51. ncbi Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto rat
    Urmila P Kodavanti
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 71:237-45. 2003
    ..These findings provide supportive evidence for the epidemiological associations of cardiovascular morbidity and ambient PM...
  52. ncbi Classification of proliferative hepatocellular lesions in harlan sprague-dawley rats chronically exposed to dioxin-like compounds
    James R Hailey
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:165-74. 2005
    ..This paper describes the morphology of these lesions, as well as the diagnostic approach taken in this series of studies...
  53. ncbi Chemical-induced atrial thrombosis in NTP rodent studies
    Katsuhiko Yoshizawa
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:517-32. 2005
    ..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
  54. ncbi Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis
    James C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 161:459-70. 2002
    ..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation...
  55. ncbi Acrylonitrile is a multisite carcinogen in male and female B6C3F1 mice
    Burhan I Ghanayem
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 68:59-68. 2002
    ..This was also considered an equivocal result. In conclusion, these studies demonstrated that acrylonitrile causes multiple carcinogenic effects after gavage administration to male and female B6C3F1 mice for 2 years...
  56. ncbi Toxicity and carcinogenicity of riddelliine in rats and mice
    Po C Chan
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709 9998, USA
    Toxicol Lett 144:295-311. 2003
    ..These studies demonstrate toxicity and carcinogenicity of riddelliine in rats and mice, and a dose-response relationship in female rats and male mice under the experimental conditions employed...
  57. ncbi Toxicity and carcinogenicity of Elmiron in F344/N rats and B6C3F1 mice following 2 years of gavage administration
    Kamal M Abdo
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, MD EC 35, PO Box 12233, Research Triangle Park, NC 27709 9998, USA
    Arch Toxicol 77:702-11. 2003
    ..Under the conditions of these 2-year studies, Elmiron was carcinogenic to mice but not rats...
  58. ncbi Effect of diet and animal care/housing protocols on body weight, survival, tumor incidences, and nephropathy severity of F344 rats in chronic studies
    Joseph K Haseman
    Biostatistics Branch, Environmental Diseases and Medicine Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 31:674-81. 2003
    ..01) in the incidence of a variety of tumors, irrespective of diet. This suggests that differences in animal care and housing protocols may impact tumor incidence in F344 rats, most notably pituitary gland and testis tumors...
  59. ncbi Forestomach tumor induction by 2,4-hexadienal in F344N rats and B6C3F1 mice
    Po C Chan
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Arch Toxicol 77:511-20. 2003
    ..Mechanistic studies indicated that the forestomach carcinogenesis in rats and mice may be due to depletion of glutathione as a result of oxidative stress induced by 2,4-Hx...
  60. ncbi Pulmonary lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin-like compounds
    Nigel J Walker
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 35:880-9. 2007
    ..Potential mechanisms leading to altered differentiation and/or proliferation of bronchiolar and alveolar epithelia may be through CYP1A1 induction or disruption of retinoid metabolism...
  61. ncbi Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice
    Ronald L Melnick
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709, USA
    Toxicology 230:126-36. 2007
    ..These studies provide critical information for future re-evaluations of health-based drinking water standards for haloacetic acids...
  62. ncbi The pivotal role of electron microscopic evaluation in investigation of the cardiotoxicity of bis(2-chloroethoxy)methane in rats and mice
    Abraham Nyska
    National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 37:873-7. 2009
    ..Oral treatment of rats with CEM caused cardiotoxic lesions similar to those reported after dermal administration (Dunnick, Johnson, et al. 2004). The F344/N rat is more sensitive than the B6C3F1 mouse to the cardiotoxic effects of CEM...
  63. ncbi Bis(2-chloroethoxy)methane-induced mitochondrial and myofibrillar damage: short-term time-course study
    June Dunnick
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 81:243-52. 2004
    ....
  64. ncbi Cardiac damage in rodents after exposure to bis(2-chloroethoxy)methane
    June K Dunnick
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:309-17. 2004
    ..CEM is metabolized to thiodiglycolic acid, a chemical that causes mitochondrial dysfunction. It is hypothesized that mitochondrial damage leads to the heart toxicity from bis(2-chloroethoxy)methane...
  65. ncbi Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers
    June K Dunnick
    National Institute of Environmental Health Sciences, Research Triangle Park, P O Box 12233, NC 27709, USA
    Exp Toxicol Pathol 61:1-12. 2009
    ..These results suggest that liver may be a target organ for carcinogenesis processes after long-term administration of PBDEs. A chronic PBDE study is currently being conducted by the National Toxicology Program...
  66. ncbi Mitochondrial damage revealed by morphometric and semiquantitative analysis of mouse pup cardiomyocytes following in utero and postnatal exposure to zidovudine and lamivudine
    Jack B Bishop
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 81:512-7. 2004
    ..Critical insights derived from animal-model data like these may be used to mitigate risks to thousands of human infants receiving essential lifesaving therapy with antiretroviral drugs...
  67. ncbi A grading scheme for the assessment of proliferative lesions of the mouse prostate in the TRAMP model
    Andrew Suttie
    Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 31:31-8. 2003
    ....
  68. ncbi Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds"
    Nigel J Walker
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27705, USA
    Environ Health Perspect 113:43-8. 2005
    ..These data support the use of the TEF approach for dioxin cancer risk assessments...
  69. ncbi Age and dose sensitivities in the 2-butoxyethanol F344 rat model of hemolytic anemia and disseminated thrombosis
    Yuval Ramot
    Hadassah Medical Center, Hebrew University, Jerusalem, Israel
    Exp Toxicol Pathol 58:311-22. 2007
    ..Because our findings show age- and dose-related sensitivities, we suggest that 12-week-old rats and doses of 250 mg/kg be used in the 2-BE model...
  70. ncbi Cardiopulmonary responses of Wistar Kyoto, spontaneously hypertensive, and stroke-prone spontaneously hypertensive rats to particulate matter (PM) exposure
    J Grace Wallenborn
    Department of Environmental Sciences and Engineering, University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
    J Toxicol Environ Health A 70:1912-22. 2007
    ..Preexisting cardiovascular disease may influence susceptibility to PM pulmonary and cardiac health effects in a disease-specific manner...
  71. ncbi Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification
    Ron Kohen
    Department of Pharmaceutics, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
    Toxicol Pathol 30:620-50. 2002
    ..This review thus includes different topics essential for understanding oxidative stress phenomena and provides tools for those intending to conduct study and research in this field...
  72. ncbi Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants
    Neville N C Tam
    Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Prostate 66:57-69. 2006
    ..CONCLUSIONS: Our data indicate that in TRAMP mice, OS/NS injuries are likely involved in early prostatic tumorigenesis and can be modulated by various antioxidants...
  73. ncbi Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
    M B Kadiiska
    Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD F0 02, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 38:698-710. 2005
    ..All other products were not changed by CCl4 or showed fewer significant effects...
  74. ncbi Characterization of bronchiolar metaplasia of the alveolar epithelium in female Sprague-Dawley rats exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126)
    Amy E Brix
    Experimental Pathology Laboratories, Inc, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:333-7. 2004
    ....
  75. ncbi Epididymal sperm granuloma induced by chronic administration of 2-methylimidazole in B6C3F1 mice
    Yoshiro Tani
    Laboratory of Experimental Pathology, National Institute of Environmental Sciences, NIH, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 33:313-9. 2005
    ..The results imply that 2-year treatment of B6C3F1 mice with 2-MI can induce epididymal SGs, primarily followed by more severe testicular GEA. The potential mechanism of SG induction by 2-MI is discussed...
  76. ncbi Ephedrine plus caffeine causes age-dependent cardiovascular responses in Fischer 344 rats
    Reuben Howden
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Heart Circ Physiol 288:H2219-24. 2005
    ..The greater mortality in the 14-wk-old rats was associated with increases in body temperature, HR, and myocardial necrosis...
  77. ncbi Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract
    Natasha P Clayton
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Exp Toxicol Pathol 58:223-36. 2007
    ..Kava-induced hepatic functional changes in the F344 rat might be relevant to human clinical cases of hepatotoxicity following exposure...
  78. ncbi Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis
    Dianne M Walters
    CIIT Centers for Health Research, P O Box 12137, Research Triangle Park, NC 27709, USA
    Am J Pathol 167:1221-9. 2005
    ....
  79. ncbi Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice
    Robert W Sobol
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    DNA Repair (Amst) 2:609-22. 2003
    ..These results suggest that either a beta-pol expression imbalance negatively affects overall fidelity and/or BER capacity or that beta-pol has a role in lens epithelial cell differentiation...
  80. ncbi A critical comparison of murine pathology and epidemiological data of TCDD, PCB126, and PeCDF
    Katsuhiko Yoshizawa
    Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma Inc, Yodogawa, Osaka, Japan
    Toxicol Pathol 35:865-79. 2007
    ....
  81. ncbi Area under the curve as a dose metric for promotional responses following 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure
    Amy H Kim
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 191:12-21. 2003
    ..74 versus 0.20%, respectively. These findings suggest that the peak magnitude of TCDD in liver rather than AUC may play a significant role in the induction of complex biological responses by TCDD...
  82. ncbi Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice
    Uri Wormser
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    Toxicol Appl Pharmacol 200:40-7. 2004
    ..These findings may indicate that COX-2 participates in the early stages of sulfur mustard-induced acute skin toxicity and that COX-1 might exert some protective function against this chemical insult...
  83. ncbi Occult cardiotoxicity: subtoxic dosage of Bis(2-chloroethoxy)methane impairs cardiac response to simulated ischemic injury
    Eliahu Golomb
    Department of Pathology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Toxicol Pathol 35:383-7. 2007
    ..01) than that of untreated rat hearts. These results demonstrate that subtoxic dosage of a cardiotoxic agent may cause occult cardiotoxicity, reflected by impaired response to ischemia...
  84. ncbi Disseminated thrombosis-induced growth plate necrosis in rat: a unique model for growth plate arrest
    Meir Nyska
    Department of Orthopaedic Surgery, Sapir Medical Center, 48 Tchernichovsky Street, Kfar Saba 44281, Israel
    J Pediatr Orthop 25:346-50. 2005
    ..The suitability of this model for investigating the pathogenesis of growth plate necrosis and as a model for potential therapy for various human growth plate disorders are discussed...
  85. ncbi Cardiovascular and blood coagulative effects of pulmonary zinc exposure
    Peter S Gilmour
    Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 211:41-52. 2006
    ..These data suggest that cardiovascular blood coagulation impairments are likely following pulmonary zinc exposure and associated pulmonary injury and inflammation...
  86. ncbi Subchronic inhalation of zinc sulfate induces cardiac changes in healthy rats
    J Grace Wallenborn
    Department of Environmental Sciences and Engineering, UNC School of Public Health, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 232:69-77. 2008
    ..These data indicate that inhalation of zinc at environmentally relevant levels induces cardiac effects. While changes are small in healthy rats, these may be especially relevant in individuals with pre-existent cardiovascular disease...
  87. ncbi A comparative immunohistochemical study of spontaneous and chemically induced pheochromocytomas in B6C3F1 mice
    Georgette D Hill
    Laboratory of Experimental Pathology, National Institute of Environmental Health Science (NIEHS, Research Triangle Park, North Carolina 27709, USA
    Endocr Pathol 14:81-91. 2003
    ..PNMT expression is a tightly regulated component of the chromaffin cell phenotype and appears to be readily lost in mouse pheochromocytomas, particularly those with aggressive characteristics...
  88. ncbi Gastrointestinal hyperplasia with altered expression of DNA polymerase beta
    Katsuhiko Yoshizawa
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 4:e6493. 2009
    ..Altered expression of DNA polymerase beta (Pol beta) has been documented in a large percentage of human tumors. However, tumor prevalence or predisposition resulting from Pol beta over-expression has not yet been evaluated in a mouse model...
  89. ncbi Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approach
    Christopher J Gordon
    National Health and Environmental Effects Research Laboratory, ORD, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Toxicol Environ Health A 73:301-18. 2010
    ..The expression of several cardiac biochemical markers of toluene exposure in the aged may also reflect differential susceptibility to this toxicant...
  90. ncbi Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome
    Jane Blood-Siegfried
    Environmental Immunology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    FEMS Immunol Med Microbiol 42:85-93. 2004
    ..This results in an increased nitric oxide synthase production, most likely the cause of liver pathology and clotting abnormalities...
  91. ncbi Synergistic effect of influenza a virus on endotoxin-induced mortality in rat pups: a potential model for sudden infant death syndrome
    Jane Blood-Siegfried
    Environmental Immunology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Pediatr Res 52:481-90. 2002
    ..Our model suggests that the developing immune system can be primed to respond in an exaggerated way to a second immune challenge resulting in unexpected death...
  92. ncbi Mechanisms of exocrine pancreatic toxicity induced by oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Harlan Sprague-Dawley Rats
    Katsuhiko Yoshizawa
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 85:594-606. 2005
    ..Changes in the expression of CYP or CCKAR may have induced the acinar-cell tumors by initiating proliferation...
  93. ncbi Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta
    John F Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MD B3 02, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 145:4693-702. 2004
    ....
  94. ncbi A new method of wet scanning electron microscopy for the analysis of myelination in EAE mouse model of multiple sclerosis
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health, Research Triangle Park, NC, USA
    Exp Toxicol Pathol 57:291-7. 2006
    ..Furthermore, we demonstrate gold immunolabeling of specific epitopes. We conclude that the new technique provides a quick, accurate, and detailed structural evaluation of the SC that can be applied to advance the research of MS...
  95. ncbi Biocompatibility of the Ex-PRESS miniature glaucoma drainage implant
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Glaucoma 12:275-80. 2003
    ..Considering the high reactivity of the rabbit eye, it is possible that this implant will induce a smaller cellular inflammatory reaction in the human eye...