Allison C Nugent

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 30:485-97. 2006
  2. pmc Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study
    Jonathan B Savitz
    Mood and Anxiety Disorders Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:336-43. 2011
  3. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013
  4. pmc Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 54:2643-51. 2011
  5. pmc Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH MAP, Bethesda, MD 20892, USA
    Neuroimage 49:2966-76. 2010
  6. ncbi request reprint Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:734-41. 2005
  7. pmc Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    1Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, USA
    J Psychopharmacol 27:894-902. 2013
  8. pmc Baseline mood-state measures as predictors of antidepressant response to scopolamine
    Maura L Furey
    Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 196:62-7. 2012
  9. pmc Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
    Neuroimage 43:764-74. 2008
  10. ncbi request reprint Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 60:207-17. 2006

Detail Information

Publications26

  1. ncbi request reprint Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Neuroimage 30:485-97. 2006
    ....
  2. pmc Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study
    Jonathan B Savitz
    Mood and Anxiety Disorders Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:336-43. 2011
    ..We conducted the first magnetic resonance imaging analysis of habenula volume in MDD and bipolar disorder (BD)...
  3. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013
    ..These findings suggest that 5-HT(1A) receptor binding is abnormally reduced in BD, and this abnormality may particularly involve the postsynaptic 5-HT(1A) receptor system of individuals with a tendency toward cortisol hypersecretion...
  4. pmc Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 54:2643-51. 2011
    ..Consistent with other neuroimaging and post-mortem neuropathological studies of MDD, we also found evidence of decreased white matter in patients with dMDD and rMDD...
  5. pmc Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH MAP, Bethesda, MD 20892, USA
    Neuroimage 49:2966-76. 2010
    ..Here we extend these results to the amygdala. We raise the possibility that neuroplastic changes in the amygdala associated with BD are moderated by some mood stabilizing medications...
  6. ncbi request reprint Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study
    Daniel P Dickstein
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 62:734-41. 2005
    ..While numerous magnetic resonance imaging (MRI) studies have evaluated adults with bipolar disorder (BPD), few have examined MRI changes in children with BPD...
  7. pmc Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    1Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, USA
    J Psychopharmacol 27:894-902. 2013
    ..These preliminary findings are consistent with the hypothesis that these mood stabilizers enhance 5-HT1A receptor expression in BD, which may underscore an important component of these agents' mechanism of action. ..
  8. pmc Baseline mood-state measures as predictors of antidepressant response to scopolamine
    Maura L Furey
    Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 196:62-7. 2012
    ..These results indicate that self-report mood-ratings obtained before treatment can predict response outcome to scopolamine, and suggest that a constellation of mood-state features may be related to clinical response...
  9. pmc Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
    Neuroimage 43:764-74. 2008
    ..The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category...
  10. ncbi request reprint Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 60:207-17. 2006
    ..This study used PET and [(11)C]DASB, a radioligand that afforded higher sensitivity and specificity for the 5-HTT than previously available radioligands, to compare 5-HTT binding between BD and control subjects...
  11. pmc Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:804-7. 2009
    ..We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation...
  12. pmc Automated subcortical segmentation using FIRST: test-retest reliability, interscanner reliability, and comparison to manual segmentation
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Brain Mapp 34:2313-29. 2013
    ..In addition, the inclusion of psychiatric patients establishes reliability in subjects exhibiting volumetric abnormalities, validating patient studies...
  13. pmc Neural correlates of rapid antidepressant response to ketamine in bipolar disorder
    Allison C Nugent
    Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD, USA
    Bipolar Disord 16:119-28. 2014
    ..Evidence supports a role for the glutamatergic system in the pathophysiology of BD. This double-blind, randomized, cross-over study sought to determine cerebral metabolic correlates of antidepressant response to ketamine...
  14. pmc Habenula volume in post-traumatic stress disorder measured with high-resolution MRI
    Jonathan B Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, NIH NIMH, Bethesda, MD, USA
    Biol Mood Anxiety Disord 1:7. 2011
    ..abstract:..
  15. pmc Association between subcortical volumes and verbal memory in unmedicated depressed patients and healthy controls
    Arlener D Turner
    National Institutes of Mental Health Experimental and Pathophysiology Branch, NIMH, CRC, Bethesda, MD 20892, USA
    Neuropsychologia 50:2348-55. 2012
    ..This suggests that larger hippocampal volume is related to better memory recall in depression, but specifically with regard to utilizing an inferior memory strategy...
  16. ncbi request reprint Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder
    Dara M Cannon
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 63:741-7. 2006
    ....
  17. pmc Sex differences in the neural correlates of autonomic arousal: a pilot PET study
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, NIMH NIH, 9 Memorial Drive, MSC 0940, Bethesda, MD 20892 0940, United States
    Int J Psychophysiol 80:182-91. 2011
    ....
  18. ncbi request reprint Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
    ..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...
  19. ncbi request reprint No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  20. ncbi request reprint Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  21. pmc Developing biomarkers in mood disorders research through the use of rapid-acting antidepressants
    Mark J Niciu
    Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, Maryland
    Depress Anxiety 31:297-307. 2014
    ..In sum, the combination of target engagement and well-qualified disease-related measures are crucial to improve our pathophysiological understanding, personalize treatment selection, and expand our armamentarium of novel therapeutics. ..
  22. ncbi request reprint Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    Alexander Neumeister
    Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:935-7. 2005
    ..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls...
  23. doi request reprint Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:1166-75. 2008
    ..However, the results of previous neuroimaging studies are in disagreement, possibly because of experimental design limitations related to sample size, matching between patients and controls, and confounding medication effects...
  24. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
    ..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure...
  25. ncbi request reprint Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
    ....
  26. ncbi request reprint Selective reduction in amygdala volume in pediatric anxiety disorders: a voxel-based morphometry investigation
    Michael P Milham
    Beckman Institute, University of Illinois, Urbana, Illinois, USA
    Biol Psychiatry 57:961-6. 2005
    ..We examine the neural correlates of pediatric anxiety disorders, to consider the validity of the categorization scheme used in recent treatment studies...