Nicholas Noinaj

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc TonB-dependent transporters: regulation, structure, and function
    Nicholas Noinaj
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 64:43-60. 2010
  2. pmc Structural insights into the catalytic mechanism of Escherichia coli selenophosphate synthetase
    Nicholas Noinaj
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Bacteriol 194:499-508. 2012
  3. pmc Structural insight into the biogenesis of β-barrel membrane proteins
    Nicholas Noinaj
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 501:385-90. 2013
  4. pmc Structural insight into the lactoferrin receptors from pathogenic Neisseria
    Nicholas Noinaj
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States
    J Struct Biol 184:83-92. 2013
  5. pmc Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis
    James W Fairman
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 20:1233-43. 2012
  6. pmc Structural basis for iron piracy by pathogenic Neisseria
    Nicholas Noinaj
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 483:53-8. 2012
  7. pmc The transferrin-iron import system from pathogenic Neisseria species
    Nicholas Noinaj
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Microbiol 86:246-57. 2012
  8. pmc Structural engineering of a phage lysin that targets gram-negative pathogens
    Petra Lukacik
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:9857-62. 2012
  9. pmc Structural insights into Ail-mediated adhesion in Yersinia pestis
    Satoshi Yamashita
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8030, USA
    Structure 19:1672-82. 2011
  10. pmc Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter
    Travis J Barnard
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 415:128-42. 2012

Collaborators

Detail Information

Publications15

  1. pmc TonB-dependent transporters: regulation, structure, and function
    Nicholas Noinaj
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 64:43-60. 2010
    ..However, the transport mechanism is still unclear. In this review, we summarize recent progress in understanding regulation, structure, and function in TBDTs and questions remaining to be answered...
  2. pmc Structural insights into the catalytic mechanism of Escherichia coli selenophosphate synthetase
    Nicholas Noinaj
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Bacteriol 194:499-508. 2012
    ....
  3. pmc Structural insight into the biogenesis of β-barrel membrane proteins
    Nicholas Noinaj
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 501:385-90. 2013
    ..And third, the β-barrel can undergo lateral opening, suggesting a route from the interior cavity in BamA into the outer membrane. ..
  4. pmc Structural insight into the lactoferrin receptors from pathogenic Neisseria
    Nicholas Noinaj
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States
    J Struct Biol 184:83-92. 2013
    ..meningitidis. We then analyzed these models to gain structural insights into the lactoferrin-iron import system and form a mechanistic model fashioned in parallel to the homologous transferrin-iron import system. ..
  5. pmc Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis
    James W Fairman
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 20:1233-43. 2012
    ..We then use this set of sequences along with our structural data to find and map the evolutionarily constrained residues within the β domain...
  6. pmc Structural basis for iron piracy by pathogenic Neisseria
    Nicholas Noinaj
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 483:53-8. 2012
    ..Our studies provide a rational basis for the specificity of TbpA for human transferrin, show how TbpA promotes iron release from transferrin, and elucidate how TbpB facilitates this process...
  7. pmc The transferrin-iron import system from pathogenic Neisseria species
    Nicholas Noinaj
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Microbiol 86:246-57. 2012
    ....
  8. pmc Structural engineering of a phage lysin that targets gram-negative pathogens
    Petra Lukacik
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:9857-62. 2012
    ....
  9. pmc Structural insights into Ail-mediated adhesion in Yersinia pestis
    Satoshi Yamashita
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8030, USA
    Structure 19:1672-82. 2011
    ..We also evaluated the contribution of laminin to delivery of Yops to HEp-2 cells. This work constitutes a structural description of how a bacterial outer membrane protein uses a multivalent approach to bind host cells...
  10. pmc Molecular basis for the activation of a catalytic asparagine residue in a self-cleaving bacterial autotransporter
    Travis J Barnard
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 415:128-42. 2012
    ..Together, these findings provide insight into factors important for asparagine cyclization, a mechanism broadly used for protein cleavage...
  11. pmc An engineered palette of metal ion quenchable fluorescent proteins
    Xiaozhen Yu
    Laboratory of Molecular Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e95808. 2014
    ..Thus, these engineered fluorescent proteins act as sensitive transition metal ion-responsive genetically encoded probes that span the visible spectrum. ..
  12. ncbi request reprint Lateral Opening and Exit Pore Formation Are Required for BamA Function
    Nicholas Noinaj
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 22:1055-62. 2014
    ..These data provide strong evidence that lateral opening and exit pore formation are required for BamA function. ..
  13. pmc Structure of the agonist-bound neurotensin receptor
    Jim F White
    Membrane Protein Structure Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Nature 490:508-13. 2012
    ....
  14. pmc FhaC takes a bow to FHA in the two-partner do-si-do
    Nicholas Noinaj
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
    Mol Microbiol 92:1155-8. 2014
    ..Guérin et al. (2014) report the first direct experimental evidence to show that the FhaC H1 helix is quite dynamic and exchanges between closed and open states upon interaction with FHA. ..
  15. pmc The structural biology of β-barrel membrane proteins: a summary of recent reports
    James W Fairman
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Struct Biol 21:523-31. 2011
    ..However, they demonstrate many of the advancements made within the field of transmembrane protein structure in the past few years...