N Noben-Trauth

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice
    N Noben-Trauth
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 94:10838-43. 1997
  2. ncbi request reprint Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:337-42. 1999
  3. ncbi request reprint Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:3047-55. 2000
  4. ncbi request reprint IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains
    N Noben-Trauth
    Laboratories ofImmunology and Parasitology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 162:6132-40. 1999
  5. ncbi request reprint Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation
    N Noben-Trauth
    Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:3620-5. 2000
  6. ncbi request reprint Susceptibility to Leishmania major infection in the absence of IL-4
    N Noben-Trauth
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Immunol Lett 75:41-4. 2000
  7. pmc A targeted mutation in the IL-4Ralpha gene protects mice against autoimmune diabetes
    D L Radu
    Department of Microbiology, Mount Sinai Medical School, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 97:12700-4. 2000
  8. ncbi request reprint Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes
    T McGaha
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Invest Dermatol 116:136-43. 2001
  9. pmc Interleukin-4 (IL-4) and IL-13 signaling pathways do not regulate Borrelia burgdorferi-induced arthritis in mice: IgG1 is not required for host control of tissue spirochetes
    M R Potter
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Infect Immun 68:5603-9. 2000
  10. ncbi request reprint Suppression of IgE responses in CD23-transgenic animals is due to expression of CD23 on nonlymphoid cells
    M Payet-Jamroz
    Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunol 166:4863-9. 2001

Collaborators

Detail Information

Publications19

  1. pmc An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice
    N Noben-Trauth
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 94:10838-43. 1997
    ..These results indicate that an IL-4-independent, beta2-microglobulin-dependent pathway exists through which the CD62L-low CD4+ population has acquired IL-4-producing capacity in vivo, strongly suggesting that these cells are NK T cells...
  2. ncbi request reprint Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:337-42. 1999
    ..Taken together, these findings argue that tissue pathology in schistosomiasis requires, in addition to egg-specific CD4+ lymphocytes, a previously unrecognized IL-4Ralpha+ non-T cell effector population...
  3. ncbi request reprint Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, and Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:3047-55. 2000
    ....
  4. ncbi request reprint IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains
    N Noben-Trauth
    Laboratories ofImmunology and Parasitology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 162:6132-40. 1999
    ..major infection. The results with LV39 infection indicate that yet another unidentified factor is capable of causing susceptibility to L. major in the absence of IL-4 or IL-4 signaling...
  5. ncbi request reprint Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation
    N Noben-Trauth
    Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 165:3620-5. 2000
    ..These data show that conventional, naive CD4+ T cells may be considered as initial sources of IL-4 and, in the absence of IFN-gamma and IL-12, this IL-4 can induce Th2 polarization...
  6. ncbi request reprint Susceptibility to Leishmania major infection in the absence of IL-4
    N Noben-Trauth
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Immunol Lett 75:41-4. 2000
    ..major. Furthermore, IL-4Ralpha - / - mice reveal that the ability of L. major to escape immune clearance depends on the parasite substrain...
  7. pmc A targeted mutation in the IL-4Ralpha gene protects mice against autoimmune diabetes
    D L Radu
    Department of Microbiology, Mount Sinai Medical School, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 97:12700-4. 2000
    ..Even as late as 270 days of age, mice homozygous for the targeted allele had no insulitis or only peri-insulitis. Thus, the inability to respond to IL-4 and/or IL-13 protects mice against IDDM in this model of autoimmunity...
  8. ncbi request reprint Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes
    T McGaha
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Invest Dermatol 116:136-43. 2001
    ....
  9. pmc Interleukin-4 (IL-4) and IL-13 signaling pathways do not regulate Borrelia burgdorferi-induced arthritis in mice: IgG1 is not required for host control of tissue spirochetes
    M R Potter
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Infect Immun 68:5603-9. 2000
    ..Furthermore, the IgG1 isotype is not required to control B. burgdorferi cell numbers in tissues. These findings suggest the host defense against B. burgdorferi infection is not dependent on the Th1-Th2 paradigm of T-cell responses...
  10. ncbi request reprint Suppression of IgE responses in CD23-transgenic animals is due to expression of CD23 on nonlymphoid cells
    M Payet-Jamroz
    Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Immunol 166:4863-9. 2001
    ..FDCs that interface with B cells in the germinal center are a candidate for explaining this CD23-mediated IgE suppression...
  11. ncbi request reprint Susceptibility to Leishmania major infection in interleukin-4-deficient mice
    N Noben-Trauth
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Science 271:987-90. 1996
    ..Despite the absence of IL-4, the genetically pure BALB/c mutant mice remained susceptible to L. major infection, showed no signs of lesion healing or parasite clearance, and did not switch to a TH1 phenotype...
  12. pmc T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice
    T Schuler
    Max Delbruck Center for Molecular Medicine, 13122 Berlin, Germany
    J Exp Med 189:803-10. 1999
    ..Together, our results demonstrate a novel and previously unanticipated role of IL-4 for the generation of Th1-associated, CTL-mediated tumor immunity...
  13. ncbi request reprint IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
    J F Urban
    United States Department of Agriculture, Beltsville, Maryland 20705, USA
    Immunity 8:255-64. 1998
    ..Additional observations made in the course of these experiments demonstrate that Stat6 signaling is not required for IL-4 enhancement of IgG1 production and actually inhibits IL-4-induction of mucosal mastocytosis...
  14. ncbi request reprint The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice
    A Metwali
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    J Immunol 157:4546-53. 1996
    ..Thus the production of IL-4 early in the inflammatory response is not the only factor preventing Th1 expression in inflammation...
  15. ncbi request reprint Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line
    N Noben-Trauth
    Max Planck Insitut für Immunbiologie, Freiburg, Germany
    Transgenic Res 5:487-91. 1996
    ..Furthermore, the genetically pure BALB/c IL-4 deficient mice will aid in studying the role of IL-4 in several infectious disease models in which the BALB/c mouse is a susceptible strain...
  16. ncbi request reprint Cutting edge: IL-4 receptor expression by non-bone marrow-derived cells is required to expel gastrointestinal nematode parasites
    J F Urban
    U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Immunology and Disease Resistance Laboratory, Beltsville, MD 20705, USA
    J Immunol 167:6078-81. 2001
    ..Thus, direct IL-4Ralpha signaling of nonimmune gastrointestinal cells may be generally required to induce worm expulsion, even when mast cell and T cell responses are also required...
  17. ncbi request reprint Effect of recombinant human IL-4 on tryptase, chymase, and Fc epsilon receptor type I expression in recombinant human stem cell factor-dependent fetal liver-derived human mast cells
    H Z Xia
    Department of Internal Medicine, Virginia Commonwealth University, Richmond 23298, USA
    J Immunol 159:2911-21. 1997
    ....
  18. ncbi request reprint Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3
    P A Schweitzer
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mamm Genome 7:394-5. 1996
  19. ncbi request reprint The interleukin-12 beta subunit (p40) maps to mouse chromosome 11
    N Noben-Trauth
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 7:392. 1996