Gang Niu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Molecular imaging with activatable reporter systems
    Gang Niu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Theranostics 2:413-23. 2012
  2. pmc Self-assembly of gold nanoparticles to silver microspheres as highly efficient 3D SERS substrates
    Shouhui Chen
    Department of Bio Nano Science and Engineering, National Key Laboratory of Nano Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro Nano Science and Technology, Shanghai Jiaotong University, Shanghai, 200240, China
    Nanoscale Res Lett 8:168. 2013
  3. pmc Vascular endothelial growth factor as an anti-angiogenic target for cancer therapy
    Gang Niu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institute of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Curr Drug Targets 11:1000-17. 2010
  4. doi request reprint Apoptosis imaging: beyond annexin V
    Gang Niu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 51:1659-62. 2010
  5. pmc Longitudinal PET imaging of doxorubicin-induced cell death with 18F-Annexin V
    Shuo Hu
    Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China
    Mol Imaging Biol 14:762-70. 2012
  6. pmc MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Mol Imaging Biol 13:1224-33. 2011
  7. pmc Improvement of CXCR4 tracer specificity for PET imaging
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, USA
    J Control Release 157:216-23. 2012
  8. pmc Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression
    Xiao Xiang Zhang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD, 20892, USA
    Mol Imaging Biol 15:758-67. 2013
  9. pmc Development of a new thiol site-specific prosthetic group and its conjugation with [Cys(40)]-exendin-4 for in vivo targeting of insulinomas
    Xuyi Yue
    National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 31 Center Drive, Bethesda, MD 20892, USA
    Bioconjug Chem 24:1191-200. 2013
  10. pmc Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery
    Xinglu Huang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
    Biomaterials 34:1772-80. 2013

Collaborators

Detail Information

Publications70

  1. pmc Molecular imaging with activatable reporter systems
    Gang Niu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Theranostics 2:413-23. 2012
    ..The applications of several types of activatable reporters will also be summarized. We conclude that activatable reporter imaging can benefit both basic biomedical research and drug development...
  2. pmc Self-assembly of gold nanoparticles to silver microspheres as highly efficient 3D SERS substrates
    Shouhui Chen
    Department of Bio Nano Science and Engineering, National Key Laboratory of Nano Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro Nano Science and Technology, Shanghai Jiaotong University, Shanghai, 200240, China
    Nanoscale Res Lett 8:168. 2013
    ..The simple self-assembly strategy may be extended to other metallic materials with great potentials in SERS, catalysis, and photoelectronic devices...
  3. pmc Vascular endothelial growth factor as an anti-angiogenic target for cancer therapy
    Gang Niu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institute of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
    Curr Drug Targets 11:1000-17. 2010
    ..This review summarizes the current status of tumor therapeutic agents targeting to VEGF and the applications of VEGF related molecular imaging...
  4. doi request reprint Apoptosis imaging: beyond annexin V
    Gang Niu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 51:1659-62. 2010
    ..It is highly possible that quantitative imaging of apoptosis will greatly improve clinical decision making in apoptosis-related diseases...
  5. pmc Longitudinal PET imaging of doxorubicin-induced cell death with 18F-Annexin V
    Shuo Hu
    Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China
    Mol Imaging Biol 14:762-70. 2012
    ....
  6. pmc MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Mol Imaging Biol 13:1224-33. 2011
    ..4 h), using the chelator desferrioxamine-p-SCN (Df) for imaging tumor integrin α(v)β(3)...
  7. pmc Improvement of CXCR4 tracer specificity for PET imaging
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, USA
    J Control Release 157:216-23. 2012
    ..The tracers reported here may allow the evaluation of CXCR4 expression in primary tumors and metastatic nodules, and enable better informed, more personalized treatment for patients with cancer...
  8. pmc Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression
    Xiao Xiang Zhang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD, 20892, USA
    Mol Imaging Biol 15:758-67. 2013
    ..The development of CXCR4-specific radiotracers for positron emission tomography (PET) imaging will allow in vivo evaluation of receptor expression level for diagnosis or therapeutic evaluation...
  9. pmc Development of a new thiol site-specific prosthetic group and its conjugation with [Cys(40)]-exendin-4 for in vivo targeting of insulinomas
    Xuyi Yue
    National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 31 Center Drive, Bethesda, MD 20892, USA
    Bioconjug Chem 24:1191-200. 2013
    ..32 ± 4.36%ID/g at 60 min postinjection) and rapid liver and kidney clearance, which was comparable to the imaging results with [(18)F]FBEM-[cys(40)]-exendin-4 reported by our group. ..
  10. pmc Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery
    Xinglu Huang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
    Biomaterials 34:1772-80. 2013
    ..As a proof-of-concept, this MSC platform opens a new vision for multifunctional applications of cell products by combining the superiority of stem cells and nanoparticles for actively targeted delivery...
  11. pmc Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MS
    Ying Ma
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 31 Center Dr, Suite 1C14, Bethesda, MD 20892 2281, USA
    Amino Acids 43:1625-32. 2012
    ..The labeled antagonists (FP-NBBN, FB-NBBN, G-NBBN and FP-G-NBBN) displayed lower internalization. The optimal imaging agent will depend on the interplay of ligand metabolism, cellular uptake, and internalization in vivo...
  12. pmc Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice
    Lixin Lang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, Radiology and Imaging Sciences, Clinical Center, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland 20892, United States
    Bioconjug Chem 22:2415-22. 2011
    ..Considering their ease of preparation and good imaging qualities, [(18)F]FAl-NOTA-PRGD2 and [(68)Ga]NOTA-PRGD2 are promising alternatives to [(18)F]FPPRGD2 for PET imaging of tumor α(v)β(3) integrin expression...
  13. pmc Longitudinal bioluminescence imaging of the dynamics of Doxorubicin induced apoptosis
    Gang Niu
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Theranostics 3:190-200. 2013
    ..This study aims to visualize the dynamics of apoptotic process with temporal bioluminescence imaging (BLI) using an apoptosis specific bioluminescence reporter gene...
  14. pmc Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model
    Ning Guo
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e37506. 2012
    ....
  15. pmc PET of insulinoma using ¹⁸F-FBEM-EM3106B, a new GLP-1 analogue
    Haokao Gao
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
    Mol Pharm 8:1775-82. 2011
    ..The favorable characteristics of (18)F-FBEM-EM3106B, such as high specific activity and high tumor uptake, and high tumor to nontarget uptake, demonstrate that it is a promising tracer for clinical insulinoma imaging...
  16. pmc Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes
    Xinglu Huang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    Biomaterials 33:4370-8. 2012
    ..These findings provide very helpful guidance for the design of robust multifunctional nanomaterials in SLNs' mapping and tumor metastasis diagnosis...
  17. pmc 18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma
    Dale O Kiesewetter
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Eur J Nucl Med Mol Imaging 39:463-73. 2012
    ..The abundance of GLP-1R in pancreatic β-cells in insulinoma, a cancer of the pancreas, and the activity of GLP-1 in the cardiovascular system have made GLP-1R a target for molecular imaging...
  18. pmc Dye-loaded ferritin nanocages for multimodal imaging and photothermal therapy
    Peng Huang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health, Bethesda, MD, 20892, USA
    Adv Mater 26:6401-8. 2014
    ....
  19. pmc Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots
    Xinglu Huang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    ACS Nano 7:5684-93. 2013
    ..More broadly, we provide a testing blueprint for in vivo behavior of nanoplatforms under various injection routes, an important step forward toward safety and efficacy analysis of nanoparticles. ..
  20. pmc Synergistic enhancement of iron oxide nanoparticle and gadolinium for dual-contrast MRI
    Fan Zhang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 425:886-91. 2012
    ..In this study, we combined the use of iron oxide (IO) particles and nonspecific extracellular gadolinium chelate (Gd) in order to further improve the sensitivity and specificity of lesion detection...
  21. pmc Imaging tumor endothelial marker 8 using an 18F-labeled peptide
    Qimeng Quan
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 9 Memorial Drive, 9 1 W111, Bethesda, MD 20892, USA
    Eur J Nucl Med Mol Imaging 38:1806-15. 2011
    ..TEM8 antagonists and TEM8-targeted delivery of toxins have been developed as effective cancer therapeutics. The ability to image TEM8 expression would be of use in evaluating TEM8-targeted cancer therapy...
  22. pmc Novel (19)F Activatable Probe for the Detection of Matrix Metalloprotease-2 Activity by MRI/MRS
    Xuyi Yue
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland 20892, United States
    Mol Pharm 11:4208-17. 2014
    ..This symmetrical fluorine dendron-based probe design extends the scope of the existing (19)F MRI agents and provides a simple but robust method for real-time (19)F MRI application. ..
  23. doi request reprint Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury
    Zhe Wang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA
    Stem Cells 33:456-67. 2015
    ..These findings indicate a new aspect of SDF1α in mediating CXCR4 engineered MSCs for brain trauma homing and recovery. This potential mechanism may be applicable to other injuries, where CXCR4-SDF1α interaction is highly associated...
  24. pmc One-pot two-step radiosynthesis of a new (18)f-labeled thiol reactive prosthetic group and its conjugate for insulinoma imaging
    Xuyi Yue
    National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 35A Convent Drive, Bethesda, Maryland 20892, United States
    Mol Pharm 11:3875-84. 2014
    ..18)F]FNEM-Cys(40)-exendin-4 showed specific targeting of glucagon-like peptide 1 receptor (GLP-1R) positive insulinomas and comparable imaging results to our recently reported [(18)F]FPenM-Cys(40)-exendin-4. ..
  25. pmc A symmetrical fluorous dendron-cyanine dye-conjugated bimodal nanoprobe for quantitative 19F MRI and NIR fluorescence bioimaging
    Zhe Wang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health, Bethesda, MD, 20892, USA
    Adv Healthc Mater 3:1326-33. 2014
    ..This unique feature can hardly be obtained by traditional (19)F MRI contrast agents. It is envisioned that this nanoprobe can hold great potential for quantitative and sensitive multi-modal molecular imaging...
  26. pmc Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressions
    Lei Zhu
    National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Maryland 20892, United States
    Bioconjug Chem 22:1001-5. 2011
    ..This strategy can be easily tuned for a wide array of applications targeting various receptors and extracellular proteases in vivo...
  27. pmc Rapid and simple one-step F-18 labeling of peptides
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, USA
    Bioconjug Chem 22:422-8. 2011
    ..Successful introduction of 4-fluoro-3-trifluoromethylbenzamide into RGD peptides may be a general strategy applicable to other biologically active peptides and proteins...
  28. pmc In vivo albumin labeling and lymphatic imaging
    Yu Wang
    Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China and Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 112:208-13. 2015
    ..The easy preparation, excellent PET and optical imaging quality, and biosafety suggest that this combination of (18)F-AlF-NEB and EB has great potential for clinical application to map sentinel LNs and provide intraoperative guidance. ..
  29. pmc Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy
    Pengfei Rong
    1 Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China 2 Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland 20892, United States 3 State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan, 410083, China
    Theranostics 4:229-39. 2014
    ..Our study identifies a role for graphene as a carrier of PDT agents to improve PDT efficacy and increase long-term survival following treatment. ..
  30. pmc A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in mice
    Shireesh Srivastava
    Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
    IUBMB Life 65:58-66. 2013
    ..5-fold higher, suggesting increased sympathetic system activity. These results demonstrate that a KD can also increase BAT mitochondrial size and protein levels...
  31. pmc Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain
    Orit Jacobson
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 52:600-7. 2011
    ..Blocking this receptor might prove useful for reducing pain and for cancer therapy. However, there is no method to quantify the levels of these receptors in vivo...
  32. pmc Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide
    Xuefeng Yan
    Department of Radiology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 31 Center Drive, Bethesda, MD 20892, United States Molecular Imaging Center of Harbin Medical University, Harbin, Heilongjiang, China
    Biomaterials 42:94-102. 2015
    ..This novel GO-PEG-DVDMS theranostics is well suited for enhanced fluorescence imaging guided PDT...
  33. pmc PET and NIR optical imaging using self-illuminating (64)Cu-doped chelator-free gold nanoclusters
    Hao Hu
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, China Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD, USA
    Biomaterials 35:9868-76. 2014
    ..This self-illuminating nanocluster with non-toxicity and good biocompatibility can be employed as a novel imaging contrast agent for biomedical applications, especially for molecular imaging...
  34. pmc Acetylcholinesterase-catalyzed hydrolysis allows ultrasensitive detection of pathogens with the naked eye
    Dingbin Liu
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892 USA
    Angew Chem Int Ed Engl 52:14065-9. 2013
    ..Owing to signal amplification strategies, the sensitivity of this assay is comparable to that of PCR. In addition, the readout of the assay is based on solution color change, which can be easily observed by the naked eye alone. ..
  35. pmc Evaluation of an [(18)F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma
    Dale O Kiesewetter
    1 Laboratory of Molecular Imaging, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD 20892, USA
    Theranostics 2:999-1009. 2012
    ..18)F]AlF-NOTA-MAL-exendin-4 shows high tumor uptake and highly selective GLP-1 tissue uptake (INS-1 tumor, lung, pancreas), but still suffers from high kidney uptake...
  36. pmc Molecular targeting of CEACAM6 using antibody probes of different sizes
    Gang Niu
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Control Release 161:18-24. 2012
    ....
  37. doi request reprint Tumor hypoxia imaging
    Xilin Sun
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892 2281, USA
    Mol Imaging Biol 13:399-410. 2011
    ..Special emphasis was placed on noninvasive imaging hypoxia with emerging new agents and new imaging technologies to detect the molecular events that are relevant to tumor hypoxia...
  38. pmc Phage display-derived peptides for osteosarcoma imaging
    Xilin Sun
    National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA
    Clin Cancer Res 16:4268-77. 2010
    ....
  39. pmc N-Alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA delivery
    Gang Liu
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Small 7:2742-9. 2011
    ..In conclusion, Alkyl-PEI2k-IOs demonstrate highly efficient delivery of siRNA and an innocuous toxic profile, making it a potential carrier for gene therapy...
  40. pmc Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425
    Abesh Kumar Bhattacharjee
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    Nucl Med Biol 38:897-906. 2011
    ....
  41. pmc Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate
    Gang Liu
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health, USA
    Angew Chem Int Ed Engl 51:445-9. 2012
    ....
  42. pmc Visualization of protease activity in vivo using an activatable photo-acoustic imaging probe based on CuS nanoparticles
    Kai Yang
    1 Institute of Functional Nano and Soft Materials FUNSOM, Soochow University, Suzhou, Jiangsu 215123, China 2 Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland 20892, United States
    Theranostics 4:134-41. 2014
    ..Our work presents a novel strategy of in vivo sensing of MMPs based on PA imaging, which should offer remarkably improved detection depth compared with traditional optical imaging techniques...
  43. pmc Longitudinal PET imaging of muscular inflammation using 18F-DPA-714 and 18F-Alfatide II and differentiation with tumors
    ChenXi Wu
    1 Department of Nuclear Medicine, Peking Union Medical College Hospital PUMCH, Chinese Academy of Medical Sciences and Peking Union Medical College CAMS and PUMC, Beijing, China 2 Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, USA
    Theranostics 4:546-55. 2014
    ..This study aims to apply these two tracers for longitudinal PET imaging of muscular inflammation, and evaluate the value of (18)F-DPA-714 in differentiating inflammation from tumor...
  44. pmc Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing
    Xinglu Huang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland 20892, United States
    ACS Nano 8:4403-14. 2014
    ..Our findings provide a simple and safe method for imaging and targeted delivery of stem cells and extend the potential applications of iron-based MNPs in regenerative medicine and oncology. ..
  45. doi request reprint Biomimetic RNA-silencing nanocomplexes: overcoming multidrug resistance in cancer cells
    Zhongliang Wang
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 China Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bio engineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892 USA Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361005 China
    Angew Chem Int Ed Engl 53:1997-2001. 2014
    ..This nanocomplex approach has the potential for both functional genomics and cancer therapy. ..
  46. pmc PET imaging of CXCR4 using copper-64 labeled peptide antagonist
    Orit Jacobson
    1 Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland
    Theranostics 1:251-62. 2011
    ..In conclusion, (64)Cu-T140-2D was easily labeled and, in its low activity form, enabled imaging of CXCR4 in tumors. It had high uptake, however, in metabolic organs. Further research with imaging tracers targeting CXCR4 is required...
  47. pmc Noninvasive monitoring of pulmonary fibrosis by targeting matrix metalloproteinases (MMPs)
    Yan Cai
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Pharm 10:2237-47. 2013
    ..In conclusion, MMPs may play an important role in PF development and the MMP-P12 probe could be a promising tool for PF detection, even at an early stage of the disease as well as an indicator of therapy response...
  48. pmc Site-Specific Labeling of scVEGF with Fluorine-18 for Positron Emission Tomography Imaging
    Hui Wang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Theranostics 2:607-17. 2012
    ..Further study of [(18)F] FBEM-scVEGF to evaluate angiogenesis in cancer and other disease types is warranted...
  49. doi request reprint 18F-FPPRGD2 and 18F-FDG PET of response to Abraxane therapy
    Xilin Sun
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892 2281, USA
    J Nucl Med 52:140-6. 2011
    ..The aim of this study was to investigate whether the integrin-specific PET tracer 18F-FPPRGD2 (investigational new drug 104150) can be used to monitor early response of tumors to Abraxane therapy...
  50. pmc New Methods for Labeling RGD Peptides with Bromine-76
    Lixin Lang
    1 Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, 20892, USA
    Theranostics 1:341-53. 2011
    ..The energy barrier difference of the transition states of bromination between the dimethoxybenzoyl group and the tyrosine residue may account for the reaction selectivity when both groups are present in the same molecule...
  51. pmc Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging
    Yunpeng Ye
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    Bioorg Med Chem Lett 21:1146-50. 2011
    ..Both 1 and 2 showed significant tumor localization in optical imaging of MDA-MB-435 tumor-bearing mice. The potential of such iRGD compounds in tumor-targeted imaging and drug delivery deserves further exploration...
  52. pmc Bioinspired nanocomplex for spatiotemporal imaging of sequential mRNA expression in differentiating neural stem cells
    Zhe Wang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
    ACS Nano 8:12386-96. 2014
    ..This nanocomplex is highly amenable as an alternative tool to explore the dynamics of intricate mRNA activities in various physiological and pathological conditions. ..
  53. pmc LC/MS evaluation of metabolism and membrane transport of bombesin peptides
    Dongyu Gu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 31 Center Dr, Suite 1C14, Bethesda, MD, 20892 2281, USA
    Amino Acids 40:669-75. 2011
    ..The antagonist ligand is potentially more useful for receptor-targeted imaging due primarily to its higher metabolic stability...
  54. pmc Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen
    Dingbin Liu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    ACS Nano 7:5568-76. 2013
    ..The efficiency and robustness of this probe were investigated in patient serum samples, demonstrating the great potential of this probe in real-world applications. ..
  55. pmc Self-illuminating 64Cu-doped CdSe/ZnS nanocrystals for in vivo tumor imaging
    Xiaolian Sun
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
    J Am Chem Soc 136:1706-9. 2014
    ..The availability of these self-illuminating integrated QDs provides an accurate and convenient tool for in vivo tumor imaging and detection. ..
  56. pmc Multiplex Imaging of an Intracellular Proteolytic Cascade by using a Broad-Spectrum Nanoquencher
    Xinglu Huang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, USA
    Angew Chem Int Ed Engl 51:1625-30. 2012
    ..In combination with dye-labeled substrates, this nanoquencher boosts multiple fluorescence signals upon specific proteolysis, which allows real-time imaging of proteolytic cascades...
  57. pmc Multimodality imaging of tumor response to doxil
    Fan Zhang
    1 Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Theranostics 1:302-9. 2011
    ....
  58. pmc Preclinical lymphatic imaging
    Fan Zhang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Mol Imaging Biol 13:599-612. 2011
    ....
  59. pmc Triphase interface synthesis of plasmonic gold bellflowers as near-infrared light mediated acoustic and thermal theranostics
    Peng Huang
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health, Bethesda, Maryland 20892, United States
    J Am Chem Soc 136:8307-13. 2014
    ....
  60. pmc Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging
    Zhe Wang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health, Bethesda, MD 20892, USA
    Biomaterials 34:6194-201. 2013
    ..This probe may open another avenue for ultrahigh contrast fluorescence molecular imaging in the future...
  61. pmc A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice
    Emilia Guirguis
    Pulmonary Cardiovascular Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 154:3152-67. 2013
    ....
  62. pmc PEGylated exendin-4, a modified GLP-1 analog exhibits more potent cardioprotection than its unmodified parent molecule on a dose to dose basis in a murine model of myocardial infarction
    Zhongchan Sun
    1 Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi an, China 710032 2 Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892 2281, USA
    Theranostics 5:240-50. 2015
    ..PEG-Ex4 is a potent long-acting GLP-1 receptor agonist for the treatment of chronic heart disease. Its protection might be attributed to enhanced angiogenesis mediated by the activation of Akt and VEGF. ..
  63. doi request reprint Polymeric materials for theranostic applications
    Zhe Wang
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering National Institutes of Health, Bldg 31, 1C22, Bethesda, Maryland, 20892, USA
    Pharm Res 31:1358-76. 2014
    ..We summarized several major polymer formulas, including polymeric conjugate complexes, nanospheres, micelles, and dendrimers for integrated molecular imaging and therapeutic applications. ..
  64. pmc Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars
    Shouju Wang
    Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu 210000, China
    Adv Mater 25:3055-61. 2013
    ..The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo...
  65. pmc Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy
    Peng Huang
    Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    Biomaterials 34:4643-54. 2013
    ....
  66. pmc Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet
    Shireesh Srivastava
    Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
    FASEB J 26:2351-62. 2012
    ..The quantitative insulin-sensitivity check index was 73% higher in the KE group. These results identify KE as a potential antiobesity supplement...
  67. pmc Chimeric ferritin nanocages for multiple function loading and multimodal imaging
    Xin Lin
    Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nano Lett 11:814-9. 2011
    ..This, in combination with the generalizability of the function loading techniques, promises ferritin particles as a powerful nanoplatfom in the era of nanomedicine...
  68. pmc Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance
    Ashwinkumar A Bhirde
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
    ACS Nano 8:4177-89. 2014
    ....
  69. pmc Cetuximab-based immunotherapy and radioimmunotherapy of head and neck squamous cell carcinoma
    Gang Niu
    Imaging Sciences Training Program, Radiology and Imaging Sciences, Clinical Center and National Institute of Biomedical Imaging and Bioengineering, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD20892, USA
    Clin Cancer Res 16:2095-105. 2010
    ....
  70. pmc Size effect in molecular imaging of vascular endothelial growth factor
    Gang Niu
    Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
    Chem Biol 18:819-20. 2011
    ..The small peptidic probes described by Fedorova et al. in this issue appear to be superior to antibodies in reflecting the dynamics of VEGF as they facilitate image quantification...