Research Topics
| Gang NiuSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Apoptosis imaging: beyond annexin VGang Niu
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
J Nucl Med 51:1659-62. 2010..It is highly possible that quantitative imaging of apoptosis will greatly improve clinical decision making in apoptosis-related diseases...
Vascular endothelial growth factor as an anti-angiogenic target for cancer therapyGang Niu
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institute of Health, 9 Memorial Drive, Bethesda, MD 20892, USA
Curr Drug Targets 11:1000-17. 2010..This review summarizes the current status of tumor therapeutic agents targeting to VEGF and the applications of VEGF related molecular imaging...
MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptidesOrit Jacobson
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
Mol Imaging Biol 13:1224-33. 2011..4 h), using the chelator desferrioxamine-p-SCN (Df) for imaging tumor integrin α(v)β(3)...- Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MSYing Ma
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, 31 Center Dr, Suite 1C14, Bethesda, MD 20892 2281, USA
Amino Acids 43:1625-32. 2012..The labeled antagonists (FP-NBBN, FB-NBBN, G-NBBN and FP-G-NBBN) displayed lower internalization. The optimal imaging agent will depend on the interplay of ligand metabolism, cellular uptake, and internalization in vivo... - Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in miceLixin Lang
Laboratory of Molecular Imaging and Nanomedicine LOMIN, Radiology and Imaging Sciences, Clinical Center, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland 20892, United States
Bioconjug Chem 22:2415-22. 2011..Considering their ease of preparation and good imaging qualities, [(18)F]FAl-NOTA-PRGD2 and [(68)Ga]NOTA-PRGD2 are promising alternatives to [(18)F]FPPRGD2 for PET imaging of tumor α(v)β(3) integrin expression... - Improvement of CXCR4 tracer specificity for PET imagingOrit Jacobson
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, USA
J Control Release 157:216-23. 2012..The tracers reported here may allow the evaluation of CXCR4 expression in primary tumors and metastatic nodules, and enable better informed, more personalized treatment for patients with cancer... - Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue modelNing Guo
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 7:e37506. 2012.... - PET of insulinoma using ¹⁸F-FBEM-EM3106B, a new GLP-1 analogueHaokao Gao
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
Mol Pharm 8:1775-82. 2011..The favorable characteristics of (18)F-FBEM-EM3106B, such as high specific activity and high tumor uptake, and high tumor to nontarget uptake, demonstrate that it is a promising tracer for clinical insulinoma imaging... - 18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinomaDale O Kiesewetter
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
Eur J Nucl Med Mol Imaging 39:463-73. 2012..The abundance of GLP-1R in pancreatic β-cells in insulinoma, a cancer of the pancreas, and the activity of GLP-1 in the cardiovascular system have made GLP-1R a target for molecular imaging... - Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobesXinglu Huang
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
Biomaterials 33:4370-8. 2012..These findings provide very helpful guidance for the design of robust multifunctional nanomaterials in SLNs' mapping and tumor metastasis diagnosis... - Synergistic enhancement of iron oxide nanoparticle and gadolinium for dual-contrast MRIFan Zhang
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
Biochem Biophys Res Commun 425:886-91. 2012..In this study, we combined the use of iron oxide (IO) particles and nonspecific extracellular gadolinium chelate (Gd) in order to further improve the sensitivity and specificity of lesion detection... - Imaging tumor endothelial marker 8 using an 18F-labeled peptideQimeng Quan
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 9 Memorial Drive, 9 1 W111, Bethesda, MD 20892, USA
Eur J Nucl Med Mol Imaging 38:1806-15. 2011..TEM8 antagonists and TEM8-targeted delivery of toxins have been developed as effective cancer therapeutics. The ability to image TEM8 expression would be of use in evaluating TEM8-targeted cancer therapy... - Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor deliveryXinglu Huang
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, United States
Biomaterials 34:1772-80. 2013..As a proof-of-concept, this MSC platform opens a new vision for multifunctional applications of cell products by combining the superiority of stem cells and nanoparticles for actively targeted delivery... - Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressionsLei Zhu
National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Maryland 20892, United States
Bioconjug Chem 22:1001-5. 2011..This strategy can be easily tuned for a wide array of applications targeting various receptors and extracellular proteases in vivo... - Rapid and simple one-step F-18 labeling of peptidesOrit Jacobson
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, USA
Bioconjug Chem 22:422-8. 2011..Successful introduction of 4-fluoro-3-trifluoromethylbenzamide into RGD peptides may be a general strategy applicable to other biologically active peptides and proteins... - Longitudinal bioluminescence imaging of the dynamics of Doxorubicin induced apoptosisGang Niu
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
Theranostics 3:190-200. 2013.... - Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory painOrit Jacobson
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
J Nucl Med 52:600-7. 2011..Blocking this receptor might prove useful for reducing pain and for cancer therapy. However, there is no method to quantify the levels of these receptors in vivo... - Evaluation of an [(18)F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in InsulinomaDale O Kiesewetter
1 Laboratory of Molecular Imaging, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD 20892, USA
Theranostics 2:999-1009. 2012..18)F]AlF-NOTA-MAL-exendin-4 shows high tumor uptake and highly selective GLP-1 tissue uptake (INS-1 tumor, lung, pancreas), but still suffers from high kidney uptake... - Molecular targeting of CEACAM6 using antibody probes of different sizesGang Niu
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Control Release 161:18-24. 2012.... - Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425Abesh Kumar Bhattacharjee
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
Nucl Med Biol 38:897-906. 2011.... - Tumor hypoxia imagingXilin Sun
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892 2281, USA
Mol Imaging Biol 13:399-410. 2011..Special emphasis was placed on noninvasive imaging hypoxia with emerging new agents and new imaging technologies to detect the molecular events that are relevant to tumor hypoxia... - Phage display-derived peptides for osteosarcoma imagingXilin Sun
National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, USA
Clin Cancer Res 16:4268-77. 2010.... - N-Alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA deliveryGang Liu
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
Small 7:2742-9. 2011..In conclusion, Alkyl-PEI2k-IOs demonstrate highly efficient delivery of siRNA and an innocuous toxic profile, making it a potential carrier for gene therapy... - Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugateGang Liu
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health, USA
Angew Chem Int Ed Engl 51:445-9. 2012.... - Site-Specific Labeling of scVEGF with Fluorine-18 for Positron Emission Tomography ImagingHui Wang
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
Theranostics 2:607-17. 2012..Further study of [(18)F] FBEM-scVEGF to evaluate angiogenesis in cancer and other disease types is warranted... - New Methods for Labeling RGD Peptides with Bromine-76Lixin Lang
1 Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland, 20892, USA
Theranostics 1:341-53. 2011..The energy barrier difference of the transition states of bromination between the dimethoxybenzoyl group and the tyrosine residue may account for the reaction selectivity when both groups are present in the same molecule... - Synthesis and evaluation of new iRGD peptide analogs for tumor optical imagingYunpeng Ye
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
Bioorg Med Chem Lett 21:1146-50. 2011..Both 1 and 2 showed significant tumor localization in optical imaging of MDA-MB-435 tumor-bearing mice. The potential of such iRGD compounds in tumor-targeted imaging and drug delivery deserves further exploration... - 18F-FPPRGD2 and 18F-FDG PET of response to Abraxane therapyXilin Sun
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892 2281, USA
J Nucl Med 52:140-6. 2011..The aim of this study was to investigate whether the integrin-specific PET tracer 18F-FPPRGD2 (investigational new drug 104150) can be used to monitor early response of tumors to Abraxane therapy... - A ketogenic diet increases brown adipose tissue mitochondrial proteins and UCP1 levels in miceShireesh Srivastava
Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA
IUBMB Life 65:58-66. 2013..5-fold higher, suggesting increased sympathetic system activity. These results demonstrate that a KD can also increase BAT mitochondrial size and protein levels... - Multimodality imaging of tumor response to doxilFan Zhang
1 Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
Theranostics 1:302-9. 2011.... - Preclinical lymphatic imagingFan Zhang
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
Mol Imaging Biol 13:599-612. 2011.... - LC/MS evaluation of metabolism and membrane transport of bombesin peptidesDongyu Gu
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 31 Center Dr, Suite 1C14, Bethesda, MD, 20892 2281, USA
Amino Acids 40:669-75. 2011..The antagonist ligand is potentially more useful for receptor-targeted imaging due primarily to its higher metabolic stability... - Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapyPeng Huang
Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, MD 20892, USA
Biomaterials 34:4643-54. 2013.... - Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester dietShireesh Srivastava
Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA
FASEB J 26:2351-62. 2012..The quantitative insulin-sensitivity check index was 73% higher in the KE group. These results identify KE as a potential antiobesity supplement... - Chimeric ferritin nanocages for multiple function loading and multimodal imagingXin Lin
Laboratory of Molecular Imaging and Nanomedicine LOMIN, National Institute of Biomedical Imaging and Bioengineering NIBIB, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
Nano Lett 11:814-9. 2011..This, in combination with the generalizability of the function loading techniques, promises ferritin particles as a powerful nanoplatfom in the era of nanomedicine... - Molecular imaging with activatable reporter systemsGang Niu
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892, USA
Theranostics 2:413-23. 2012..The applications of several types of activatable reporters will also be summarized. We conclude that activatable reporter imaging can benefit both basic biomedical research and drug development... - Size effect in molecular imaging of vascular endothelial growth factorGang Niu
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
Chem Biol 18:819-20. 2011..The small peptidic probes described by Fedorova et al. in this issue appear to be superior to antibodies in reflecting the dynamics of VEGF as they facilitate image quantification... - Cetuximab-based immunotherapy and radioimmunotherapy of head and neck squamous cell carcinomaGang Niu
Imaging Sciences Training Program, Radiology and Imaging Sciences, Clinical Center and National Institute of Biomedical Imaging and Bioengineering, National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD20892, USA
Clin Cancer Res 16:2095-105. 2010....