L K Nieman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Update in the medical therapy of Cushing's disease
    Lynnette K Nieman
    Program in Reproductive and Adult Endocrinology, The Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, NIH, Building 10, CRC, 1 East, Rm 1 3140, 10 Center Dr, MSC 1109, Bethesda MD 20892 1109, USA
    Curr Opin Endocrinol Diabetes Obes 20:330-4. 2013
  2. pmc Neuroendocrine ACTH-producing tumor of the thymus--experience with 12 patients over 25 years
    Nicola M Neary
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:2223-30. 2012
  3. doi request reprint Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study
    Lynnette K Nieman
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 95:767-72.e1-2. 2011
  4. pmc Approach to the patient with an adrenal incidentaloma
    Lynnette K Nieman
    Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 95:4106-13. 2010
  5. ncbi request reprint Diagnostic tests for Cushing's syndrome
    Lynnette K Nieman
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:112-8. 2002
  6. ncbi request reprint Medical therapy of Cushing's disease
    Lynnette K Nieman
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA
    Pituitary 5:77-82. 2002
  7. ncbi request reprint Management of surgically hypogonadal patients unable to take sex hormone replacement therapy
    Lynnette K Nieman
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 9D42 MSC 1583, 10 Center Drive, Bethesda, MD 20892, USA
    Endocrinol Metab Clin North Am 32:325-36. 2003
  8. ncbi request reprint Difficulty in the diagnosis of Cushing disease
    Lynnette K Nieman
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Nat Clin Pract Endocrinol Metab 2:53-7; quiz following 57. 2006
  9. ncbi request reprint Dynamic evaluation of adrenal hypofunction
    L K Nieman
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    J Endocrinol Invest 26:74-82. 2003
  10. ncbi request reprint Evaluation and treatment of Cushing's syndrome
    Lynnette K Nieman
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Med 118:1340-6. 2005

Detail Information

Publications79

  1. doi request reprint Update in the medical therapy of Cushing's disease
    Lynnette K Nieman
    Program in Reproductive and Adult Endocrinology, The Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, NIH, Building 10, CRC, 1 East, Rm 1 3140, 10 Center Dr, MSC 1109, Bethesda MD 20892 1109, USA
    Curr Opin Endocrinol Diabetes Obes 20:330-4. 2013
    ..Recently developed agents treat Cushing's disease by inhibiting ACTH secretion from corticotrope tumors or antagonizing cortisol action...
  2. pmc Neuroendocrine ACTH-producing tumor of the thymus--experience with 12 patients over 25 years
    Nicola M Neary
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:2223-30. 2012
    ..ACTH-producing neuroendocrine tumor (NET) of the thymus is a rare cause of Cushing's syndrome (CS). The literature consists mainly of isolated case reports...
  3. doi request reprint Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study
    Lynnette K Nieman
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 95:767-72.e1-2. 2011
    ..To evaluate the efficacy and tolerability of the P receptor modulator CDB-2914 (Ulipristal, CDB)...
  4. pmc Approach to the patient with an adrenal incidentaloma
    Lynnette K Nieman
    Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 95:4106-13. 2010
    ..For more indeterminate lesions, repeat evaluation for growth after 3-12 months is useful, with subsequent testing intervals based on the rate of growth...
  5. ncbi request reprint Diagnostic tests for Cushing's syndrome
    Lynnette K Nieman
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:112-8. 2002
    ....
  6. ncbi request reprint Medical therapy of Cushing's disease
    Lynnette K Nieman
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA
    Pituitary 5:77-82. 2002
    ..Mitotane and metyrapone may be effective as single agents, while aminoglutethimide generally must be given in combination. The intravenously-administered etomidate may used when patients cannot take medications by mouth...
  7. ncbi request reprint Management of surgically hypogonadal patients unable to take sex hormone replacement therapy
    Lynnette K Nieman
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 9D42 MSC 1583, 10 Center Drive, Bethesda, MD 20892, USA
    Endocrinol Metab Clin North Am 32:325-36. 2003
    ..Low dose local estrogen treatment is a promising approach for the latter complaints...
  8. ncbi request reprint Difficulty in the diagnosis of Cushing disease
    Lynnette K Nieman
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Nat Clin Pract Endocrinol Metab 2:53-7; quiz following 57. 2006
    ..Previous medication history included 2.5 mg lisinopril daily and 25.0 mg hydrochlorothiazide daily for 12 months...
  9. ncbi request reprint Dynamic evaluation of adrenal hypofunction
    L K Nieman
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    J Endocrinol Invest 26:74-82. 2003
    ..Ultimately, the choice of test should be individualized for each patient, with knowledge of the available reference assays and the vagaries of each test...
  10. ncbi request reprint Evaluation and treatment of Cushing's syndrome
    Lynnette K Nieman
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Am J Med 118:1340-6. 2005
    ..The medical treatment of choice is ketoconazole. The prognosis is better for Cushing's disease and benign adrenal causes of Cushing's syndrome than adrenocortical cancer and malignant ACTH-producing tumors...
  11. ncbi request reprint Addison's disease
    Lynnette K Nieman
    Reproductive and Biology Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Dermatol 24:276-80. 2006
    ..Synthetic adrenocorticotropin 1-24 at a dose of 250 microg works well as a dynamic test. Elevated plasma levels of adrenocorticotropin and renin confirm the diagnosis. Treatment involves replacement of the deficient hormones...
  12. ncbi request reprint Glucocorticoid excess and hypertension
    Smita Baid
    National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 9D42 MSC 1583, 10 Center Drive, Bethesda, MD 20892 1583, USA
    Curr Hypertens Rep 6:493-9. 2004
    ..Although treatment of hypertension with available antihypertensive medications is only moderately successful, after cure of Cushing's syndrome, approximately 30% of patients have persistent hypertension...
  13. ncbi request reprint Urine free cortisol in the high-dose dexamethasone suppression test for the differential diagnosis of the Cushing syndrome
    M R Flack
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
    Ann Intern Med 116:211-7. 1992
    ..The diagnostic performance of the test is improved by measuring both urine free cortisol and 17-hydroxysteroid excretion and by requiring greater suppression of both steroids...
  14. ncbi request reprint Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states
    J A Yanovski
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    JAMA 269:2232-8. 1993
    ..CONCLUSION--The dexamethasone-CRH test is a more accurate test to distinguish Cushing's syndrome from pseudo-Cushing's states in patients with mild hypercortisolism...
  15. ncbi request reprint Inferior petrosal sinus AVP in patients with Cushing's syndrome
    J A Yanovski
    Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Clin Endocrinol (Oxf) 47:199-206. 1997
    ....
  16. ncbi request reprint The dexamethasone-suppressed corticotropin-releasing hormone stimulation test differentiates mild Cushing's disease from normal physiology
    J A Yanovski
    Office of the Director, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    J Clin Endocrinol Metab 83:348-52. 1998
    ..These results suggest that the Dex-CRH test may be useful in the evaluation of CS in patients without significant hypercortisoluria. However, its value in patients with episodic hormonogenesis has not been tested...
  17. pmc Cortisol, obesity, and the metabolic syndrome: a cross-sectional study of obese subjects and review of the literature
    S B Abraham
    The Program in Reproductive and Adult Endocrinology, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Obesity (Silver Spring) 21:E105-17. 2013
    ..To evaluate these relationships, a cross-sectional study of 369 overweight and obese subjects and 60 healthy volunteers was performed and reviewed the previous literature...
  18. ncbi request reprint A single midnight serum cortisol measurement distinguishes Cushing's syndrome from pseudo-Cushing states
    D A Papanicolaou
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 83:1163-7. 1998
    ..5 microg/dL at midnight discriminates CS from PCS with higher sensitivity than 24-h urinary cortisol or 17OHCS, or other individual or combined measures of serum cortisol...
  19. ncbi request reprint The hypoplastic inferior petrosal sinus: a potential source of false-negative results in petrosal sampling for Cushing's disease
    J L Doppman
    Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1182, USA
    J Clin Endocrinol Metab 84:533-40. 1999
    ..We conclude that the presence of a unilateral hypoplastic or plexiform inferior petrosal sinus can result in anomalous drainage from the pituitary gland that may lead to false-negative sampling results in patients with Cushing's disease...
  20. ncbi request reprint Paradoxical response to dexamethasone in the diagnosis of primary pigmented nodular adrenocortical disease
    C A Stratakis
    National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Ann Intern Med 131:585-91. 1999
    ..Primary pigmented nodular adrenocortical disease causes the Cushing syndrome in children and young adults and is most frequently associated with the Carney complex...
  21. ncbi request reprint Plasma levels of corticotropin-releasing hormone in the inferior petrosal sinuses of healthy volunteers, patients with Cushing's syndrome, and patients with pseudo-Cushing states
    J A Yanovski
    Office of the Director, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 83:1485-8. 1998
    ..We conclude that inferior petrosal sinus human CRH levels are not easily measured in the inferior petrosal sinuses and cannot be used to determine whether individual patients may have hypersecretion of CRH causing their ACTH secretion...
  22. ncbi request reprint Role of preoperative iodocholesterol scintiscanning in patients undergoing adrenalectomy for Cushing's syndrome
    K C Yu
    Surgical Metabolism Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Surgery 118:981-6; discussion 986-7. 1995
    ..Iodocholesterol scintiscanning (IS) is a noninvasive, functional diagnostic test. We report our experience with IS as an adjunct for adrenal surgery for Cushing's syndrome...
  23. pmc Specificity of screening tests for Cushing's syndrome in an overweight and obese population
    Smita K Baid
    The Program in Reproductive and Adult Endocrinology, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 94:3857-64. 2009
    ..Recent reports suggest a higher prevalence (1-5%) of Cushing's syndrome in certain patient populations with features of the disorder (e.g., diabetes), but the prevalence in the overweight and obese population is not known...
  24. ncbi request reprint Persistence of dysmenorrhea and nonmenstrual pain after optimal endometriosis surgery may indicate adenomyosis
    Jason D Parker
    National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Fertil Steril 86:711-5. 2006
    ..To evaluate whether persistence of pelvic pain after excision of endometriosis was associated with adenomyosis as defined by a thickened uterine junctional zone (JZ) on magnetic resonance (MR) imaging...
  25. pmc Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACTH secretion
    S T Sharma
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, 1 East, Rm 3140, Bethesda, Maryland 20892 1109, USA
    Eur J Endocrinol 166:531-6. 2012
    ..The pathophysiology remains unclear but may involve several different mechanisms...
  26. ncbi request reprint A comparison of immunometric and radioimmunoassay measurement of ACTH for the differential diagnosis of Cushing's syndrome
    J R Lindsay
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda MD 20892 1109, USA
    J Endocrinol Invest 29:983-8. 2006
    ..We wished to determine whether diagnostic criteria developed with RIA would also be applicable for immunoradiometric (IRMA) or immunochemiluminescent (ICMA) assays...
  27. ncbi request reprint High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis
    N Sinaii
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Drive, Building 10, Room 9D42, MSC 1583, Bethesda, MD 20892 1583, USA
    Hum Reprod 17:2715-24. 2002
    ..This study examined whether the prevalence of autoimmune, chronic pain and fatigue and atopic disorders is higher in women with endometriosis than in the general female population...
  28. ncbi request reprint Assessing the effects of thyroid suppression on benign solitary thyroid nodules. A model for using quantitative research synthesis
    G Csako
    Clinical Pathology Department, Clin Ctr, NIH, Bethesda, MD 20892 1508, USA
    Medicine (Baltimore) 79:9-26. 2000
    ..Finally, quantitative assessment of available evidence as described here may be applicable to the review of other controversial issues as well...
  29. pmc Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial
    Pamela Stratton
    Reproductive Biology and Medicine Branch, National Institutes of Health, Bethesda, Maryland, USA
    Obstet Gynecol 111:88-96. 2008
    ..To evaluate whether 6 months of raloxifene was effective in treatment of chronic pelvic pain in women with endometriosis...
  30. ncbi request reprint The role of [(18)F]fluorodeoxyglucose positron emission tomography and [(111)In]-diethylenetriaminepentaacetate-D-Phe-pentetreotide scintigraphy in the localization of ectopic adrenocorticotropin-secreting tumors causing Cushing's syndrome
    Karel Pacak
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Clin Endocrinol Metab 89:2214-21. 2004
    ..As H-OCT identified a tumor in one patient with otherwise negative imaging, it should be considered only when other imaging modalities fail to localize the ACTH-secreting tumor in patients with EAS...
  31. pmc Recruitment and retention of women for clinical leiomyoma trials
    DesireƩ McCarthy-Keith
    Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, United States
    Contemp Clin Trials 31:44-8. 2010
    ..Subject recruitment and retention in clinical leiomyoma trials is challenging. We evaluated strategies to increase patient enrollment and completion in leiomyoma trials...
  32. ncbi request reprint Deficits in hippocampus-mediated Pavlovian conditioning in endogenous hypercortisolism
    Christian Grillon
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Biol Psychiatry 56:837-43. 2004
    ..The aim of this study was to examine the performance of Cushing's syndrome patients on trace eyeblink conditioning, a cross-species, hippocampal-mediated test of learning and memory...
  33. pmc Using location, color, size, and depth to characterize and identify endometriosis lesions in a cohort of 133 women
    Barbara J Stegmann
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Fertil Steril 89:1632-6. 2008
    ..To correlate histology with endometriosis characteristics...
  34. ncbi request reprint CD10 immunohistochemical staining enhances the histological detection of endometriosis
    Clariss Potlog-Nahari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1583, USA
    Fertil Steril 82:86-92. 2004
    ..To determine whether the use of CD10 immunohistochemistry in addition to hematoxylin and eosin (H&E) staining would increase the sensitivity of surgically suspected endometriosis lesions...
  35. ncbi request reprint Development of the selective progesterone receptor modulator CDB-2914 for clinical indications
    Diana L Blithe
    Department of Health and Human Services, National Institute of Child Health and Human Development, National Institutes of Health Building 61E, Room 8B13, Bethesda, MD 20892, USA
    Steroids 68:1013-7. 2003
    ..On average, CDB-2914 tends to lengthen the menstrual cycle by approximately 1-2 days although the amount of delay varies with timing in the menstrual cycle and dose...
  36. ncbi request reprint Urine vascular endothelial growth factor-A is not a useful marker for endometriosis
    Clariss Potlog-Nahari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1583, USA
    Fertil Steril 81:1507-12. 2004
    ..To determine whether urine VEGF is elevated in women with endometriosis...
  37. ncbi request reprint Location, color, size, depth, and volume may predict endometriosis in lesions resected at surgery
    Pamela Stratton
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1853, USA
    Fertil Steril 78:743-9. 2002
    ..To correlate the diagnosis of endometriosis in lesions excised at laparoscopy with pathologic diagnosis...
  38. ncbi request reprint Diagnostic accuracy of laparoscopy, magnetic resonance imaging, and histopathologic examination for the detection of endometriosis
    Pamela Stratton
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Fertil Steril 79:1078-85. 2003
    ..To evaluate the utility of fat-suppressed magnetic resonance imaging (MRI) in the diagnosis of endometriosis...
  39. ncbi request reprint Is there a therapeutic role for octreotide in patients with ectopic Cushing's syndrome?
    G I Uwaifo
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD, USA
    J Endocrinol Invest 26:710-7. 2003
    ..Before therapy an octreotide challenge test may predict therapeutic response. Cortisol levels should be monitored regularly on somatostatin analog therapy, because of its unpredictable long-term pharmacodynamic profile...
  40. ncbi request reprint Use of a parenteral propylene glycol-containing etomidate preparation for the long-term management of ectopic Cushing's syndrome
    J Krakoff
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    J Clin Endocrinol Metab 86:4104-8. 2001
    ..Parenteral propylene glycol containing etomidate can be used safely for a prolonged period to reduce hypercortisolemia in patients unable to take oral medications...
  41. pmc The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline
    Lynnette K Nieman
    Program on Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 93:1526-40. 2008
    ..The objective of the study was to develop clinical practice guidelines for the diagnosis of Cushing's syndrome...
  42. pmc CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial
    Eric D Levens
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Obstet Gynecol 111:1129-36. 2008
    ..To evaluate whether 3-month administration of CDB-2914, a selective progesterone receptor modulator, reduces leiomyoma size and symptoms...
  43. pmc Outcome of using the histological pseudocapsule as a surgical capsule in Cushing disease
    Jay Jagannathan
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    J Neurosurg 111:531-9. 2009
    ..In this study the authors examined the results of using the pseudocapsule as a surgical capsule in the resection of adenomas in patients with Cushing disease...
  44. pmc Diagnostic accuracy of chromogranin A and calcitonin precursors measurements for the discrimination of ectopic ACTH secretion from Cushing's disease
    Marina S Zemskova
    The Program in Reproductive and Adult Endocrinology, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1109, USA
    J Clin Endocrinol Metab 94:2962-5. 2009
    ..Neuroendocrine tumors may secrete chromogranin A (CgA), calcitonin (CT), procalcitonin (ProCT), a fragment of the amino terminus of procalcitonin (NProCT), and/or ACTH...
  45. ncbi request reprint Surgical remission of pituitary adenomas confined to the neurohypophysis in Cushing's disease
    Robert J Weil
    Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5D37, MSC 1414, 9000 Rockville Pike, Bethesda, Maryland 20892 1414, USA
    J Clin Endocrinol Metab 91:2656-64. 2006
    ..Many patients who fail complete or partial hypophysectomy are cured by sellar and parasellar irradiation...
  46. ncbi request reprint Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: a comparison of assays to establish hypercortisolism
    Smita K Baid
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 92:3102-7. 2007
    ..Although bedtime salivary cortisol measurement has been proposed as the optimal screening test for the diagnosis of Cushing's syndrome, its performance using commercially available assays has not been widely evaluated...
  47. pmc Prolactin as a marker of successful catheterization during IPSS in patients with ACTH-dependent Cushing's syndrome
    S T Sharma
    Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:3687-94. 2011
    ..8 ipsilateral to the highest ACTH ratio has been proposed to verify successful catheterization. Prolactin-normalized ACTH IPS/P ratios may differentiate Cushing's disease (CD) from ectopic ACTH syndrome (EAS)...
  48. ncbi request reprint Glucocorticoid excess during adolescence leads to a major persistent deficit in bone mass and an increase in central body fat
    V Abad
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    J Bone Miner Res 16:1879-85. 2001
    ..These observations suggest that hypercortisolism (exogenous or endogenous) during adolescence may have persistent adverse effects on bone and fat mass...
  49. ncbi request reprint Long-term impaired quality of life in Cushing's syndrome despite initial improvement after surgical remission
    John R Lindsay
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Clinical Research Center, Room 1 3140, 10 Center Drive, Bethesda, MD 20892 1109, USA
    J Clin Endocrinol Metab 91:447-53. 2006
    ..Cushing's syndrome (CS) is associated with symptoms that may impair health-related quality of life (HRQL)...
  50. pmc Endometrial effects of a single early luteal dose of the selective progesterone receptor modulator CDB-2914
    Pamela Stratton
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892 1109, USA
    Fertil Steril 93:2035-41. 2010
    ..To test potential contraceptive mechanisms of the selective P receptor modulator CDB-2914 in the early luteal phase...
  51. pmc Reduced expression of biomarkers associated with the implantation window in women with endometriosis
    Qingxiang Wei
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Fertil Steril 91:1686-91. 2009
    ..To evaluate the expression of biomarkers of implantation, glycodelin A (GdA), osteopontin (OPN), lysophosphatidic acid receptor 3 (LPA3), and HOXA10, in eutopic endometrium of women with and without endometriosis...
  52. ncbi request reprint Cushing's syndrome during pregnancy: personal experience and review of the literature
    John R Lindsay
    Reproductive Biology and Medicine Branch, National Institute for Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3140, 10 Center Drive, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 90:3077-83. 2005
    ..It is likely that earlier recognition and treatment would improve outcome. There is a need for development of criteria for interpretation of diagnostic tests and increased consideration of CS in pregnancy...
  53. ncbi request reprint Jugular venous sampling: an alternative to petrosal sinus sampling for the diagnostic evaluation of adrenocorticotropic hormone-dependent Cushing's syndrome
    Ioannis Ilias
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:3795-800. 2004
    ..86% CI, 78-94%). Centers with limited sampling experience may choose to use the simpler JVS and refer patients for IPSS when the results are negative...
  54. doi request reprint Is prolactin measurement of value during inferior petrosal sinus sampling in patients with adrenocorticotropic hormone-dependent Cushing's Syndrome?
    S T Sharma
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    J Endocrinol Invest 36:1112-6. 2013
    ..Larger prospective studies are also needed for further evaluation of the role of contralateral prolactin IPS/P ratios, post- CRH prolactin values, and prolactin-adjusted ACTH inter-sinus ratios for tumor localization in CD...
  55. ncbi request reprint Therapeutic doses of glucocorticoids: implications for oral medicine
    S K Baid
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD 20892 1109, USA
    Oral Dis 12:436-42. 2006
    ..The aim of this review is to provide oral healthcare practitioners with a practical guide to commonly used glucocorticoids, their adverse effects, and perioperative use...
  56. ncbi request reprint The Keeper, a menstrual collection device, as a potential cause of endometriosis and adenomyosis
    Stacey Spechler
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, MSC 1583, 10 Center Drive, Bethesda, MD 20892 1583, USA
    Gynecol Obstet Invest 56:35-7. 2003
    ..We describe the case of a woman with a prior tubal ligation who after four years of regular use of the Keeper, a menstrual collecting device, developed endometriosis and adenomyosis...
  57. ncbi request reprint Luteal phase dose-response relationships of the antiprogestin CDB-2914 in normally cycling women
    Maureen D Passaro
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Reprod 18:1820-7. 2003
    ..The synthetic steroid CDB-2914 binds to the progesterone and glucocorticoid receptors. In animals it has antiprogestational activity at doses 50-fold less than those required for antiglucocorticoid effects...
  58. ncbi request reprint Differential diagnosis and imaging in Cushing's syndrome
    John R Lindsay
    Reproductive Biology and Medicine Branch, National Institute for Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, CRC 1 3140, Bethesda, MD 20892 1109, USA
    Endocrinol Metab Clin North Am 34:403-21, x. 2005
    ..This article focuses on current biochemical and radiologic strategies for the differential diagnosis of CS...
  59. pmc Utility of various functional and anatomic imaging modalities for detection of ectopic adrenocorticotropin-secreting tumors
    Marina S Zemskova
    Building 10, CRC, 1 East, Room 1 3140, 10 Center Drive, MSC 1109, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 95:1207-19. 2010
    ..Eight occult EAS patients had 64 +/- 58 (9-198) months follow-up; others had none. Conclusions: High sensitivity and PPV suggest thoracic CT/MRI plus LOCT scans for initial imaging, with lesion confirmation by two modalities...
  60. ncbi request reprint Ectopic luteinizing hormone secretion and anovulation
    Boaz Hirshberg
    Transplantation and Autoimmunity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 348:312-7. 2003
  61. ncbi request reprint Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology
    William H Catherino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Fertil Steril 80:282-90. 2003
    ..Our previous study identified several genes that might contribute to the fibroid phenotype. We therefore sought to confirm genes involved in three distinct signal transduction pathways...
  62. ncbi request reprint Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids
    William H Catherino
    Pediatric and Reproductive Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    Genes Chromosomes Cancer 40:204-17. 2004
    ..In particular, decreased expression of dermatopontin represents a molecular link between the leiomyoma and keloid phenotypes...
  63. pmc A change in pituitary magnetic resonance imaging protocol detects ACTH-secreting tumours in patients with previously negative results
    Iffat N Chowdhury
    Reproductive Biology and Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
    Clin Endocrinol (Oxf) 72:502-6. 2010
    ..We hypothesized that specific MR scanning parameters influence detection of corticotropinomas...
  64. ncbi request reprint Spoiled gradient recalled acquisition in the steady state technique is superior to conventional postcontrast spin echo technique for magnetic resonance imaging detection of adrenocorticotropin-secreting pituitary tumors
    Nicholas Patronas
    Department of Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Clin Endocrinol Metab 88:1565-9. 2003
    ..4%). We recommend the addition of SPGR to SE sequences using pituitary-specific technical parameters to improve the MRI detection of ACTH-secreting pituitary tumors...
  65. ncbi request reprint The hypothalamic-pituitary-adrenal axis in pregnancy: challenges in disease detection and treatment
    John R Lindsay
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Endocr Rev 26:775-99. 2005
    ..Appropriate treatment and management of labor are reviewed...
  66. ncbi request reprint Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health
    Ioannis Ilias
    Pediatric and Reproductive Endocrinology Branch, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 90:4955-62. 2005
    ..Ectopic ACTH secretion (EAS) is difficult to diagnose and treat. We present our experience with EAS from 1983 to 2004...
  67. ncbi request reprint Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders
    Antonis Voutetakis
    Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA
    J Endocrinol 185:363-72. 2005
    ....
  68. pmc A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (Chronocort) vs. conventional hydrocortisone (Cortef) in the treatment of congenital adrenal hyperplasia
    Somya Verma
    Reproductive Biology and Medicine Branch, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
    Clin Endocrinol (Oxf) 72:441-7. 2010
    ..We compared hormonal profiles during therapy with a new modified-release hydrocortisone (MR-HC), Chronocort, to conventional hydrocortisone (HC), Cortef, in patients with CAH...
  69. ncbi request reprint Effects of child- and adolescent-onset endogenous Cushing syndrome on bone mass, body composition, and growth: a 7-year prospective study into young adulthood
    Gary M Leong
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    J Bone Miner Res 22:110-8. 2007
    ..In 14 children followed for 3-7 years into young adulthood after cure of CS, whereas bone mass largely recovered, persisting increases in total body and visceral fat suggests an increase risk of the metabolic syndrome...
  70. pmc A logistic model for the prediction of endometriosis
    Barbara J Stegmann
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Fertil Steril 91:51-5. 2009
    ..To develop a model that uses individual and lesion characteristics to help surgeons choose lesions that have a high probability of containing histologically confirmed endometriosis...
  71. pmc Selective venous sampling for androgen-producing ovarian pathology
    Eric D Levens
    Eunice Kenedy Shriver National Institute of Child Health and Human Development Bethesda, MD 20892, USA
    Clin Endocrinol (Oxf) 70:606-14. 2009
    ..Multiple diagnostic modalities may be needed to establish the source of excessive androgen production in women. The role of selective venous catheterization in this process has not been established fully...
  72. pmc Magnetic resonance imaging and transvaginal ultrasound for determining fibroid burden: implications for research and clinical care
    Eric D Levens
    Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 200:537.e1-7. 2009
    ..To compare magnetic resonance and ultrasound imaging for uterine fibroid measurement...
  73. ncbi request reprint Nighttime salivary cortisol: a useful test for the diagnosis of Cushing's syndrome
    Dimitris A Papanicolaou
    Department of Internal Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 87:4515-21. 2002
    ..We concluded that bedtime salivary cortisol measurement is a practical and accurate screening test for the diagnosis of Cushing's syndrome...
  74. ncbi request reprint Cushing's disease after surgical resection and radiation therapy for nonfunctioning pituitary adenoma
    Sjoberg A Kho
    Division of Endocrinology and Metabolism, SUNY School of Medicine, Stony Brook, New York, USA
    Endocr Pract 8:292-5. 2002
    ..To describe a patient with an aggressive nonfunctioning pituitary adenoma in whom Cushing's disease developed after two resections of tumor and radiation therapy...
  75. ncbi request reprint Cushing's syndrome
    John Newell-Price
    Division of Clinical Sciences, University of Sheffield, Northern General Hospital, Sheffield, UK
    Lancet 367:1605-17. 2006
    ..Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We provide diagnostic algorithms and recommendations for management...
  76. ncbi request reprint Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases
    David J Torpy
    University of Queensland, Department of Medicine, Greenslopes Hospital, Newdegate Street, Brisbane, Queensland 4120, Australia
    Ann N Y Acad Sci 970:134-44. 2002
    ....
  77. ncbi request reprint Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppression
    Catherine A Roca
    Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
    J Clin Endocrinol Metab 90:4224-31. 2005
    ..Sex-related differences in reproductive steroid levels further confound efforts to define the specific role of the sex of the individual in stress axis responsivity...
  78. ncbi request reprint Aggressive pituitary tumors in MEN1: do they refute the two-hit model of tumorigenesis?
    Stephen J Marx
    J Clin Endocrinol Metab 87:453-6. 2002
  79. ncbi request reprint Screening for reversible osteoporosis: is cortisol a culprit?
    Lynnette K Nieman
    Ann Intern Med 147:582-4. 2007