Michael L Nickerson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi The UBIAD1 prenyltransferase links menaquione-4 synthesis to cholesterol metabolic enzymes
    Michael L Nickerson
    Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
    Hum Mutat 34:317-29. 2013
  2. ncbi UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy
    Michael L Nickerson
    Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA
    PLoS ONE 5:e10760. 2010
  3. ncbi Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome
    Laura S Schmidt
    Basic Research Program, Science Applications International Corporation Frederick Inc, Frederick, MD, USA
    Am J Hum Genet 76:1023-33. 2005
  4. ncbi High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dubé-associated renal tumors
    Cathy D Vocke
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 97:931-5. 2005
  5. ncbi Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 7:e1002312. 2011
  6. ncbi Early onset hereditary papillary renal carcinoma: germline missense mutations in the tyrosine kinase domain of the met proto-oncogene
    Laura S Schmidt
    Basic Research Program, SAIC Frederick, Inc, Frederick, Maryland, USA
    J Urol 172:1256-61. 2004
  7. ncbi Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
    Masaya Baba
    Laboratories of Immunobiology, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 103:15552-7. 2006
  8. ncbi Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America
    Jorge R Toro
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Executive Plaza South, Rockville, MD 20892, USA
    Am J Hum Genet 73:95-106. 2003
  9. ncbi Expression of Birt-Hogg-Dubé gene mRNA in normal and neoplastic human tissues
    Michelle B Warren
    Laboratory of Immunobiology, Center for Cancer Research, NCI Frederick, Frederick, MD, USA
    Mod Pathol 17:998-1011. 2004
  10. ncbi Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
    Michael L Nickerson
    Transgenomic, Gaithersburg, Maryland, USA
    Clin Cancer Res 14:4726-34. 2008

Detail Information

Publications12

  1. ncbi The UBIAD1 prenyltransferase links menaquione-4 synthesis to cholesterol metabolic enzymes
    Michael L Nickerson
    Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
    Hum Mutat 34:317-29. 2013
    ..Our data suggest a role for endogenous MK-4 in maintaining cornea health and visual acuity...
  2. ncbi UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy
    Michael L Nickerson
    Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA
    PLoS ONE 5:e10760. 2010
    ..We characterized lesions in the UBIAD1 gene in new SCD families and examined protein homology, localization, and structure...
  3. ncbi Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome
    Laura S Schmidt
    Basic Research Program, Science Applications International Corporation Frederick Inc, Frederick, MD, USA
    Am J Hum Genet 76:1023-33. 2005
    ..This study expands the BHD-mutation spectrum and evaluates genotype-phenotype correlations among families with BHD...
  4. ncbi High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dubé-associated renal tumors
    Cathy D Vocke
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 97:931-5. 2005
    ..These results support a role for BHD as a tumor suppressor gene that predisposes to the development of renal tumors when both copies are inactivated...
  5. ncbi Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors
    Lee E Moore
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 7:e1002312. 2011
    ..A proportion of tumors from current smokers lacked VHL alterations and may represent a biologically distinct clinical entity from inactivated cases...
  6. ncbi Early onset hereditary papillary renal carcinoma: germline missense mutations in the tyrosine kinase domain of the met proto-oncogene
    Laura S Schmidt
    Basic Research Program, SAIC Frederick, Inc, Frederick, Maryland, USA
    J Urol 172:1256-61. 2004
    ..In the current study we evaluated the clinical phenotype and germline MET mutation of 3 new HPRC families. We describe the early onset clinical features of HPRC...
  7. ncbi Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
    Masaya Baba
    Laboratories of Immunobiology, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 103:15552-7. 2006
    ..Our data suggest that FLCN, mutated in Birt-Hogg-Dubé syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways...
  8. ncbi Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America
    Jorge R Toro
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Executive Plaza South, Rockville, MD 20892, USA
    Am J Hum Genet 73:95-106. 2003
    ..HLRCC is associated with clinically significant uterine fibroids and aggressive renal tumors. The present study also expands the histologic spectrum of renal tumors and FH mutations associated with HLRCC...
  9. ncbi Expression of Birt-Hogg-Dubé gene mRNA in normal and neoplastic human tissues
    Michelle B Warren
    Laboratory of Immunobiology, Center for Cancer Research, NCI Frederick, Frederick, MD, USA
    Mod Pathol 17:998-1011. 2004
    ..These results indicate a wide expression pattern for BHD mRNA in many tissues, including skin, lung and kidney, which are involved in the BHD phenotype, and support a tumor suppressor role for BHD in renal cancer...
  10. ncbi Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
    Michael L Nickerson
    Transgenomic, Gaithersburg, Maryland, USA
    Clin Cancer Res 14:4726-34. 2008
    ..Identify relationships between the prevalence of VHL gene alterations and alteration subtypes with patient and tumor characteristics...
  11. ncbi Patterns of aneuploidy in stage IV clear cell renal cell carcinoma revealed by comparative genomic hybridization and spectral karyotyping
    Christian P Pavlovich
    Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Chromosomes Cancer 37:252-60. 2003
    ..e., whole chromosomal gains and losses (7.8/case)] or chromosomal rearrangements (10.7/case), of which the majority were unbalanced translocations...
  12. ncbi Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome
    Michael L Nickerson
    Laboratory of Immunobiology, Center for Cancer Research, SAIC Frederick, Inc, National Center for Cancer Research, Frederick, MD 21702, USA
    Cancer Cell 2:157-64. 2002
    ....