David Ng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genomic characterization of esophageal squamous cell carcinoma from a high-risk population in China
    Nan Hu
    Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7236, USA
    Cancer Res 69:5908-17. 2009
  2. pmc Association of a de novo 16q copy number variant with a phenotype that overlaps with Lenz microphthalmia and Townes-Brocks syndromes
    Tanya M Bardakjian
    Clinical Genetics, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    BMC Med Genet 10:137. 2009
  3. pmc Replication of a genome-wide case-control study of esophageal squamous cell carcinoma
    David Ng
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 7112, Bethesda, MD 20892 7236, USA
    Int J Cancer 123:1610-5. 2008
  4. pmc Mutation screening of CHD5 in melanoma-prone families linked to 1p36 revealed no deleterious coding or splice site changes
    David Ng
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    BMC Res Notes 1:86. 2008
  5. ncbi request reprint Retrospective family study of childhood medulloblastoma
    David Ng
    Genetic Epidemiology Branch, DCEG, NCI, NIH, DHHS, Bethesda, Maryland, USA
    Am J Med Genet A 134:399-403. 2005
  6. ncbi request reprint High-density mapping and follow-up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia
    David Ng
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, Bethesda, MD 20892 7236, USA
    Br J Haematol 133:59-61. 2006
  7. ncbi request reprint Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia
    David Ng
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892 7231, USA
    Blood 109:916-25. 2007
  8. ncbi request reprint Gonadal mosaicism in severe Pallister-Hall syndrome
    David Ng
    Genetic Disease Research Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 4472, USA
    Am J Med Genet A 124:296-302. 2004
  9. ncbi request reprint Designation of the TARP syndrome and linkage to Xp11.23-q13.3 without samples from affected patients
    Kyle T Kurpinski
    Genetic Diseases Research Branch, National Human Genome Research Institute NIH, Building 49 Room 4C72, Bethesda, MD 20892 4472, USA
    Am J Med Genet A 120:1-4. 2003
  10. pmc Common genetic variants in candidate genes and risk of familial lymphoid malignancies
    Xueying Sharon Liang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Br J Haematol 146:418-23. 2009

Collaborators

Detail Information

Publications21

  1. pmc Genomic characterization of esophageal squamous cell carcinoma from a high-risk population in China
    Nan Hu
    Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7236, USA
    Cancer Res 69:5908-17. 2009
    ..Our findings show the potential utility of combining CN analysis and gene expression data to identify genes involved in esophageal carcinogenesis...
  2. pmc Association of a de novo 16q copy number variant with a phenotype that overlaps with Lenz microphthalmia and Townes-Brocks syndromes
    Tanya M Bardakjian
    Clinical Genetics, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    BMC Med Genet 10:137. 2009
    ..Townes-Brocks syndrome manifests thumb anomalies, imperforate anus, and ear anomalies. We present a 13-year-old boy with a syndromic microphthalmia phenotype and a clinical diagnosis of Lenz microphthalmia syndrome...
  3. pmc Replication of a genome-wide case-control study of esophageal squamous cell carcinoma
    David Ng
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 7112, Bethesda, MD 20892 7236, USA
    Int J Cancer 123:1610-5. 2008
    ....
  4. pmc Mutation screening of CHD5 in melanoma-prone families linked to 1p36 revealed no deleterious coding or splice site changes
    David Ng
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    BMC Res Notes 1:86. 2008
    ..Based on these findings, we felt it was important to screen CHD5 as a familial CMM/DN susceptibility gene...
  5. ncbi request reprint Retrospective family study of childhood medulloblastoma
    David Ng
    Genetic Epidemiology Branch, DCEG, NCI, NIH, DHHS, Bethesda, Maryland, USA
    Am J Med Genet A 134:399-403. 2005
    ..We conclude that clinically recognizable syndromes are uncommon among patients with medulloblastoma, however, PTCH1 and SUFU mutations are present at a low but significant frequency...
  6. ncbi request reprint High-density mapping and follow-up studies on chromosomal regions 1, 3, 6, 12, 13 and 17 in 28 families with chronic lymphocytic leukaemia
    David Ng
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, Bethesda, MD 20892 7236, USA
    Br J Haematol 133:59-61. 2006
    ..2, 3q22.1, 3q26.2, 6q22.31-q23.2, 12q24.23, 14q32.13, 17p13.3. Chromosome 13q21.33 remains a region of interest with a P-value of 0.013 (marker D13S1291) and warrants additional molecular investigation as a susceptibility region for CLL...
  7. ncbi request reprint Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia
    David Ng
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892 7231, USA
    Blood 109:916-25. 2007
    ..In conclusion, we identified a novel candidate region that may predispose to familial CLL...
  8. ncbi request reprint Gonadal mosaicism in severe Pallister-Hall syndrome
    David Ng
    Genetic Disease Research Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892 4472, USA
    Am J Med Genet A 124:296-302. 2004
    ..Published 2003 Wiley-Liss, Inc...
  9. ncbi request reprint Designation of the TARP syndrome and linkage to Xp11.23-q13.3 without samples from affected patients
    Kyle T Kurpinski
    Genetic Diseases Research Branch, National Human Genome Research Institute NIH, Building 49 Room 4C72, Bethesda, MD 20892 4472, USA
    Am J Med Genet A 120:1-4. 2003
    ..We have designated this locus as TARP. This locus was mapped without genotyping any affecteds and demonstrates that rare, lethal disorders can be evaluated by genetic linkage, even when no affected probands are available for study...
  10. pmc Common genetic variants in candidate genes and risk of familial lymphoid malignancies
    Xueying Sharon Liang
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Br J Haematol 146:418-23. 2009
    ..Polymorphisms in TNFSF10 were associated with both CLL and WM. Future replication and functional studies are needed to clarify the role of these genetic variants. Finally, our data further support the close association of WM and CLL...
  11. pmc Secondary variants in individuals undergoing exome sequencing: screening of 572 individuals identifies high-penetrance mutations in cancer-susceptibility genes
    Jennifer J Johnston
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 91:97-108. 2012
    ....
  12. ncbi request reprint Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR
    David Ng
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 36:411-6. 2004
    ....
  13. pmc T (brachyury) gene duplication confers major susceptibility to familial chordoma
    Xiaohong R Yang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Nat Genet 41:1176-8. 2009
    ..Our findings highlight the value of screening for complex genomic rearrangements in searches for cancer-susceptibility genes...
  14. doi request reprint Interpreting secondary cardiac disease variants in an exome cohort
    David Ng
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD and Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
    Circ Cardiovasc Genet 6:337-46. 2013
    ..We conclude that clinically important cardiomyopathy and dysrhythmia secondary variants can be identified in unselected exomes. ..
  15. ncbi request reprint Chronic lymphocytic leukaemia genetics overview
    Neil Caporaso
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Br J Haematol 139:630-4. 2007
    ..In this summary we highlight selected themes in the genetics of CLL emphasizing the opportunities and challenges of this malignancy...
  16. pmc A mosaic activating mutation in AKT1 associated with the Proteus syndrome
    Marjorie J Lindhurst
    National Human Genome Research Institute, Bethesda, Maryland, USA
    N Engl J Med 365:611-9. 2011
    ..The Proteus syndrome is characterized by the overgrowth of skin, connective tissue, brain, and other tissues. It has been hypothesized that the syndrome is caused by somatic mosaicism for a mutation that is lethal in the nonmosaic state...
  17. pmc Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes
    Matthew G Rees
    National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 122:205-17. 2012
    ..In sum, this study utilizes computational, cell biological, and biochemical methods to present a model for interpreting the clinical significance of rare genetic variants in common disease...
  18. pmc Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance
    Penelope P Feuillan
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
    J Clin Endocrinol Metab 96:E528-35. 2011
    ..To study the pathophysiology of obesity in BBS, we compared patients with BBS and body mass index Z-score (BMI-Z)-matched controls...
  19. ncbi request reprint Genetic heterogeneity of syndromic X-linked recessive microphthalmia-anophthalmia: is Lenz microphthalmia a single disorder?
    David Ng
    Medical Genetics Branch, NHGRI, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
    Am J Med Genet 110:308-14. 2002
    ..In addition, it suggests that Lenz microphthalmia syndrome, previously thought to be a single disorder, may represent an amalgam of two distinct disorders...
  20. ncbi request reprint No association of ARLTS1 polymorphisms and risk for familial chronic lymphocytic leukaemia
    David Ng
    Br J Haematol 137:173-5. 2007
  21. ncbi request reprint Combined C-11 methionine and F-18 FDG PET imaging in a case of neurosarcoidosis
    David Ng
    Department of Internal Medicine, Kettering Medical Center, Dayton, Ohio 45429, USA
    Clin Nucl Med 31:373-5. 2006
    ..Most positive PET scans indicate malignancy. However, this case report demonstrates positive F-18 FDG and C-11 MET PET scans in a patient with a nonmalignant condition, neurosarcoidosis...