Genomes and Genes
Timothy K Newman
Affiliation: National Institutes of Health
- The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?Jonathan B Savitz
MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Int J Neuropsychopharmacol 11:149-61. 2008..The current findings support the involvement of the COMT Val158Met polymorphism in mediating the relationship between trauma and psychopathology...
- Effectiveness of human microsatellite loci for assessing paternity in a captive colony of vervets (Chlorocebus aethiops sabaeus)Timothy K Newman
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Am J Primatol 56:237-43. 2002..Our results provide a panel of markers derived from the human genome that is suitable for assessing genetic variation and paternity in vervets...
- Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeysTimothy K Newman
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA
Biol Psychiatry 57:167-72. 2005..We tested the hypothesis that a repeat polymorphism in the rhesus macaque MAOA gene promoter region influences aggressive behavior in male subjects...
- Mitochondrial phylogeny and systematics of baboons (Papio)Timothy K Newman
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
Am J Phys Anthropol 124:17-27. 2004..The overall phylogeny, when combined with paleontological data, suggests a southern African origin for extant Papio baboons, with all extant lineages sharing a common mitochondrial ancestor at approximately 1.8 Ma...
- Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primatesChristina S Barr
National Institute on Alcoholism and Alcohol Abuse, Laboratory of Clinical Studies and National Institute of Child Health and Human Development, Laboratory of Comparative Ethology, National Institutes of Health, Poolesville, MD, USA
Arch Gen Psychiatry 61:1146-52. 2004....
- Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaquesChristina S Barr
Primate Unit, Laboratory of Clinical Studies, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA
Proc Natl Acad Sci U S A 101:12358-63. 2004..This interactive effect may underlie the increased incidence of certain stress-related disorders in women...
- Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaquesChristina S Barr
Laboratory of Clinical Studies, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Poolesville, Maryland 20837, USA
Biol Psychiatry 55:733-8. 2004..We wanted to determine whether serotonin transporter gene promoter variation (rh-5HTTLPR) and rearing condition would interact to influence endocrine responses to stress in infant rhesus macaques...
- Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigmSimona Spinelli
National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, P O Box 529, Poolesville, MD 20837, USA
Dev Psychopathol 19:977-87. 2007....
- Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stressChristina S Barr
Labortatory of Clinical Studies, Primate Unit, National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, PO Box 529, Building 112, Poolesville, MD 20837, USA
Alcohol Clin Exp Res 27:812-7. 2003..In addition, we have demonstrated that macaques separated from their mothers and reared in peer-only groups are more likely to consume alcohol as adults...
- Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeysAlicia Izquierdo
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:14128-33. 2007..Because behaviors modulated by the 5-HTTLPR are a subset of those dependent on the VMPFC, analysis of structural and functional correlates of gene variation in this region may inform the nature of the genetic modulation of cognition...
- A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behaviorRickard L Sjoberg
Uppsala University Centre for Clinical Research, Central Hospital, Vasteras, Sweden
Neuropsychopharmacology 33:425-30. 2008....
- Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traitsJonathan Savitz
MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Behav Genet 40:415-23. 2010..We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits...
- The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychological variablesChristina S Barr
V Research Fellow, NIH Animal Center, Building 112, P O Box 529, Poolesville, MD 20837 0529, USA
Ann N Y Acad Sci 1021:221-33. 2004....
- Early maternal rejection affects the development of monoaminergic systems and adult abusive parenting in rhesus macaques (Macaca mulatta)Dario Maestripieri
Department of Comparative Human Development, The University of Chicago, Chicago, IL 60637, USA
Behav Neurosci 120:1017-24. 2006....
- Differential functional variability of serotonin transporter and monoamine oxidase a genes in macaque species displaying contrasting levels of aggression-related behaviorJens R Wendland
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, 97080, Wurzburg, Germany
Behav Genet 36:163-72. 2006..Taken together, these findings suggest that genetic variation of serotonergic neurotransmission may play an important role in determining inter-species differences in aggression related behavior in macaques...
- Mitochondrial evidence for the origin of hamadryas baboonsDerek E Wildman
Department of Anthropology, New York Univesity, USA
Mol Phylogenet Evol 32:287-96. 2004..The mitochondrial paraphyly of Ethiopian hamadryas and anubis (P. anubis) baboons suggests an extensive and complex history of sex-specific introgression...
- Moderate level fetal alcohol exposure and serotonin transporter gene promoter polymorphism affect neonatal temperament and limbic-hypothalamic-pituitary-adrenal axis regulation in monkeysGary W Kraemer
Department of Kinesiology, University of Wisconsin Madison, Madison, Wisconsin, USA
Biol Psychiatry 63:317-24. 2008..This study determined whether moderate FA-exposure interacts with polymorphism in the 5-HT transporter gene to increase the incidence or severity of fetal alcohol effects in rhesus monkeys...
- Genetic contributions to social impulsivity and aggressiveness in vervet monkeysLynn A Fairbanks
Neuropsychiatric Institute, University of California Los Angeles, California 90024, USA
Biol Psychiatry 55:642-7. 2004..This study assessed the genetic contribution to impulsivity and aggressiveness in a social context using a nonhuman primate model...
- Warriors versus worriers: the role of COMT gene variantsDan J Stein
Department of Mental Health and Psychiatry, University of Cape Town, South Africa
CNS Spectr 11:745-8. 2006..Some evidence suggests that Val158 alleles are associated with schizophrenia, while Met158 alleles are associated with anxiety...