David J Newman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Natural products as sources of new drugs over the 30 years from 1981 to 2010
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, P O Box B, Frederick, Maryland 21702, United States
    J Nat Prod 75:311-35. 2012
  2. ncbi request reprint Natural products as sources of new drugs over the period 1981-2002
    David J Newman
    Natural Products Branch and Pharmaceutical Resources Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Nat Prod 66:1022-37. 2003
  3. ncbi request reprint Natural products as sources of new drugs over the last 25 years
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, P O Box B, Frederick, MD 21702, USA
    J Nat Prod 70:461-77. 2007
  4. ncbi request reprint Advanced preclinical and clinical trials of natural products and related compounds from marine sources
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
    Curr Med Chem 11:1693-713. 2004
  5. ncbi request reprint Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
    Curr Cancer Drug Targets 2:279-308. 2002
  6. ncbi request reprint Marine natural products and related compounds in clinical and advanced preclinical trials
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
    J Nat Prod 67:1216-38. 2004
  7. ncbi request reprint Microbial antitumor drugs: natural products of microbial origin as anticancer agents
    David J Newman
    National Cancer Institute, Natural Products Branch, Developmental Therapeutics Program, 1003 West 7th Street, Frederick, MD 21702, USA
    Curr Opin Investig Drugs 10:1280-96. 2009
  8. ncbi request reprint New horizons for old drugs and drug leads
    Gordon M Cragg
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory, P O Box B, Frederick, Maryland 21702, United States
    J Nat Prod 77:703-23. 2014
  9. ncbi request reprint Plants as a source of anti-cancer agents
    Gordon M Cragg
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, P O Box B, Frederick, MD 21702 1201, USA
    J Ethnopharmacol 100:72-9. 2005
  10. pmc Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia
    Tamara L Meragelman
    Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA
    J Nat Prod 70:1133-8. 2007

Collaborators

Detail Information

Publications37

  1. pmc Natural products as sources of new drugs over the 30 years from 1981 to 2010
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, P O Box B, Frederick, Maryland 21702, United States
    J Nat Prod 75:311-35. 2012
    ....
  2. ncbi request reprint Natural products as sources of new drugs over the period 1981-2002
    David J Newman
    Natural Products Branch and Pharmaceutical Resources Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Nat Prod 66:1022-37. 2003
    ....
  3. ncbi request reprint Natural products as sources of new drugs over the last 25 years
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, P O Box B, Frederick, MD 21702, USA
    J Nat Prod 70:461-77. 2007
    ....
  4. ncbi request reprint Advanced preclinical and clinical trials of natural products and related compounds from marine sources
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
    Curr Med Chem 11:1693-713. 2004
    ....
  5. ncbi request reprint Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
    Curr Cancer Drug Targets 2:279-308. 2002
    ....
  6. ncbi request reprint Marine natural products and related compounds in clinical and advanced preclinical trials
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
    J Nat Prod 67:1216-38. 2004
    ..A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases...
  7. ncbi request reprint Microbial antitumor drugs: natural products of microbial origin as anticancer agents
    David J Newman
    National Cancer Institute, Natural Products Branch, Developmental Therapeutics Program, 1003 West 7th Street, Frederick, MD 21702, USA
    Curr Opin Investig Drugs 10:1280-96. 2009
    ....
  8. ncbi request reprint New horizons for old drugs and drug leads
    Gordon M Cragg
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory, P O Box B, Frederick, Maryland 21702, United States
    J Nat Prod 77:703-23. 2014
    ..This review briefly outlines some of these developments as applied to a number of selected natural product examples, which may also include advances in chemical synthesis of derivatives with extended biological activities. ..
  9. ncbi request reprint Plants as a source of anti-cancer agents
    Gordon M Cragg
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, P O Box B, Frederick, MD 21702 1201, USA
    J Ethnopharmacol 100:72-9. 2005
    ....
  10. pmc Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia
    Tamara L Meragelman
    Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA
    J Nat Prod 70:1133-8. 2007
    ..The candidaspongiolide mixture was potently cytotoxic, exhibiting a mean panel 50% growth inhibition (GI50) of 14 ng/mL in the National Cancer Institute's 60-cell-line in vitro antitumor screen...
  11. doi request reprint Natural product scaffolds as leads to drugs
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, MD 21702, USA
    Future Med Chem 1:1415-27. 2009
    ....
  12. ncbi request reprint Investigations of the marine flora and fauna of the Islands of Palau
    D John Faulkner
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, NCI Frederick, Frederick, MD 21702, USA
    Nat Prod Rep 21:50-76. 2004
    ....
  13. ncbi request reprint Natural products as leads to potential drugs: an old process or the new hope for drug discovery?
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, DCTD, National Cancer Institute Frederick, P O Box B, Frederick, Maryland 21702, USA
    J Med Chem 51:2589-99. 2008
  14. ncbi request reprint A natural products chemist looks at the bystander effect!
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, PO Box B Frederick, MD 21702, USA
    Mutat Res 597:39-42. 2006
    ....
  15. ncbi request reprint Microbial natural products: molecular blueprints for antitumor drugs
    Lesley Ann Giddings
    Natural Products Branch, Developmental Therapeutics Program, DCTD, Frederick National Laboratory for Cancer Research, P O Box B, Frederick, MD, 21702, USA
    J Ind Microbiol Biotechnol 40:1181-210. 2013
    ....
  16. pmc Tetramic acid analogues produced by coculture of Saccharopolyspora erythraea with Fusarium pallidoroseum
    James Whitt
    SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, P O Box B, Frederick, Maryland 21702, United States
    J Nat Prod 77:173-7. 2014
    ..The structures were determined by spectroscopic methods. The absolute configurations were established by circular dichroism spectroscopy and comparing the data with those of equisetin. ..
  17. doi request reprint The impact of the United Nations Convention on Biological Diversity on natural products research
    Gordon M Cragg
    Natural Products Branch, National Cancer Institute Frederick, P O Box B, Frederick, Maryland 21702 1201, USA
    Nat Prod Rep 29:1407-23. 2012
    ....
  18. pmc Natural products: a continuing source of novel drug leads
    Gordon M Cragg
    Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, Frederick, MD 21702 1201, USA
    Biochim Biophys Acta 1830:3670-95. 2013
    ..Combinatorial chemistry (late 1980s), shifted the focus of drug discovery efforts from Nature to the laboratory bench...
  19. ncbi request reprint Natural product extracts of plant and marine origin having antileukemia potential. The NCI experience
    Gordon M Cragg
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NCI Frederick, Maryland 21702 1201, USA
    J Nat Prod 69:488-98. 2006
    ..The "hot" terrestrial plant families Myrsinaceae and Sapindaceae have not been studied to any extent and appear to merit special attention, although leukemia cell line selectivity is also noted for other families...
  20. doi request reprint Induced production of N-formyl alkaloids from Aspergillus fumigatus by co-culture with Streptomyces peucetius
    Karina M Zuck
    SAIC Frederick, Inc, P O Box B, Frederick, Maryland 21702, USA
    J Nat Prod 74:1653-7. 2011
    ..Cytotoxic activity of all the analogues was tested on the NCI-60 cell line screen, and compound 2 exhibited significant activity against several cell lines. The analogues did not show antimicrobial activity...
  21. pmc Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory, P O Box B, Frederick, MD 21702, USA
    Mar Drugs 12:255-78. 2014
    ....
  22. ncbi request reprint Therapeutic agents from the sea: biodiversity, chemo-evolutionary insight and advances to the end of Darwin's 200th year
    David J Newman
    Current Chief at the Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, MD, 21702, USA
    Diving Hyperb Med 39:216-25. 2009
    ..The simple prime argument in support of this is the fact that we can exploit over four billion years of evolution in combinatorial chemistry in marine organisms, directed at relevant and effective biological activity...
  23. ncbi request reprint A tale of two tumor targets: topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy
    Gordon M Cragg
    Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Nat Prod 67:232-44. 2004
    ..This review is not meant to be exhaustive, but does illustrate the profound impact that these two plant-derived agents have had on cancer chemotherapy...
  24. pmc Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regions
    Denise Whitby
    Viral Epidemiology Section, AIDS Vaccine Program, SAIC Frederick, NCI Frederick, Frederick, MD 21702, USA
    Int J Cancer 120:321-8. 2007
    ..These in vitro data provide support for the "oncoweed" hypothesis by demonstrating basic biological plausibility...
  25. ncbi request reprint The US National Cancer Institute's natural products repository; origins and utility
    Erma C Brown
    Natural Products Branch, NCI, Fairview Center, Frederick, MD 21702, USA
    J Environ Monit 8:800-5. 2006
    ..This paper describes the history of the program...
  26. ncbi request reprint New drugs from marine microbes: the tide is turning
    David J Newman
    Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, MD 21702, USA
    J Ind Microbiol Biotechnol 33:539-44. 2006
    ..The work reported at that symposium has been integrated into a fuller discussion of current published literature on the subject with examples drawn from bacteria, cyanophytes and fungi...
  27. ncbi request reprint Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin
    Zobeida Cruz-Monserrate
    Building 469, Room 104, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Mol Pharmacol 63:1273-80. 2003
    ..If the latter is correct, diazonamide A and its oxygen analog should have uniquely potent inhibitory effects on the dynamic properties of microtubules...
  28. ncbi request reprint Biomedicinals from the phytosymbionts of marine invertebrates: a molecular approach
    Walter C Dunlap
    Australian Institute of Marine Science, Townsville, Queensland, Australia
    Methods 42:358-76. 2007
    ..Additionally, new cloning and biosynthetic expression strategies may provide a sustainable method for the supply of new pharmaceuticals derived from the uncultured phytosymbionts of marine organisms...
  29. ncbi request reprint The search for novel drug leads for predominately antitumor therapies by utilizing mother nature's pharmacophoric libraries
    David G I Kingston
    Virginia Polytechnic Institute and State University, Department of Chemistry, M C 0212, Blacksburg, VA 24061, USA
    Curr Opin Drug Discov Devel 8:207-27. 2005
    ..It can be concluded that, despite a perceived lack of popularity in recent years, the use of natural product scaffolds in searching for drug leads is still being practiced...
  30. ncbi request reprint Mother nature's combinatorial libraries; their influence on the synthesis of drugs
    David G I Kingston
    Virginia Polytechnic Institute and State University, Department of Chemistry, M C 0212, Blacksburg, VA 24061, USA
    Curr Opin Drug Discov Devel 5:304-16. 2002
    ..Examples of the application of combinatorial methods to nature's combinatorial library will be presented and discussed, with an emphasis on the antitumor, anti-infective and pain control disease areas...
  31. ncbi request reprint Taxoids: cancer-fighting compounds from nature
    David G I Kingston
    Virginia Polytechnic and State University, Department of Chemistry, M C 0212, Blacksburg, VA 24061, USA
    Curr Opin Drug Discov Devel 10:130-44. 2007
    ..In addition, paclitaxel, and perhaps other taxanes in due course, has activities beyond the known antitumor indications, with an example being the use of paclitaxel-coated stents in cardiovascular therapies...
  32. pmc Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest
    John E Leet
    Bristol Myers Squibb Company, Wallingford, Connecticut 06492, USA
    J Nat Prod 71:460-3. 2008
    ..A new hydroxyprenylated xanthone ( 5) is also described. Xanthones 1 and 4 showed selective in vitro cytotoxicity against ABAE cells (bovine endothelial cell line)...
  33. ncbi request reprint Mother Nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery
    Mark S Butler
    MerLion Pharmaceuticals, Singapore Science Park II, Singapore 117528
    Prog Drug Res 65:1, 3-44. 2008
    ..Finishing with a discussion of the current and evolving role(s) of microbes (bacteria and fungi) in the production of old and new agents ostensibly produced by higher organisms...
  34. ncbi request reprint Umbelactonyl cinnamate derivatives from Crypteronia paniculata that mediate DNA strand scission
    Jing Zhen Deng
    Departments of Chemistry and Biology, University of Virginia, Charlottesville, Virginia 22901, USA
    J Nat Prod 68:465-7. 2005
    ..Compound 1 exhibited strong Cu(2+)-dependent relaxation of supercoiled pSP64 DNA, while compounds 2 and 3 had only weak DNA cleavage activity...
  35. ncbi request reprint Detection of low-molecular-weight proteins in urine by dipsticks
    Michael Pugia
    Diagnostic Business Group, Bayer Corporation, Elkhart, IN, USA
    Clin Chim Acta 326:177-83. 2002
    ..is common practice. A deficiency with currently available dipsticks is their lack of chemical sensitivity and underestimation of low-molecular-weight proteins such as light chains...
  36. ncbi request reprint Chemical diversity: a function of biodiversity
    Gordon M Cragg
    Trends Pharmacol Sci 23:404-5; author reply 405. 2002
  37. ncbi request reprint Natural products as drug leads: an old process or the new hope for drug discovery?
    David Gi Kingston
    Virginia Polytechnic Institute and State University, Department of Chemistry, Blacksburg, 24061, USA
    IDrugs 8:990-2. 2005
    ..In this short article, we propose why we consider natural products are poised for a renaissance as tools for drug discovery...