Research Topics
| David J NewmanSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Natural products as sources of new drugs over the 30 years from 1981 to 2010David J Newman
Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, P O Box B, Frederick, Maryland 21702, United States
J Nat Prod 75:311-35. 2012....
Natural products as sources of new drugs over the period 1981-2002David J Newman
Natural Products Branch and Pharmaceutical Resources Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
J Nat Prod 66:1022-37. 2003....- Natural products as sources of new drugs over the last 25 yearsDavid J Newman
Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute Frederick, P O Box B, Frederick, MD 21702, USA
J Nat Prod 70:461-77. 2007.... - Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapyDavid J Newman
Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA
Curr Cancer Drug Targets 2:279-308. 2002.... - Advanced preclinical and clinical trials of natural products and related compounds from marine sourcesDavid J Newman
Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
Curr Med Chem 11:1693-713. 2004.... - Marine natural products and related compounds in clinical and advanced preclinical trialsDavid J Newman
Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
J Nat Prod 67:1216-38. 2004..A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases... - Microbial antitumor drugs: natural products of microbial origin as anticancer agentsDavid J Newman
National Cancer Institute, Natural Products Branch, Developmental Therapeutics Program, 1003 West 7th Street, Frederick, MD 21702, USA
Curr Opin Investig Drugs 10:1280-96. 2009.... - Plants as a source of anti-cancer agentsGordon M Cragg
Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, P O Box B, Frederick, MD 21702 1201, USA
J Ethnopharmacol 100:72-9. 2005.... 
Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus CandidaspongiaTamara L Meragelman
Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA
J Nat Prod 70:1133-8. 2007..The candidaspongiolide mixture was potently cytotoxic, exhibiting a mean panel 50% growth inhibition (GI50) of 14 ng/mL in the National Cancer Institute's 60-cell-line in vitro antitumor screen...- Natural products as leads to potential drugs: an old process or the new hope for drug discovery?David J Newman
Natural Products Branch, Developmental Therapeutics Program, DCTD, National Cancer Institute Frederick, P O Box B, Frederick, Maryland 21702, USA
J Med Chem 51:2589-99. 2008 - Investigations of the marine flora and fauna of the Islands of PalauD John Faulkner
Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, NCI-Frederick, Frederick, MD 21702, USA
Nat Prod Rep 21:50-76. 2004.... - A natural products chemist looks at the bystander effect!David J Newman
Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, PO Box B Frederick, MD 21702, USA
Mutat Res 597:39-42. 2006.... - Natural product extracts of plant and marine origin having antileukemia potential. The NCI experienceGordon M Cragg
Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NCI-Frederick, Maryland 21702-1201, USA
J Nat Prod 69:488-98. 2006..The "hot" terrestrial plant families Myrsinaceae and Sapindaceae have not been studied to any extent and appear to merit special attention, although leukemia cell line selectivity is also noted for other families... - Natural product scaffolds as leads to drugsDavid J Newman
Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, MD 21702, USA
Future Med Chem 1:1415-27. 2009.... - Induced production of N-formyl alkaloids from Aspergillus fumigatus by co-culture with Streptomyces peucetiusKarina M Zuck
SAIC Frederick, Inc, P O Box B, Frederick, Maryland 21702, USA
J Nat Prod 74:1653-7. 2011..Cytotoxic activity of all the analogues was tested on the NCI-60 cell line screen, and compound 2 exhibited significant activity against several cell lines. The analogues did not show antimicrobial activity... - The impact of the United Nations Convention on Biological Diversity on natural products researchGordon M Cragg
Natural Products Branch, National Cancer Institute Frederick, P O Box B, Frederick, Maryland 21702 1201, USA
Nat Prod Rep 29:1407-23. 2012.... - Therapeutic agents from the sea: biodiversity, chemo-evolutionary insight and advances to the end of Darwin's 200th yearDavid J Newman
Current Chief at the Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, MD, 21702, USA
Diving Hyperb Med 39:216-25. 2009..The simple prime argument in support of this is the fact that we can exploit over four billion years of evolution in combinatorial chemistry in marine organisms, directed at relevant and effective biological activity... - Reactivation of Kaposi's sarcoma-associated herpesvirus by natural products from Kaposi's sarcoma endemic regionsDenise Whitby
Viral Epidemiology Section, AIDS Vaccine Program, SAIC Frederick, NCI Frederick, Frederick, MD 21702, USA
Int J Cancer 120:321-8. 2007..These in vitro data provide support for the "oncoweed" hypothesis by demonstrating basic biological plausibility... - The US National Cancer Institute's natural products repository; origins and utilityErma C Brown
Natural Products Branch, NCI, Fairview Center, Frederick, MD 21702, USA
J Environ Monit 8:800-5. 2006..This paper describes the history of the program... - New drugs from marine microbes: the tide is turningDavid J Newman
Natural Products Branch, Developmental Therapeutics Program, NCI Frederick, P O Box B, Frederick, MD 21702, USA
J Ind Microbiol Biotechnol 33:539-44. 2006..The work reported at that symposium has been integrated into a fuller discussion of current published literature on the subject with examples drawn from bacteria, cyanophytes and fungi... - A tale of two tumor targets: topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapyGordon M Cragg
Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
J Nat Prod 67:232-44. 2004..This review is not meant to be exhaustive, but does illustrate the profound impact that these two plant-derived agents have had on cancer chemotherapy... - Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulinZobeida Cruz-Monserrate
Building 469, Room 104, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Mol Pharmacol 63:1273-80. 2003..If the latter is correct, diazonamide A and its oxygen analog should have uniquely potent inhibitory effects on the dynamic properties of microtubules... - The search for novel drug leads for predominately antitumor therapies by utilizing mother nature's pharmacophoric librariesDavid G I Kingston
Virginia Polytechnic Institute and State University, Department of Chemistry, M/C 0212, Blacksburg, VA 24061, USA
Curr Opin Drug Discov Devel 8:207-27. 2005..It can be concluded that, despite a perceived lack of popularity in recent years, the use of natural product scaffolds in searching for drug leads is still being practiced... - Mother nature's combinatorial libraries; their influence on the synthesis of drugsDavid G I Kingston
Virginia Polytechnic Institute and State University, Department of Chemistry, M C 0212, Blacksburg, VA 24061, USA
Curr Opin Drug Discov Devel 5:304-16. 2002..Examples of the application of combinatorial methods to nature's combinatorial library will be presented and discussed, with an emphasis on the antitumor, anti-infective and pain control disease areas... - Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forestJohn E Leet
Bristol Myers Squibb Company, Wallingford, Connecticut 06492, USA
J Nat Prod 71:460-3. 2008..A new hydroxyprenylated xanthone ( 5) is also described. Xanthones 1 and 4 showed selective in vitro cytotoxicity against ABAE cells (bovine endothelial cell line)... - Mother Nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discoveryMark S Butler
MerLion Pharmaceuticals, Singapore Science Park II, Singapore 117528
Prog Drug Res 65:1, 3-44. 2008..Finishing with a discussion of the current and evolving role(s) of microbes (bacteria and fungi) in the production of old and new agents ostensibly produced by higher organisms... - Biomedicinals from the phytosymbionts of marine invertebrates: a molecular approachWalter C Dunlap
Australian Institute of Marine Science, Townsville, Queensland, Australia
Methods 42:358-76. 2007..Additionally, new cloning and biosynthetic expression strategies may provide a sustainable method for the supply of new pharmaceuticals derived from the uncultured phytosymbionts of marine organisms... - Taxoids: cancer-fighting compounds from natureDavid G I Kingston
Virginia Polytechnic and State University, Department of Chemistry, M C 0212, Blacksburg, VA 24061, USA
Curr Opin Drug Discov Devel 10:130-44. 2007..In addition, paclitaxel, and perhaps other taxanes in due course, has activities beyond the known antitumor indications, with an example being the use of paclitaxel-coated stents in cardiovascular therapies... - Natural products as drug leads: an old process or the new hope for drug discovery?David Gi Kingston
Virginia Polytechnic Institute and State University, Department of Chemistry, Blacksburg, 24061, USA
IDrugs 8:990-2. 2005..In this short article, we propose why we consider natural products are poised for a renaissance as tools for drug discovery... - Detection of low-molecular-weight proteins in urine by dipsticksMichael Pugia
Diagnostic Business Group, Bayer Corporation, Elkhart, IN, USA
Clin Chim Acta 326:177-83. 2002..The dipsticks are easy to use and are suitable for outpatient or point-of-care testing. The precision of the dipsticks is satisfactory and is only marginally lower than quantitative spectrophotometric methods using pyrogallol red (PYR)... - Chemical diversity: a function of biodiversityGordon M Cragg
Trends Pharmacol Sci 23:404-5; author reply 405. 2002 - Umbelactonyl cinnamate derivatives from Crypteronia paniculata that mediate DNA strand scissionJing-Zhen Deng
Departments of Chemistry and Biology, University of Virginia, Charlottesville, Virginia 22901, USA
J Nat Prod 68:465-7. 2005..Compound 1 exhibited strong Cu(2+)-dependent relaxation of supercoiled pSP64 DNA, while compounds 2 and 3 had only weak DNA cleavage activity...