Retha R Newbold

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Developmental exposure to endocrine-disrupting chemicals programs for reproductive tract alterations and obesity later in life
    Retha R Newbold
    Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Am J Clin Nutr 94:1939S-1942S. 2011
  2. pmc Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 24:253-8. 2007
  3. ncbi request reprint Perinatal exposure to environmental estrogens and the development of obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    Mol Nutr Food Res 51:912-7. 2007
  4. pmc Environmental estrogens and obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Mol Cell Endocrinol 304:84-9. 2009
  5. ncbi request reprint Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Mail Drop E4 02, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 147:S11-7. 2006
  6. ncbi request reprint Cell response endpoints enhance sensitivity of the immature mouse uterotropic assay
    R R Newbold
    Laboratory of Toxicology, Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 15:245-52. 2001
  7. ncbi request reprint Uterine adenocarcinoma in mice treated neonatally with genistein
    R R Newbold
    Developmental Endocrinology Section, Laboratory of Toxicology, Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Res 61:4325-8. 2001
  8. ncbi request reprint Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol
    R R Newbold
    Developmental Endocrinology Section, Reproductive Toxicology Group, Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 21:1355-63. 2000
  9. doi request reprint Prenatal exposure to diethylstilbestrol (DES)
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH DHHS, Research Triangle Park, North Carolina 27709, USA
    Fertil Steril 89:e55-6. 2008
  10. ncbi request reprint Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens
    R R Newbold
    Developmental Endocrinology Section, Reproductive Toxicology Group, Laboratory of Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 60:235-7. 2000

Collaborators

Detail Information

Publications56

  1. pmc Developmental exposure to endocrine-disrupting chemicals programs for reproductive tract alterations and obesity later in life
    Retha R Newbold
    Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Am J Clin Nutr 94:1939S-1942S. 2011
    ....
  2. pmc Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 24:253-8. 2007
    ..These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation...
  3. ncbi request reprint Perinatal exposure to environmental estrogens and the development of obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    Mol Nutr Food Res 51:912-7. 2007
    ....
  4. pmc Environmental estrogens and obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Mol Cell Endocrinol 304:84-9. 2009
    ....
  5. ncbi request reprint Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Mail Drop E4 02, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 147:S11-7. 2006
    ....
  6. ncbi request reprint Cell response endpoints enhance sensitivity of the immature mouse uterotropic assay
    R R Newbold
    Laboratory of Toxicology, Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 15:245-52. 2001
    ..All compounds elicited estrogen-responsive changes in these endpoints that were individually more sensitive than uterine weight alone. We conclude that these endpoints enhance the sensitivity of the uterotropic bioassay...
  7. ncbi request reprint Uterine adenocarcinoma in mice treated neonatally with genistein
    R R Newbold
    Developmental Endocrinology Section, Laboratory of Toxicology, Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Res 61:4325-8. 2001
    ..Thus, the use of soy-based infant formulas in the absence of medical necessity and the marketing of soy products designed to appeal to children should be closely examined...
  8. ncbi request reprint Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol
    R R Newbold
    Developmental Endocrinology Section, Reproductive Toxicology Group, Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 21:1355-63. 2000
    ..These data suggest that, while fertility of the DES F(2) mice appeared unaltered, increased susceptibility for tumors is transmitted from the DES 'grandmothers' to subsequent generations...
  9. doi request reprint Prenatal exposure to diethylstilbestrol (DES)
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH DHHS, Research Triangle Park, North Carolina 27709, USA
    Fertil Steril 89:e55-6. 2008
  10. ncbi request reprint Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens
    R R Newbold
    Developmental Endocrinology Section, Reproductive Toxicology Group, Laboratory of Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 60:235-7. 2000
    ..These data demonstrate that both 2- and 4-hydroxyestradiol are carcinogenic metabolites. The high tumor incidence induced by 4-hydroxyestradiol supports the postulated role of this metabolite in hormone-associated cancers...
  11. doi request reprint Effects of endocrine disruptors on obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Androl 31:201-8. 2008
    ..The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers...
  12. ncbi request reprint Lessons learned from perinatal exposure to diethylstilbestrol
    Retha R Newbold
    Developmental Endocrinology Section, Laboratory of Toxicology, Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 199:142-50. 2004
    ....
  13. pmc Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life
    Retha R Newbold
    Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 117:879-85. 2009
    ..Bisphenol A (BPA), an environmental estrogen used in the synthesis of plastics, is of concern because its chemical structure resembles that of DES, and it is a "high-volume production" chemical with widespread human exposure...
  14. ncbi request reprint Ontogeny of lactoferrin in the developing mouse uterus: a marker of early hormone response
    R R Newbold
    Environmental Toxicology Program, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 56:1147-57. 1997
    ..The early appearance of LF suggests that it may play an important role in the hormonal regulation of growth and differentiation of developing uterine tissues...
  15. ncbi request reprint Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol
    R R Newbold
    Developmental Endocrinology Section, Laboratory of Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 19:1655-63. 1998
    ..These data suggest that the reduced fertility observed in the DES F1 female mice was not transmitted to their descendants; however, increased susceptibility to tumor formation is apparently transmitted to subsequent generations...
  16. ncbi request reprint Developmental exposure to diethylstilbestrol (DES) alters uterine response to estrogens in prepubescent mice: low versus high dose effects
    Retha R Newbold
    Developmental Endocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 18:399-406. 2004
    ....
  17. pmc Developmental exposure to endocrine disruptors and the obesity epidemic
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Mail Drop E4 02, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 23:290-6. 2007
    ..This experimental animal model provides an example of the growing scientific field termed "the developmental origins of adult disease" and suggests new targets of abnormal programming by endocrine disrupting chemicals...
  18. pmc Neonatal exposure to genistein disrupts ability of female mouse reproductive tract to support preimplantation embryo development and implantation
    Wendy N Jefferson
    Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 80:425-31. 2009
    ....
  19. pmc Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in life
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Mol Carcinog 46:783-96. 2007
    ..These data suggested altered gene expression profiles observed 2 wk after treatment ceased, were established at the time of developmental exposure and maybe related to the initiation events resulting in carcinogenesis...
  20. ncbi request reprint Disruption of the developing female reproductive system by phytoestrogens: genistein as an example
    Wendy N Jefferson
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA
    Mol Nutr Food Res 51:832-44. 2007
    ....
  21. ncbi request reprint Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions
    Wendy N Jefferson
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 67:1285-96. 2002
    ..Given that human infants are exposed to high levels of genistein in soy-based foods, this study indicates that the effects of such exposure on the developing reproductive tract warrant further investigation...
  22. ncbi request reprint Studies of the effects of neonatal exposure to genistein on the developing female reproductive system
    Wendy N Jefferson
    National Institute of Environmental Health Sciences, NIH, DHHS, Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Research Triangle Park, NC 27709, USA
    J AOAC Int 89:1189-96. 2006
    ..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on ovarian development and reproductive function...
  23. ncbi request reprint Developmental exposure to estrogenic compounds and obesity
    Retha R Newbold
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res A Clin Mol Teratol 73:478-80. 2005
  24. ncbi request reprint Assessing estrogenic activity of phytochemicals using transcriptional activation and immature mouse uterotrophic responses
    Wendy N Jefferson
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 777:179-89. 2002
    ..Furthermore, having an estrogenic "fingerprint" for each phytochemical is an essential first step in determining potential adverse effects of exposure to phytoestrogens...
  25. doi request reprint Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol
    Vicki L Davis
    Receptor Biology Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 34:512-21. 2012
    ..These findings indicate that expression of this ERĪ± variant can influence determining events in uterine cancer development and its natural occurrence in the human uterus would unlikely be protective...
  26. ncbi request reprint Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses
    Wendy N Jefferson
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Biol Reprod 73:798-806. 2005
    ..In summary, neonatal treatment with Gen caused abnormal estrous cycles, altered ovarian function, early reproductive senescence, and subfertility/infertility at environmentally relevant doses...
  27. ncbi request reprint Neonatal exposure to the phytoestrogen genistein alters mammary gland growth and developmental programming of hormone receptor levels
    Elizabeth Padilla-Banks
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 147:4871-82. 2006
    ..In summary, neonatal Gen exposure altered mammary gland growth and development as well as hormone receptor levels at all doses examined; higher doses of Gen led to permanent long-lasting morphological changes...
  28. pmc Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay
    Darlene Dixon
    National Toxicology Program NTP Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 33:506-12. 2012
    ..01 PFOA only mice. These data suggest that at a low dose PFOA produces minimal histopathologic changes in the reproductive tract of immature female mice, and does not antagonize the histopathologic effects of E(2)...
  29. ncbi request reprint Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES)
    Retha R Newbold
    Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 30:611-6. 2002
    ....
  30. pmc Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure
    Wendy N Jefferson
    National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, PO Box 12233, MD E4 05, Research Triangle Park, North Carolina 27709
    Mol Endocrinol 27:1666-77. 2013
    ....
  31. pmc Perinatal environmental exposures affect mammary development, function, and cancer risk in adulthood
    Suzanne E Fenton
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, U S Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Annu Rev Pharmacol Toxicol 52:455-79. 2012
    ..Such research is required to halt the increasing trend toward puberty at earlier ages...
  32. ncbi request reprint Disruption of the female reproductive system by the phytoestrogen genistein
    Wendy N Jefferson
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, PO Box 12233, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 23:308-16. 2007
    ..Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on reproduction in adulthood...
  33. ncbi request reprint Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis
    R R Newbold
    Developmental Endocrinology and Pharmacology Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709
    Cancer Res 50:7677-81. 1990
    ..The experimental induction of these tumors will provide the basis for additional studies in mechanisms of hormonal carcinogenesis...
  34. ncbi request reprint Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:237-45. 2000
    ....
  35. ncbi request reprint Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 mice
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:325-33. 1999
    ..The data show that cell cycle kinetics, in addition to changes in morphology, are altered in the developing mouse uterus following neonatal exposure to DES...
  36. ncbi request reprint Mutagenesis of a single AT basepair in mice transgenic for PhiX174 am3, cs70. II. Brain
    H V Malling
    Mammalian Mutagenesis Group, Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, NC 27709 2233, USA
    Mutat Res 444:85-95. 1999
    ..This decrease in the revertant frequency among the treated animals was likely due to selective killing of cells with a higher spontaneous revertant frequency than cells with lower frequency...
  37. pmc Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays
    M D Shelby
    Reproductive Toxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 104:1296-300. 1996
    ....
  38. ncbi request reprint Response of the mouse uterus to nafoxidine stimulation: agonism and antagonism
    V E Quarmby
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Biol Reprod 38:945-54. 1988
    ..These studies show that NAF stimulates some of the receptor-mediated responses attributed to an estrogen agonist in the mouse uterus; but, when co-administered with estradiol, NAF antagonizes some aspects of estrogen action...
  39. pmc The immature mouse is a suitable model for detection of estrogenicity in the uterotropic bioassay
    E Padilla-Banks
    Developmental Endocrinology Section, Laboratory of Toxicology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 109:821-6. 2001
    ..Because of the advantages of using mice, including lower costs, less space required, and smaller amounts of compound needed for tests, mice should be given appropriate consideration in testing paradigms for EDCs...
  40. ncbi request reprint Impact of environmental endocrine disrupting chemicals on the development of obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, and National Toxicology Program, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27713, USA
    Hormones (Athens) 9:206-17. 2010
    ..Potential mechanisms are summarized and future research needs are discussed...
  41. ncbi request reprint Estrogenic effect on the expression of estrogen receptor, COUP-TF, and lactoferrin mRNA in developing mouse tissues
    H Shigeta
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    Mol Reprod Dev 45:21-30. 1996
    ..These data point to the complexity of differential expression of LF gene in estrogen responsive and nonresponsive tissues during development...
  42. ncbi request reprint Promoter CpG methylation of Hox-a10 and Hox-a11 in mouse uterus not altered upon neonatal diethylstilbestrol exposure
    S Li
    Laboratory of Biosystems and Cancer, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Carcinog 32:213-9. 2001
    ....
  43. ncbi request reprint Expression of estrogen receptor beta is developmentally regulated in reproductive tissues of male and female mice
    W N Jefferson
    Developmental Endocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 62:310-7. 2000
    ..These studies provide information useful in studying the role of both ER subtypes in normal differentiation, and they provide indications of differential tissue expression during development...
  44. pmc Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration
    A B Moore
    Comparative Pathobiology Group, Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, NC 27709, USA
    Hum Reprod 22:2623-31. 2007
    ..001-50 microg/ml) on human uterine leiomyoma (UtLM) cells versus uterine smooth muscle cells (UtSMCs) in vitro...
  45. ncbi request reprint Lactational transfer of the soy isoflavone, genistein, in Sprague-Dawley rats consuming dietary genistein
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Reprod Toxicol 21:307-12. 2006
    ....
  46. ncbi request reprint A natural antioxidant mixture from spinach does not have estrogenic or antiestrogenic activity in immature CD-1 mice
    Liat Lomnitski
    Life Science Faculty, Bar Ilan University, Ramat Gan, Israel
    J Nutr 133:3584-7. 2003
    ..These data suggest that NAO does not have estrogenic or antiestrogenic activity. Thus, an antioxidant mixture has been identified that does not have potentially adverse estrogenic activity...
  47. ncbi request reprint Dietary ethinyl estradiol exposure during development causes increased voluntary sodium intake and mild maternal and offspring toxicity in rats
    Sherry A Ferguson
    HFT 132 Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 25:491-501. 2003
    ..Here, while EE(2) exposure had few effects on the conventional tests of sexually dimorphic behaviors, exposure to 200 ppb in the diet appeared to feminize genetic males and hyperfeminize genetic females with regard to sodium intake...
  48. ncbi request reprint Multigenerational exposure to dietary nonylphenol has no severe effects on spatial learning in female rats
    Katherine M Flynn
    Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA
    Neurotoxicology 23:87-94. 2002
    ..These data suggest that multigenerational dietary nonylphenol exposure does not cause gross alterations in Morris water maze performance in young adult or middle aged ovariectomized female rats...
  49. ncbi request reprint Pharmacokinetic analysis in serum of genistein administered subcutaneously to neonatal mice
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
    Cancer Lett 184:21-7. 2002
    ..These results are consistent with a diminished capacity for enzymatic conjugation of genistein, based on the ontogeny, as an important determinant of estrogenicity in neonatal mice...
  50. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  51. ncbi request reprint Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo
    Ying Chen
    Department of Biology, Syracuse University, 130 College Place, Syracuse, New York 13244, USA
    Endocrinology 148:3580-90. 2007
    ..These findings also provide insight into the mechanism of multiple oocyte follicle formation...
  52. ncbi request reprint Effects of lifelong dietary exposure to genistein or nonylphenol on amphetamine-stimulated striatal dopamine release in male and female rats
    Sherry A Ferguson
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, HFT 132, Jefferson, AR 72079, USA
    Neurotoxicol Teratol 24:37-45. 2002
    ..Dietary exposure to 200 or 750 ppm nonylphenol had no significant effects in males or females. These results suggest that dietary genistein exposure may act similarly to estradiol in augmenting amphetamine-stimulated DA release...
  53. pmc Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 mice
    Rachel L Ruhlen
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 116:322-8. 2008
    ..Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful...
  54. ncbi request reprint Effect of nonylphenol on serum testosterone levels and testicular steroidogenic enzyme activity in neonatal, pubertal, and adult rats
    Elizabeth M Laurenzana
    Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT 110, Jefferson, AR 72079, USA
    Chem Biol Interact 139:23-41. 2002
    ..These results indicate that NP can inhibit the activity of enzymes involved in testosterone synthesis, but suggest minimal effects on testosterone or testosterone-dependent endpoints via this mechanism...
  55. pmc In vivo effects of bisphenol A in laboratory rodent studies
    Catherine A Richter
    U S Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, United States
    Reprod Toxicol 24:199-224. 2007
    ..We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system...
  56. ncbi request reprint Mass spectrometric determination of p-nonylphenol metabolism and disposition following oral administration to Sprague-Dawley rats
    Daniel R Doerge
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Reprod Toxicol 16:45-56. 2002
    ..These data provide a basis for future correlations of biologic effects observed following dietary exposure in rats with those predicted from environmental exposures to humans...