Research Topics
Genomes and GenesSpecies | A NeumeisterSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Reduced serotonin type 1A receptor binding in panic disorderAlexander Neumeister
National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
J Neurosci 24:589-91. 2004..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...- Tryptophan depletion, serotonin, and depression: where do we stand?Alexander Neumeister
National Institute for Mental Health s Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
Psychopharmacol Bull 37:99-115. 2003..This may lead to the development of truly novel treatment approaches for depression... - Monoaminergic function in the pathogenesis of seasonal affective disorderA Neumeister
National Institutes of Health, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
Int J Neuropsychopharmacol 4:409-20. 2001..Altogether, disturbances in brain monoaminergic transmission seem to play a key role in the pathogenesis of SAD; monoaminergic systems may also play an important role in the mechanisms of the action of light therapy... - Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controlsAlexander Neumeister
Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
Arch Gen Psychiatry 61:765-73. 2004.... - Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depressionAlexander Neumeister
National Institutes of Health, NIMH, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670
Arch Gen Psychiatry 59:613-20. 2002..We studied the behavioral responses to tryptophan depletion (TD) in healthy women with and without a first-degree family history of depression and examined the relationship to 5HTTLPR alleles... - Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapyA Neumeister
National Institute of Mental Health, Clinical Psychobiology Branch, Bethesda, MD, USA
Arch Gen Psychiatry 55:524-30. 1998..Although hypotheses about the therapeutic mechanism of action of light therapy have focused on serotonergic mechanisms, the potential role, if any, of catecholaminergic pathways has not been fully explored... - Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapyA Neumeister
Department of General Psychiatry, Vienna University, Austria
Arch Gen Psychiatry 54:133-8. 1997..Light therapy-induced remission from depression may be associated with changes in brain serotonin function... - Monorhinal odor identification and depression scores in patients with seasonal affective disorderT T Postolache
Section on Biological Rhythms NIMH, Bethesda, MD 20892 1390, USA
J Affect Disord 56:27-35. 1999.... - Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humansAlexander Neumeister
Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
Pharmacogenet Genomics 15:143-9. 2005..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk... - A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative studyNicole Praschak-Rieder
Department of General Psychiatry, Medical University of Vienna, Austria
J Psychiatr Res 39:561-7. 2005.... - Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depressionAlexander Neumeister
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Neuropsychopharmacology 31:1750-6. 2006..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD... - Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjectsAlexander Neumeister
NIMH Mood and Anxiety Disorders Program, Bethesda, MD, USA
Am J Psychiatry 162:805-7. 2005.... - Untangling depression and anxiety: clinical challengesMartin B Keller
J Clin Psychiatry 66:1477-84. 2005 - Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controlsAlexander Neumeister
Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
Arch Gen Psychiatry 63:978-86. 2006.... - Cerebral metabolic effects of intravenous glycine in healthy human subjectsAlexander Neumeister
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
J Clin Psychopharmacol 26:595-9. 2006.... 
Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid AMitchel A Kling
Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
Biol Psychiatry 62:309-13. 2007..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...- Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy peopleEspen Walderhaug
Department of Psychology, University of Oslo, Blindern, 0317 Oslo, Norway
Biol Psychiatry 62:593-9. 2007..We also studied the relative contribution of a functional length triallelic polymorphism in the promoter region of the serotonin transporter, designated 5-HTTLPR, to the behavioral responses to ATD... - Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjectsGregor Hasler
Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
Arch Gen Psychiatry 65:521-31. 2008..An instructive paradigm for more directly investigating the relationship between catecholaminergic function and depression has involved the mood response to experimental catecholamine depletion (CD)... - No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorderOmer Bonne
Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
Am J Psychiatry 162:383-5. 2005..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)... - Reduced posterior hippocampal volume in posttraumatic stress disorderOmer Bonne
Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
J Clin Psychiatry 69:1087-91. 2008..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure... - Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorderNicole Praschak-Rieder
Department of General Psychiatry, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Eur Neuropsychopharmacol 12:129-34. 2002..The elevated rate of affective disorders in relatives of patients with SAD and PMDD suggests higher genetic vulnerability in this subgroup when compared to patients with SAD alone... - Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacologySiegfried Kasper
Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
World J Biol Psychiatry 3:133-46. 2002..Our data provide insight into the pathophysiology of neuropsychiatric disorders and may guide future psychopharmacological drug developments... - Effects of tryptophan depletion and catecholamine depletion on immune parameters in patients with seasonal affective disorder in remission with light therapyJürgen Stastny
Department of General Psychiatry, University of Vienna, Vienna, Austria
Biol Psychiatry 53:332-7. 2003.... - Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preferenceCarolina Johansson
Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
Neuropsychopharmacology 28:734-9. 2003..In conclusion, our results suggest involvement of circadian clock-related polymorphisms both in susceptibility to SAD and diurnal preference... - Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controlsNikolaus Thierry
Department of General Psychiatry, Waehringer Guertel 18 20, University of Vienna, A 1090 Vienna, Austria
Eur Neuropsychopharmacol 14:53-8. 2004..The s allele was associated with lower Self-Directedness scores in SAD patients, whereas there were no significant differences in TCI dimensions between patients and controls in carriers of the long allele... - Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphismCarolina Johansson
Neurogenetics Unit, Department of Molecular Medicine, Center for Molecular Medicine L8 00, Karolinska Institutet and Karolinska Hospital, S 171 76 Stockholm, Sweden
Biol Psychiatry 55:317-9. 2004..Association with seasonal affective disorder (SAD) has been found for the higher activity T-allele of the G-protein beta-3-subunit C825T polymorphism... - Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapyOmer Bonne
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
Neurosci Biobehav Rev 28:65-94. 2004..The implications of this model for the discovery of novel pharmacological approaches to the treatment of severe psychological distress are discussed... - Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporterAlexander Neumeister
Clinical Neuroscience Division, Department of Psychiatry, VA National Center for PTSD 116 A, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
Psychopharmacology (Berl) 174:512-24. 2004.... - Experimental evaluation of an altered tryptophan metabolism in fibromyalgiaMarkus J Schwarz
Psychiatric Hospital, University of Munich, Nussbaumstr 7, D 80336 Munich, Germany
Adv Exp Med Biol 527:265-75. 2003..Our findings may have diagnostic as well as therapeutic implications in the field of fibromyalgia... - C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorderMatthaus Willeit
Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
Biol Psychiatry 54:682-6. 2003.... - Hippocampus, VI. Depression and the HippocampusAlexander Neumeister
UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390-9070, USA
Am J Psychiatry 162:1057. 2005 - Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive DisorderJohanna S Kaplan
Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, DHHS, Bethesda MD, USA
J Affect Disord 95:165-71. 2006..In addition, patients with comorbid depression provided qualitatively different responses in the areas of affective and decision-making processes... - Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjectsAlexander Neumeister
Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
Biol Psychiatry 57:935-7. 2005..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls... 
beta2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorderChristoph Czermak
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Int J Neuropsychopharmacol 11:419-24. 2008..66, p=0.019, Bonferroni corrected). These findings not only suggest an involvement of beta2-nAChRs in the pathophysiology of PTSD but also raise the possibility that this receptor may be a novel molecular target for drug development...- Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopyGregor Hasler
Mood and Anxiety Disorders Program, Section on Experimental Therapeutics, National Institutes of Health, Bethesda, MD 20892 2670, USA
Biol Psychiatry 58:969-73. 2005..As a result, the current study investigates whether GABA levels in the prefrontal cortex differ between unmedicated subjects with remitted major depressive disorder (rMDD) and healthy control subjects... - Evidence for continuing neuropsychological impairments in depressionPetra Weiland-Fiedler
Mood and Anxiety Disorders Program, National Institute of Mental Health, North Drive, Building 15K, Room 200, Bethesda, MD 20892-2670, USA
J Affect Disord 82:253-8. 2004..CONCLUSIONS: These findings suggest deficits in sustained attention as vulnerability marker for MDD. The functional importance of this finding and the neuronal networks involved remain to be elucidated...