A Neumeister

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
  2. ncbi request reprint Tryptophan depletion, serotonin, and depression: where do we stand?
    Alexander Neumeister
    National Institute for Mental Health s Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Psychopharmacol Bull 37:99-115. 2003
  3. ncbi request reprint Monoaminergic function in the pathogenesis of seasonal affective disorder
    A Neumeister
    National Institutes of Health, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Int J Neuropsychopharmacol 4:409-20. 2001
  4. ncbi request reprint Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
  5. ncbi request reprint Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression
    Alexander Neumeister
    National Institutes of Health, NIMH, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670
    Arch Gen Psychiatry 59:613-20. 2002
  6. ncbi request reprint Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapy
    A Neumeister
    National Institute of Mental Health, Clinical Psychobiology Branch, Bethesda, MD, USA
    Arch Gen Psychiatry 55:524-30. 1998
  7. ncbi request reprint Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy
    A Neumeister
    Department of General Psychiatry, Vienna University, Austria
    Arch Gen Psychiatry 54:133-8. 1997
  8. ncbi request reprint Monorhinal odor identification and depression scores in patients with seasonal affective disorder
    T T Postolache
    Section on Biological Rhythms NIMH, Bethesda, MD 20892 1390, USA
    J Affect Disord 56:27-35. 1999
  9. ncbi request reprint Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
  10. ncbi request reprint A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study
    Nicole Praschak-Rieder
    Department of General Psychiatry, Medical University of Vienna, Austria
    J Psychiatr Res 39:561-7. 2005

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
    ..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...
  2. ncbi request reprint Tryptophan depletion, serotonin, and depression: where do we stand?
    Alexander Neumeister
    National Institute for Mental Health s Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Psychopharmacol Bull 37:99-115. 2003
    ..This may lead to the development of truly novel treatment approaches for depression...
  3. ncbi request reprint Monoaminergic function in the pathogenesis of seasonal affective disorder
    A Neumeister
    National Institutes of Health, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Int J Neuropsychopharmacol 4:409-20. 2001
    ..Altogether, disturbances in brain monoaminergic transmission seem to play a key role in the pathogenesis of SAD; monoaminergic systems may also play an important role in the mechanisms of the action of light therapy...
  4. ncbi request reprint Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  5. ncbi request reprint Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression
    Alexander Neumeister
    National Institutes of Health, NIMH, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670
    Arch Gen Psychiatry 59:613-20. 2002
    ..We studied the behavioral responses to tryptophan depletion (TD) in healthy women with and without a first-degree family history of depression and examined the relationship to 5HTTLPR alleles...
  6. ncbi request reprint Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapy
    A Neumeister
    National Institute of Mental Health, Clinical Psychobiology Branch, Bethesda, MD, USA
    Arch Gen Psychiatry 55:524-30. 1998
    ..Although hypotheses about the therapeutic mechanism of action of light therapy have focused on serotonergic mechanisms, the potential role, if any, of catecholaminergic pathways has not been fully explored...
  7. ncbi request reprint Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy
    A Neumeister
    Department of General Psychiatry, Vienna University, Austria
    Arch Gen Psychiatry 54:133-8. 1997
    ..Light therapy-induced remission from depression may be associated with changes in brain serotonin function...
  8. ncbi request reprint Monorhinal odor identification and depression scores in patients with seasonal affective disorder
    T T Postolache
    Section on Biological Rhythms NIMH, Bethesda, MD 20892 1390, USA
    J Affect Disord 56:27-35. 1999
    ....
  9. ncbi request reprint Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  10. ncbi request reprint A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study
    Nicole Praschak-Rieder
    Department of General Psychiatry, Medical University of Vienna, Austria
    J Psychiatr Res 39:561-7. 2005
    ....
  11. ncbi request reprint Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:1750-6. 2006
    ..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD...
  12. ncbi request reprint Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects
    Alexander Neumeister
    NIMH Mood and Anxiety Disorders Program, Bethesda, MD, USA
    Am J Psychiatry 162:805-7. 2005
    ....
  13. ncbi request reprint Untangling depression and anxiety: clinical challenges
    Martin B Keller
    J Clin Psychiatry 66:1477-84. 2005
  14. ncbi request reprint Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
    ....
  15. ncbi request reprint Cerebral metabolic effects of intravenous glycine in healthy human subjects
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    J Clin Psychopharmacol 26:595-9. 2006
    ....
  16. pmc Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A
    Mitchel A Kling
    Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Biol Psychiatry 62:309-13. 2007
    ..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...
  17. ncbi request reprint Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people
    Espen Walderhaug
    Department of Psychology, University of Oslo, Blindern, 0317 Oslo, Norway
    Biol Psychiatry 62:593-9. 2007
    ..We also studied the relative contribution of a functional length triallelic polymorphism in the promoter region of the serotonin transporter, designated 5-HTTLPR, to the behavioral responses to ATD...
  18. pmc Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:521-31. 2008
    ..An instructive paradigm for more directly investigating the relationship between catecholaminergic function and depression has involved the mood response to experimental catecholamine depletion (CD)...
  19. ncbi request reprint No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  20. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
    ..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure...
  21. ncbi request reprint Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder
    Nicole Praschak-Rieder
    Department of General Psychiatry, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 12:129-34. 2002
    ..The elevated rate of affective disorders in relatives of patients with SAD and PMDD suggests higher genetic vulnerability in this subgroup when compared to patients with SAD alone...
  22. ncbi request reprint Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    World J Biol Psychiatry 3:133-46. 2002
    ..Our data provide insight into the pathophysiology of neuropsychiatric disorders and may guide future psychopharmacological drug developments...
  23. ncbi request reprint Effects of tryptophan depletion and catecholamine depletion on immune parameters in patients with seasonal affective disorder in remission with light therapy
    Jürgen Stastny
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Biol Psychiatry 53:332-7. 2003
    ....
  24. ncbi request reprint Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 28:734-9. 2003
    ..In conclusion, our results suggest involvement of circadian clock-related polymorphisms both in susceptibility to SAD and diurnal preference...
  25. ncbi request reprint Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls
    Nikolaus Thierry
    Department of General Psychiatry, Waehringer Guertel 18 20, University of Vienna, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:53-8. 2004
    ..The s allele was associated with lower Self-Directedness scores in SAD patients, whereas there were no significant differences in TCI dimensions between patients and controls in carriers of the long allele...
  26. ncbi request reprint Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Center for Molecular Medicine L8 00, Karolinska Institutet and Karolinska Hospital, S 171 76 Stockholm, Sweden
    Biol Psychiatry 55:317-9. 2004
    ..Association with seasonal affective disorder (SAD) has been found for the higher activity T-allele of the G-protein beta-3-subunit C825T polymorphism...
  27. ncbi request reprint Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy
    Omer Bonne
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
    Neurosci Biobehav Rev 28:65-94. 2004
    ..The implications of this model for the discovery of novel pharmacological approaches to the treatment of severe psychological distress are discussed...
  28. ncbi request reprint Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter
    Alexander Neumeister
    Clinical Neuroscience Division, Department of Psychiatry, VA National Center for PTSD 116 A, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 174:512-24. 2004
    ....
  29. ncbi request reprint Experimental evaluation of an altered tryptophan metabolism in fibromyalgia
    Markus J Schwarz
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Adv Exp Med Biol 527:265-75. 2003
    ..Our findings may have diagnostic as well as therapeutic implications in the field of fibromyalgia...
  30. ncbi request reprint C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorder
    Matthaus Willeit
    Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
    Biol Psychiatry 54:682-6. 2003
    ....
  31. ncbi request reprint Hippocampus, VI. Depression and the Hippocampus
    Alexander Neumeister
    UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:1057. 2005
  32. ncbi request reprint Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive Disorder
    Johanna S Kaplan
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, DHHS, Bethesda MD, USA
    J Affect Disord 95:165-71. 2006
    ..The present study investigated neuropsychological functioning in patients with PD and PD + MDD by focusing on tasks that assess attention, psychomotor speed, executive function, decision-making, and affective processing...
  33. ncbi request reprint Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    Alexander Neumeister
    Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:935-7. 2005
    ..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls...
  34. doi request reprint beta2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder
    Christoph Czermak
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Int J Neuropsychopharmacol 11:419-24. 2008
    ..66, p=0.019, Bonferroni corrected). These findings not only suggest an involvement of beta2-nAChRs in the pathophysiology of PTSD but also raise the possibility that this receptor may be a novel molecular target for drug development...
  35. ncbi request reprint Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy
    Gregor Hasler
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Biol Psychiatry 58:969-73. 2005
    ..As a result, the current study investigates whether GABA levels in the prefrontal cortex differ between unmedicated subjects with remitted major depressive disorder (rMDD) and healthy control subjects...
  36. ncbi request reprint Evidence for continuing neuropsychological impairments in depression
    Petra Weiland-Fiedler
    Mood and Anxiety Disorders Program, National Institute of Mental Health, North Drive, Building 15K, Room 200, Bethesda, MD 20892 2670, USA
    J Affect Disord 82:253-8. 2004
    ..The purpose of the present study was to describe the neuropsychological functioning of fully remitted, unmedicated patients with a history of MDD by focusing on tasks related to prefrontal cortex functioning...