Maria Nesterova

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc An immortalized human cell line bearing a PRKAR1A-inactivating mutation: effects of overexpression of the wild-type Allele and other protein kinase A subunits
    Maria Nesterova
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 93:565-71. 2008
  2. pmc Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:E687-93. 2012
  3. pmc Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions
    Madson Q Almeida
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:E728-38. 2011
  4. pmc Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice KennedyShriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1387-98. 2010
  5. pmc 8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors
    Audrey J Robinson-White
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 94:4061-9. 2009
  6. pmc Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes
    Eirini I Bimpaki
    Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, NIH, Building 10, CRC East Laboratories, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    Eur J Endocrinol 161:153-61. 2009
  7. pmc Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors
    Madson Q Almeida
    PDEGEN, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 20:165-75. 2011
  8. pmc Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition
    Monalisa F Azevedo
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 98:E1393-400. 2013
  9. pmc Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors
    Elise Meoli
    Section on Endocrinology and Genetics, Program in Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:3133-41. 2008
  10. ncbi request reprint Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion
    Catherine L Neary
    Cellular Biochemistry Section, Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1750, USA
    Oncogene 23:8847-56. 2004

Collaborators

Detail Information

Publications29

  1. pmc An immortalized human cell line bearing a PRKAR1A-inactivating mutation: effects of overexpression of the wild-type Allele and other protein kinase A subunits
    Maria Nesterova
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 93:565-71. 2008
    ..Inactivating mutations of PRKAR1A, the regulatory subunit type 1A (RIalpha) of protein kinase A (PKA), are associated with tumor formation...
  2. pmc Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:E687-93. 2012
    ....
  3. pmc Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions
    Madson Q Almeida
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:E728-38. 2011
    ..Massive macronodular adrenocortical disease or ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a clinically and genetically heterogeneous disorder...
  4. pmc Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice KennedyShriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1387-98. 2010
    ....
  5. pmc 8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors
    Audrey J Robinson-White
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 94:4061-9. 2009
    ..PKA controls cell proliferation in many cell types. The cAMP analogue 8-Cl-adenosine (8-Cl-ADO) is thought to inhibit cancer cell proliferation...
  6. pmc Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes
    Eirini I Bimpaki
    Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, NIH, Building 10, CRC East Laboratories, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    Eur J Endocrinol 161:153-61. 2009
    ..Little is known about cAMP signaling in adrenal lesions associated with ACTH-independent Cushing syndrome (AICS) that do not harbor mutations in known genes...
  7. pmc Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors
    Madson Q Almeida
    PDEGEN, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 20:165-75. 2011
    ....
  8. pmc Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition
    Monalisa F Azevedo
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 98:E1393-400. 2013
    ....
  9. pmc Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors
    Elise Meoli
    Section on Endocrinology and Genetics, Program in Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 68:3133-41. 2008
    ....
  10. ncbi request reprint Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion
    Catherine L Neary
    Cellular Biochemistry Section, Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1750, USA
    Oncogene 23:8847-56. 2004
    ..Differential expression of PKA R subunits may therefore serve as a tumor-target-based gene therapy for PC3M prostate and other cancers...
  11. pmc Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours
    Anya Rothenbuhler
    Section on Endocrinology and Genetics and Pediatric Endocrinology Training Program, both at Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    Clin Endocrinol (Oxf) 77:195-9. 2012
    ..Genetic aberrations in various components of cAMP signalling pathway predispose to endocrine tumours. Mutations in the phosphodiesterases (PDEs) are involved in the predisposition to adrenocortical neoplastic conditions...
  12. pmc In vitro studies of novel PRKAR1A mutants that extend the predicted RIα protein sequence into the 3'-untranslated open reading frame: proteasomal degradation leads to RIα haploinsufficiency and Carney complex
    Yianna Patronas
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:E496-502. 2012
    ..Most PRKAR1A mutations are subject to nonsense mRNA decay (NMD) and, thus, lead to haploinsufficiency...
  13. pmc Anxiety phenotype in mice that overexpress protein kinase A
    Margaret F Keil
    Section on Endocrinology and Genetics, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Psychoneuroendocrinology 37:836-43. 2012
    ..These results suggest that the alteration in PKA signaling in Prkar1a(+/-) mice is not a ubiquitous effect; and supports the importance of cAMP/PKA pathway in neurobiological processes involved in anxiety and fear sensitization...
  14. pmc Differences in adiposity in Cushing syndrome caused by PRKAR1A mutations: clues for the role of cyclic AMP signaling in obesity and diagnostic implications
    Edra London
    Section on Endocrinology and Genetics E L, A R, M L, E G, M K, C L, M d l L S, M N, C A S, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Inter Institute Pediatric Endocrinology Training Program E G, and Department of Diagnostic Radiology N P, C A S, Clinical Research Center, National Institutes of Health, Bethesda, Maryland 20892 and Service d Endocrinologie Pédiatrique A R, Universite Paris Sud 11, Hopital Bicetre, 94270 Le Kremlin Bicetre, France
    J Clin Endocrinol Metab 99:E303-10. 2014
    ..Although CS is invariably associated with obesity, its different forms, including those associated with PKA defects, have not been compared...
  15. pmc A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex
    Anelia Horvath
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Eur J Hum Genet 16:1245-53. 2008
    ..We conclude that PDE8B is another PDE gene linked to iMAD; it is a candidate causative gene for other adrenocortical lesions linked to the cAMP signaling pathway and possibly for tumors in other tissues...
  16. pmc Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer
    Fabio Rueda Faucz
    Section of Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:E135-40. 2011
    ..In addition, the combined cancer genome expression metaanalysis datasets included PDE11A among the top 1% down-regulated genes in PCa...
  17. pmc Does somatostatin have a role in the regulation of cortisol secretion in primary pigmented nodular adrenocortical disease (ppnad)? a clinical and in vitro investigation
    Zakariae Bram
    INSERM Unité 982 Z B, E L, H L, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, University of Rouen, 76821 Rouen, France Section on Endocrinology and Genetics P X, D A, C G, M N, R C, C A S, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Pediatric Endocrinology Inter Institute Training Program M F K, C A S, National Institute of Child Health and Human Development, National Institutes of Health, and Clinical Center N S, National Institutes of Health, Bethesda, Maryland 20892 Erasmus Medical Center L J H, 3015 GE Rotterdam, The Netherlands and Department of Endocrinology H L, Institute for Research and Innovation in Biomedicine, University Hospital of Rouen, 76031 Rouen, France
    J Clin Endocrinol Metab 99:E891-901. 2014
    ..Somatostatin (SST) receptors (SSTRs) are expressed in a number of tissues, including the adrenal cortex, but their role in cortisol secretion has not been well characterized...
  18. pmc Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors
    Hui Pin Hsiao
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 94:2930-7. 2009
    ..We characterized a large series of patients of AIMAH and compared them with patients with other adrenocortical tumors...
  19. pmc Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine
    Audrey J Robinson-White
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 93:1020-9. 2008
    ..We have investigated the antiproliferative effects of 8-Cl-cAMP and 8-CL-ADO on human thyroid cancer cells and determined PKA's involvement...
  20. doi request reprint In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay
    Elizabeth L Greene
    Section on Endocrinology and Genetics, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Hum Mutat 29:633-9. 2008
    ..In some cases, as with the Delta-exon 3 mutation, we may even conclude that the presence of a mutant PRKAR1A protein may be more harmful than allelic loss...
  21. pmc Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors
    Anelia Horvath
    Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 10 Center Drive, CRC, Room 1 3330, Bethesda, MD 20892, USA
    Cancer Res 69:5301-6. 2009
    ..In conclusion, we report that PDE11A-inactivating sequence variants may modify the risk of familial and bilateral TGCT...
  22. pmc A large family with Carney complex caused by the S147G PRKAR1A mutation shows a unique spectrum of disease including adrenocortical cancer
    João Anselmo
    Serviço de Endocrinologia e Nutriço, Ponta Delgada, São Miguel 9500, Azores, Portugal
    J Clin Endocrinol Metab 97:351-9. 2012
    ..Herein, we describe a large Azorean family with CNC caused by a point mutation in the PRKAR1A gene coding for type 1-α (RIα) regulatory subunit of the cAMP-dependent protein kinase A, in which the index patient presented with AC...
  23. pmc Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone
    Kit Man Tsang
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics and Pediatric Endocrinology Inter institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:8683-8. 2010
    ....
  24. doi request reprint Large deletions of the PRKAR1A gene in Carney complex
    Anelia Horvath
    Section on Endocrinology and Genetics and Pediatric Endocrinology Training Program, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    Clin Cancer Res 14:388-95. 2008
    ..Although a few families map to chromosome 2, it is possible that current sequencing techniques do not detect larger gene changes in PRKAR1A -- mutation-negative individuals with Carney complex...
  25. doi request reprint Comprehensive analysis of LC/MS data using pseudocolor plots
    Christopher A Crutchfield
    National Institutes of Health, Bethesda, MD 20892, USA
    J Am Soc Mass Spectrom 24:230-7. 2013
    ..We present an approach to discovery using MS that essentially eliminates alignment or preprocessing of spectra. Moreover, we demonstrate the concept that untargeted metabolomics can be achieved using low mass resolution instrumentation...
  26. pmc Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?
    Paraskevi Xekouki
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:E357-66. 2012
    ....
  27. pmc Role of nonselective cation channels in spontaneous and protein kinase A-stimulated calcium signaling in pituitary cells
    Melanija Tomic
    National Institute of Child Health and Human Development NIH, 49 Convent Dr, Bethesda, MD 20892 4510, USA
    Am J Physiol Endocrinol Metab 301:E370-9. 2011
    ....
  28. ncbi request reprint Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy
    Yoon S Cho-Chung
    Cellular Biochemistry Section, BRL, CCR, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1750, USA
    Ann N Y Acad Sci 968:22-36. 2002
    ..Thus, a complex circuitry of cAMP signaling comprises cAMP growth regulatory function, and deregulation of the effector molecule by this circuitry may underlie cancer genesis and tumor progression...
  29. ncbi request reprint A rapid method for microarray cross platform comparisons using gene expression signatures
    Chris Cheadle
    Genomics Core, Division of Allergy and Clinical Immunology, School of Medicine, Johns Hopkins University, Mason Lord Bldg, Center Tower, Rm 664, 5200 Eastern Avenue, Baltimore, MD 21224, USA
    Mol Cell Probes 21:35-46. 2007
    ....