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Genomes and GenesSpecies | R G NelsonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Changing course of diabetic nephropathy in the Pima IndiansRobert G Nelson
Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014 4972, USA
Diabetes Res Clin Pract 82:S10-4. 2008..A continued increase in the incidence of type 2 diabetes in youth, however, threatens to reverse this trend...
The new KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and CKDRobert G Nelson
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA
Blood Purif 25:112-4. 2007..The National Kidney Foundation (NKF) recently published new guidelines and clinical practice recommendations for the diagnosis and management of patients with diabetes and chronic kidney disease (CKD)...- Periodontal disease and diabetesR G Nelson
Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014-4972, USA
Oral Dis 14:204-5. 2008 - Plasma lipoproteins and incidence of non-insulin-dependent diabetes mellitus in Pima Indians: protective effect of HDL cholesterol in womenA Fagot-Campagna
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ 85014, USA
Atherosclerosis 128:113-9. 1997..8 mmol/1) or impaired (7.8 mmol/l < or = 2-h glucose < 11.1 mmol/l) glucose tolerance at baseline. These results indicate that lipoprotein disorders are an early accompaniment of the abnormalities that lead to NIDDM... - Intrauterine diabetes exposure and the risk of renal disease in diabetic Pima IndiansR G Nelson
Phoenix Epidemiology and Clinical Research Branch, National Insitute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014 4972, USA
Diabetes 47:1489-93. 1998..The effect of this exposure appears to be independent of other susceptibility factors that lead to nephropathy in diabetes... - An epidemic of proteinuria in Pima Indians with type 2 diabetes mellitusR G Nelson
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona, USA
Kidney Int 54:2081-8. 1998..Little is known about secular changes in the risk of proteinuria in Type 2 diabetes... - Survival during renal replacement therapy for diabetic end-stage renal disease in Pima IndiansR G Nelson
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, AZ 85014, USA
Diabetes Care 19:1333-7. 1996..To examine survival in Pima Indians receiving renal replacement therapy for end-stage renal disease attributed to NIDDM... - Increasing incidence of proteinuria and declining incidence of end-stage renal disease in diabetic Pima IndiansM E Pavkov
Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Kidney Int 70:1840-6. 2006..On the other hand, the incidence of ESRD declined after 1990, coinciding with improved control of blood pressure, hyperglycemia, and perhaps other risk factors... - The effect of Indian or Anglo dietary preference on the incidence of diabetes in Pima IndiansD E Williams
Phoenix Epidemiology and Clinical Research Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, Arizona 85014, USA
Diabetes Care 24:811-6. 2001..We examined the long-term effects of a self-assessed traditional or nontraditional dietary pattern on the development of type 2 diabetes in 165 nondiabetic Pima Indians... - Serum cholesterol and mortality rates in a Native American population with low cholesterol concentrations: a U-shaped associationA Fagot-Campagna
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Ariz 85014, USA
Circulation 96:1408-15. 1997..The present report evaluates whether low cholesterol is likely to be a causal factor for mortality from all causes or from specific causes... - Predictive power of sequential measures of albuminuria for progression to ESRD or death in Pima Indians with type 2 diabetesMeda E Pavkov
Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014 4972, USA
Am J Kidney Dis 51:759-66. 2008.... - Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association studyRobert L Hanson
Translational Genomics Research Institute, 445 North Fifth St, Phoenix, AZ 85004, USA
Diabetes 56:975-83. 2007..01. The strongest evidence for association was found for rs2648875 (P = 0.0000018; 2.97 [1.90-4.65]), which maps to intron 8 of PVT1. Together, these results suggest that PVT1 may contribute to ESRD susceptibility in diabetes... - Periodontal disease and mortality in type 2 diabetesAramesh Saremi
National Institute of Diabetes and Digestive and Kidney Disease, Phoenix, Arizona, USA
Diabetes Care 28:27-32. 2005..The effect of periodontal disease is in addition to the effects of traditional risk factors for these diseases... - Course of renal disease in Pima Indians with non-insulin-dependent diabetes mellitusR G Nelson
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Kidney Int Suppl 63:S45-8. 1997.... - Predictive value of albuminuria in American Indian youth with or without type 2 diabetesNan Hee Kim
Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Pediatrics 125:e844-51. 2010..To examine the prognostic significance of elevated albuminuria in youth with type 2 diabetes... - Diabetic nephropathy in American Indians, with a special emphasis on the Pima IndiansMeda E Pavkov
Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014 4972, USA
Curr Diab Rep 8:486-93. 2008..We also review therapeutic strategies for managing diabetic kidney disease... - The impact of disadvantage on the development and progression of diabetic kidney diseaseE J Weil
Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
Clin Nephrol 74:S32-8. 2010..They are also at increased risk of kidney disease attributable to diabetes, and for many, the cost of managing their kidney disease far exceeds their available resources... - Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetesWendy A Shultis
Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health, 1550 E Indian School Rd, Phoenix, AZ 85014 4972, USA
Diabetes Care 30:306-11. 2007..The purpose of this study was to investigate the effect of periodontitis on development of overt nephropathy, defined as macroalbuminuria, and end-stage renal disease (ESRD) in type 2 diabetes... - Genome-wide linkage analyses to identify Loci for diabetic retinopathyHelen C Looker
PECRB, NIDDK, 1550 E Indian School Rd, Phoenix, AZ 85014, USA
Diabetes 56:1160-6. 2007..2 cM), whereas with multipoint analysis the peak LOD was 2.58 at 35 cM. No other areas of suggestive linkage were found. We propose that an area on chromosome 1 may harbor a gene or genes conferring susceptibility to diabetic retinopathy... - Changing patterns of type 2 diabetes incidence among Pima IndiansMeda E Pavkov
Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Rd, Phoenix, AZ 85014 4972, USA
Diabetes Care 30:1758-63. 2007..We examined trends in the incidence rate of type 2 diabetes among Pima Indians between 1965 and 2003... - Plasma glucose regulation and mortality in pima IndiansNan Hee Kim
Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014 4972, USA
Diabetes Care 31:488-92. 2008.... - Change in the distribution of albuminuria according to estimated glomerular filtration rate in Pima Indians with type 2 diabetesMeda E Pavkov
Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes Care 32:1845-50. 2009.... - Effect of intrauterine diabetes exposure on the incidence of end-stage renal disease in young adults with type 2 diabetesMeda E Pavkov
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Diabetes Care 33:2396-8. 2010..We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes... - Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima IndiansMeda E Pavkov
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Ariz 85014 4972, USA
JAMA 296:421-6. 2006..The long-term outcome of persons with youth-onset type 2 diabetes mellitus has not been well described... - Predominant effect of kidney disease on mortality in Pima Indians with or without type 2 diabetesMeda E Pavkov
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014 4972, USA
Kidney Int 68:1267-74. 2005..We examined the effect of kidney disease (KD) on mortality in nondiabetic and diabetic Pima Indians aged > or = 45 years old... - Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetesHelen C Looker
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85014, USA
J Clin Endocrinol Metab 89:4010-7. 2004..0001). Serum adiponectin is lowest in the presence of impaired glucose regulation and early diabetes. In the presence of diabetes, serum adiponectin is positively associated with abnormal renal function and diabetes duration... - Trends in heart disease death rates in diabetic and nondiabetic Pima IndiansChristine M Hoehner
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
J Diabetes Complications 20:8-13. 2006..This finding suggests that, in the absence of diabetes, the underlying susceptibility to IHD in this population has not changed... - An explanation for the increase in heart disease mortality rates in diabetic Pima Indians: effect of renal replacement therapyMeda E Pavkov
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85011 4972, USA
Diabetes Care 27:1132-6. 2004..This study tests the hypothesis that the rise in the IHD death rate between 1965 and 1998 is attributable to access to renal replacement therapy (RRT)... - Incidence of retinopathy and nephropathy in youth-onset compared with adult-onset type 2 diabetesJonathan Krakoff
National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
Diabetes Care 26:76-81. 2003..To examine the risk of retinopathy and nephropathy in participants in whom type 2 diabetes was diagnosed in youth (before 20 years of age) compared with those in whom type 2 diabetes was diagnosed at older ages... - Electrocardiographic abnormalities predict deaths from cardiovascular disease and ischemic heart disease in Pima Indians with type 2 diabetesAida Jimenez-Corona
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85014 4972, USA
Am Heart J 151:1080-6. 2006.... - Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetesHelen C Looker
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, USA
Diabetes Metab Res Rev 23:193-201. 2007..To assess the role of homocysteine as a risk factor for mortality in diabetic subjects... 
HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretionR C Williams
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ 85014, USA
Diabetologia 54:1684-92. 2011..We sought to identify the physiological implications of genetic variation at the HLA-DRB1 region in full-heritage Pima Indians in Arizona...- Kidney disease among the indigenous peoples of OceaniaE Jennifer Weil
Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014-4972, USA
Ethn Dis 16:S2-24-30. 2006..Consequently, clinical management should emphasize prevention, screening, and early intervention... - Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American IndiansJ K Wolford
Translational Genomics Research Institute, Diabetes Research Unit, Phoenix, AZ 85004, USA
Diabet Med 23:367-76. 2006..As AKR1B1 is located on 7q35, where we have previously reported linkage to diabetic nephropathy in Pima Indians, this study examined the association of AKR1B1 variants with diabetic nephropathy in this population... - Advances and emerging opportunities in type 1 diabetes: a strategic planRobert G Nelson
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Nephrol News Issues 21:28, 31. 2007 - Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research GroupAlka Malhotra
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
Diabetes Metab Res Rev 25:740-7. 2009..The goal of the current study is to identify regions of linkage for T2DM in ethnically diverse populations... - NKF releases new KDOQI guidelines for diabetes and CKDRobert G Nelson
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Ariz, USA
Nephrol News Issues 20:29. 2006 - Diabetic end-stage renal disease in the indigenous population of the Commonwealth of the Northern Mariana IslandsSyed M Abidi
Department of Public Health, Commonwealth Health Center, Commonwealth of the Northern Mariana Islands
Nephrology (Carlton) 10:291-5. 2005..The number of diabetic patients in CNMI who are receiving renal replacement therapy is rising rapidly. Considerable improvement in survival after the onset of haemodialysis has occurred over the past 21 years... - Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathyHasan H Otu
Genomics Center and DF HCC Cancer Proteomics Core, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Diabetes Care 30:638-43. 2007..We examined whether proteomic technologies identify novel urine proteins associated with subsequent development of diabetic nephropathy in subjects with type 2 diabetes before evidence of microalbuminuria... - Testing for microalbuminuria in 2002: barriers to implementing current guidelinesTodd S Harwell
Montana Department of Public Health and Human Services, Helena, MT 59620 2951, USA
Am J Kidney Dis 42:245-8. 2003..Testing for microalbuminuria is recommended to detect early kidney damage in patients with diabetes or other diseases. However, few studies have examined laboratory practices for microalbuminuria testing in the general community... - Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND)Sudha K Iyengar
FIND Genetic Analysis and Data Coordinating Center, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106 7281, USA
Diabetes 56:1577-85. 2007..Large family collections consisting of multiple members with diabetes and advanced nephropathy are likely to accelerate the identification of genes causing diabetic nephropathy, a life-threatening complication of diabetes... - Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stressPaul J Beisswenger
Department of Medicine, Diabetes, Endocrinology and Metabolism, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Diabetes 54:3274-81. 2005.... - Evaluation of the modification of diet in renal disease study equation in a large diverse populationLesley A Stevens
Division of Nephrology, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
J Am Soc Nephrol 18:2749-57. 2007..73 m(2). In individual patients, interpretation of GFR estimates near 60 ml/min per 1.73 m(2) should be interpreted with caution to avoid misclassification of chronic kidney disease in the context of the clinical setting... - Cystatin C and the risk of deathBruce A Perkins
N Engl J Med 353:842-4; author reply 842-4. 2005 - Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up studyBruce A Perkins
Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
J Am Soc Nephrol 16:1404-12. 2005..35). Serial measures of serum cystatin C accurately detect trends in renal function in patients with normal or elevated GFR and provide means for studying early renal function decline in diabetes... - Heritability of the severity of diabetic retinopathy: the FIND-Eye studyNedal H Arar
Family Investigation of Nephropathy and Diabetes FIND Genetic Analysis and Data Coordinating Center, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
Invest Ophthalmol Vis Sci 49:3839-45. 2008.... - Modeling GFR trajectories in diabetic nephropathyKevin V Lemley
Division of Pediatric Nephrology, Stanford Univ School of Medicine, Stanford, CA 94305 5208, USA
Am J Physiol Renal Physiol 289:F863-70. 2005.... - Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND)Jeffrey R Schelling
Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, Rm 1300, 10900 Euclid Ave, Cleveland, OH 44106 7281, USA
Diabetes 57:235-43. 2008..Glomerular filtration rate (GFR), which characterizes diabetic nephropathy, was employed as a quantitative trait in a preliminary whole-genome scan...