Lawrence M Nelson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Mechanisms of follicular dysfunction in 46,XX spontaneous premature ovarian failure
    Lawrence M Nelson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10N262, Bethesda, MD 20892 1862, USA
    Endocrinol Metab Clin North Am 32:613-37. 2003
  2. pmc Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men
    Joyce Y Tung
    Human Embryonic Stem Cell Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94143, USA
    Reprod Biol Endocrinol 4:40. 2006
  3. ncbi request reprint Autoimmune ovarian failure: comparing the mouse model and the human disease
    L M Nelson
    Gynecologic Endocrinology Unit, Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    J Soc Gynecol Investig 8:S55-7. 2001
  4. pmc Sexual function in young women with spontaneous 46,XX primary ovarian insufficiency
    Sophia N Kalantaridou
    Integrative Reproductive Medicine Unit, Reproductive Biology and Medicine Branch, Intramural Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Fertil Steril 90:1805-11. 2008
  5. pmc A prospective evaluation of antral follicle function in women with 46,XX spontaneous primary ovarian insufficiency
    Ziad R Hubayter
    Integrative Reproductive Medicine Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 94:1769-74. 2010
  6. pmc Bone mineral density in estrogen-deficient young women
    Vaishali B Popat
    Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    J Clin Endocrinol Metab 94:2277-83. 2009
  7. ncbi request reprint Effects of ovarian failure and X-chromosome deletion on body composition and insulin sensitivity in young women
    Emily C Corrigan
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    Menopause 13:911-6. 2006
  8. ncbi request reprint Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failure
    Sophia N Kalantaridou
    Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 86:1475-82. 2006
  9. pmc Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency
    Vladimir K Bakalov
    Section on Epigenetics and Development, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, 10 Center Dr CRC 1 3330 Bethesda, MD 20892 1103, USA
    J Autoimmun 38:315-21. 2012
  10. ncbi request reprint Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 84:958-65. 2005

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Mechanisms of follicular dysfunction in 46,XX spontaneous premature ovarian failure
    Lawrence M Nelson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10N262, Bethesda, MD 20892 1862, USA
    Endocrinol Metab Clin North Am 32:613-37. 2003
    ..With appropriate medical management and emotional support provided by a sensitive clinician, most young women with 46,XX spontaneous premature ovarian failure will lead happy, healthy, and fulfilling lives...
  2. pmc Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men
    Joyce Y Tung
    Human Embryonic Stem Cell Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94143, USA
    Reprod Biol Endocrinol 4:40. 2006
    ..Recently, we showed that there are several common polymorphisms within the DAZL gene that are associated with age at ovarian failure/menopause and sperm count...
  3. ncbi request reprint Autoimmune ovarian failure: comparing the mouse model and the human disease
    L M Nelson
    Gynecologic Endocrinology Unit, Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    J Soc Gynecol Investig 8:S55-7. 2001
    ..MATER provides a new determinant with which to investigate the mechanisms of autoimmune premature ovarian failure...
  4. pmc Sexual function in young women with spontaneous 46,XX primary ovarian insufficiency
    Sophia N Kalantaridou
    Integrative Reproductive Medicine Unit, Reproductive Biology and Medicine Branch, Intramural Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Fertil Steril 90:1805-11. 2008
    ..To assess sexual function in women with spontaneous 46,XX primary ovarian insufficiency after at least 3 months of a standardized hormone replacement regimen...
  5. pmc A prospective evaluation of antral follicle function in women with 46,XX spontaneous primary ovarian insufficiency
    Ziad R Hubayter
    Integrative Reproductive Medicine Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 94:1769-74. 2010
    ..To assess ovarian follicle function in women with 46,XX spontaneous primary ovarian insufficiency...
  6. pmc Bone mineral density in estrogen-deficient young women
    Vaishali B Popat
    Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    J Clin Endocrinol Metab 94:2277-83. 2009
    ..Osteoporosis primarily affects postmenopausal women. However, young women with estrogen deficiency also are at increased risk for low bone density...
  7. ncbi request reprint Effects of ovarian failure and X-chromosome deletion on body composition and insulin sensitivity in young women
    Emily C Corrigan
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    Menopause 13:911-6. 2006
    ..It remains unclear whether these changes are due primarily to ovarian failure or aging. The aim of this study was to clarify the impact of ovarian failure on body composition and insulin sensitivity in young women...
  8. ncbi request reprint Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failure
    Sophia N Kalantaridou
    Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 86:1475-82. 2006
    ..To determine whether women with 46,XX spontaneous premature ovarian failure have lower serum free-T levels than do control women...
  9. pmc Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency
    Vladimir K Bakalov
    Section on Epigenetics and Development, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, 10 Center Dr CRC 1 3330 Bethesda, MD 20892 1103, USA
    J Autoimmun 38:315-21. 2012
    ..The absence of a normal second X-chromosome further contributes to increased autoimmunity in TS...
  10. ncbi request reprint Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 84:958-65. 2005
    ..To assess the association between serum adrenal cortex autoantibodies and histologically confirmed autoimmune lymphocytic oophoritis...
  11. ncbi request reprint Functional well-being is positively correlated with spiritual well-being in women who have spontaneous premature ovarian failure
    June L Ventura
    Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1103, USA
    Fertil Steril 87:584-90. 2007
    ..To examine the relationship between spiritual well-being and functional well-being in women who have spontaneous premature ovarian failure...
  12. pmc Normalization of serum luteinizing hormone levels in women with 46,XX spontaneous primary ovarian insufficiency
    Vaishali B Popat
    Integrative Reproductive Medicine Unit, Reproductive Biology and Medicine Branch, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    Fertil Steril 89:429-33. 2008
    ..To determine the proportion of women with primary ovarian insufficiency who achieve normal serum LH levels on transdermal E(2) therapy...
  13. pmc Women with spontaneous 46,XX primary ovarian insufficiency (hypergonadotropic hypogonadism) have lower perceived social support than control women
    Susan A Orshan
    Integrated Reproductive Medicine Unit, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    Fertil Steril 92:688-93. 2009
    ..To test the hypothesis that women with spontaneous primary ovarian insufficiency differ from control women with regard to perceived social support and to investigate the relationship between perceived social support and self-esteem...
  14. pmc The menstrual cycle: a biological marker of general health in adolescents
    Vaishali B Popat
    Integrative Reproductive Medicine Unit, Intramural Research Program on Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Ann N Y Acad Sci 1135:43-51. 2008
    ..Both patients and clinicians need to view the ovary as an important endocrine organ that helps maintain health, especially bone health...
  15. ncbi request reprint Pilot study investigating the age-related decline in ovarian function of regularly menstruating normal women
    Carmen L Pastor
    Developmental Endocrinology Branch, Intramural Research Program, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 84:1462-9. 2005
    ..To use a pilot study to investigate markers of the age-related decline in ovarian function of regularly menstruating normal women...
  16. pmc Depression in women with spontaneous 46, XX primary ovarian insufficiency
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, 10 Center Drive MSC 1277, Bethesda, Maryland 20892 1277, USA
    J Clin Endocrinol Metab 96:E278-87. 2011
    ..Indeed, studies suggest that depression and/or its pharmacological treatment contribute to the onset of POI...
  17. ncbi request reprint The FMR1 premutation and reproduction
    Michael D Wittenberger
    Intramural Research Program, Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    Fertil Steril 87:456-65. 2007
    ..It is now recognized that this was incorrect, specifically with respect to female reproduction...
  18. pmc Five mutations of mitochondrial DNA polymerase-gamma (POLG) are not a prevalent etiology for spontaneous 46,XX primary ovarian insufficiency
    Zhi Bin Tong
    Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    Fertil Steril 94:2932-4. 2010
    ..Of 201 women with 46,XX sPOI analyzed, we found only one case (0.5%, 95% confidence interval 0-3%) of heterozygosity for a POLG mutation, suggesting that this is not a common genetic etiology for this form of infertility...
  19. ncbi request reprint Investigation of the human stem cell factor KIT ligand gene, KITLG, in women with 46,XX spontaneous premature ovarian failure
    Emily S Hui
    Section on Women s Health Research, Developmental Endocrinology Branch, National Institutes of Health, Bethesda, Maryland, USA
    Fertil Steril 85:1502-7. 2006
    ..This ligand-receptor interaction is known to play important roles in mouse germ cell migration and proliferation...
  20. ncbi request reprint Impaired insulin secretion in the Turner metabolic syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10 10N262, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 89:3516-20. 2004
    ....
  21. ncbi request reprint A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development
    Zhi Bin Tong
    Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Reprod 17:903-11. 2002
    ..Mater is a maternal effect gene required for early embryonic development in mice, and its protein serves as an autoantigen in a mouse model of autoimmune premature ovarian failure...
  22. ncbi request reprint Developmental expression and subcellular localization of mouse MATER, an oocyte-specific protein essential for early development
    Zhi Bin Tong
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1862, USA
    Endocrinology 145:1427-34. 2004
    ..The presence of MATER protein in mitochondria and nucleoli suggests that it may participate in both cytoplasmic and nuclear events during early development...
  23. pmc A new approach to primary ovarian insufficiency
    Saima Rafique
    Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, CRC, Room 1 3140, Bethesda, MD 20892 1109, USA
    Obstet Gynecol Clin North Am 39:567-86. 2012
    ..They also need assessment with regard to bone health, thyroid and adrenal function, determination of FMR1 premutation and karyotype status, and ongoing estradiol-progestin hormone replacement...
  24. pmc The psychology of antecedents to adult reproductive disorders in adolescent girls
    Sharon N Covington
    Integrative Reproductive Medicine Unit, Intramural Research Program on Reproductive and Adult Endocrinology, National Institutes of Child Health and Human Development, Bethesda, MD, USA
    Ann N Y Acad Sci 1135:155-62. 2008
    ..The goal for parent and clinician is to help the adolescent girl formulate positive self-esteem and body image, despite impaired fertility...
  25. ncbi request reprint An update: spontaneous premature ovarian failure is not an early menopause
    Lawrence M Nelson
    Intramural Research Program, Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Fertil Steril 83:1327-32. 2005
    ..To update clinicians regarding the management of women with spontaneous premature ovarian failure (POF)...
  26. ncbi request reprint Assessing the emotional needs of women with spontaneous premature ovarian failure
    Allison A Groff
    Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Fertil Steril 83:1734-41. 2005
    ..To examine women's emotional responses to learning the diagnosis of premature ovarian failure (POF) and identify the sources of support used for coping...
  27. ncbi request reprint A pilot study of an investigational testosterone transdermal patch system in young women with spontaneous premature ovarian failure
    Sophia N Kalantaridou
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 90:6549-52. 2005
    ..Evidence suggests that young women with spontaneous premature ovarian failure (sPOF) have significantly lower androgen levels than age-matched regularly menstruating women...
  28. ncbi request reprint A woman with spontaneous premature ovarian failure gives birth to a child with fragile X syndrome
    Emily C Corrigan
    Section on Women s Health Research, Developmental Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    Fertil Steril 84:1508. 2005
    ..To inform clinicians about a reproductive risk associated with spontaneous premature ovarian failure and the fragile X mental retardation 1 gene (FMR1)...
  29. ncbi request reprint Dry eye signs and symptoms in women with premature ovarian failure
    Janine A Smith
    Division of Epidemiology and Clinical Research, National Eye Institute, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1863, USA
    Arch Ophthalmol 122:151-6. 2004
    ..To examine whether women with premature ovarian failure (POF) have abnormal findings in ocular surface or tear parameters and whether they report symptoms of ocular discomfort compared with age-matched controls...
  30. ncbi request reprint Selective reduction in cortical bone mineral density in turner syndrome independent of ovarian hormone deficiency
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:5717-22. 2003
    ..We conclude that there is a selective deficiency in forearm cortical bone in TS that appears independent of ovarian hormone exposure and is probably related to X-chromosome gene(s) haploinsufficiency...
  31. pmc A family systems approach to primary ovarian insufficiency
    Sharon N Covington
    Integrative Reproductive Medicine Group, Intramural Research Program on Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    J Pediatr Adolesc Gynecol 24:137-41. 2011
    ..This paper provides a starting point for parents and clinicians with "Tips and Tools for Talking: Helping Your Daughter Understand Primary Ovarian Insufficiency"...
  32. ncbi request reprint Meeting the needs of young women with secondary amenorrhea and spontaneous premature ovarian failure
    Nahrain H Alzubaidi
    Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Obstet Gynecol 99:720-5. 2002
    ..To investigate the experiences of young women with spontaneous premature ovarian failure with regard to the initial presenting symptom, promptness of diagnosis, and patient education...
  33. pmc Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea
    Teresa D Gallardo
    Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA
    Hum Reprod 23:216-21. 2008
    ..The forkhead transcription factor Foxo3 is a master regulator and potent suppressor of primordial follicle activation. Loss of Foxo3 function in the mouse leads to premature ovarian failure (POF) due to global follicle activation...
  34. ncbi request reprint Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women
    Joyce Y Tung
    Department of Obstetrics, Program in Human Embryonic Stem Cell Biology, Center for Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94143, USA
    Hum Genet 118:730-40. 2006
    ..Single SNP and haplotype analysis suggested that SNPs in the DAZL gene may act jointly to affect common reproductive characteristics in the human population...
  35. ncbi request reprint Adolescent girls, the menstrual cycle, and bone health
    Paula J Adams Hillard
    Department of Ob Gyn, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Pediatr Endocrinol Metab 16:673-81. 2003
    ..Attention to menstrual irregularity and the earlier diagnosis of conditions causing it may lead to interventions that will benefit life-long bone health...
  36. ncbi request reprint Amenorrhea and bone health in adolescents and young women
    Catherine M Gordon
    Children s Hospital Bone Health Center and Department of Pediatrics, Harvard Medical School, Divisions of Adolescent Young Adult Medicine and Endocrinology, Children s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Obstet Gynecol 15:377-84. 2003
    ..We present an update on amenorrhea in adolescent girls and young women. Amenorrhea may herald the onset of estrogen deficiency, which can adversely affect peak bone mass and ultimate risk of osteoporosis...
  37. ncbi request reprint Identification of new variants of human BMP15 gene in a large cohort of women with premature ovarian failure
    Elisa Di Pasquale
    Department of Medical Sciences, University of Milan, Italy
    J Clin Endocrinol Metab 91:1976-9. 2006
    ..The pathogenesis is unknown in most cases. We recently reported two sisters with PA carrying a heterozygous mutation of BMP15 gene (locus Xp11.2), but the prevalence of BMP15 variations in the POF population is unknown...