Research Topics
| Harold S NelsonSummaryAffiliation: National Jewish Medical and Research Center Country: USA Publications
| Collaborators
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Detail Information
Publications
One-year treatment with mometasone furoate in chronic obstructive pulmonary diseasePeter M A Calverley
Department of Medicine, University Hospital Aintree, Liverpool, UK
Respir Res 9:73. 2008..031). MF-DPI treatment was well tolerated.Once-daily MF-DPI improved lung function and health status in subjects with moderate-to-severe COPD and was comparable to BID MF-DPI...- Efficacy and safety of fluticasone propionate 44 microg/salmeterol 21 microg administered in a hydrofluoroalkane metered-dose inhaler as an initial asthma maintenance treatmentHarold S Nelson
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Ann Allergy Asthma Immunol 91:263-9. 2003.... - Allergen immunotherapy: where is it now?Harold S Nelson
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:769-79. 2007.... - Advances in upper airway diseases and allergen immunotherapyHarold S Nelson
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:872-80. 2007.... - Combination therapy of long-acting beta agonists and inhaled corticosteroids in the management of chronic asthmaHarold S Nelson
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Curr Allergy Asthma Rep 5:123-9. 2005..Also, at least for combination therapies including formoterol, adjustable dosing and perhaps even use as a rescue as well as a maintenance therapy may be possible... - Advances in upper airway diseases and allergen immunotherapyHarold S Nelson
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Allergy Clin Immunol 115:676-84. 2005..No symptom improvement was seen the first year, but symptoms were reduced the second year without further treatment... - Long-acting beta-agonists in adult asthma: Evidence that these drugs are safeHarold S Nelson
National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
Prim Care Respir J 15:271-7. 2006..Studies in subjects receiving combination therapy with LABAs plus ICSs suggest that, if anything, there is an enhanced anti-inflammatory action with the LABA/ICS combination superior to that achieved with ICS alone at the same dose... - Advances in upper airway diseases and allergen immunotherapyHarold S Nelson
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Allergy Clin Immunol 117:1047-53. 2006..In addition, an update of the "Practice parameters on sinusitis" was published. The major focus in allergen immunotherapy continues to be sublingual administration... - Is there a problem with inhaled long-acting beta-adrenergic agonists?Harold S Nelson
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 117:3-16; quiz 17. 2006..This suggests that these outcomes were not a direct toxic effect of the drugs and increases the possibility that they resulted from an interaction between relief of symptoms by beta(2)-agonists and delay in seeking medical care... - Efficacy and safety of allergen immunotherapy in childrenHarold S Nelson
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Ann Allergy Asthma Immunol 96:S2-5. 2006..To determine the efficacy and safety of immunotherapy in children with allergic rhinitis and allergic asthma... - Update on the safety of long-acting beta-agonists in combination with inhaled corticosteroids for the treatment of asthmaHarold S Nelson
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Ann Allergy Asthma Immunol 102:11-5. 2009.... - Multiallergen immunotherapy for allergic rhinitis and asthmaHarold S Nelson
Department of Medicine, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 123:763-9. 2009..It is concluded that simultaneous administration of more than 1 allergen extract is clinically effective. However, more studies are needed, particularly with more than 2 allergen extracts and with sublingual administration... - Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program studyJohn M Brehm
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
J Allergy Clin Immunol 126:52-8.e5. 2010..Vitamin D status might play a role in preventing asthma exacerbations... - Hydrofluoroalkane-134A beclomethasone or chlorofluorocarbon fluticasone: effect on small airways in poorly controlled asthmaTorpong Thongngarm
Division of Allergy and Clinical Immunology, Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson St, Denver, CO 80206, USA
J Asthma 42:257-63. 2005.... - Immunologic response to administration of standardized dog allergen extract at differing dosesAnne M Lent
Division of Allergy and Clinical Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 118:1249-56. 2006..The immunologic response to immunotherapy with dog extract is not well characterized... - The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterolHarold S Nelson
National Jewish Medical and Research Center, Denver, CO, USA
Chest 129:15-26. 2006..Whether this risk is due to factors including but not limited to a physiologic treatment effect, genetic factors, or patient behaviors leading to poor outcomes remains unknown... - In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthmaRobyn T Cohen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachussetts, USA
J Allergy Clin Immunol 126:491-7. 2010..Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma... - Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management programSunita Sharma
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Allergy Clin Immunol 122:921-928.e4. 2008..Among asthmatic subjects, bronchodilator response (BDR) to inhaled beta(2)-adrenergic agonists is variable, and the significance of a consistent response over time is unknown... - Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalersHarold S Nelson
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 112:29-36. 2003..After administration from a single inhaler, fluticasone propionate and salmeterol might codeposit in the airways. It is hypothesized that this codeposition offers an increased opportunity for synergistic interaction to occur... - Advances in upper airway diseases and allergen immunotherapyHarold S Nelson
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 111:S793-8. 2003..The latter, because of cross-reacting profilins, is often clinically irrelevant... - Cardiac safety profile of nebulized formoterol in adults with COPD: a 12-week, multicenter, randomized, double- blind, double-dummy, placebo- and active-controlled trialHarold S Nelson
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Clin Ther 29:2167-78. 2007.... - Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trialWilliam W Busse
Department of Medicine, Section of Allergy, Pulmonary, and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
Am J Respir Crit Care Med 178:1002-8. 2008..The mechanism of action likely involves inhibition of proinflammatory cytokine generation by IL-2R blockade in activated T cells. Clinical trial registered with www.clinicaltrials.gov (NCT00028288)... - Advances in upper airway diseases and allergen immunotherapyHarold S Nelson
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Allergy Clin Immunol 113:635-42. 2004.... - Specific immunotherapy with allergen mixes: what is the evidence?Harold S Nelson
National Jewish Health, Denver, Colorado 80206, USA
Curr Opin Allergy Clin Immunol 9:549-53. 2009..The purpose is to review the published evidence for the use of multiallergen mixes in subcutaneous and sublingual immunotherapy... - Short-term safety of somatropin inhalation powder in adults with mild to moderate asthmaHarold S Nelson
Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
Allergy Asthma Proc 30:325-32. 2009..Future studies of SIP may enroll subjects with mild to moderate asthma for longer-term evaluation of safety and efficacy... - Effect of the inhaled corticosteroid mometasone on small airway patency in patients with asthmaHarold S Nelson
Department of Medicine, National Jewish Health, Denver, Colorado 80206, USA
Allergy Asthma Proc 30:284-92. 2009..M. and P.M. peak expiratory flows, and albuterol use. Mometasone delivered by a dry powder inhaler improved asthma control and pulmonary function in tests reflecting both large and small airways... - Response to sublingual immunotherapy with grass pollen extract: monotherapy versus combination in a multiallergen extractSheila M Amar
National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 124:150-156.e1-5. 2009..To date, there have been no randomized, double-blind studies showing the effectiveness of sublingual immunotherapy with multiple allergens... - Budesonide Turbuhaler delivered once daily improves health-related quality of life and maintains improvements with a stepped-down dose in adults with mild to moderate asthmaThomas B Casale
Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
Ann Allergy Asthma Immunol 90:323-30. 2003..Budesonide inhalation powder administered via Turbuhaler (budesonide Turbuhaler, AstraZeneca LP, Wilmington, DE) is proven efficacious and safe in the treatment of mild to severe asthma... - Dose dependence and time course of the immunologic response to administration of standardized cat allergen extractAnil Nanda
Department of Medicine, National Jewish Medical Center, University of Colorado, Denver, CO 80206, USA
J Allergy Clin Immunol 114:1339-44. 2004..CONCLUSION: The response to titrated nasal allergen challenge, titrated skin prick testing, and allergen-specific IgG4 measurement to cat immunotherapy at 5 weeks is predictive of the response at 1 year... - Mediator measurements after daily instillation of allergen: Increased IL-5 and decreased IFN-gammaRobert A McDermott
Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Allergy Asthma Proc 29:146-51. 2008..01) and a decrease in IFN-gamma (p = 0.02) at day 9. Daily instillation of moderate doses of allergen intranasally is characterized by persistent symptoms, elevation of IL-5, and reduced levels of IFN-gamma... - Prospects for antihistamines in the treatment of asthmaHarold S Nelson
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 112:S96-100. 2003..If higher doses are sedative, the addition of decongestants or leukotriene-receptor antagonists might enhance the effects of lower doses of the antihistamines... - A comparison of methods for assessing hypothalamic-pituitary-adrenal (HPA) axis activity in asthma patients treated with inhaled corticosteroidsHarold S Nelson
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Clin Pharmacol 42:319-26. 2002..Because it is noninvasive, salivary cortisol measurement offers distinct advantages as a screening method for detecting pronounced HPA axis suppression in asthma patients receiving corticosteroid therapy... - A double-blind, placebo-controlled immunotherapy dose-response study with standardized cat extractPenelope A Ewbank
National Jewish Medical and Research Center, Denver, Colo 80206, USA
J Allergy Clin Immunol 111:155-61. 2003..These findings suggest that a maintenance dose of 15.0 microg of Fel d 1 is most apt to be clinically effective for allergen immunotherapy... - A 47-year-old woman with progressive dyspnea and coughSitesh R Roy
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Ann Allergy Asthma Immunol 88:364-9. 2002 - Unresponsive wheezing to asthma therapy in a 32-year-old femalePeck Y Ong
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
Ann Allergy Asthma Immunol 90:199-202. 2003..This will prevent unnecessary side effects of asthma therapy and provide prompt treatment for other diseases that may require urgent attention... - Subcutaneous injection immunotherapy for optimal effectivenessHarold S Nelson
Department of Medicine, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson Street, Denver, CO 80206, USA
Immunol Allergy Clin North Am 31:211-26, viii. 2011.... - Preparing and mixing allergen vaccinesHarold S Nelson
National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
Clin Allergy Immunol 18:457-79. 2004 - Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitisBrenda J Guyer
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Allergy Asthma Proc 27:208-13. 2006..Single-dose R112 appears safe and significantly reduces PGD2 but not histamine or tryptase release in response to allergen challenge in subjects with AR... - Evaluation of cytokines in nasal secretions after nasal antigen challenge: lack of influence of antihistaminesGreg W Bensch
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Ann Allergy Asthma Immunol 88:457-62. 2002..Symptoms of allergic rhinitis using this type of antigen challenge did not differ from treatment with fexofenadine versus placebo... - Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adultsHarold S Nelson
Department of Medicine, Division of Allergy and Immunology, National Jewish Health, Denver, Colo, USA
J Allergy Clin Immunol 127:72-80, 80.e1-2. 2011..Trials of sublingual formulations in North America are needed to confirm European efficacy and safety data... - Measurement of changes in mRNA for IL-5 in noninvasive scrapings of nasal epithelium taken from patients undergoing nasal allergen challengeStephen C Dreskin
Department of Medicine, Division of Allergy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box B164, Denver 80262, USA
J Immunol Methods 268:189-95. 2002..Furthermore, these changes can be measured quantitatively in very small amounts of tissue... - Pairwise comparison of levalbuterol versus racemic albuterol in the treatment of moderate-to-severe asthmaWarren W Pleskow
Radiant Research, Encinitas, California, USA
Allergy Asthma Proc 25:429-36. 2004..Levalbuterol in the absence of the (S)-isomer provided greater bronchodilation than the same quantity of (R)-albuterol delivered as the racemate. These data suggest that (S)-albuterol may compromise the efficacy of (R)-albuterol... - Effects of esomeprazole 40 mg twice daily on asthma: a randomized placebo-controlled trialToni O Kiljander
Department of Pulmonary Diseases, Tampere University Hospital, FIN 33521, Tampere, Finland
Am J Respir Crit Care Med 173:1091-7. 2006..Gastroesophageal reflux disease (GERD) is common in patients with asthma, suggesting an interaction between the two conditions... - Sublingual immunotherapy: a comprehensive reviewLinda S Cox
Nova Southeastern University School of Osteopathic Medicine, Davie, Florida, USA
J Allergy Clin Immunol 117:1021-35. 2006..All of these factors should be given careful consideration by anyone contemplating initiating SLIT treatment for their allergic patients... - Fluticasone propionate nasal spray is superior to montelukast for allergic rhinitis while neither affects overall asthma controlRobert A Nathan
Asthma and Allergy Associates, P C, 2709 North Tejon St, Colorado Springs, CO 80907, USA
Chest 128:1910-20. 2005..Asthma and allergic rhinitis are both highly prevalent diseases and often coexist in patients... - Clarification of salmeterol studiesHarold S Nelson
Chest 123:965. 2003 - Efficacy and safety of formoterol fumarate delivered by nebulization to COPD patientsNicholas J Gross
Hines VA Hospital, Stritch Loyola School of Medicine, P O Box 1485, Hines, IL 60141, USA
Respir Med 102:189-97. 2008..Nebulized FFIS provided significant improvement in respiratory status and quality of life in subjects with COPD relative to placebo and was well tolerated. The efficacy and safety profile of FFIS was comparable to FA DPI... - Safety of long-acting beta-agonists in asthma: a reviewJohn Oppenheimer
UMDNJ New Jersey Medical School, Pulmonary and Allergy Association, Summit, New Jersey 07901, USA
Curr Opin Pulm Med 14:64-9. 2008..This review highlights a growing literature regarding the safety of long-acting beta-2 agonists as add-on therapy to inhaled corticosteroids... - Comparison of patient preference and ease of teaching inhaler technique for Pulmicort Turbuhaler versus pressurized metered-dose inhalersMichael J Welch
Allergy and Asthma Medical Group and Research Center, San Diego, California 92123, USA
J Aerosol Med 17:129-39. 2004..05). Overall, patients preferred Pulmicort Turbuhaler over pMDIs and required less time to be taught how to correctly use Turbuhaler trade mark... - Safety of long-acting beta-agonistsHarold S Nelson
Ann Intern Med 145:706; author reply 708-10. 2006 - Skin testingJohn Oppenheimer
Department of Internal Medicine, Section of Allergy and Immunology, Morristown Memorial Hospital, Morristown, New Jersey, USA
Ann Allergy Asthma Immunol 96:S6-12. 2006..CONCLUSIONS: Allergists must consider controllable variables that affect skin test results and their interpretation. When not considered, they may be responsible for some of the inaccuracies associated with allergy skin testing... - A possible role for cyclooxygenase 2 inhibitors in the treatment of chronic urticariaMiriam K Anand
J Allergy Clin Immunol 111:1133-6. 2003 - How ill the wind? Issues in aeroallergen samplingHarold S Nelson
Department of Internal Medicine, University of Michigan, Medical Center Ann Arbor, MI 48109 0380, USA
J Allergy Clin Immunol 112:3-8; quiz 9. 2003..Resulting data describing airborne prevalence gain special value in light of competent inspection of implicated venues and consideration of alternative sources, such as incursion of bioaerosols into enclosed spaces... - Clinically important differences in health-related quality of life for patients with asthma: an expert consensus panel reportKathleen W Wyrwich
Saint Louis University Department of Research Methodology, St Louis, Missouri, USA
Ann Allergy Asthma Immunol 91:148-53. 2003.... - Potential adverse effects of the inhaled corticosteroidsH William Kelly
Department of Pediatrics, University of New Mexico Children's Hospital, ACC Building 3rd Floor, 2211 Lomas Boulevard NE, Albuquerque, NM 87131-5311, USA
J Allergy Clin Immunol 112:469-78; quiz 479. 2003..The data are insufficient to determine whether there is an effect on attainment of predicted adult height. The ICSs affect bone mineral density and risk of fractures in a dose-dependent fashion that appears significant at high doses... - Skin testing: a survey of allergistsJohn Oppenheimer
Department of Internal Medicine, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
Ann Allergy Asthma Immunol 96:19-23. 2006..Although anecdotal data suggest widely varying practices in skin testing by allergists, the diversity and relative frequency of these practices have not been documented... - A comparison of multiheaded devices for allergy skin testingHarold S Nelson
J Allergy Clin Immunol 113:1218-9. 2004 - Effect of long-term corticosteroid use on bone mineral density in children: a prospective longitudinal assessment in the childhood Asthma Management Program (CAMP) studyH William Kelly
Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
Pediatrics 122:e53-61. 2008..Thus, we assessed the effects of multiple short courses of oral corticosteroids and long-term inhaled corticosteroids on bone mineral accretion over a period of years...