T E Nash

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Unraveling how Giardia infections cause disease
    Theodore E Nash
    Gastrointestinal Parasites Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 123:2346-7. 2013
  2. doi request reprint Edema surrounding calcified intracranial cysticerci: clinical manifestations, natural history, and treatment
    Theodore Nash
    Laboratory of Parasitic Diseases, National Institues of Health, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Pathog Glob Health 106:275-9. 2012
  3. pmc The Giardia lamblia vsp gene repertoire: characteristics, genomic organization, and evolution
    Rodney D Adam
    Departments of Medicine and Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA
    BMC Genomics 11:424. 2010
  4. ncbi request reprint Surface antigenic variation in Giardia lamblia
    Theodore E Nash
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Mol Microbiol 45:585-90. 2002
  5. ncbi request reprint Human case management and treatment of cysticercosis
    Theodore E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Bldg 4, Rm B1 06, Bethesda, MD 21043, USA
    Acta Trop 87:61-9. 2003
  6. pmc Calcific neurocysticercosis and epileptogenesis
    T E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Neurology 62:1934-8. 2004
  7. pmc Treatment of neurocysticercosis: current status and future research needs
    T E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Neurology 67:1120-7. 2006
  8. ncbi request reprint Calcified cysticerci provoke perilesional edema and seizures
    T E Nash
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Infect Dis 33:1649-53. 2001
  9. pmc Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study
    Theodore E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 7:1099-105. 2008
  10. pmc Variant-specific surface protein switching in Giardia lamblia
    T E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 69:1922-3. 2001

Collaborators

Detail Information

Publications36

  1. pmc Unraveling how Giardia infections cause disease
    Theodore E Nash
    Gastrointestinal Parasites Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 123:2346-7. 2013
    ..He denied any symptoms and was not allowed to prepare food. Treatment with metronidazole, nitazoxanide, and albendazole failed to eradicate the infection. He was successfully treated with the combination of paromomycin and metronidazole...
  2. doi request reprint Edema surrounding calcified intracranial cysticerci: clinical manifestations, natural history, and treatment
    Theodore Nash
    Laboratory of Parasitic Diseases, National Institues of Health, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Pathog Glob Health 106:275-9. 2012
    ..Immunosuppressive and anti-inflammatory agents may be useful in prevention and/or treatment of this phenomenon...
  3. pmc The Giardia lamblia vsp gene repertoire: characteristics, genomic organization, and evolution
    Rodney D Adam
    Departments of Medicine and Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA
    BMC Genomics 11:424. 2010
    ..The variable expression of the variant-specific surface protein (VSP) genes may contribute to this prolonged infection. Only one is expressed at a time, and switching expression from one gene to another occurs by an epigenetic mechanism...
  4. ncbi request reprint Surface antigenic variation in Giardia lamblia
    Theodore E Nash
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Mol Microbiol 45:585-90. 2002
    ..The molecular mechanisms involved in antigenic variation are not known but appear to differ from those known to occur in other protozoa...
  5. ncbi request reprint Human case management and treatment of cysticercosis
    Theodore E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, 9000 Rockville Pike, Bldg 4, Rm B1 06, Bethesda, MD 21043, USA
    Acta Trop 87:61-9. 2003
    ....
  6. pmc Calcific neurocysticercosis and epileptogenesis
    T E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Neurology 62:1934-8. 2004
    ..A better understanding of the natural history, frequency, epidemiology, and pathophysiology of calcific cysticercosis and associated disease manifestations is needed to define its importance, treatment, and prevention...
  7. pmc Treatment of neurocysticercosis: current status and future research needs
    T E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Neurology 67:1120-7. 2006
    ....
  8. ncbi request reprint Calcified cysticerci provoke perilesional edema and seizures
    T E Nash
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Infect Dis 33:1649-53. 2001
    ..Those with an increased proportion of enhancing calcified lesions were more likely to show perilesional edema. Edema around calcified lesions is common in this population and is associated with seizures and neurological morbidity...
  9. pmc Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study
    Theodore E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 7:1099-105. 2008
    ..Transient perilesional brain oedema is seen around the calcified foci but its importance, association with seizures, incidence, and pathophysiology are unknown...
  10. pmc Variant-specific surface protein switching in Giardia lamblia
    T E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 69:1922-3. 2001
    ..Two VSPs were detected on the surface of single trophozoites. Dual expression persisted for 13 h but disappeared at 36 h, as in other parasites that undergo surface antigenic variation...
  11. ncbi request reprint Biological selection of variant-specific surface proteins in Giardia lamblia
    S M Singer
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    J Infect Dis 183:119-24. 2001
    ..Thus, the large number of VSP genes in G. lamblia may allow the parasite to infect multiple different hosts, and antigenic variation could be a mechanism to expand the parasite's host range...
  12. pmc T-cell-dependent control of acute Giardia lamblia infections in mice
    S M Singer
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Infect Immun 68:170-5. 2000
    ..lamblia. We conclude that a T-cell-dependent mechanism is essential for controlling acute Giardia infections and that this mechanism is independent of antibody and B cells...
  13. ncbi request reprint Episomal and integrated maintenance of foreign DNA in Giardia lamblia
    S M Singer
    Laboratory of Parasitic Disease, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Mol Biochem Parasitol 92:59-69. 1998
    ..Together these tools should greatly enhance our ability to study both the basic biology and the pathogenesis of this ubiquitous parasite...
  14. ncbi request reprint Cysteine-rich variant surface proteins of Giardia lamblia
    A Aggarwal
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
    Mol Biochem Parasitol 32:39-47. 1989
    ..Surface antigenic variation occurs commonly in Giardia isolates, and the major surface antigens appear to comprise a family of cysteine-rich proteins...
  15. pmc Developmental expression of two spore wall proteins during maturation of the microsporidian Encephalitozoon intestinalis
    J R Hayman
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Infect Immun 69:7057-66. 2001
    ..The characterization of two immunogenic SWPs from E. intestinalis will allow the study of exospore structure and function and may lead to the development of useful tools in the diagnosis and treatment of microsporidiosis...
  16. ncbi request reprint Edema associated with calcified lesions in neurocysticercosis
    T E Nash
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Neurology 53:777-81. 1999
    ..To determine serial MRI and CT abnormalities around calcified cysts due to cysticercosis in previously treated patients during periods of seizure activity...
  17. ncbi request reprint Transcriptional analysis of the glutamate dehydrogenase gene in the primitive eukaryote, Giardia lamblia. Identification of a primordial gene promoter
    J Yee
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:11432-9. 2000
    ..This report describes one of the first functional gene promoter and its cognate DNA-binding protein in this primitive eukaryote...
  18. ncbi request reprint Initiator and upstream elements in the alpha2-tubulin promoter of Giardia lamblia
    H G Elmendorf
    Laboratory of Parasitic Diseases, NIH, Bethesda, MD 20892 0425, USA
    Mol Biochem Parasitol 113:157-69. 2001
    ..In particular, the short and diverse sequences that function in transcription initiation in Giardia suggest the potential for relaxed transcriptional regulation...
  19. ncbi request reprint Treatment of patients with refractory giardiasis
    T E Nash
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Infect Dis 33:22-8. 2001
    ..We report our experience with 6 patients with giardiasis, for whom therapy with a combination of quinacrine and metronidazole resulted in cures for 5 of the 6 patients...
  20. pmc The abundance of sterile transcripts in Giardia lamblia
    H G Elmendorf
    Laboratory of Parasitic Diseases, NIH, Bethesda, MD 20892 0425, USA
    Nucleic Acids Res 29:4674-83. 2001
    ..In either case, the presence of such a large pool of sterile antisense transcripts is dramatic evidence of the unusual molecular machinery of the early diverging protist G.lamblia...
  21. ncbi request reprint A novel palmitoyl acyl transferase controls surface protein palmitoylation and cytotoxicity in Giardia lamblia
    Maria C Touz
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Mol Microbiol 58:999-1011. 2005
    ..These results show that VSPs are palmitoylated at the cysteine within the conserved tail by gPAT and indicate an essential function of palmitoylation in control of VSP-mediated signalling and processing...
  22. ncbi request reprint Epigenetic mechanisms are involved in the control of Giardia lamblia antigenic variation
    Liudmila Kulakova
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Mol Microbiol 61:1533-42. 2006
    ..Lack of vsp rearrangements and acetylation of expressed immediate upstream regions implicates involvement of epigenetic mechanisms in antigenic variation...
  23. ncbi request reprint Identification and characterization of a novel secretory granule calcium-binding protein from the early branching eukaryote Giardia lamblia
    Maria C Touz
    Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, CP 5000 Cordoba, Argentina
    J Biol Chem 277:50557-63. 2002
    ..Inhibition of gGSP expression abolishes cyst wall formation, suggesting that this secretory granule protein regulates Ca(2+)-dependent degranulation of ESVs during cyst wall formation...
  24. ncbi request reprint Prolonged perilesional edema after treatment of parenchymal neurocysticercosis: methotrexate as a corticosteroid-sparing agent
    Paul B Keiser
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Infect Dis 36:e122-6. 2003
    ....
  25. pmc Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi-like organelle to peripheral vacuoles in the primitive eukaryote Giardia lamblia
    Maria C Touz
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 15:3053-60. 2004
    ....
  26. ncbi request reprint Sorting of encystation-specific cysteine protease to lysosome-like peripheral vacuoles in Giardia lamblia requires a conserved tyrosine-based motif
    Maria C Touz
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:6420-6. 2003
    ..Because Giardia is one of the earliest branching protist, these results demonstrate that sorting motifs for specific protein traffic developed very early during eukaryotic evolution...
  27. ncbi request reprint Genetic manipulation of Giardia lamblia
    Sara R Davis-Hayman
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Mol Biochem Parasitol 122:1-7. 2002
    ..In the near future, both transfection systems will be potent tools in our investigations of the perplexing questions in Giardia biology...
  28. ncbi request reprint The activity of a developmentally regulated cysteine proteinase is required for cyst wall formation in the primitive eukaryote Giardia lamblia
    Maria C Touz
    Catedra de Bioquimica y Biologia Molecular, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, CP5000 Argentina
    J Biol Chem 277:8474-81. 2002
    ..These features make this enzyme the most divergent cathepsin C identified to date and provide new insights regarding cyst wall formation in Giardia...
  29. ncbi request reprint New concepts in the diagnosis and management of neurocysticercosis (Taenia solium)
    Hector H Garcia
    Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima, Peru
    Am J Trop Med Hyg 72:3-9. 2005
    ..These advances now permit a much better integration of clinical, serologic, and imaging data for diagnosis and therapeutic purposes...
  30. pmc Current consensus guidelines for treatment of neurocysticercosis
    Hector H Garcia
    Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Universidad Peruana Cayetano Heredia School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
    Clin Microbiol Rev 15:747-56. 2002
    ....
  31. ncbi request reprint Methotrexate as a corticosteroid-sparing agent in complicated neurocysticercosis
    Edward Mitre
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, USA
    Clin Infect Dis 44:549-53. 2007
    ..The purpose of this study was to determine whether methotrexate can be used as an effective corticosteroid-sparing or replacement agent in patients with complicated neurocysticercosis...
  32. ncbi request reprint Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia
    Andrey Galkin
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 282:4859-67. 2007
    ..Determinants of catalysis and substrate recognition, derived from comparison of the G. lamblia FBPA structure with Escherichia coli FBPA and with a closely related enzyme, E. coli tagatose-1,6-bisphosphate aldolase (TBPA), are described...
  33. ncbi request reprint Encystation-specific regulation of the cyst wall protein 2 gene in Giardia lamblia by multiple cis-acting elements
    Sara R Davis-Hayman
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Int J Parasitol 33:1005-12. 2003
    ..These results indicate that Giardia has developed a classic repressor mechanism(s) that allows tight, encystation-specific control by the cwp2 promoter...
  34. ncbi request reprint Sterol and fatty acid regulatory pathways in a Giardia lamblia-derived promoter: evidence for SREBP as an ancient transcription factor
    Tilla S Worgall
    Department of Pathology, Columbia University, New York, NY 10032, USA
    J Lipid Res 45:981-8. 2004
    ..The data show that SREBP binds to and can modulate transcription of a regulatory element from an ancient eukaryote and suggest the existence of an SREBP homolog in GL...
  35. ncbi request reprint Examination of a novel head-stalk protein family in Giardia lamblia characterised by the pairing of ankyrin repeats and coiled-coil domains
    Heidi G Elmendorf
    Biology Department, 348 Reiss Building, 37th and O Sts NW, Georgetown University, Washington, DC 20057, USA
    Int J Parasitol 35:1001-11. 2005
    ..The combination of the localisation and the structural and functional motifs of GASP-180 make it a strong candidate to participate in control of flagellar activity...