Research Topics
Genomes and Genes | Toshihiro NankiSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Blocking tumor necrosis factor inhibits radiographic damage even in patients who show minimal or no clinical improvement: comment on the concise communication by BoersPeter E Lipsky
Arthritis Rheum 46:2817-8; author reply 2718-21. 2002- Integrating biologic therapy into the comprehensive care of patients with rheumatoid arthritisPeter E Lipsky
Intramural Research Program, The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA
J Rheumatol Suppl 72:54-7. 2005.... 
Interleukin-6 and rheumatic diseasesPeter E Lipsky
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Rockville Pike, Bethesda, Maryland, USA
Arthritis Res Ther 8:S4. 2006....- Why does rheumatoid arthritis involve the joints?Peter E Lipsky
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
N Engl J Med 356:2419-20. 2007 - Why do we not have a cure for rheumatoid arthritis?Hani D El-Gabalawy
Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
Arthritis Res 4:S297-301. 2002..The means to do this are currently unknown but should serve as a major focus of research... 
Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordii Hook F on nephritis in NZB/W F1 miceXuelian Tao
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Rockville Pike, Bethesda, MD 20892, USA
Arthritis Res Ther 8:R24. 2006..Treatment with the EA extract significantly inhibited the progression of kidney disease in NZB/W F1 mice, though had no significant effect on the levels of anti-dsDNA antibody...- B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissueArne Hansen
Charite Center CC 12, Department of Medicine, Charite Universitatsmedizin Berlin, Charité Platz 01, 10098 Berlin, Germany
Arthritis Res Ther 9:218. 2007..These findings add to our understanding of the pathogenesis of this autoimmune inflammatory disorder and may result in new therapeutic approaches... - Cytokine, activation marker, and chemokine receptor expression by individual CD4(+) memory T cells in rheumatoid arthritis synoviumT Nanki
Department of Internal Medicine and Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Arthritis Res 2:415-23. 2000..A correlation between expression of IL-10 and CCR7, LT-alpha and CCR6, IFN-gamma and CCR5, and TRANCE and CXCR4 was also detected... - Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study GroupP E Lipsky
University of Texas Southwestern Medical Center at Dallas, USA
N Engl J Med 343:1594-602. 2000..However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known... - The kappa gene repertoire of human neonatal B cellsHermann J Girschick
Department of Internal Medicine, Harold C Simmons Arthritis Research Center, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
Mol Immunol 38:1113-27. 2002..The evidence of selection indicates that the Vkappa repertoire is shaped by self antigens, since exposure to exogenous antigens is limited at the time of birth... - Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8K Hayashida
University of Texas, Southwestern Medical Center, Dallas, Texas, USA
Arthritis Res 3:118-26. 2001..These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally... - Flow cytometric measurement of fluorescence (Förster) resonance energy transfer from cyan fluorescent protein to yellow fluorescent protein using single-laser excitation at 458 nmLiusheng He
Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculosketal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Room 9N228, Bethesda, MD 20892, USA
Cytometry A 53:39-54. 2003.... - TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activationLiusheng He
Flow Cytometry Section in the Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
J Biol Chem 279:55855-65. 2004..Together, these results reveal a novel association between TRAF2 and TRAF3 that is mediated by unique portions of each protein and that specifically regulates activation of NF-kappaB, but not AP-1... - Role of CD11/CD18 in adhesion and transendothelial migration of T cells. Analysis utilizing CD18-deficient T cell clonesA F Kavanaugh
Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
J Immunol 146:4149-56. 1991..Finally, it is likely that, during both binding and transendothelial migration of T cells, additional cell surface molecules play a role... - Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cellN Oppenheimer Marks
Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
J Immunol 145:140-8. 1990.... - Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probeXiaoli Wu
Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
Cytometry A 69:477-86. 2006..Simultaneous detection of two caspase activities using this probe has clearly provided information of the ordering of caspase-3 and -6 in the apoptotic pathway... - Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytesN Oppenheimer Marks
Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern, Medical Center, Dallas 75235
J Immunol 147:2913-21. 1991..Moreover, ICAM-1 but not VCAM-1 plays a role in transendothelial migration, regardless of the receptor-counter-receptor pairs used for initial binding... - Human CD4+ T cell differentiation and effector function: implications for autoimmunityL S Davis
UT Southwestern Medical Center, Department of Internal Medicine, Dallas, TX 75235 8884, USA
Immunol Res 19:25-34. 1999..Moreover, these studies support the concept that in autoimmune individuals, the chronic accumulation of differentiated proinflammatory T cells perpetuate the inflammatory response resulting in aggressive disease... - Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6Katsutoshi Ozaki
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
J Immunol 173:5361-71. 2004..Finally, BXSB-Yaa mice, which develop a systemic lupus erythematosus-like disease, have greatly elevated IL-21, suggesting a role for IL-21 in the development of autoimmune disease... - Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaborationStefan Kuchen
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 179:5886-96. 2007..These data are the first to document that B cell activation, expansion, and PC differentiation induced by direct interaction of B cells with activated T cells requires IL-21... - Rheumatoid synovial CD4+ T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cellsL S Davis
The Harold C Simmons Arthritis Research Center and Rheumatic Diseases Division, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8884, USA
Arthritis Res 3:54-64. 2001..RA synovial fluid (RASF) Tm demonstrated defective responsiveness, exhibiting diminished differentiation of IL-4 effectors, whereas RA synovial tissue (RAST) Tm exhibited defective generation of IFN-gamma and IL-4 producers... - Comparative characteristics of mu chain and alpha chain transcripts expressed by individual tonsil plasma cellsS Yavuz
Department of Internal Medicine, Harold C Simmons Arthritis Research Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
Mol Immunol 38:19-34. 2001..These results indicate that antigen driven stimulation and selection shape the entire expressed PC repertoire, but the impact is greater in alpha expressing PCs... - Human peripheral blood dendritic cells and monocyte subsets display similar chemokine receptor expression profiles with differential migratory responsesP D Cravens
The Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX, USA
Scand J Immunol 65:514-24. 2007..Despite the finding that APC did not exhibit unique surface chemokine receptor expression patterns, they exhibited differential migration to CXCL12, CXCL10 and CCL21 but not to CCL20 or CCL19... - TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaBLiusheng He
Flow Cytometry Section, Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:11235-49. 2006..Reciprocal transfer of this connecting region completely exchanged the ability of human and murine TRAF6 to induce apoptosis and activate NF-kappaB. Unique regions of TRAF6 therefore play an important role in determining cell fate... - Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targetingNancy S Longo
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1560, USA
Blood 113:3706-15. 2009.... - Pre-clinical evaluation of an in vitro selection protocol for the enrichment of transduced CD34+ cell-derived human dendritic cellsJ T Evans
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9113, USA
Gene Ther 8:1427-35. 2001..Thus, MLV-based vectors and in vitro selection of transduced human DC show great promise for immunotherapy protocols... - Association of clonally expanded T cells with the syndrome of primary biliary cirrhosis and limited sclerodermaM J Mayo
University of Texas Southwestern Medical Center at Dallas, Department of Internal Medicine, Dallas, TX, USA
Hepatology 29:1635-42. 1999..These clonal expansions provide evidence that stimulation of clonal populations of CD8(+) T cells is associated with the clinical syndrome of PBC with CREST... - Sustained secretion of immunoglobulin by long-lived human tonsil plasma cellsJacob M van Laar
B Cell Biology Group, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Am J Pathol 171:917-27. 2007..Taken together, the present study demonstrates that human lymphoid tissue harbors a population of nonproliferating plasma cells that are dependent on an intact microenvironment for ongoing Ig secretion... - Abnormal differentiation of memory T cells in systemic lupus erythematosusRuth D Fritsch
NIAMS, NIH, Building 10, Room 6D47C, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arthritis Rheum 54:2184-97. 2006..The goal of this study was to examine maturational disturbances in CD4 T cell differentiation in systemic lupus erythematosus (SLE), using these phenotypic markers... - Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiationSheng Chen
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 179:1634-47. 2007..These results indicate that 1,25(OH)(2)D(3) may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B cell-mediated autoimmune disorders... 
The role of IL-21 in regulating B-cell function in health and diseaseRachel Ettinger
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
Immunol Rev 223:60-86. 2008....- Immunomodulatory effects of therapeutic gold compounds. Gold sodium thiomalate inhibits the activity of T cell protein kinase CK Hashimoto
Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
J Clin Invest 89:1839-48. 1992..These data suggest that the immunomodulatory effects of GST may result from its capacity to inhibit PKC activity... - Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivoN Oppenheimer-Marks
Rheumatic Diseases Division of the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75235 8577, USA
J Clin Invest 101:1261-72. 1998..These results demonstrate that EC produce IL-15 and imply that endothelial IL-15 plays a critical role in stimulation of T cells to extravasate into inflammatory tissue... - The role of CD40-CD40 ligand (CD154) interactions in immunoglobulin light chain repertoire generation and somatic mutationN L Monson
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
Clin Immunol 100:71-81. 2001..Importantly, however, targeting of mutations to RGYW/WRCY motifs and subsequent selection of these mutated motifs does not occur in the absence of CD40 ligation... - Novel, non-antigen-specific therapeutic approaches to autoimmune/inflammatory diseasesG G Illei
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
Curr Opin Immunol 12:712-8. 2000..Moreover, the progression of joint damage noted in patients with rheumatoid arthritis treated with methotrexate was prevented by an anti-TNF-alpha antibody, suggesting a genuine disease-modifying potential of TNF-alpha blockade... - Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritisLaurie S Davis
Department of Internal Medicine and the Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8884, USA
Am J Pathol 160:357-67. 2002..These studies demonstrate that the RA-SCID model maintains many of the phenotypic and functional features of the inflamed RA synovium... - Identification and characterization of circulating human transitional B cellsGary P Sims
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD, USA
Blood 105:4390-8. 2005..Notably, increased proportions of T1 B cells were found in blood of patients with systemic lupus erythematosus (SLE), although bone marrow production and selection appeared to be normal... - Interleukin 21 as a target of intervention in autoimmune diseaseR Ettinger
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health Bethesda, Maryland, USA
Ann Rheum Dis 67:iii83-6. 2008..The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies... - The role of surface ig binding in the activation of human B cells by phosphorothioate oligodeoxynucleotidesH Liang
Harold C. Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas South-western Medical Center, Dallas 75235, USA
Scand J Immunol 54:551-63. 2001..Together, these results indicate that sODNs engage surface Ig by charge-charge interactions that lead to activation of human B cells... - Biomarkers in systemic lupus erythematosusGabor G Illei
National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Room 9S205, Bethesda, MD 20892, USA
Curr Rheumatol Rep 6:382-90. 2004..We also report on the current status of a multicenter initiative to concentrate efforts of biomarker development... - Monitoring caspase activity in living cells using fluorescent proteins and flow cytometryLiusheng He
Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculosketal and Skin Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
Am J Pathol 164:1901-13. 2004..Taken together, the data indicate that this caspase-sensitive probe can be used to monitor the basal and apoptosis-related activities of caspases, including an initiator caspase, caspase 8, and effector caspases, such as caspase 6... - Biomarkers in systemic lupus erythematosus: II. Markers of disease activityGabor G Illei
National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, DHHS, Bethesda, Maryland 20892, USA
Arthritis Rheum 50:2048-65. 2004 - Determination of tumor necrosis factor receptor-associated factor trimerization in living cells by CFP->YFP->mRFP FRET detected by flow cytometryLiusheng He
Flow Cytometry Section, Office of Science and Technology, National Institutes of Health Bethesda, MD 20892, USA
Nucleic Acids Res 33:e61. 2005..Based upon this, TRAF2 homotrimerization could be detected. This method should have great utility in studying the dynamics of interactions between three specific proteins in vivo... - Biomarkers in systemic lupus erythematosus. I. General overview of biomarkers and their applicabilityGabor G Illei
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Arthritis Rheum 50:1709-20. 2004 - B cell abnormalities in systemic lupus erythematosusAmrie C Grammer
Autoimmunity Branch of the Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
Arthritis Res Ther 5:S22-7. 2003.... - TNF downmodulates the function of human CD4+CD25hi T-regulatory cellsXavier Valencia
Autoimmunity Branch, the Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Health NIAMS NIH, Bethesda, MD 20892, USA
Blood 108:253-61. 2006..Thus, TNF has a novel action in modulating autoimmunity, by inhibiting CD4+CD25+ Treg activity... - Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosusLarissa Lapteva
Sjögren s Syndrome Clinic, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 54:2505-14. 2006..To assess the association of cognitive dysfunction and depression with serum antibodies to N-methyl-D-aspartate (NMDA) receptor (anti-NR2) and analyze clinical and neuroimaging correlates in patients with systemic lupus erythematosus (SLE)... - IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cellsRachel Ettinger
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
J Immunol 175:7867-79. 2005..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses... - A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinibCem Akin
Laboratory of Allergic Diseases, National Instititute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 103:3222-5. 2004.... - Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trialRaphaela Goldbach-Mansky
National Institute of Arthritis and Musculoskeletal and Skin Diseases and Clinical Center, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 0001, USA
Ann Intern Med 151:229-40, W49-51. 2009..Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases... - CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseasesXavier Valencia
National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
Nat Clin Pract Rheumatol 3:619-26. 2007..This Review will focus on the current state of knowledge on human T(REGs) and their association with specific autoimmune diseases... - CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosusAmrie C Grammer
National Institute of Arthritis and Musculoskeletal and Skin Diseases/NIH, 9000 Rockville Pike, Building 10, Room 6D47A, Bethesda, MD 20892, USA
Arthritis Rheum 46:1417-29. 2002 - Dendritic cells, chemokine receptors and autoimmune inflammatory diseasesPetra D Cravens
Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, USA
Immunol Cell Biol 80:497-505. 2002..Subsequent reactivation of memory T cells that enter the autoimmune lesions by DC present in the inflammatory lesion is thought to play a central role in tissue inflammation... - New concepts in the treatment of rheumatoid arthritisRaphaela Goldbach-Mansky
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Med 54:197-216. 2003..We review clinical evidence supporting these therapeutic approaches. Diagnostic and therapeutic challenges are highlighted, and a decision tree to guide treatment in patients with early or established RA is provided... - IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cellsRachel Ettinger
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 178:2872-82. 2007.... - T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissueDavid R Withers
B Cell Biology Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Blood 109:4856-64. 2007..In addition, an important role for contact-dependent interactions with T cells in human plasma cell survival within secondary lymphoid tissue was identified... - Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosusXavier Valencia
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 178:2579-88. 2007.... - Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactionsAmrie C Grammer
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 112:1506-20. 2003.... - A flow cytometric method to detect protein-protein interaction in living cells by directly visualizing donor fluorophore quenching during CFP-->YFP fluorescence resonance energy transfer (FRET)Liusheng He
Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Cytometry A 55:71-85. 2003..In this study we describe a new approach to visualize donor CFP quenching during CFP-->YFP FRET and demonstrate how this parameter can be used to calculate FRET efficiency... - Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27Ruth D Fritsch
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS, Bethesda, MD 20892, USA
J Immunol 175:6489-97. 2005..IL-4 secretion was predominantly conducted by CCR7-CD27- memory CD4 T cells. Thus, by using both CCR7 and CD27, distinct maturational stages of CD4 memory T cells with different functional activities were defined... - Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation studyGabor G Illei
National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA
Arthritis Rheum 62:542-52. 2010..To assess the safety of interleukin-6 receptor inhibition and to collect preliminary data on the clinical and immunologic efficacy of tocilizumab in patients with systemic lupus erythematosus (SLE)... - Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosusHermann J Girschick
University of Texas Southwestern Medical Center, Dallas, TX, USA
Arthritis Rheum 46:1255-63. 2002.... - Stimulation of T-Cell activation by CXCL12/stromal cell derived factor-1 involves a G-protein mediated signaling pathwayT Nanki
National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892 1820, USA
Cell Immunol 214:145-54. 2001..Thus, CXCL12 upregulated T-cell activation, and a G-coupled protein mediated signaling pathway was necessary for stimulation of T cells by CXCL12... - RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral bloodH J Girschick
Department of Internal Medicine, Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
J Immunol 166:377-86. 2001..With the exception of centroblasts, RAG1 and RAG2 expression can be found in all components of the GC, including postswitch memory B cells, some of which may circulate in the blood of normal subjects... - Expression of gamma-glutamyl transpeptidase protects ramos B cells from oxidation-induced cell deathD R Karp
Harold C. Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
J Biol Chem 276:3798-804. 2001..These data indicate that GGT cleavage of GSH and the subsequent recapture of cysteine and cystine allow cells to maintain low levels of cellular ROS and thereby avoid apoptosis induced by oxidative stress... - Rationale for interleukin-6 blockade in systemic lupus erythematosusE Tackey
Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, USA
Lupus 13:339-43. 2004..Based on these data, we propose that blocking the effect of IL-6 in humans may improve lupus by interacting with the autoinflammatory process both systemically and locally... - Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytesWen Zhang
National Institute of Arthritis and Musculoskeletal and Skin Diseases, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
Chin Med Sci J 25:1-12. 2010..To investigate the role of TNF receptor-associated factor 2 (TRAF-2) and TRAF6 in CD40-induced nuclear factor-kappaB (NF-kappaB) signaling pathway and whether CD40 signaling requires TRAF2... - Normalization of LDL receptor function by lymphocytes of patients with heterozygous familial hypercholesterolemia after treatment with plasma cholesterol lowering agentsJ A Cuthbert
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas
Am J Med Sci 298:152-60. 1989..These results provide direct evidence that therapy with lovastatin and a bile acid-binding resin can lead to increased expression of functional LDL receptors by lymphocytes in the majority (eight of 12) of patients with heterozygous FH... - Measurement of human and murine interleukin 2 and interleukin 4L S Davis
University of Texas Southwestern Medical Center, Dallas, Texas, USA
Curr Protoc Immunol . 2001..Support protocols also describe the calculation of cytokine units from samples based on DNA synthesis data and procedures for the maintenance of the CTLL-2, CT.4S, and CT.h4S cell lines... - Similar T-cell oligoclonality in antimitochondrial antibody-positive and -negative primary biliary cirrhosisM J Mayo
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390-9151, USA
Dig Dis Sci 46:345-51. 2001.... - The evaluation of bone damage in rheumatoid arthritis with magnetic resonance imagingR Goldbach-Mansky
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
Clin Exp Rheumatol 21:S50-3. 2003.... - Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook FXuelian Tao
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
Arthritis Rheum 58:1774-83. 2008..This study was undertaken to examine the therapeutic effect of triptolide and tripdiolide on established lupus nephritis in (NZB x NZW)F1 mice... - Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit geneA Selim Yavuz
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
Blood 100:661-5. 2002.... - B-cell repertoire and clonal analysis in unaffected first degree relatives in familial chronic lymphocytic leukaemia kindredFatima Abbasi
Center for Biologics Evaluation and Research, US Food and Drug Administration, NIH, Bethesda, MD, USA
Br J Haematol 139:820-3. 2007..Three of these individuals all showed evidence of hyper-somatic mutations. The B-cell repertoire in unaffected FDR in familial CLL offers a new area to investigate the interface between the immune system and lymphoid neoplasm... - Why do B cells mutate their immunoglobulin receptors?Nancy S Longo
Repertoire Analysis Group, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892 1560, USA
Trends Immunol 27:374-80. 2006..If enhanced antigen binding is not essential for immune responses, what is the purpose of SHM? An alternative benefit of SHM might be to enhance the ability of B cells to track antigens expressed by rapidly mutating microorganisms... - Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding proteinChang Hoon Lee
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:63-72. 2006..These results suggest previously unappreciated roles for IRF8 in the transcriptional regulation of B cell GC reactions that include direct regulation of AICDA and BCL6... - Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcriptionB Wang
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 50:2995-303. 2004..CONCLUSION: The EA extract of TWHF and triptolide inhibit transcription of the iNOS gene. This may contribute to the antiinflammatory effects of this traditional herbal remedy... - A type I collagen defect leads to rapidly progressive osteoarthritis in a mouse modelJ M Blair-Levy
National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892 1560, USA
Arthritis Rheum 58:1096-106. 2008..This study was undertaken to test the hypothesis that abnormalities of the subchondral bone can result in osteoarthritis (OA)... - The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosusG Oroszi
Laboratory of Neurogenetics, National Institute of Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
Ann Rheum Dis 65:1330-5. 2006..As cognitive function is commonly impaired in patients with systemic lupus erythematosus (SLE), the association of the BDNF Val66Met with neurocognitive function was studied... - The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editingJ Lee
Department of Internal Medicine and Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
J Immunol 165:6322-33. 2000..These events imply that the expressed fetal repertoire is shaped by exposure to self Ags... - Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolismJ A Cuthbert
Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, 75235 9151, USA
Cancer Res 57:3498-505. 1997..As a result, inhibition of the growth of these transformed cells might be specifically accomplished by Fmev... - Cloning and characterization of the cDNA encoding mouse dipeptidyl peptidase I (cathepsin C)M J McGuire
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas 75235 8577, USA
Biochim Biophys Acta 1351:267-73. 1997..Sequences encoding DPPI are highly conserved among mouse, rat and human and include an unusually long propeptide and a distinctive tyrosine adjacent to the active site cysteine... - Characterization of Ig gene somatic hypermutation in the absence of activation-induced cytidine deaminaseNancy S Longo
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
J Immunol 181:1299-306. 2008..Similar results were observed in V(L) rearrangements. The residual mutations were predominantly G:C substitutions, indicating that AICDA-independent cytidine deamination was a likely, yet inefficient, mechanism for mutating Ig genes... - The NF-kappaB canonical pathway is involved in the control of the exonucleolytic processing of coding ends during V(D)J recombinationM Margarida Souto-Carneiro
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1560, USA
J Immunol 180:1040-9. 2008..However, selection of the primary B cell repertoire appeared to be intact and was partially able to correct the defects generated by abnormal V(D)J recombination... - Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled studyXuelian Tao
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
Arthritis Rheum 46:1735-43. 2002..CONCLUSION: The ethanol/ethyl acetate extract of TWHF shows therapeutic benefit in patients with treatment-refractory RA. At therapeutic dosages, the TWHF extract was well tolerated by most patients in this study... - Effect of a culturally sensitive cholesterol lowering diet program on lipid and lipoproteins, body weight, nutrient intakes, and quality of life in patients with systemic lupus erythematosusMeena Shah
Department of Internal Medicine, University of Texas at Southwestern Medical Center, Dallas, Texas, USA
J Rheumatol 29:2122-8. 2002..A larger randomized study with a longer intervention period is necessary to test the effectiveness of a cholesterol-lowering diet on lipids and lipoproteins in patients with SLE... - The relationship between hepatic immunoglobulin production and CD154 expression in chronic liver diseasesMarlyn J Mayo
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9151, USA
Liver Int 26:187-96. 2006..CD154 is a member of the tumor necrosis factor superfamily, which is primarily expressed by activated T cells... - The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variantSule Yavuz
Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
J Immunol 169:3825-30. 2002..However, its overall contribution to the somatic hypermutational process does not appear to be indispensable and in its absence other mechanisms maintain mutational activity... - Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signatureCan N Kocabas
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases/NIH, Bethesda, MD 20892, USA
J Allergy Clin Immunol 115:1155-61. 2005..These results argue against the presence of a bilineage-restricted committed progenitor for mast cells and basophils... - Receptor revision and atypical mutational characteristics in clonally expanded B cells from the cerebrospinal fluid of recently diagnosed multiple sclerosis patientsNancy L Monson
Department of Neurology, UT Southwestern Medical Center, Dallas, TX 75390, USA
J Neuroimmunol 158:170-81. 2005..These observations are consistent with the presence of intense specific B cell stimulation and expansion in the CNS of MS patients early in the disease process... - Isolation of human B cell populationsGary P Sims
National Institutes of Health, Bethesda, Maryland, USA
Curr Protoc Immunol . 2006..Here we detail three methods of isolating B cells from human blood or mononuclear cells and describe how these techniques can be combined with fluorescent cell sorting for the characterization of specific B cell populations... - CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritisAndrew L Rankin
The Wistar Institute, Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA
J Immunol 180:833-41. 2008.... - Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95Annett M Jacobi
Charite Universitatsmedizin Berlin, Berlin, Germany
Arthritis Rheum 58:1762-73. 2008..Focusing on CD27- B cells, this study aimed to identify abnormalities in peripheral B cell subsets in patients with SLE... - The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cellsFrancis Dodeller
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen-Nuremberg, Erlangen, Germany
Eur J Immunol 35:3631-42. 2005..Together, the data suggest that p38 plays a key role in human Th2 cell immune responses... - Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein LMuriel Viau
Institut National de Sante et de Recherche Medicale (INSERM U 430, Immunopathologie Humaine, 75006 Paris, France
Infect Immun 72:3515-23. 2004..Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense... - The role of the T cell in autoimmune inflammationAlla Skapenko
Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Arthritis Res Ther 7:S4-14. 2005..Here, we review the functional abnormalities and the contribution of different T cell subsets to rheumatoid inflammation... - Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosusAnnett M Jacobi
University Hospital Charit, Berlin, Germany
Arthritis Rheum 48:1332-42. 2003.... - The V(lambda)-J(lambda) repertoire of patients with systemic lupus erythematosus manifests characteristics of the natural antibody repertoireJisoo Lee
Ewha Women's University College of Medicine, Seoul, South Korea
Arthritis Rheum 50:2604-14. 2004..CONCLUSION: These data demonstrate that the SLE V(lambda)-J(lambda) repertoire manifests characteristics of normal adult IgM+,CD5+ and fetal B cell populations that are known to be enriched for the production of natural autoantibodies... - Staphylococcal protein a deletes B-1a and marginal zone B lymphocytes expressing human immunoglobulins: an immune evasion mechanismMuriel Viau
, Immunopathologie Humaine, Paris, France
J Immunol 175:7719-27. 2005..Since the two B lymphocyte subsets targeted are involved in innate immune functions, our data suggest that crippling of humoral immunity by S. aureus represents an immune evasion mechanism that may aggravate recurrent infections... - Different patterns of bcl-6 and p53 gene mutations in tonsillar B cells indicate separate mutational mechanismsAkif S Yavuz
Department of Internal Medicine and Harold C Simmons Arthritis Research Center, The University of Texas Southwestern Medical Center at Dallas, 20892, USA
Mol Immunol 39:485-93. 2002..Moreover, a comparable mutational frequency of p53 was noted in tonsillar B and T cells. Hence, mutations in p53 do not appear to be the result of the B-cell hypermutational mechanism... - B-cell lymphoproliferation in chronic inflammatory rheumatic diseasesArne Hansen
Outpatients Department of Medicine, Charite University Hospital, Berlin, Germany
Nat Clin Pract Rheumatol 3:561-9. 2007..This Review will focus on the risk of lymphoma, common and disease-specific mechanisms of B-cell lymphoma development, and on the clinical consequences of lymphoma in patients with inflammatory rheumatic diseases...