Toshihiro Nanki

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Blocking tumor necrosis factor inhibits radiographic damage even in patients who show minimal or no clinical improvement: comment on the concise communication by Boers
    Peter E Lipsky
    Arthritis Rheum 46:2817-8; author reply 2718-21. 2002
  2. ncbi request reprint Integrating biologic therapy into the comprehensive care of patients with rheumatoid arthritis
    Peter E Lipsky
    Intramural Research Program, The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA
    J Rheumatol Suppl 72:54-7. 2005
  3. pmc Interleukin-6 and rheumatic diseases
    Peter E Lipsky
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Rockville Pike, Bethesda, Maryland, USA
    Arthritis Res Ther 8:S4. 2006
  4. ncbi request reprint Why does rheumatoid arthritis involve the joints?
    Peter E Lipsky
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 356:2419-20. 2007
  5. pmc Why do we not have a cure for rheumatoid arthritis?
    Hani D El-Gabalawy
    Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Arthritis Res 4:S297-301. 2002
  6. pmc Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordii Hook F on nephritis in NZB/W F1 mice
    Xuelian Tao
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 8:R24. 2006
  7. pmc B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue
    Arne Hansen
    Charite Center CC 12, Department of Medicine, Charite Universitatsmedizin Berlin, Charité Platz 01, 10098 Berlin, Germany
    Arthritis Res Ther 9:218. 2007
  8. pmc Cytokine, activation marker, and chemokine receptor expression by individual CD4(+) memory T cells in rheumatoid arthritis synovium
    T Nanki
    Department of Internal Medicine and Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Arthritis Res 2:415-23. 2000
  9. ncbi request reprint Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
    P E Lipsky
    University of Texas Southwestern Medical Center at Dallas, USA
    N Engl J Med 343:1594-602. 2000
  10. ncbi request reprint The kappa gene repertoire of human neonatal B cells
    Hermann J Girschick
    Department of Internal Medicine, Harold C Simmons Arthritis Research Center, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Mol Immunol 38:1113-27. 2002

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Blocking tumor necrosis factor inhibits radiographic damage even in patients who show minimal or no clinical improvement: comment on the concise communication by Boers
    Peter E Lipsky
    Arthritis Rheum 46:2817-8; author reply 2718-21. 2002
  2. ncbi request reprint Integrating biologic therapy into the comprehensive care of patients with rheumatoid arthritis
    Peter E Lipsky
    Intramural Research Program, The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA
    J Rheumatol Suppl 72:54-7. 2005
    ....
  3. pmc Interleukin-6 and rheumatic diseases
    Peter E Lipsky
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Rockville Pike, Bethesda, Maryland, USA
    Arthritis Res Ther 8:S4. 2006
    ....
  4. ncbi request reprint Why does rheumatoid arthritis involve the joints?
    Peter E Lipsky
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 356:2419-20. 2007
  5. pmc Why do we not have a cure for rheumatoid arthritis?
    Hani D El-Gabalawy
    Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Arthritis Res 4:S297-301. 2002
    ..The means to do this are currently unknown but should serve as a major focus of research...
  6. pmc Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordii Hook F on nephritis in NZB/W F1 mice
    Xuelian Tao
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Res Ther 8:R24. 2006
    ..Treatment with the EA extract significantly inhibited the progression of kidney disease in NZB/W F1 mice, though had no significant effect on the levels of anti-dsDNA antibody...
  7. pmc B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue
    Arne Hansen
    Charite Center CC 12, Department of Medicine, Charite Universitatsmedizin Berlin, Charité Platz 01, 10098 Berlin, Germany
    Arthritis Res Ther 9:218. 2007
    ..These findings add to our understanding of the pathogenesis of this autoimmune inflammatory disorder and may result in new therapeutic approaches...
  8. pmc Cytokine, activation marker, and chemokine receptor expression by individual CD4(+) memory T cells in rheumatoid arthritis synovium
    T Nanki
    Department of Internal Medicine and Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Arthritis Res 2:415-23. 2000
    ..A correlation between expression of IL-10 and CCR7, LT-alpha and CCR6, IFN-gamma and CCR5, and TRANCE and CXCR4 was also detected...
  9. ncbi request reprint Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
    P E Lipsky
    University of Texas Southwestern Medical Center at Dallas, USA
    N Engl J Med 343:1594-602. 2000
    ..However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known...
  10. ncbi request reprint The kappa gene repertoire of human neonatal B cells
    Hermann J Girschick
    Department of Internal Medicine, Harold C Simmons Arthritis Research Center, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Mol Immunol 38:1113-27. 2002
    ..The evidence of selection indicates that the Vkappa repertoire is shaped by self antigens, since exposure to exogenous antigens is limited at the time of birth...
  11. pmc Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8
    K Hayashida
    University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    Arthritis Res 3:118-26. 2001
    ..These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally...
  12. ncbi request reprint Flow cytometric measurement of fluorescence (Förster) resonance energy transfer from cyan fluorescent protein to yellow fluorescent protein using single-laser excitation at 458 nm
    Liusheng He
    Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculosketal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Room 9N228, Bethesda, MD 20892, USA
    Cytometry A 53:39-54. 2003
    ....
  13. ncbi request reprint TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation
    Liusheng He
    Flow Cytometry Section in the Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
    J Biol Chem 279:55855-65. 2004
    ..Together, these results reveal a novel association between TRAF2 and TRAF3 that is mediated by unique portions of each protein and that specifically regulates activation of NF-kappaB, but not AP-1...
  14. ncbi request reprint Role of CD11/CD18 in adhesion and transendothelial migration of T cells. Analysis utilizing CD18-deficient T cell clones
    A F Kavanaugh
    Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    J Immunol 146:4149-56. 1991
    ..Finally, it is likely that, during both binding and transendothelial migration of T cells, additional cell surface molecules play a role...
  15. ncbi request reprint Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell
    N Oppenheimer Marks
    Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    J Immunol 145:140-8. 1990
    ....
  16. ncbi request reprint Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe
    Xiaoli Wu
    Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Cytometry A 69:477-86. 2006
    ..To date, all substrates have measured only one caspase activity. Here, we describe a FRET-based probe for simultaneously measuring two distinct caspase activities in living cells...
  17. ncbi request reprint Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes
    N Oppenheimer Marks
    Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern, Medical Center, Dallas 75235
    J Immunol 147:2913-21. 1991
    ..Moreover, ICAM-1 but not VCAM-1 plays a role in transendothelial migration, regardless of the receptor-counter-receptor pairs used for initial binding...
  18. ncbi request reprint Human CD4+ T cell differentiation and effector function: implications for autoimmunity
    L S Davis
    UT Southwestern Medical Center, Department of Internal Medicine, Dallas, TX 75235 8884, USA
    Immunol Res 19:25-34. 1999
    ..Moreover, these studies support the concept that in autoimmune individuals, the chronic accumulation of differentiated proinflammatory T cells perpetuate the inflammatory response resulting in aggressive disease...
  19. ncbi request reprint Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Immunol 173:5361-71. 2004
    ..Finally, BXSB-Yaa mice, which develop a systemic lupus erythematosus-like disease, have greatly elevated IL-21, suggesting a role for IL-21 in the development of autoimmune disease...
  20. ncbi request reprint Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration
    Stefan Kuchen
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:5886-96. 2007
    ..These data are the first to document that B cell activation, expansion, and PC differentiation induced by direct interaction of B cells with activated T cells requires IL-21...
  21. pmc Rheumatoid synovial CD4+ T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells
    L S Davis
    The Harold C Simmons Arthritis Research Center and Rheumatic Diseases Division, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 8884, USA
    Arthritis Res 3:54-64. 2001
    ..RA synovial fluid (RASF) Tm demonstrated defective responsiveness, exhibiting diminished differentiation of IL-4 effectors, whereas RA synovial tissue (RAST) Tm exhibited defective generation of IFN-gamma and IL-4 producers...
  22. ncbi request reprint Comparative characteristics of mu chain and alpha chain transcripts expressed by individual tonsil plasma cells
    S Yavuz
    Department of Internal Medicine, Harold C Simmons Arthritis Research Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Mol Immunol 38:19-34. 2001
    ..These results indicate that antigen driven stimulation and selection shape the entire expressed PC repertoire, but the impact is greater in alpha expressing PCs...
  23. ncbi request reprint Human peripheral blood dendritic cells and monocyte subsets display similar chemokine receptor expression profiles with differential migratory responses
    P D Cravens
    The Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX, USA
    Scand J Immunol 65:514-24. 2007
    ..Despite the finding that APC did not exhibit unique surface chemokine receptor expression patterns, they exhibited differential migration to CXCL12, CXCL10 and CCL21 but not to CCL20 or CCL19...
  24. ncbi request reprint TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB
    Liusheng He
    Flow Cytometry Section, Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:11235-49. 2006
    ..Reciprocal transfer of this connecting region completely exchanged the ability of human and murine TRAF6 to induce apoptosis and activate NF-kappaB. Unique regions of TRAF6 therefore play an important role in determining cell fate...
  25. pmc Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting
    Nancy S Longo
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1560, USA
    Blood 113:3706-15. 2009
    ....
  26. ncbi request reprint Pre-clinical evaluation of an in vitro selection protocol for the enrichment of transduced CD34+ cell-derived human dendritic cells
    J T Evans
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9113, USA
    Gene Ther 8:1427-35. 2001
    ..Thus, MLV-based vectors and in vitro selection of transduced human DC show great promise for immunotherapy protocols...
  27. ncbi request reprint Association of clonally expanded T cells with the syndrome of primary biliary cirrhosis and limited scleroderma
    M J Mayo
    University of Texas Southwestern Medical Center at Dallas, Department of Internal Medicine, Dallas, TX, USA
    Hepatology 29:1635-42. 1999
    ..These clonal expansions provide evidence that stimulation of clonal populations of CD8(+) T cells is associated with the clinical syndrome of PBC with CREST...
  28. pmc Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells
    Jacob M van Laar
    B Cell Biology Group, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Pathol 171:917-27. 2007
    ..Taken together, the present study demonstrates that human lymphoid tissue harbors a population of nonproliferating plasma cells that are dependent on an intact microenvironment for ongoing Ig secretion...
  29. ncbi request reprint Abnormal differentiation of memory T cells in systemic lupus erythematosus
    Ruth D Fritsch
    NIAMS, NIH, Building 10, Room 6D47C, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arthritis Rheum 54:2184-97. 2006
    ..The goal of this study was to examine maturational disturbances in CD4 T cell differentiation in systemic lupus erythematosus (SLE), using these phenotypic markers...
  30. ncbi request reprint Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation
    Sheng Chen
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:1634-47. 2007
    ..These results indicate that 1,25(OH)(2)D(3) may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B cell-mediated autoimmune disorders...
  31. doi request reprint The role of IL-21 in regulating B-cell function in health and disease
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 223:60-86. 2008
    ....
  32. pmc Immunomodulatory effects of therapeutic gold compounds. Gold sodium thiomalate inhibits the activity of T cell protein kinase C
    K Hashimoto
    Harold C Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    J Clin Invest 89:1839-48. 1992
    ..These data suggest that the immunomodulatory effects of GST may result from its capacity to inhibit PKC activity...
  33. pmc Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo
    N Oppenheimer-Marks
    Rheumatic Diseases Division of the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75235 8577, USA
    J Clin Invest 101:1261-72. 1998
    ..These results demonstrate that EC produce IL-15 and imply that endothelial IL-15 plays a critical role in stimulation of T cells to extravasate into inflammatory tissue...
  34. ncbi request reprint The role of CD40-CD40 ligand (CD154) interactions in immunoglobulin light chain repertoire generation and somatic mutation
    N L Monson
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Clin Immunol 100:71-81. 2001
    ..Importantly, however, targeting of mutations to RGYW/WRCY motifs and subsequent selection of these mutated motifs does not occur in the absence of CD40 ligation...
  35. ncbi request reprint Novel, non-antigen-specific therapeutic approaches to autoimmune/inflammatory diseases
    G G Illei
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA
    Curr Opin Immunol 12:712-8. 2000
    ..Moreover, the progression of joint damage noted in patients with rheumatoid arthritis treated with methotrexate was prevented by an anti-TNF-alpha antibody, suggesting a genuine disease-modifying potential of TNF-alpha blockade...
  36. pmc Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritis
    Laurie S Davis
    Department of Internal Medicine and the Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8884, USA
    Am J Pathol 160:357-67. 2002
    ..These studies demonstrate that the RA-SCID model maintains many of the phenotypic and functional features of the inflamed RA synovium...
  37. pmc Identification and characterization of circulating human transitional B cells
    Gary P Sims
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD, USA
    Blood 105:4390-8. 2005
    ..Notably, increased proportions of T1 B cells were found in blood of patients with systemic lupus erythematosus (SLE), although bone marrow production and selection appeared to be normal...
  38. doi request reprint Interleukin 21 as a target of intervention in autoimmune disease
    R Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health Bethesda, Maryland, USA
    Ann Rheum Dis 67:iii83-6. 2008
    ..The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies...
  39. ncbi request reprint The role of surface ig binding in the activation of human B cells by phosphorothioate oligodeoxynucleotides
    H Liang
    Harold C. Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas South-western Medical Center, Dallas 75235, USA
    Scand J Immunol 54:551-63. 2001
    ..Together, these results indicate that sODNs engage surface Ig by charge-charge interactions that lead to activation of human B cells...
  40. ncbi request reprint Biomarkers in systemic lupus erythematosus
    Gabor G Illei
    National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Room 9S205, Bethesda, MD 20892, USA
    Curr Rheumatol Rep 6:382-90. 2004
    ..We also report on the current status of a multicenter initiative to concentrate efforts of biomarker development...
  41. pmc Monitoring caspase activity in living cells using fluorescent proteins and flow cytometry
    Liusheng He
    Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculosketal and Skin Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    Am J Pathol 164:1901-13. 2004
    ..Taken together, the data indicate that this caspase-sensitive probe can be used to monitor the basal and apoptosis-related activities of caspases, including an initiator caspase, caspase 8, and effector caspases, such as caspase 6...
  42. ncbi request reprint Biomarkers in systemic lupus erythematosus: II. Markers of disease activity
    Gabor G Illei
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, DHHS, Bethesda, Maryland 20892, USA
    Arthritis Rheum 50:2048-65. 2004
  43. pmc Determination of tumor necrosis factor receptor-associated factor trimerization in living cells by CFP->YFP->mRFP FRET detected by flow cytometry
    Liusheng He
    Flow Cytometry Section, Office of Science and Technology, National Institutes of Health Bethesda, MD 20892, USA
    Nucleic Acids Res 33:e61. 2005
    ..Based upon this, TRAF2 homotrimerization could be detected. This method should have great utility in studying the dynamics of interactions between three specific proteins in vivo...
  44. ncbi request reprint Biomarkers in systemic lupus erythematosus. I. General overview of biomarkers and their applicability
    Gabor G Illei
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Arthritis Rheum 50:1709-20. 2004
  45. pmc B cell abnormalities in systemic lupus erythematosus
    Amrie C Grammer
    Autoimmunity Branch of the Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Res Ther 5:S22-7. 2003
    ....
  46. pmc TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
    Xavier Valencia
    Autoimmunity Branch, the Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Health NIAMS NIH, Bethesda, MD 20892, USA
    Blood 108:253-61. 2006
    ..Thus, TNF has a novel action in modulating autoimmunity, by inhibiting CD4+CD25+ Treg activity...
  47. ncbi request reprint Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosus
    Larissa Lapteva
    Sjögren s Syndrome Clinic, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 54:2505-14. 2006
    ..To assess the association of cognitive dysfunction and depression with serum antibodies to N-methyl-D-aspartate (NMDA) receptor (anti-NR2) and analyze clinical and neuroimaging correlates in patients with systemic lupus erythematosus (SLE)...
  48. ncbi request reprint IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 175:7867-79. 2005
    ..Taken together, our data show that IL-21 plays a central role in CSR and plasma cell differentiation during T cell-dependent B cell responses...
  49. ncbi request reprint A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib
    Cem Akin
    Laboratory of Allergic Diseases, National Instititute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 103:3222-5. 2004
    ....
  50. pmc Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases and Clinical Center, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 0001, USA
    Ann Intern Med 151:229-40, W49-51. 2009
    ..Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases...
  51. ncbi request reprint CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases
    Xavier Valencia
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    Nat Clin Pract Rheumatol 3:619-26. 2007
    ..This Review will focus on the current state of knowledge on human T(REGs) and their association with specific autoimmune diseases...
  52. ncbi request reprint CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus
    Amrie C Grammer
    National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, 9000 Rockville Pike, Building 10, Room 6D47A, Bethesda, MD 20892, USA
    Arthritis Rheum 46:1417-29. 2002
  53. ncbi request reprint Dendritic cells, chemokine receptors and autoimmune inflammatory diseases
    Petra D Cravens
    Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, USA
    Immunol Cell Biol 80:497-505. 2002
    ..Subsequent reactivation of memory T cells that enter the autoimmune lesions by DC present in the inflammatory lesion is thought to play a central role in tissue inflammation...
  54. ncbi request reprint New concepts in the treatment of rheumatoid arthritis
    Raphaela Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Med 54:197-216. 2003
    ..We review clinical evidence supporting these therapeutic approaches. Diagnostic and therapeutic challenges are highlighted, and a decision tree to guide treatment in patients with early or established RA is provided...
  55. ncbi request reprint IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells
    Rachel Ettinger
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:2872-82. 2007
    ....
  56. pmc T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue
    David R Withers
    B Cell Biology Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Blood 109:4856-64. 2007
    ..In addition, an important role for contact-dependent interactions with T cells in human plasma cell survival within secondary lymphoid tissue was identified...
  57. ncbi request reprint Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus
    Xavier Valencia
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:2579-88. 2007
    ....
  58. pmc Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
    Amrie C Grammer
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:1506-20. 2003
    ....
  59. ncbi request reprint A flow cytometric method to detect protein-protein interaction in living cells by directly visualizing donor fluorophore quenching during CFP-->YFP fluorescence resonance energy transfer (FRET)
    Liusheng He
    Flow Cytometry Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cytometry A 55:71-85. 2003
    ..In this study we describe a new approach to visualize donor CFP quenching during CFP-->YFP FRET and demonstrate how this parameter can be used to calculate FRET efficiency...
  60. ncbi request reprint Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27
    Ruth D Fritsch
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS, Bethesda, MD 20892, USA
    J Immunol 175:6489-97. 2005
    ..IL-4 secretion was predominantly conducted by CCR7-CD27- memory CD4 T cells. Thus, by using both CCR7 and CD27, distinct maturational stages of CD4 memory T cells with different functional activities were defined...
  61. pmc Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study
    Gabor G Illei
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA
    Arthritis Rheum 62:542-52. 2010
    ..To assess the safety of interleukin-6 receptor inhibition and to collect preliminary data on the clinical and immunologic efficacy of tocilizumab in patients with systemic lupus erythematosus (SLE)...
  62. ncbi request reprint Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus
    Hermann J Girschick
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arthritis Rheum 46:1255-63. 2002
    ....
  63. ncbi request reprint Stimulation of T-Cell activation by CXCL12/stromal cell derived factor-1 involves a G-protein mediated signaling pathway
    T Nanki
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892 1820, USA
    Cell Immunol 214:145-54. 2001
    ..Thus, CXCL12 upregulated T-cell activation, and a G-coupled protein mediated signaling pathway was necessary for stimulation of T cells by CXCL12...
  64. ncbi request reprint RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood
    H J Girschick
    Department of Internal Medicine, Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    J Immunol 166:377-86. 2001
    ..With the exception of centroblasts, RAG1 and RAG2 expression can be found in all components of the GC, including postswitch memory B cells, some of which may circulate in the blood of normal subjects...
  65. ncbi request reprint Expression of gamma-glutamyl transpeptidase protects ramos B cells from oxidation-induced cell death
    D R Karp
    Harold C. Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 276:3798-804. 2001
    ..These data indicate that GGT cleavage of GSH and the subsequent recapture of cysteine and cystine allow cells to maintain low levels of cellular ROS and thereby avoid apoptosis induced by oxidative stress...
  66. pmc Rationale for interleukin-6 blockade in systemic lupus erythematosus
    E Tackey
    Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, USA
    Lupus 13:339-43. 2004
    ..Based on these data, we propose that blocking the effect of IL-6 in humans may improve lupus by interacting with the autoinflammatory process both systemically and locally...
  67. ncbi request reprint Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes
    Wen Zhang
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Chin Med Sci J 25:1-12. 2010
    ..To investigate the role of TNF receptor-associated factor 2 (TRAF-2) and TRAF6 in CD40-induced nuclear factor-kappaB (NF-kappaB) signaling pathway and whether CD40 signaling requires TRAF2...
  68. ncbi request reprint Normalization of LDL receptor function by lymphocytes of patients with heterozygous familial hypercholesterolemia after treatment with plasma cholesterol lowering agents
    J A Cuthbert
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas
    Am J Med Sci 298:152-60. 1989
    ..These results provide direct evidence that therapy with lovastatin and a bile acid-binding resin can lead to increased expression of functional LDL receptors by lymphocytes in the majority (eight of 12) of patients with heterozygous FH...
  69. ncbi request reprint Measurement of human and murine interleukin 2 and interleukin 4
    L S Davis
    University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Protoc Immunol . 2001
    ..Support protocols also describe the calculation of cytokine units from samples based on DNA synthesis data and procedures for the maintenance of the CTLL-2, CT.4S, and CT.h4S cell lines...
  70. ncbi request reprint Similar T-cell oligoclonality in antimitochondrial antibody-positive and -negative primary biliary cirrhosis
    M J Mayo
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390-9151, USA
    Dig Dis Sci 46:345-51. 2001
    ....
  71. ncbi request reprint The evaluation of bone damage in rheumatoid arthritis with magnetic resonance imaging
    R Goldbach-Mansky
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Clin Exp Rheumatol 21:S50-3. 2003
    ....
  72. pmc Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F
    Xuelian Tao
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA
    Arthritis Rheum 58:1774-83. 2008
    ..This study was undertaken to examine the therapeutic effect of triptolide and tripdiolide on established lupus nephritis in (NZB x NZW)F1 mice...
  73. ncbi request reprint Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene
    A Selim Yavuz
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 100:661-5. 2002
    ....
  74. ncbi request reprint B-cell repertoire and clonal analysis in unaffected first degree relatives in familial chronic lymphocytic leukaemia kindred
    Fatima Abbasi
    Center for Biologics Evaluation and Research, US Food and Drug Administration, NIH, Bethesda, MD, USA
    Br J Haematol 139:820-3. 2007
    ..Three of these individuals all showed evidence of hyper-somatic mutations. The B-cell repertoire in unaffected FDR in familial CLL offers a new area to investigate the interface between the immune system and lymphoid neoplasm...
  75. ncbi request reprint Why do B cells mutate their immunoglobulin receptors?
    Nancy S Longo
    Repertoire Analysis Group, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, Bethesda, MD 20892 1560, USA
    Trends Immunol 27:374-80. 2006
    ..If enhanced antigen binding is not essential for immune responses, what is the purpose of SHM? An alternative benefit of SHM might be to enhance the ability of B cells to track antigens expressed by rapidly mutating microorganisms...
  76. pmc Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
    Chang Hoon Lee
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:63-72. 2006
    ..These results suggest previously unappreciated roles for IRF8 in the transcriptional regulation of B cell GC reactions that include direct regulation of AICDA and BCL6...
  77. ncbi request reprint Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription
    B Wang
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 50:2995-303. 2004
    ..This study was therefore undertaken to examine the effects of the EA extract and triptolide on the production of NO and inducible NO synthase (iNOS) gene expression and transcription in vivo and in vitro...
  78. doi request reprint A type I collagen defect leads to rapidly progressive osteoarthritis in a mouse model
    J M Blair-Levy
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892 1560, USA
    Arthritis Rheum 58:1096-106. 2008
    ..This study was undertaken to test the hypothesis that abnormalities of the subchondral bone can result in osteoarthritis (OA)...
  79. pmc The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus
    G Oroszi
    Laboratory of Neurogenetics, National Institute of Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    Ann Rheum Dis 65:1330-5. 2006
    ..As cognitive function is commonly impaired in patients with systemic lupus erythematosus (SLE), the association of the BDNF Val66Met with neurocognitive function was studied...
  80. ncbi request reprint The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing
    J Lee
    Department of Internal Medicine and Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    J Immunol 165:6322-33. 2000
    ..These events imply that the expressed fetal repertoire is shaped by exposure to self Ags...
  81. ncbi request reprint Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism
    J A Cuthbert
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, 75235 9151, USA
    Cancer Res 57:3498-505. 1997
    ..As a result, inhibition of the growth of these transformed cells might be specifically accomplished by Fmev...
  82. ncbi request reprint Cloning and characterization of the cDNA encoding mouse dipeptidyl peptidase I (cathepsin C)
    M J McGuire
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas 75235 8577, USA
    Biochim Biophys Acta 1351:267-73. 1997
    ..Sequences encoding DPPI are highly conserved among mouse, rat and human and include an unusually long propeptide and a distinctive tyrosine adjacent to the active site cysteine...
  83. pmc Characterization of Ig gene somatic hypermutation in the absence of activation-induced cytidine deaminase
    Nancy S Longo
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Immunol 181:1299-306. 2008
    ..Similar results were observed in V(L) rearrangements. The residual mutations were predominantly G:C substitutions, indicating that AICDA-independent cytidine deamination was a likely, yet inefficient, mechanism for mutating Ig genes...
  84. ncbi request reprint The NF-kappaB canonical pathway is involved in the control of the exonucleolytic processing of coding ends during V(D)J recombination
    M Margarida Souto-Carneiro
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1560, USA
    J Immunol 180:1040-9. 2008
    ..However, selection of the primary B cell repertoire appeared to be intact and was partially able to correct the defects generated by abnormal V(D)J recombination...
  85. ncbi request reprint Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study
    Xuelian Tao
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:1735-43. 2002
    ..To examine the safety and efficacy of an extract of Tripterygium wilfordii Hook F (TWHF) in the treatment of patients with rheumatoid arthritis (RA)...
  86. ncbi request reprint Effect of a culturally sensitive cholesterol lowering diet program on lipid and lipoproteins, body weight, nutrient intakes, and quality of life in patients with systemic lupus erythematosus
    Meena Shah
    Department of Internal Medicine, University of Texas at Southwestern Medical Center, Dallas, Texas, USA
    J Rheumatol 29:2122-8. 2002
    ..To evaluate the effect of a culturally sensitive cholesterol lowering diet program on lipid and lipoproteins, body weight, nutrient intakes, and quality of life (QOL) in patients with systemic lupus erythematosus (SLE)...
  87. ncbi request reprint The relationship between hepatic immunoglobulin production and CD154 expression in chronic liver diseases
    Marlyn J Mayo
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9151, USA
    Liver Int 26:187-96. 2006
    ..CD154 is a member of the tumor necrosis factor superfamily, which is primarily expressed by activated T cells...
  88. ncbi request reprint The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant
    Sule Yavuz
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    J Immunol 169:3825-30. 2002
    ..However, its overall contribution to the somatic hypermutational process does not appear to be indispensable and in its absence other mechanisms maintain mutational activity...
  89. ncbi request reprint Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature
    Can N Kocabas
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 115:1155-61. 2005
    ..Mast cells and basophils share similar morphologic and functional properties; however, it is not known whether they are derived from a bilineage (basophil/mast cell)-restricted progenitor...
  90. ncbi request reprint Receptor revision and atypical mutational characteristics in clonally expanded B cells from the cerebrospinal fluid of recently diagnosed multiple sclerosis patients
    Nancy L Monson
    Department of Neurology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    J Neuroimmunol 158:170-81. 2005
    ..These observations are consistent with the presence of intense specific B cell stimulation and expansion in the CNS of MS patients early in the disease process...
  91. doi request reprint Isolation of human B cell populations
    Gary P Sims
    National Institutes of Health, Bethesda, Maryland, USA
    Curr Protoc Immunol . 2006
    ..Here we detail three methods of isolating B cells from human blood or mononuclear cells and describe how these techniques can be combined with fluorescent cell sorting for the characterization of specific B cell populations...
  92. ncbi request reprint CD4+ T cells recognizing a single self-peptide expressed by APCs induce spontaneous autoimmune arthritis
    Andrew L Rankin
    The Wistar Institute, Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Immunol 180:833-41. 2008
    ....
  93. doi request reprint Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95
    Annett M Jacobi
    Charite Universitatsmedizin Berlin, Berlin, Germany
    Arthritis Rheum 58:1762-73. 2008
    ..Focusing on CD27- B cells, this study aimed to identify abnormalities in peripheral B cell subsets in patients with SLE...
  94. ncbi request reprint The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cells
    Francis Dodeller
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 35:3631-42. 2005
    ..Together, the data suggest that p38 plays a key role in human Th2 cell immune responses...
  95. pmc Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L
    Muriel Viau
    Institut National de Santé et de Recherche Médicale INSERM U 430, Immunopathologie Humaine, 75006 Paris, France
    Infect Immun 72:3515-23. 2004
    ..Thus, the present study reveals a novel mechanism that may be used by some infectious agents to subvert a first line of the host's immune defense...
  96. pmc The role of the T cell in autoimmune inflammation
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 7:S4-14. 2005
    ..Here, we review the functional abnormalities and the contribution of different T cell subsets to rheumatoid inflammation...
  97. ncbi request reprint Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
    Annett M Jacobi
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 48:1332-42. 2003
    ..In order to determine whether SLE disease activity correlates with abnormal B lymphocyte activity, B cell subsets were analyzed, and their relationship to clinical and humoral measures of disease activity was assessed...
  98. ncbi request reprint The V(lambda)-J(lambda) repertoire of patients with systemic lupus erythematosus manifests characteristics of the natural antibody repertoire
    Jisoo Lee
    Ewha Women s University College of Medicine, Seoul, South Korea
    Arthritis Rheum 50:2604-14. 2004
    ....
  99. ncbi request reprint Staphylococcal protein a deletes B-1a and marginal zone B lymphocytes expressing human immunoglobulins: an immune evasion mechanism
    Muriel Viau
    Institut National de Santé et de Recherche Médicale Unite 430, Immunopathologie Humaine, Paris, France
    J Immunol 175:7719-27. 2005
    ..Since the two B lymphocyte subsets targeted are involved in innate immune functions, our data suggest that crippling of humoral immunity by S. aureus represents an immune evasion mechanism that may aggravate recurrent infections...
  100. ncbi request reprint Different patterns of bcl-6 and p53 gene mutations in tonsillar B cells indicate separate mutational mechanisms
    Akif S Yavuz
    Department of Internal Medicine and Harold C Simmons Arthritis Research Center, The University of Texas Southwestern Medical Center at Dallas, 20892, USA
    Mol Immunol 39:485-93. 2002
    ..Moreover, a comparable mutational frequency of p53 was noted in tonsillar B and T cells. Hence, mutations in p53 do not appear to be the result of the B-cell hypermutational mechanism...
  101. ncbi request reprint B-cell lymphoproliferation in chronic inflammatory rheumatic diseases
    Arne Hansen
    Outpatients Department of Medicine, Charite University Hospital, Berlin, Germany
    Nat Clin Pract Rheumatol 3:561-9. 2007
    ..This Review will focus on the risk of lymphoma, common and disease-specific mechanisms of B-cell lymphoma development, and on the clinical consequences of lymphoma in patients with inflammatory rheumatic diseases...