Shingo Nakayamada

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Early Th1 cell differentiation is marked by a Tfh cell-like transition
    Shingo Nakayamada
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:919-31. 2011
  2. pmc Helper T cell diversity and plasticity
    Shingo Nakayamada
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 24:297-302. 2012
  3. pmc STATs shape the active enhancer landscape of T cell populations
    Golnaz Vahedi
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    Cell 151:981-93. 2012
  4. pmc TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells
    Hayato Takahashi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:587-95. 2012
  5. pmc Helper T-cell differentiation and plasticity: insights from epigenetics
    Kiyoshi Hirahara
    Department of Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    Immunology 134:235-45. 2011
  6. pmc Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation
    Ofir Hakim
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Res 23:462-72. 2013

Collaborators

Detail Information

Publications6

  1. pmc Early Th1 cell differentiation is marked by a Tfh cell-like transition
    Shingo Nakayamada
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:919-31. 2011
    ..Our data argue that Tfh and Th1 cells share a transitional stage through the signal mediated by STAT4, which promotes both phenotypes. However, T-bet represses Tfh cell functionalities, promoting full Th1 cell differentiation...
  2. pmc Helper T cell diversity and plasticity
    Shingo Nakayamada
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin Immunol 24:297-302. 2012
    ..In this review, we highlight recent advances that pertain to this topic and the mechanisms that contribute to helper CD4(+) T cell differentiation and plasticity...
  3. pmc STATs shape the active enhancer landscape of T cell populations
    Golnaz Vahedi
    Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    Cell 151:981-93. 2012
    ..Thus, these findings point to a critical role of STATs as environmental sensors in dynamically molding the specialized enhancer architecture of differentiating cells...
  4. pmc TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells
    Hayato Takahashi
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:587-95. 2012
    ..We also found that miR-10a limited differentiation into the T(H)17 subset of helper T cells and therefore represents a factor that can fine-tune the plasticity and fate of helper T cells...
  5. pmc Helper T-cell differentiation and plasticity: insights from epigenetics
    Kiyoshi Hirahara
    Department of Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    Immunology 134:235-45. 2011
    ..In this review, we will discuss recent progress in the understanding of how cytokines influence gene expression and epigenetic modifications, and the impact of these findings on our views of helper cell lineage commitment and plasticity...
  6. pmc Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation
    Ofir Hakim
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genome Res 23:462-72. 2013
    ..Such subnuclear environments have significant implications for efficient functioning of the mature effector lymphocytes...