N L Nadon
Affiliation: National Institutes of Health
- Of mice and monkeys: National Institute on Aging resources supporting the use of animal models in biogerontology researchNancy L Nadon
Biology of Aging Program, National Institute on Aging NIH, 7201 Wisconsin Avenue, GW 2C231, Bethesda, MD 20892, USA
J Gerontol A Biol Sci Med Sci 61:813-5. 2006..To facilitate this research, the National Institute on Aging has developed several resources to assist investigators and promote the use of the nonhuman primate model in aging research...
- Animal models in gerontology researchNancy L Nadon
National Institute on Aging, Bethesda, Maryland 20892, USA
Int Rev Neurobiol 81:15-27. 2007..This chapter will focus on rodent models and will summarize important considerations for the use of animals in aging research in general and in modeling geriatric epilepsy...
- Design of aging intervention studies: the NIA interventions testing programN L Nadon
Biology of Aging Program, National Institute on Aging, 7201 Wisconsin Ave GW 2C231, Bethesda, MD, 20892, USA
Age (Dordr) 30:187-99. 2008..The development of this program highlights the challenges of long-term intervention studies and provides approaches to cope with the stringent requirements of a multi-site testing program...
- Exploiting the rodent model for studies on the pharmacology of lifespan extensionNancy L Nadon
National Institute on Aging, Bethesda, MD 20892, USA
Aging Cell 5:9-15. 2006..These issues are discussed in this review of the use of the rodent model. The National Institute on Aging (NIA) Interventions Testing Program, which has grappled with all of these issues, is described...
- National Institute on Aging microarray facility--resources for gerontology researchNancy L Nadon
Office of Biological Resources and Resource Development, National Institute on Aging, 7201 Wisconsin Ave, GW2C231, Bethesda, MD 20892
J Gerontol A Biol Sci Med Sci 60:413-5. 2005..This article introduces the National Institute on Aging Microarray Facility, developed to provide DNA microarrays to the biogerontology research community and to promote the use of this new technology...
- Maintaining aged rodents for biogerontology researchNancy L Nadon
Office of Biological Resources and Resource Development, National Institute on Aging, 7201 Wisconsin Avenue, Ste 2C231, Bethesda, MD 20892, USA
Lab Anim (NY) 33:36-41. 2004
- Aberrant dendrite growth in central nervous system white matter induced by a mutant proteolipid protein transgeneN L Nadon
Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
J Comp Neurol 416:262-8. 2000..One interpretation of these findings is that expression of the mutant DM20 alters signaling between oligodendrocytes and neurons, producing abnormal neurite outgrowth...
- Program for testing biological interventions to promote healthy agingH R Warner
National Institute on Aging, Biology of Aging Program, 7201 Wisconsin Avenue, Gateway Building, Suite 2C231, Bethesda, MD 20892, USA
Mech Ageing Dev 115:199-207. 2000....
- A point mutation in the proteolipid protein gene of the 'shaking pup' interrupts oligodendrocyte developmentN L Nadon
Laboratory of Viral and Molecular Pathogenesis, NINDS, NIH, Bethesda, MD
Development 110:529-37. 1990..We propose that, while the more abundant PLP is the primary structural component of myelin, DM-20 may be critical to oligodendrocyte maturation...
- An Aging Interventions Testing Program: study design and interim reportRichard A Miller
Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48109 2200, USA
Aging Cell 6:565-75. 2007..More data will be needed to determine if any of these compounds can extend maximal lifespan, but the current data show that NDGA reduces early life mortality risks in genetically heterogeneous mice at multiple test sites...