Kyungjae Myung

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Cell-based high-throughput screens for the discovery of chemotherapeutic agents
    Jennifer T Fox
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Oncotarget 3:581-5. 2012
  2. pmc DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange
    Hungjiun Liaw
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e21424. 2011
  3. pmc ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin
    Kyoo Young Lee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 200:31-44. 2013
  4. pmc Fanconi-like crosslink repair in yeast
    Danielle L Daee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD, 20892, USA
    Genome Integr 3:7. 2012
  5. pmc Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications
    Ji Young Hwang
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892 USA
    DNA Repair (Amst) 7:1426-36. 2008
  6. pmc Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae
    Akira Motegi
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Building 49, Room 4A22, Bethesda, MD 20892, USA
    Mol Cell Biol 26:1424-33. 2006
  7. pmc Dynamic regulation of single-stranded telomeres in Saccharomyces cerevisiae
    Stephanie Smith
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 178:693-701. 2008
  8. pmc The Rad1-Rad10 complex promotes the production of gross chromosomal rearrangements from spontaneous DNA damage in Saccharomyces cerevisiae
    Ji Young Hwang
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 169:1927-37. 2005
  9. pmc Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
    Akira Motegi
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:12411-6. 2008
  10. pmc Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1
    Danielle L Daee
    Genome Instability Section, Genetics, and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:26563-75. 2012

Collaborators

Detail Information

Publications29

  1. pmc Cell-based high-throughput screens for the discovery of chemotherapeutic agents
    Jennifer T Fox
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Oncotarget 3:581-5. 2012
    ..Here we discuss the ATAD5- luciferase assay and expand upon the value of HTS in identifying other potential cancer drugs, focusing on cell-based assays that involve DNA damage or repair pathways...
  2. pmc DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange
    Hungjiun Liaw
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e21424. 2011
    ..This pathway thus permits cells to repair DNA damage properly and increase cell viability...
  3. pmc ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin
    Kyoo Young Lee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 200:31-44. 2013
    ..Taken together, our data imply that ATAD5 regulates the cycle of DNA replication factories, probably through its PCNA-unloading activity...
  4. pmc Fanconi-like crosslink repair in yeast
    Danielle L Daee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD, 20892, USA
    Genome Integr 3:7. 2012
    ..Future studies in this simplistic model organism promise to greatly improve our basic understanding of complex interstrand crosslink repair pathways like the Fanconi pathway...
  5. pmc Smc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications
    Ji Young Hwang
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892 USA
    DNA Repair (Amst) 7:1426-36. 2008
    ....
  6. pmc Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae
    Akira Motegi
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Building 49, Room 4A22, Bethesda, MD 20892, USA
    Mol Cell Biol 26:1424-33. 2006
    ..We propose a mechanism for how defects in these proteins could lead to diverse outcomes (proper repair or GCR formation) through different regulation of DNA repair machinery...
  7. pmc Dynamic regulation of single-stranded telomeres in Saccharomyces cerevisiae
    Stephanie Smith
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 178:693-701. 2008
    ....
  8. pmc The Rad1-Rad10 complex promotes the production of gross chromosomal rearrangements from spontaneous DNA damage in Saccharomyces cerevisiae
    Ji Young Hwang
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 169:1927-37. 2005
    ..Results presented here suggest that Rad1-Rad10 functions at different stages of GCR formation and that there is an alternative pathway for the GCR formation that is independent of Rad1-Rad10...
  9. pmc Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
    Akira Motegi
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:12411-6. 2008
    ..Our results suggest that HLTF and SHPRH are functional homologues of yeast Rad5 that cooperatively mediate PCNA polyubiquitination and maintain genomic stability...
  10. pmc Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1
    Danielle L Daee
    Genome Instability Section, Genetics, and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:26563-75. 2012
    ..These studies reveal the functional conservation of the FA pathway and validate the yeast model for future studies to further elucidate the mechanism of the FA pathway...
  11. pmc Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination
    Soma Banerjee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 181:1083-93. 2008
    ..Furthermore, spontaneous RPA foci at DSBs are destabilized by the mph1Delta mutation. Therefore, Mph1p promotes GCR formation by partially suppressing HR, likely through its interaction with RPA...
  12. pmc Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway
    Nilabja Sikdar
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 4:e1000290. 2008
    ..Lastly, high transcription in the chromosome V, the location at which GCR is monitored, also enhanced GCR formation. We propose a new pathway for GCR where DNA intermediates formed during transcription can lead to genomic instability...
  13. pmc A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability
    Zhijiang Yan
    Laboratory of Genetics, National Institute of Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 37:865-78. 2010
    ..Thus, FANCM-MHF is an essential DNA-remodeling complex that protects replication forks from yeast to human...
  14. pmc Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1
    Kyoo Young Lee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:10362-9. 2010
    ..Taken together, ELG1 specifically directs USP1-UAF1 complex for PCNA deubiquitination...
  15. pmc Increased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints
    Soma Banerjee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Building 49, Room 4A22, Bethesda, MD 20892, USA
    Eukaryot Cell 3:1557-66. 2004
    ....
  16. ncbi request reprint Suppression of gross chromosomal rearrangements by the multiple functions of the Mre11-Rad50-Xrs2 complex in Saccharomyces cerevisiae
    Stephanie Smith
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    DNA Repair (Amst) 4:606-17. 2005
    ..However, the non-homologous end joining function of MRX complex does not appear to participate in the suppression of GCRs...
  17. pmc DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity
    Nilabja Sikdar
    Genome Instability Section, Genetics and Molecular Biology Branch, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 8:3199-207. 2009
    ..Taken together, we propose that ELG1 would be a new member of proteins involved in maintenance of genomic integrity...
  18. pmc Suppression of gross chromosomal rearrangements by a new alternative replication factor C complex
    Soma Banerjee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Room 4A22, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 362:546-9. 2007
    ....
  19. pmc Dynamic regulation of PCNA ubiquitylation/deubiquitylation
    Jennifer T Fox
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    FEBS Lett 585:2780-5. 2011
    ..Here, we review the molecular mechanisms to remove ubiquitin from PCNA including the emerging role of USP1 and ELG1 in this fascinating process...
  20. pmc Suppression of gross chromosomal rearrangements by yKu70-yKu80 heterodimer through DNA damage checkpoints
    Soma Banerjee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:1816-21. 2006
    ..Lastly, Ku overexpression causes cell growth delay, which depends on intact Rad27. In summary, the results presented here suggest that Ku functions as a genomic gatekeeper through its crosstalk with DNA damage checkpoints...
  21. pmc Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination
    Akira Motegi
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 175:703-8. 2006
    ..Therefore, the yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress...
  22. pmc Predisposition to cancer caused by genetic and functional defects of mammalian Atad5
    Daphne W Bell
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 7:e1002245. 2011
    ..Taken together, our findings indicate that loss-of-function mutations in mammalian Atad5 are sufficient to cause genomic instability and tumorigenesis...
  23. pmc The exon junction complex component Magoh controls brain size by regulating neural stem cell division
    Debra L Silver
    Genetic Disease Research Branch, National Human Genome Research Institute NHGRI, National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Neurosci 13:551-8. 2010
    ..Our results uncover requirements for the EJC in brain development, NSC maintenance and mitosis, thereby implicating this complex in the pathogenesis of microcephaly...
  24. pmc PCNA modifications for regulation of post-replication repair pathways
    Kyoo Young Lee
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892 USA
    Mol Cells 26:5-11. 2008
    ..Mutations of some PRR genes are associated with a higher risk for cancers in mice and human patients, strongly supporting the importance of PRR as a tumor suppressor pathway...
  25. ncbi request reprint Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer
    Akira Motegi
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA
    Methods 41:168-76. 2007
    ..We will also summarize the pathways that suppress and enhance GCR formation. Finally, we will briefly describe similar assays developed by others and discuss their potential in studying GCR metabolism...
  26. pmc High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death
    Jennifer T Fox
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:5423-8. 2012
    ..Furthermore, resveratrol and genistein killed multidrug-resistant cancer cells. We therefore propose that resveratrol, genistein, and baicalein are attractive candidates for improved chemotherapeutic agents...
  27. pmc Myelodysplasia in autosomal dominant and sporadic monocytopenia immunodeficiency syndrome: diagnostic features and clinical implications
    Katherine R Calvo
    Hematology Section, Department of Laboratory Medicine, NIH Clinical Center, 10 Center Dr, Bethesda, MD 20892 1508, USA
    Haematologica 96:1221-5. 2011
    ..MonoMAC appears to be a unique, inherited syndrome of bone marrow failure. We describe distinctive bone marrow features to help in its recognition and diagnosis. (Clinicaltrials.gov identifiers: NCT00018044, NCT00923364, NCT01212055)...
  28. pmc Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae
    Kyungjae Myung
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:15980-5. 2004
    ..These data suggest that functional mitotic checkpoints can play a role in the formation of genome rearrangements...
  29. pmc Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity
    Stephanie Smith
    Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e87203. 2014
    ..Here, we used a panel of isogenic chicken DT40 B lymphocyte mutant and human cell lines to investigate the ability of TSA to define selective pathways that promote HDACi toxicity...