Research Topics
| Elisabeth A MurraySummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Why is there a special issue on perirhinal cortex in a journal called hippocampus? The perirhinal cortex in historical perspectiveElisabeth A Murray
Section on the Neurobiology of Learning and Memory, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Hippocampus 22:1941-51. 2012..2012 Wiley Periodicals, Inc...
Interactions between orbital prefrontal cortex and amygdala: advanced cognition, learned responses and instinctive behaviorsElisabeth A Murray
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Building 49, MSC 4415, 49 Convent Drive, Bethesda, MD 20892 4415, USA
Curr Opin Neurobiol 20:212-20. 2010..A role for PFo in advanced cognition, for the amygdala in instinctive behavior, and for cortex-subcortex interactions in prioritizing behaviors provides one account for these findings...- What, if anything, can monkeys tell us about human amnesia when they can't say anything at all?Elisabeth A Murray
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 4415, USA
Neuropsychologia 48:2385-405. 2010.... - Perirhinal cortex and its neighbours in the medial temporal lobe: contributions to memory and perceptionElisabeth A Murray
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892-4415, USA
Q J Exp Psychol B 58:378-96. 2005 - Visual perception and memory: a new view of medial temporal lobe function in primates and rodentsElisabeth A Murray
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Neurosci 30:99-122. 2007..In both primates and rodents, the hippocampus contributes to the memory and perception of places and paths, whereas the perirhinal cortex does so for objects and the contents of scenes... - What we know and do not know about the functions of the orbitofrontal cortex after 20 years of cross-species studiesElisabeth A Murray
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 27:8166-9. 2007..These similarities suggest that OFC function can be usefully modeled in nonhuman and even nonprimate species. Here, we review some of these similarities... - The amygdala, reward and emotionElisabeth A Murray
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892 4415, USA
Trends Cogn Sci 11:489-97. 2007.... - Orbitofrontal cortex and amygdala contributions to affect and action in primatesElisabeth A Murray
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892 4415, USA
Ann N Y Acad Sci 1121:273-96. 2007..Both regions contribute to the expression of defensive responses to a potential predator. Contrary to the prevailing view, the amygdala and OFC make distinct contributions to emotional responses and reward processing... - Distinct contributions of the amygdala and hippocampus to fear expressionYogita Chudasama
Neurobiology of Learning and Memory Section, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Eur J Neurosci 30:2327-37. 2009..These data show that the hippocampus and amygdala contribute independently to the overall expression of defensive responses... - Dissociable effects of subtotal lesions within the macaque orbital prefrontal cortex on reward-guided behaviorPeter H Rudebeck
Section on Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 31:10569-78. 2011..Our data indicate that anatomically defined subregions within macaque PFo make dissociable contributions to reward-guided behavior... - Perirhinal cortex removal dissociates two memory systems in matching-to-sample performance in rhesus monkeysHsiao Wei Tu
Department of Psychology and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 31:16336-43. 2011..PDP can be applied in monkeys in a way that parallels its use in humans, providing a new tool for investigating the neurobiology of memory in nonhuman animals and for comparing memory across species... - Functional interaction of medial mediodorsal thalamic nucleus but not nucleus accumbens with amygdala and orbital prefrontal cortex is essential for adaptive response selection after reinforcer devaluationAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892 4415, USA
J Neurosci 30:661-9. 2010..In contrast, monkeys that sustained MDm disconnection failed to adjust their object choices. Thus, MDm, but not NA, works together with the amygdala and PFo to support reward-based decision making... - Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeysAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
Eur J Neurosci 22:2341-6. 2005..For comparison, we evaluated the effects of ablation of PFo on the same task. Amygdala lesions facilitated the extinction of instrumental responses, whereas lesions of PFo had the opposite effect... - Impairments in visual discrimination after perirhinal cortex lesions: testing 'declarative' vs. 'perceptual-mnemonic' views of perirhinal cortex functionTimothy J Bussey
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Convent Drive, Building 49, Room 1880, MSC4415, Bethesda, MD 20892, USA
Eur J Neurosci 17:649-60. 2003..These and other recent findings suggest the need for a revision of prevailing views regarding the neural organization of perception and memory... - Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeysAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurophysiol 91:2023-39. 2004.... 
Hippocampal lesions in rhesus monkeys disrupt emotional responses but not reinforcer devaluation effectsYogita Chudasama
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 63:1084-91. 2008..Although the role of the hippocampus in emotional behavior has long been recognized, the extent to which the hippocampus plays a role in the regulation and expression of emotion in rhesus monkeys has not been systematically explored...- Selective ablations reveal that orbital and lateral prefrontal cortex play different roles in estimating predicted reward valueJanine M Simmons
National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4415, USA
J Neurosci 30:15878-87. 2010..L-PFC appears necessary for integration of predicted reward value across these different scales... - Comparison of the effects of bilateral orbital prefrontal cortex lesions and amygdala lesions on emotional responses in rhesus monkeysAlicia Izquierdo
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 25:8534-42. 2005..In addition, they point to a divergence of the roles of the PFo and amygdala in responding to a social stimulus, the human intruder... - Localization of dysfunction in major depressive disorder: prefrontal cortex and amygdalaElisabeth A Murray
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4415, USA
Biol Psychiatry 69:e43-54. 2011.... - What, if anything, is the medial temporal lobe, and how can the amygdala be part of it if there is no such thing?Elisabeth A Murray
Laboratory of Neuropsychology, National Institute of Mental Health, Building 49, Room 1B80, MSC 4415, 49 Convent Drive, Bethesda, MD 20892 4415, USA
Neurobiol Learn Mem 82:178-98. 2004..The empirical neuropsychological evidence favors the balkanization theory, as do some new concepts in theoretical neuroanatomy... - Perirhinal cortex resolves feature ambiguity in complex visual discriminationsTimothy J Bussey
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Convent Drive, Building 49, Room 1880, MSC4415, Bethesda, MD 20892, USA
Eur J Neurosci 15:365-74. 2002..These results confirm the predictions of the PMFC model, and force a reconsideration of prevailing views regarding perirhinal cortex function... - Interaction of ventral and orbital prefrontal cortex with inferotemporal cortex in conditional visuomotor learningTimothy J Bussey
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892 4415, USA
Behav Neurosci 116:703-15. 2002..In addition to those associations, which might be considered lower order rules for choosing a response, frontotemporal interaction also appears to be important for higher order rules, such as those involved in the matching task... - Interaction between orbital prefrontal and rhinal cortex is required for normal estimates of expected valueAndrew M Clark
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Neurosci 33:1833-45. 2013..These results support a model whereby information about rewards signaled in PFo is combined with associative and contextual information signaled within Rh to estimate expected value... - Balkanizing the primate orbitofrontal cortex: distinct subregions for comparing and contrasting valuesPeter H Rudebeck
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892 4415, USA
Ann N Y Acad Sci 1239:1-13. 2011..The medial OFC reduces these contrasting representations of value to a single dimension, a common currency, in order to compare alternative choices... - Amygdala and orbitofrontal cortex lesions differentially influence choices during object reversal learningPeter H Rudebeck
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 28:8338-43. 2008..These findings demonstrate that the OFC and AMG make different contributions to object reversal learning not highlighted previously... - Selective hippocampal damage in rhesus monkeys impairs spatial memory in an open-field testRobert R Hampton
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4415, USA
Hippocampus 14:808-18. 2004..In Experiment 4, probe trials using symmetrical test arrays found no evidence for egocentric coding of the rewarded location... - Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeysAlicia Izquierdo
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:14128-33. 2007..Because behaviors modulated by the 5-HTTLPR are a subset of those dependent on the VMPFC, analysis of structural and functional correlates of gene variation in this region may inform the nature of the genetic modulation of cognition... - Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingencyAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4415, USA
J Neurosci 24:7540-8. 2004.... - Prospective memory in the formation of learning sets by rhesus monkeys (Macaca mulatta)Elisabeth A Murray
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, USA
J Exp Psychol Anim Behav Process 32:87-90. 2006..Confirming their expectation, the authors found no indication of learning-set formation under these conditions... - Amygdala lesions disrupt modulation of functional MRI activity evoked by facial expression in the monkey inferior temporal cortexFadila Hadj-Bouziane
Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 109:E3640-8. 2012..Moreover, these modulatory effects are consistent with an anterior-to-posterior gradient of projections, as suggested by classical tracer studies... - Amygdala lesions in rhesus monkeys fail to disrupt object choices based on internal contextSarah E V Rhodes
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 4415, USA
Behav Neurosci 126:270-8. 2012..We conclude that the involvement of the amygdala in selective-satiation tasks, which depends in part on a change in internal context, is not due to the amygdala playing a general role in representing, or using, internal context... - An assessment of memory awareness in tufted capuchin monkeys (Cebus apella)Benjamin M Basile
National Institute of Mental Health, Bethesda, MD, USA
Anim Cogn 12:169-80. 2009..None of the five monkeys looked more often on unseen trials. These findings provide equivocal evidence for memory awareness in capuchin monkeys using tests that have yielded clear evidence in humans, apes, and rhesus monkeys... - Selective bilateral amygdala lesions in rhesus monkeys fail to disrupt object reversal learningAlicia Izquierdo
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:1054-62. 2007..Second, the results implicate a critical contribution to object reversal learning of structures nearby the amygdala, perhaps the subjacent rhinal cortex... - Method for making selective lesions of the hippocampus in macaque monkeys using NMDA and a longitudinal surgical approachRobert R Hampton
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Hippocampus 14:9-18. 2004..Finally, the new surgical approach may provide a mechanism for infusing agents into the hippocampus from a single cannula... - Rhesus monkeys (Macaca mulatta) discriminate between knowing and not knowing and collect information as needed before actingRobert R Hampton
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892 4415, USA
Anim Cogn 7:239-46. 2004..This result extends similar observations made of children and apes to a species of Old World monkey, suggesting that the underlying cognitive capacities may be widely distributed among primates... - DNA targeting of rhinal cortex D2 receptor protein reversibly blocks learning of cues that predict rewardZheng Liu
Laboratory of Neuropsychology, Clinical Neuroscience Branch, and Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12336-41. 2004..The specificity of the receptor manipulation reported here suggests that this approach could be generalized in this or other brain pathways to relate molecular mechanisms to cognitive functions... - Learning of discriminations is impaired, but generalization to altered views is intact, in monkeys (Macaca mulatta) with perirhinal cortex removalRobert R Hampton
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health NIH, Bethesda, Maryland 20892 4415, USA
Behav Neurosci 116:363-77. 2002..These results indicate an important role for perirhinal cortex in visual learning, memory, or both, and show that under a variety of conditions, perirhinal cortex is not critical for the identification of stimuli... - Effects of combined and separate removals of rostral dorsal superior temporal sulcus cortex and perirhinal cortex on visual recognition memory in rhesus monkeysWendy S Hadfield
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurophysiol 90:2419-27. 2003..We conclude that STSd is not critically involved in visual recognition memory... - Fornix transection impairs conditional visuomotor learning in tasks involving nonspatially differentiated responsesPeter J Brasted
Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurophysiol 87:631-3. 2002..These findings challenge the view that the hippocampal system participates in associative learning only when spatial information is relevant to either the stimulus or the response... - Differential effects of amygdala, orbital prefrontal cortex, and prelimbic cortex lesions on goal-directed behavior in rhesus macaquesSarah E V Rhodes
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 33:3380-9. 2013..Notably, the findings for PFo challenge the idea that orbital and medial prefrontal regions are exclusively dedicated to object- and action-based processes, respectively... - The amygdala and rewardMark G Baxter
Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
Nat Rev Neurosci 3:563-73. 2002..Indeed, the amygdala's role in stimulus-reward learning might be just as important as its role in processing negative affect and fear conditioning... - Perceptual deficits in amnesia: challenging the medial temporal lobe 'mnemonic' viewAndy C H Lee
MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, UK
Neuropsychologia 43:1-11. 2005..These novel observations imply that the human MTL subserves both perceptual and mnemonic functions, with the hippocampus and perirhinal cortex playing distinct roles in spatial and object discrimination, respectively... - The perceptual-mnemonic/feature conjunction model of perirhinal cortex functionTimothy J Bussey
Department of Experimental Psychology, University of Cambridge, UK
Q J Exp Psychol B 58:269-82. 2005.... - Functional specialization in the human medial temporal lobeMorgan D Barense
Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, United Kingdom
J Neurosci 25:10239-46. 2005..These findings resolve contradictions between published studies in humans and animals and introduce a new way of characterizing the impairments that arise after damage to the MTL... - Impairment and facilitation of transverse patterning after lesions of the perirhinal cortex and hippocampus, respectivelyLisa M Saksida
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Cereb Cortex 17:108-15. 2007..These results are, however, compatible with a view that perirhinal cortex, and not the hippocampus, contains complex configural representations of visual stimuli critical to the solution of the transverse-patterning task... - No effect of hippocampal lesions on perirhinal cortex-dependent feature-ambiguous visual discriminationsLisa M Saksida
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Hippocampus 16:421-30. 2006..The findings support the perceptual-mnemonic/feature conjunction model of perirhinal cortex function, and provide further evidence for heterogeneity of function within the putative medial temporal lobe memory system... - Perirhinal cortex and feature-ambiguous discriminationsTimothy J Bussey
Learn Mem 13:103-5; author reply 106-7. 2006 - Linking affect to action: critical contributions of the orbitofrontal cortex. PrefaceGeoffrey Schoenbaum
Ann N Y Acad Sci 1121:xi-xiii. 2007 - Total number, distribution, and phenotype of cells expressing chondroitin sulfate proteoglycans in the normal human amygdalaHarry Pantazopoulos
Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
Brain Res 1207:84-95. 2008..These results suggest that astrocytes are the main cell type expressing CSPGs in the adult human amygdala. Their highly segregated distribution pattern suggests that these cells serve specialized functions within human amygdalar nuclei...