W J Murphy

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. pmc Evolution of mammalian genome organization inferred from comparative gene mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    Genome Biol 2:REVIEWS0005. 2001
  2. pmc Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps
    William J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Hum Genomics 1:30-40. 2003
  3. pmc A radiation hybrid map of the cat genome: implications for comparative mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201 USA
    Genome Res 10:691-702. 2000
  4. pmc Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201, USA
    Genome Res 9:1223-30. 1999
  5. pmc The origin of human chromosome 1 and its homologs in placental mammals
    William J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Genome Res 13:1880-8. 2003
  6. ncbi request reprint A radiation hybrid mapping panel for the rhesus macaque
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    J Hered 92:516-9. 2001
  7. ncbi request reprint Molecular dating and biogeography of the early placental mammal radiation
    E Eizirik
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    J Hered 92:212-9. 2001
  8. ncbi request reprint Radiation hybrid mapping of 304 novel microsatellites in the domestic cat genome
    M Menotti-Raymond
    Laboratory of Genomic Diversity, National Cancer Institute, Department of Health and Human Services, Frederick, MD 21702, USA
    Cytogenet Genome Res 102:272-6. 2003
  9. ncbi request reprint Development of a feline whole genome radiation hybrid panel and comparative mapping of human chromosome 12 and 22 loci
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, 21702, USA
    Genomics 57:1-8. 1999
  10. ncbi request reprint NK cell subsets in the regulation of murine hematopoiesis. I. 5E6+ NK cells promote hematopoietic growth in H-2d strain mice
    W J Murphy
    Biological Response Modifiers Program, Inc DynCorp, National Cancer Institute Frederick Cancer Research and Development Center, MD 21702, USA
    J Immunol 155:2911-7. 1995

Detail Information

Publications96

  1. pmc Evolution of mammalian genome organization inferred from comparative gene mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    Genome Biol 2:REVIEWS0005. 2001
    ....
  2. pmc Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps
    William J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Hum Genomics 1:30-40. 2003
    ....
  3. pmc A radiation hybrid map of the cat genome: implications for comparative mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201 USA
    Genome Res 10:691-702. 2000
    ..These data demonstrate that ordered RH-based gene maps provide the most precise assessment of comparing genomes, short of contig construction or full-sequence determination...
  4. pmc Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201, USA
    Genome Res 9:1223-30. 1999
    ....
  5. pmc The origin of human chromosome 1 and its homologs in placental mammals
    William J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Genome Res 13:1880-8. 2003
    ..Further, historic chromosome exchange appears to have been disproportionately clustered in two breakpoint hotspots on the long arm...
  6. ncbi request reprint A radiation hybrid mapping panel for the rhesus macaque
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    J Hered 92:516-9. 2001
    ..Concordant marker order between all three species maps suggests that the current panel represents a powerful mapping resource for generating high-density comparative maps of the rhesus macaque and other species genomes...
  7. ncbi request reprint Molecular dating and biogeography of the early placental mammal radiation
    E Eizirik
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    J Hered 92:212-9. 2001
    ..We propose an integrated genomic, paleontological, and biogeographic hypothesis to account for these earliest splits on the placental mammal family tree and address current discrepancies between fossil and molecular evidence...
  8. ncbi request reprint Radiation hybrid mapping of 304 novel microsatellites in the domestic cat genome
    M Menotti-Raymond
    Laboratory of Genomic Diversity, National Cancer Institute, Department of Health and Human Services, Frederick, MD 21702, USA
    Cytogenet Genome Res 102:272-6. 2003
    ..These resources can also be extended to the remaining 36 species of the cat family for population genetic and evolutionary genomic analyses...
  9. ncbi request reprint Development of a feline whole genome radiation hybrid panel and comparative mapping of human chromosome 12 and 22 loci
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, 21702, USA
    Genomics 57:1-8. 1999
    ..Assessment of concordant and discordant marker order for these loci provides improved resolution into the evolution of subchromosomal genome organizations and the methods to track them in these species...
  10. ncbi request reprint NK cell subsets in the regulation of murine hematopoiesis. I. 5E6+ NK cells promote hematopoietic growth in H-2d strain mice
    W J Murphy
    Biological Response Modifiers Program, Inc DynCorp, National Cancer Institute Frederick Cancer Research and Development Center, MD 21702, USA
    J Immunol 155:2911-7. 1995
    ..These results demonstrate that physiologically relevant subsets of NK cells exist that are involved in the homeostatic regulation of hematopoiesis and that they can be distinguished on the basis of 5E6 expression...
  11. ncbi request reprint Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo
    C Y Koh
    Laboratory of Leukocyte Biology, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD, USA
    Blood 97:3132-7. 2001
    ..Therefore, strategies to block inhibitory receptors may be of potential use in increasing the efficacy of immunotherapy. (Blood. 2001;97:3132-3137)..
  12. ncbi request reprint Integration of the feline radiation hybrid and linkage maps
    S Sun
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702-1201, USA
    Mamm Genome 12:436-41. 2001
    ..This integrated map provides the foundation for gene mapping assessments in the domestic cat and in related species of the Felidae family...
  13. ncbi request reprint Thymic emigrants isolated by a new method possess unique phenotypic and functional properties
    C K Lee
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute and Intramural Research Support Program, Science Application International Corporation, Frederick, MD 21702-1201, USA
    Blood 97:1360-9. 2001
    ..This suggests that a mechanism operating in vivo, perhaps tolerance or migration pattern, attenuates the response of emigrants against antigens that did not induce their deletion in the thymus...
  14. ncbi request reprint Phylogenetic assessment of introns and SINEs within the Y chromosome using the cat family felidae as a species tree
    J Pecon-Slattery
    National Cancer Institute Frederick, Frederick, Maryland, USA
    Mol Biol Evol 21:2299-309. 2004
    ..Overall, our data suggest X-degenerate genes within the NRY are singularly powerful markers and offer a valuable patrilineal perspective in species evolution...
  15. ncbi request reprint Resolution of the early placental mammal radiation using Bayesian phylogenetics
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Science 294:2348-51. 2001
    ..Crown-group Eutheria may have their most recent common ancestry in the Southern Hemisphere (Gondwana)...
  16. ncbi request reprint Second-generation integrated genetic linkage/radiation hybrid maps of the domestic cat (Felis catus)
    M Menotti-Raymond
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    J Hered 94:95-106. 2003
    ....
  17. ncbi request reprint Molecular phylogenetics and the origins of placental mammals
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Nature 409:614-8. 2001
    ..Our results provide new insight into the pattern of the early placental mammal radiation...
  18. ncbi request reprint Gastrointestinal cells of IL-7 receptor null mice exhibit increased sensitivity to irradiation
    L A Welniak
    Laboratory of Leukocyte Biology, Division of Basic Sciences, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    J Immunol 166:2924-8. 2001
    ..This study describes a novel role of IL-7 in nonhematopoietic tissues...
  19. pmc Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice
    W J Murphy
    SAIC Frederick, Division of Basic Science, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Clin Invest 102:1742-8. 1998
    ..These results therefore indicate, with regard to the TH1/ TH2 cytokine paradigm, the absence of a TH1-type cytokine can be deleterious in acute GVHD, whereas absence of a TH2 cytokine can be protective...
  20. ncbi request reprint The potential role of NK cells in the separation of graft-versus-tumor effects from graft-versus-host disease after allogeneic bone marrow transplantation
    W J Murphy
    NCI FCRDC, SAIC Frederick Intramural Research Support Program, MD 21702 1201, USA
    Immunol Rev 157:167-76. 1997
    ..Thus, the use of activated NK cells after allogeneic BMT may provide GVT effects without inducing GVHD...
  21. ncbi request reprint CD16 cross-linking blocks rearrangement of the TCR beta locus and development of alpha beta T cells and induces development of NK cells from thymic progenitors
    S K Durum
    Laboratory of Immunoregulation, Division of Basic Sciences, National Cancer Institute, Frederick, MD 21702 1201, USA
    J Immunol 161:3325-9. 1998
    ..These results suggest that common lymphoid precursors can respond to environmental signals to commit to the alpha beta T vs NK developmental pathways...
  22. ncbi request reprint Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studies
    W J Murphy
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute at Frederick, Maryland 21702, USA
    Immunol Rev 181:279-89. 2001
    ..Understanding their role in BMT provides insights as to their physiological roles and points the way to potential clinical uses...
  23. ncbi request reprint CD40 stimulation promotes human secondary immunoglobulin responses in HuPBL-SCID chimeras
    W J Murphy
    Laboratory of Leukocyte Biology, Division of Basic Sciences, Frederick, Maryland, 21702 1201, USA
    Clin Immunol 90:22-7. 1999
    ..Thus, CD40 stimulation promotes human secondary IgG responses in huPBL-SCID mice. These data demonstrate that CD40 stimulation is capable of promoting antigen-specific human B-cell responses in vivo...
  24. ncbi request reprint Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells
    R Salcedo
    Laboratory of Molecular Immunoregulation, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    J Immunol 166:7571-8. 2001
    ..This suggests that CCL11 may contribute to angiogenesis in conditions characterized by increased CCL11 production and eosinophil infiltration such as Hodgkin's lymphoma, nasal polyposis, endometriosis, and allergic diathesis...
  25. ncbi request reprint Antibodies to CD40 induce a lethal cytokine cascade after syngeneic bone marrow transplantation
    J A Hixon
    Intramural Research Support Program (Science Applications International Corporation-Frederick, Maryland 21702, USA
    Biol Blood Marrow Transplant 7:136-43. 2001
    ..These results indicate that CD40 stimulation using agonistic antibodies following lethal irradiation leads to a fatal, cytokine-induced disease affecting the intestine...
  26. ncbi request reprint New strategies for preventing graft-versus-host disease
    W J Murphy
    Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Curr Opin Immunol 11:509-15. 1999
    ..Questions about these features need answers to enable us to design successful approaches for intervention...
  27. pmc Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha
    R Salcedo
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Frederick Cancer Research and Development Center, Frederick, MD 21702 1202, USA
    Am J Pathol 154:1125-35. 1999
    ..Taken together, our data indicate that SDF-1alpha acts as a potent chemoattractant for endothelial cells of different origins bearing CXCR4 and is a participant in angiogenesis that is regulated at the receptor level by VEGF and bFGF...
  28. ncbi request reprint The neutrophil granule protein cathepsin G activates murine T lymphocytes and upregulates antigen-specific IG production in mice
    K Tani
    Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Biochem Biophys Res Commun 282:971-6. 2001
    ..Thus, neutrophil granule cathepsin G, in addition to its capacity to kill microbes and to enhance leukocyte motility, activates T lymphocytes and modulates humoral immunity...
  29. ncbi request reprint Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells
    R A Kirken
    IRSP, SAIC Frederick, Frederick Cancer Research and Development Center, Maryland, USA
    J Leukoc Biol 65:891-9. 1999
    ....
  30. ncbi request reprint A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion
    L Xu
    Biological Carcinogenesis and Development Program, Program Resources Inc DynCorp, Frederick Cancer Research and Development Center, MD 21702, USA
    J Immunol 155:1184-90. 1995
    ..These results suggest that SAA may play an important role in recruiting T lymphocytes, as well as neutrophils and monocytes into inflammatory lesions...
  31. ncbi request reprint Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils
    O Chertov
    Laboratory of Molecular Immunoregulation, Biological Response Modifiers Program, Division of Cancer Treatment, NCI, National Institutes of Health, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 271:2935-40. 1996
    ..These proteins represent primordial antimicrobial peptides which may have evolved into acute inflammatory cell-derived signals that mobilize immunocompetent T-cells and other inflammatory cells...
  32. ncbi request reprint Immunologic and hematologic effects of neuroendocrine hormones. Studies on DW/J dwarf mice
    W J Murphy
    Division of Cancer Treatment, Program Resources, Inc DynCorp, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702 1201
    J Immunol 148:3799-805. 1992
    ..Thus, these mice display significant myeloid and lymphoid deficiencies that have been previously undetected...
  33. pmc Differential effects of growth hormone and prolactin on murine T cell development and function
    W J Murphy
    Laboratory of Leukocyte Biology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
    J Exp Med 178:231-6. 1993
    ..GH appears to promote thymocyte proliferation, while PRL appears to decrease thymus size and yet augment the number and function of antigen-specific T cells in the periphery...
  34. ncbi request reprint The diverse role of chemokines in tumor progression: prospects for intervention (Review)
    G P Schneider
    Laboratory of Molecular Immunoregulation, National Cancer Institute-Frederick, Frederick, MD 21702, USA
    Int J Mol Med 8:235-44. 2001
    ..The role of chemokines in tumor biology as well as various means of blocking chemokines in cancer models in order to develop successful therapeutic strategies will be discussed...
  35. pmc Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes
    R Badolato
    Laboratory of Molecular Immunoregulation, Program Resources, Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
    J Exp Med 180:203-9. 1994
    ..On the basis of these data, we suggest that SAA may participate in enhancing the migration of monocytes and PMN to inflamed tissues during an acute phase response...
  36. ncbi request reprint Effects of prolactin on hematopoiesis
    L A Welniak
    Laboratory of Molecular Immunoregulation, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Lupus 10:700-5. 2001
    ..A review of this literature is provided as well as discussion of conditions under which lymphohematopoietic activity of prolactin may be evident...
  37. ncbi request reprint IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy
    Vanessa Berner
    Department of Microbiology and Immunology, University of Nevada at Reno, Reno, Nevada 89557, USA
    Nat Med 13:354-60. 2007
    ..Thus, although immunotherapeutic regimens inducing strong IFN-gamma responses can lead to successful early antitumor efficacy, they may also impair the development of durable antitumor responses...
  38. pmc Using genomic data to unravel the root of the placental mammal phylogeny
    William J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Genome Res 17:413-21. 2007
    ..We discuss the impacts of this topology on earlier phylogenetic reconstructions and repeat-based inferences of phylogeny...
  39. ncbi request reprint [Relationship between CCR5 and acute graft-versus-host disease in murine bone marrow transplantation]
    Zhao Wang
    Department of Hematology, Beijing Friendship Hospital, Capital University of Medicine Science, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:934-40. 2006
    ..It is concluded that the knock-out of CCR5 on donor cells results in increase of GVHD and donor CD8(+) T cell expansion, as well as hepatic and renal lesions in allo-HSCT, which indicates that CCR5 is very important in allo-BMT...
  40. pmc A 1.5-Mb-resolution radiation hybrid map of the cat genome and comparative analysis with the canine and human genomes
    William J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, Mail Stop 4458, College Station, TX 77843, USA
    Genomics 89:189-96. 2007
    ..This improved RH comparative map provides a useful tool to facilitate positional cloning studies in the feline model...
  41. ncbi request reprint Positive and negative regulation of Natural Killer cells: therapeutic implications
    William H D Hallett
    Department of Microbiology and Immunology, MS 199, University of Nevada School of Medicine, University of Nevada Reno, Reno, NV 89557, USA
    Semin Cancer Biol 16:367-82. 2006
    ....
  42. ncbi request reprint Stimulation through CD40 on mouse and human renal cell carcinomas triggers cytokine production, leukocyte recruitment, and antitumor responses that can be independent of host CD40 expression
    Lynnette Shorts
    Laboratory of Experimental Immunology, National Cancer Institute for Cancer Research, Frederick, MD 21702 1201, USA
    J Immunol 176:6543-52. 2006
    ..These results show that CD40 stimulation of CD40+ tumor cells can enhance immune responses and result in antitumor activity...
  43. pmc Novel gene acquisition on carnivore Y chromosomes
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 2:e43. 2006
    ..Specific plans to identify the male-specific genes encoded in the Y chromosome of mammals should be a priority...
  44. pmc Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells
    Isabel Barao
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 103:5460-5. 2006
    ..Thus, CD4(+)CD25(+) Treg cells can potently inhibit NK cell function in vivo, and their depletion may have therapeutic ramifications for NK cell function in BM transplantation and cancer therapy...
  45. pmc Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis
    Qing Zhou
    Department of Microbiology and Immunology, University of Nevada, Reno, 1664 N Virginia St, Reno, NV 89557, USA
    Infect Immun 74:2161-8. 2006
    ..These studies indicate that immunotherapy using anti-CD40 and IL-2 has therapeutic potential in augmenting host resistance to disseminated cryptococcosis and that IFN-gamma is essential for efficacy...
  46. ncbi request reprint The late Miocene radiation of modern Felidae: a genetic assessment
    Warren E Johnson
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    Science 311:73-7. 2006
    ..The phylogenetic performance of distinct gene classes showed that Y-chromosome segments are appreciably more informative than mitochondrial DNA, X-linked, or autosomal genes in resolving the rapid Felidae species radiation...
  47. ncbi request reprint The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAIL-mediated apoptosis
    Alan D Brooks
    Basic Research Program, SAIC Frederick Inc, MD 21702 1201, USA
    Ann N Y Acad Sci 1059:160-7. 2005
    ..Although the molecular basis of bortezomib sensitization of tumor cells to Apo2L/TRAIL remains to be determined, this combination can have an enhanced apoptotic effect over either agent alone for certain human cancer cells...
  48. ncbi request reprint Natural killer cells: biology and clinical use in cancer therapy
    William H D Hallett
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, Reno, NV 89557, USA
    Cell Mol Immunol 1:12-21. 2004
    ..This review will attempt to be a synthesis of current knowledge concerning NK cells, their involvement in BMT, and their use as an immunotherapy for cancer and other hematologic malignancies...
  49. ncbi request reprint The synthetic triterpenoid, CDDO, suppresses alloreactive T cell responses and reduces murine early acute graft-versus-host disease mortality
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, Reno, Nevada, USA
    Biol Blood Marrow Transplant 13:521-9. 2007
    ..These findings indicate that CDDO has a significant immunomodulatory effects in vitro and on early lethal aGVHD development, particularly affecting the liver, in a murine allo-HSCT model...
  50. ncbi request reprint Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: a potential mechanism for receptor dimerization
    Nuria Vazquez-Salat
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Genomics 90:213-24. 2007
    ....
  51. pmc TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection
    Patricia A Taylor
    Cancer Center and the Department of Pediatrics, Division of BMT, University of Minnesota, Minneapolis, USA
    Blood 112:3508-16. 2008
    ..Collectively, these data offer new insight into the mechanism of alloresponses regulating GVHD and BM rejection...
  52. pmc CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus
    Roman Puliaev
    Pathology Department, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA
    J Immunol 181:47-61. 2008
    ....
  53. pmc Differential effects of donor T-cell cytokines on outcome with continuous bortezomib administration after allogeneic bone marrow transplantation
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, School of Medicine, Reno, NV 89557, USA
    Blood 112:1522-9. 2008
    ..These results indicate that decreased toxicity and increased efficacy of bortezomib in murine allo-BMT can be achieved by removal of CD4(+) T cells from the graft or by inhibiting TNFalpha...
  54. pmc Regulatory and conventional CD4+ T cells show differential effects correlating with PD-1 and B7-H1 expression after immunotherapy
    Kory L Alderson
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    J Immunol 180:2981-8. 2008
    ..These results suggest that subset-specific expansion may contribute to marked shifts in the composition of the T cell compartment, potentially influencing the effectiveness of some immunotherapeutic approaches that rely on IFN-gamma...
  55. pmc Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor
    Roger S Holmes
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    BMC Evol Biol 8:54. 2008
    ..We also discuss the likely sequence of gene duplication events generating multiple CES genes during vertebrate evolution...
  56. doi request reprint Tracking genome organization in rodents by Zoo-FISH
    Alexander S Graphodatsky
    Institute of Cytology and Genetics, SB RAS 6300090, Novosibirsk, Russia
    Chromosome Res 16:261-74. 2008
    ..These findings provide insights into the likely composition of the ancestral rodent karyotype and an improved understanding of placental genome evolution...
  57. ncbi request reprint Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition
    William H D Hallett
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, NV 89557, USA
    J Immunol 180:163-70. 2008
    ..These results suggest that the combination of proteasome inhibition with immune therapy may result in increased antitumor efficacy...
  58. ncbi request reprint Designing and optimizing comparative anchor primers for comparative gene mapping and phylogenetic inference
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843 4458, USA
    Nat Protoc 2:3022-30. 2007
    ..We discuss factors that have to be considered for experimental design of broad-scope phylogenetic studies. With this protocol, primers can be designed, optimized and implemented within as little as 1-2 weeks...
  59. pmc 28-way vertebrate alignment and conservation track in the UCSC Genome Browser
    Webb Miller
    Center for Comparative Genomics and Bioinformatics, Penn State University, University Park, Pennsylvania 16802, USA
    Genome Res 17:1797-808. 2007
    ..Each functional class has a distinctive period of stringent constraint, followed by decays that allow (for the case of regulatory regions) or reject (for coding regions and ultraconserved elements) insertions and deletions...
  60. pmc Initial sequence and comparative analysis of the cat genome
    Joan U Pontius
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Genome Res 17:1675-89. 2007
    ..9-fold) coverage mammal genome sequence...
  61. ncbi request reprint Molecular and genomic data identify the closest living relative of primates
    Jan E Janecka
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Science 318:792-4. 2007
    ..Our data show that colugos are the closest living relatives of primates and indicate that their divergence occurred in the Cretaceous...
  62. ncbi request reprint The adequacy of morphology for reconstructing the early history of placental mammals
    Mark S Springer
    Department of Biology, University of California Riverside, Riverside, CA 92521, USA
    Syst Biol 56:673-84. 2007
  63. ncbi request reprint Mammalian evolution and biomedicine: new views from phylogeny
    Mark S Springer
    Department of Biology, University of California, Riverside, CA 92521, USA
    Biol Rev Camb Philos Soc 82:375-92. 2007
    ....
  64. pmc Combination therapy using IL-2 and anti-CD25 results in augmented natural killer cell-mediated antitumor responses
    William H D Hallett
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, NV 89557, USA
    Biol Blood Marrow Transplant 14:1088-99. 2008
    ..These findings demonstrate that superior NK cell-mediated antileukemic effects can be achieved with IL-2 administration and concurrent depletion of CD25(+) cells...
  65. ncbi request reprint Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Science 309:613-7. 2005
    ..We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement...
  66. ncbi request reprint An absence of CCR5 on donor cells results in acceleration of acute graft-vs-host disease
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada, Reno, Nev 89557, USA
    Exp Hematol 32:318-24. 2004
    ..We therefore assessed the role of CCR5 on donor cells in models where intensive conditioning of the recipient occurs, thus more appropriately mirroring the clinical experience...
  67. ncbi request reprint Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides
    John R Ortaldo
    Laboratory of Experimental Immunology, National Cancer Institute Center for Cancer Research, Building 560, Room 31 93, Frederick, MD 21702, USA
    J Immunol 172:943-53. 2004
    ..These results indicate the use of different TCR-binding ceramides can provide a unique approach for understanding the intricate immunoregulatory contributions of these two cell types...
  68. ncbi request reprint The immunobiology of natural killer cells and bone marrow allograft rejection
    Isabel Barao
    Department of Microbiology and Immunology, University of Nevada School of Medicine, University of Nevada, Reno, Nevda 89557, USA
    Biol Blood Marrow Transplant 9:727-41. 2003
    ....
  69. ncbi request reprint Genomics. A dog's breakfast?
    STEPHEN J O'BRIEN
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Science 301:1854-5. 2003
    ..As they explain, even though the coverage of the dog genome (1.5x) is lower than that of mouse (8x), there are many valuable insights to be gained from comparing the sequence of dog with those of mouse and human...
  70. ncbi request reprint NK-cell purging of leukemia: superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockade
    Crystal Y Koh
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Applied Research Facility, Bldg 344 MS 199, Reno, NV 89557, USA
    Blood 102:4067-75. 2003
    ..These results demonstrate that H2-allogeneic NK cells mediate more potent antitumor effects than syngeneic NK cells without adverse hematologic effects and thus may be useful in cancer therapy...
  71. ncbi request reprint Nuclear gene sequences confirm an ancient link between New Zealand's short-tailed bat and South American noctilionoid bats
    Emma C Teeling
    Basic Research Program, Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute Inc, Frederick, MD 21702, USA
    Mol Phylogenet Evol 28:308-19. 2003
    ..It is most probable that Mystacina dispersed from Australia to New Zealand while other noctilionoid bats either remained in or dispersed to South America...
  72. ncbi request reprint Immunologic and hematopoietic effects of recombinant human prolactin after syngeneic bone marrow transplantation in mice
    Rui Sun
    School of Life Sciences, University of Sciences and Technology of China, Anhui, China
    Biol Blood Marrow Transplant 9:426-34. 2003
    ..Mitogenic responses by both T and B cells were observed after PRL treatment. These results suggest that PRL may be of use to promote immune and myeloid reconstitution after BMT...
  73. ncbi request reprint Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells
    Rosalba Salcedo
    Laboratory of Molecular Immunoregulation, Cancer Center Research, National Cancer Institute NIH, Bldg 567, Rm 210, Frederick, MD 21702, USA
    Blood 102:1966-77. 2003
    ..These findings indicate that PGE2 is a mediator of VEGF- and bFGF-induced CXCR4-dependent neovessel assembly in vivo and show that angiogenic effects of PGE2 require CXCR4 expression...
  74. ncbi request reprint The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP
    Thomas J Sayers
    Basic Sciences Program, SAIC Frederick, Center for Cancer Research, National Cancer Institute NIH, Bldg 560, Rm 31 30, Frederick, MD 21702 1201, USA
    Blood 102:303-10. 2003
    ..These data therefore support the targeting of apoptotic pathways in tumor cells, using combinations of agents such as PS-341 and TRAIL that interact synergistically to preferentially promote tumor cell apoptosis...
  75. ncbi request reprint Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responses
    William J Murphy
    Department of Microbiology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Immunol 170:2727-33. 2003
    ..CD40 stimulation and IL-2 may therefore be of use to promote antitumor responses in advanced metastatic cancer...
  76. pmc Placental mammal diversification and the Cretaceous-Tertiary boundary
    Mark S Springer
    Department of Biology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 100:1056-61. 2003
    ..In these analyses, interordinal splits remained in the Cretaceous...
  77. ncbi request reprint The Feline Genome Project
    STEPHEN J O'BRIEN
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    Annu Rev Genet 36:657-86. 2002
    ..Here we review the advantages, rationale, and present strategy of a feline genome project, and we describe the disease models, comparative genomics, and biological applications posed by the full resolution of the cat's genome...
  78. pmc Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 101:8120-5. 2004
    ..Increased cytotoxic T cell killing of the tumor was also observed. Thus, the combination of proteasome inhibition with selective immune attack can markedly increase the efficacy of BMT in cancer...
  79. ncbi request reprint NK inhibitory-receptor blockade for purging of leukemia: effects on hematopoietic reconstitution
    Crystal Y Koh
    Transplantation Biology Laboratory, Laboratory of Molecular Immunoregulation, National Cancer Institute at Frederick, Maryland, USA
    Biol Blood Marrow Transplant 8:17-25. 2002
    ....
  80. ncbi request reprint Mesozoic origin for West Indian insectivores
    Alfred L Roca
    Laboratory of Genomic Diversity, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702, USA
    Nature 429:649-51. 2004
    ..Efforts to prevent extinction of the two surviving solenodon species would conserve an entire lineage as old or older than many mammalian orders...
  81. ncbi request reprint A rhesus macaque radiation hybrid map and comparative analysis with the human genome
    William J Murphy
    Basic Research Laboratory, SAIC Frederick, Inc, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Genomics 86:383-95. 2005
    ....
  82. ncbi request reprint In vivo hydrodynamic delivery of cDNA encoding IL-2: rapid, sustained redistribution, activation of mouse NK cells, and therapeutic potential in the absence of NKT cells
    John R Ortaldo
    Laboratory of Experimental Immunology, National Cancer Institute Center for Cancer Research, Frederick, MD 21702, USA
    J Immunol 175:693-9. 2005
    ....
  83. pmc Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity
    Kai Sun
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA
    Blood 106:3293-9. 2005
    ..These results indicate that the differential effects of proteasome inhibition with bortezomib on GVHD are critically dependent on the timing of bortezomib administration...
  84. ncbi request reprint Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy
    Thomas J Sayers
    Intramural Research Program, SAIC Frederick, Laboratory of Experimental Immunology, National Cancer Institute Center for Cancer Research, Frederick, MD 21702 1201, USA
    Cancer Immunol Immunother 55:76-84. 2006
    ..In addition, we present recent information from our groups concerning the possible therapeutic benefits of combining Apo2L/TRAIL with the proteasome inhibitor bortezomib...
  85. ncbi request reprint Lack of correlation between an assay used to determine early marrow allograft rejection and long-term chimerism after murine allogeneic bone marrow transplantation: effects of marrow dose
    Crystal Y Koh
    Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Biol Blood Marrow Transplant 11:252-9. 2005
    ....
  86. pmc Insertional polymorphisms of endogenous feline leukemia viruses
    Alfred L Roca
    Laboratory of Genomic Diversity, Basic Research Program, SAIC Frederick, Maryland, USA
    J Virol 79:3979-86. 2005
    ..Since endogenous FeLVs may affect the infectiousness or pathogenicity of exogenous FeLVs, genomic variation in enFeLVs represents a candidate for genetic influences on FeLV leukemogenesis in cats...
  87. ncbi request reprint A molecular phylogeny for bats illuminates biogeography and the fossil record
    Emma C Teeling
    Laboratory of Genomic Diversity, Basic Research Program, SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
    Science 307:580-4. 2005
    ....
  88. ncbi request reprint The feline major histocompatibility complex is rearranged by an inversion with a breakpoint in the distal class I region
    Thomas W Beck
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD, 21702 1201, USA
    Immunogenetics 56:702-9. 2005
    ..50 Mb of MHC class I/extended class I region, such that TRIM39 is adjacent to the Chromosome B2 centromere and TRIM26 is adjacent to the B2 telomere in the domestic cat...
  89. ncbi request reprint Mammalian phylogenomics comes of age
    William J Murphy
    Basic Research Laboratory, SAIC Frederick, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA
    Trends Genet 20:631-9. 2004
    ....
  90. ncbi request reprint Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administration
    Maria Gendelman
    Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 105:428-31. 2005
    ....
  91. ncbi request reprint Tumor regression by anti-CD40 and interleukin-2: role of CD40 in hematopoietic cells and organ-specific effects
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada, Reno, Nevada 89557, USA
    Biol Blood Marrow Transplant 10:534-9. 2004
    ..The results also suggest that the immunologic events in the liver may be more revealing that those in lymphoid organs with regard to critical events related to responses after therapy...
  92. ncbi request reprint Increased bone marrow allograft rejection by depletion of NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens
    Arati Raziuddin
    Intramural Research Support Program, SAIC Frederick and Laboratory of Experimental Immunology, National Cancer Institute at Frederick, MD 21702, USA
    Blood 100:3026-33. 2002
    ..Altering the balance of Ly49 NK subsets may also affect other in vivo activities of these cells...
  93. doi request reprint Morphology and placental mammal phylogeny
    Mark S Springer
    Department of Biology, University of California, Riverside, CA 92521, USA
    Syst Biol 57:499-503. 2008
  94. pmc Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation
    Lisbeth A Welniak
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Mail Stop 199, Reno, NV 89557, USA
    Blood 107:410-2. 2006
    ..We conclude that neither PPs nor host TNF-alpha is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT...
  95. ncbi request reprint Use of systemic proteasome inhibition as an immune-modulating agent in disease
    Lauren H Mattingly
    Department of Microbiology and Immunology, University of Nevada School of Medicine, Mail Stop 320, Reno, NV 89557, USA
    Endocr Metab Immune Disord Drug Targets 7:29-34. 2007
    ....
  96. ncbi request reprint Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor formyl peptide receptor 2 in murine microglial cells
    You hong Cui
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute, Building 560, Frederick, MD 21702, USA
    J Immunol 168:434-42. 2002
    ..Thus, LPS selectively modulates the function of chemoattractant receptors in microglia and may promote host response in inflammatory diseases in the CNS...