Philip M Murphy

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Defective antitumor responses in CX3CR1-deficient mice
    Yen Rei A Yu
    Thurston Arthritis Research Center and the Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Int J Cancer 121:316-22. 2007
  2. ncbi request reprint International union of pharmacology. XXII. Nomenclature for chemokine receptors
    P M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 52:145-76. 2000
  3. ncbi request reprint Viral exploitation and subversion of the immune system through chemokine mimicry
    P M Murphy
    Molecular Signaling Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bldg 10, Room 11N113, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 2:116-22. 2001
  4. ncbi request reprint International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature
    Philip M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 54:227-9. 2002
  5. pmc WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4
    Toshinao Kawai
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bldg 10 CRC 5 West Labs, Rm 5 3750, 10 Center Dr MSC 1456, Bethesda, MD 20892 1456, USA
    Blood 109:78-84. 2007
  6. pmc Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 116:2793-802. 2010
  7. ncbi request reprint Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms
    Jana Barlic
    Molecular Signaling Section, Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:48520-34. 2004
  8. ncbi request reprint Atherogenic lipids induce adhesion of human coronary artery smooth muscle cells to macrophages by up-regulating chemokine CX3CL1 on smooth muscle cells in a TNFalpha-NFkappaB-dependent manner
    Jana Barlic
    Molecular Signaling Section, Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:19167-76. 2007
  9. ncbi request reprint IL-15 alters expression and function of the chemokine receptor CX3CR1 in human NK cells
    Joan M Sechler
    Molecular Signaling Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Cell Immunol 230:99-108. 2004
  10. pmc An oxidized lipid-peroxisome proliferator-activated receptor gamma-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesion
    Jana Barlic
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cardiovasc Med 17:269-74. 2007

Detail Information

Publications78

  1. ncbi request reprint Defective antitumor responses in CX3CR1-deficient mice
    Yen Rei A Yu
    Thurston Arthritis Research Center and the Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Int J Cancer 121:316-22. 2007
    ..Our studies indicate that CX3CR1 is an important contributor to innate immunity at multiple levels. Its role in tumor immunity is not limited by expression of CX3CL1 by tumor cells...
  2. ncbi request reprint International union of pharmacology. XXII. Nomenclature for chemokine receptors
    P M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 52:145-76. 2000
    ....
  3. ncbi request reprint Viral exploitation and subversion of the immune system through chemokine mimicry
    P M Murphy
    Molecular Signaling Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bldg 10, Room 11N113, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 2:116-22. 2001
    ..The study of viral mimicry of chemokines and chemokine receptors is providing important new concepts in viral immunopathogenesis, new anti-inflammatory drug leads and new targets and concepts for antiviral drug and vaccine development...
  4. ncbi request reprint International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature
    Philip M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 54:227-9. 2002
    ..An update of the International Union of Pharmacology nomenclature for chemokines is outlined, defining one new receptor type, CXCR6, and disqualifying the putative receptor, CCR11...
  5. pmc WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4
    Toshinao Kawai
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bldg 10 CRC 5 West Labs, Rm 5 3750, 10 Center Dr MSC 1456, Bethesda, MD 20892 1456, USA
    Blood 109:78-84. 2007
    ..We conclude that increased apoptosis of mature myeloid cells in WHIM is secondary to a failure of marrow release and progression to normal myeloid cell senescence, and not a direct effect of activation of mutated CXCR4...
  6. pmc Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 116:2793-802. 2010
    ..Thus, myelokathexis associated with abnormally high neutrophil CXCR4 expression may contribute to neutropenia in G6PC3 deficiency and responds well to granulocyte colony-stimulating factor...
  7. ncbi request reprint Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms
    Jana Barlic
    Molecular Signaling Section, Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:48520-34. 2004
    ..We propose that expression of CX3CR1 and possibly other immunoregulatory genes may be determined in part by the balance of NFAT1 and NFAT2 activity in leukocytes...
  8. ncbi request reprint Atherogenic lipids induce adhesion of human coronary artery smooth muscle cells to macrophages by up-regulating chemokine CX3CL1 on smooth muscle cells in a TNFalpha-NFkappaB-dependent manner
    Jana Barlic
    Molecular Signaling Section, Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:19167-76. 2007
    ....
  9. ncbi request reprint IL-15 alters expression and function of the chemokine receptor CX3CR1 in human NK cells
    Joan M Sechler
    Molecular Signaling Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Cell Immunol 230:99-108. 2004
    ..The data imply that the use of IL-15 alone to expand NK cells ex vivo for immunotherapy may produce cells impaired in their ability to traffic to sites of inflammation...
  10. pmc An oxidized lipid-peroxisome proliferator-activated receptor gamma-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesion
    Jana Barlic
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cardiovasc Med 17:269-74. 2007
    ..Switching CX3CR1 on and CCR2 off in vivo may result in cessation of CCR2-dependent migration and activation of CX3CR1-dependent retention that together may promote foam cell accumulation in the vessel wall...
  11. pmc WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4
    Qian Liu
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 120:181-9. 2012
    ..Therefore, in addition to truncating mutations in the C-terminal domain of CXCR4, WHIM syndrome may be caused by a single charge-changing amino acid substitution in this domain, E343K, that results in increased receptor signaling...
  12. ncbi request reprint Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions
    So Youn Kim
    Section on Cellular Differentiation, Heritable Disorders Branch, NICHD, Molecular Signaling Section, Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:28794-801. 2006
    ..These findings demonstrate that Glc-6-PT expression in bone marrow and neutrophils is required for normal myeloid functions and that non-marrow Glc-6-PT activity also influences some myeloid functions...
  13. ncbi request reprint Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome
    Toshinao Kawai
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1456, USA
    Exp Hematol 33:460-8. 2005
    ....
  14. ncbi request reprint On the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2
    Jeremy J Rose
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:24372-86. 2004
    ..Rather than being integral to the process of cell migration, receptor endocytosis may be a terminal stop signal when cells reach the focus of inflammation where the chemoattractant concentrations are the highest...
  15. pmc The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 118:4957-62. 2011
    ..This study is registered at http://www.clinicaltrials.gov as NCT00967785...
  16. ncbi request reprint CXCL12 signaling is independent of Jak2 and Jak3
    Masato Moriguchi
    Molecular Immunology and Inflammation Branch, NIAMS, Laboratory of Host Defenses, NIAID, and Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:17408-14. 2005
    ..Thus, we conclude that in contrast to previous reports, Jaks, especially Jak3, are unlikely to play an essential role in chemokine signaling...
  17. pmc Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection
    William G Glass
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 202:1087-98. 2005
    ..We conclude that CCR5 is a critical antiviral and survival determinant in WNV infection of mice that acts by regulating trafficking of leukocytes to the infected brain...
  18. pmc Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-beta-deficient neutrophils in a congenital neutropenia syndrome
    Hyun Sik Jun
    Section on Cellular Differentiation, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 116:2783-92. 2010
    ..The results establish that in nonapoptotic neutrophils, G6Pase-β is essential for normal energy homeostasis. A G6Pase-β deficiency prevents recycling of ER glucose to the cytoplasm, leading to neutrophil dysfunction...
  19. pmc Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000321. 2009
    ..0001). Together, these data identify OAS1 SNP rs10774671 as a host genetic risk factor for initial infection with WNV in humans...
  20. pmc CCR5 deficiency is a risk factor for early clinical manifestations of West Nile virus infection but not for viral transmission
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, Laboratory of Cellular and Molecular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 201:178-85. 2010
    ....
  21. doi request reprint The major leukocyte chemotactic and activating factors in the mouse gut lumen are not N-formylpeptide receptor 1 agonists
    Teresa Ojode
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Innate Immun 5:2-14. 2013
    ..Thus, mouse intestinal lumen contains small, potent and highly efficacious leukocyte chemotactic and activating factors that may be distinct from neutrophils and peripheral blood mononuclear cells and distinct from Fpr1 agonists...
  22. pmc Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis
    Michail S Lionakis
    Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 8:e1002865. 2012
    ..Thus, neutrophil Ccr1 amplifies late renal immunopathology and increases mortality in invasive candidiasis by mediating excessive recruitment of neutrophils from the blood to the target organ...
  23. ncbi request reprint Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function
    Yuko Ishida
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:569-79. 2008
    ..Together, the data support a molecular model of skin wound repair in which CX3CR1 mediates direct recruitment of bone marrow-derived monocytes/macrophages which release profibrotic and angiogenic mediators...
  24. pmc Chemokine receptor CX3CR1 regulates renal interstitial fibrosis after ischemia-reperfusion injury
    Kengo Furuichi
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N113, Bethesda, MD 20892 9000, USA
    Am J Pathol 169:372-87. 2006
    ..CX3CR1 is the first chemokine receptor shown to contribute to fibrogenesis in renal ischemia-reperfusion injury...
  25. pmc Organ-specific innate immune responses in a mouse model of invasive candidiasis
    Michail S Lionakis
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Innate Immun 3:180-99. 2011
    ..The results delineate immune responses to the same pathogen that are highly idiosyncratic for each organ tested. The work provides novel insights into the balance between effective host defense and immunopathology in IC...
  26. pmc Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 186:471-8. 2011
    ..We conclude that Ccr2 mediates highly selective peripheral blood monocytosis during WNV infection of mice and that this is critical for accumulation of monocytes in the brain...
  27. ncbi request reprint Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor gamma-dependent pathway
    Jana Barlic
    Molecular Signaling SectionLaboratory of Molecular Immunology, National Institute ofAllergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circulation 114:807-19. 2006
    ..Recent genetic data in mouse and humans suggest that the chemokine receptors CCR2 and CX3CR1 are involved in atherogenesis; however, detailed molecular and cellular mechanisms have not been fully delineated...
  28. doi request reprint Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 197:262-5. 2008
    ..1 [95% CI, 0.9-11.2] [P= .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P= .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States...
  29. pmc Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 109:374-81. 2011
    ..Recent evidence suggests that both CCR6 and its ligand CCL20 are also present in human atheroma; however, their functional roles in atherogenesis remain undefined...
  30. pmc Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg 10, Rm11N113, Bethesda, MD 20892, USA
    Cardiovasc Res 97:580-8. 2013
    ..Here, we addressed this question by using the classic apolipoprotein E-deficient (ApoE(-/-)) mouse model of atherosclerosis...
  31. pmc Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion
    Jana Barlic
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:7928-36. 2009
    ..Thus, our findings support the hypothesis that CXCL16 mediates atheroprotection through its scavenger role in macrophages and not by cell-cell adhesion...
  32. pmc Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97
    Tao Wang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 75:1144-53. 2007
    ..Our results suggest that CD97 plays a role in peripheral granulocyte homeostasis...
  33. pmc Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury
    Kengo Furuichi
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:8670-6. 2008
    ..Thus, CCR1 appears to regulate trafficking of macrophages and neutrophils to kidney in a mouse model of renal ischemia-reperfusion injury, however this activity does not appear to affect tissue injury...
  34. pmc CCR5 deficiency increases risk of symptomatic West Nile virus infection
    William G Glass
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:35-40. 2006
    ..03). We conclude that CCR5 mediates resistance to symptomatic WNV infection. Because CCR5 is also the major HIV coreceptor, these findings have important implications for the safety of CCR5-blocking agents under development for HIV/AIDS...
  35. pmc AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Cell Mol Med 15:2071-81. 2011
    ..Together, our data provide further evidence that CXCR4(R334X) is a gain-of-function mutation, and support clinical evaluation of AMD3100 as mechanism-based treatment in patients with WHIM syndrome...
  36. pmc The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites
    Hyeseon Cho
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 32:4561-71. 2012
    ..Neutrophil RGS proteins establish a threshold for Gα(i) activation, helping to coordinate desensitization mechanisms. Their loss renders neutrophils functionally incompetent...
  37. ncbi request reprint CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells
    Sebastian Brenner
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Stem Cells 22:1128-33. 2004
    ..We conclude that transduction-mediated overexpression of CXCR4 significantly improves marrow engraftment of cultured PBSCs...
  38. pmc Characterization of Fpr-rs8, an atypical member of the mouse formyl peptide receptor gene family
    H Lee Tiffany
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Innate Immun 3:519-29. 2011
    ..Since ΨFpr-rs2 is expressed in phagocytes and regulated by bacterial products, and may affect longevity, we propose renaming it Fpr-rs8, an atypical member of the formyl peptide receptor gene family...
  39. ncbi request reprint Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice
    William G Glass
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 173:4030-9. 2004
    ..In this species, proinflammatory chemokines may coordinate a rapid and highly effective innate antiviral response in the lung, but NK cells and adaptive cellular immunity are not required for viral clearance...
  40. pmc Complete genome sequence of a tenth human polyomavirus
    Christopher B Buck
    NCI, Bethesda, Maryland, USA
    J Virol 86:10887. 2012
    ....
  41. pmc IL-10 limits parasite burden and protects against fatal myocarditis in a mouse model of Trypanosoma cruzi infection
    Ester Roffe
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:649-60. 2012
    ..Adoptive transfer experiments indicated that T cells were a source of protective IL-10. Thus, in this system, IL-10 production by T cells promotes T. cruzi control and protection from fatal acute myocarditis...
  42. ncbi request reprint Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter
    Li Yuan Chen
    Section on Cellular Differentiation, Heritable Disorders Branch, Natioanl Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 12:2547-58. 2003
    ..These findings demonstrate that G6PT is not just a G6P transport protein but also an important immunomodulatory protein whose activities need to be addressed in treating the myeloid complications in GSD-Ib patients...
  43. ncbi request reprint CCR5: no longer a "good for nothing" gene--chemokine control of West Nile virus infection
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Immunol 27:308-12. 2006
    ..Although CCR5 might be a logical target for new drug development in HIV/AIDS, the benefits of blocking CCR5 could carry the cost of an increased risk of WNV disease in co-infected patients...
  44. ncbi request reprint F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor
    Ji Liang Gao
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:1450-6. 2007
    ..Moreover, neutrophils from mice genetically deficient in Fpr2 failed to respond to F2L. Thus, Fpr2 is a mouse receptor for F2L, and can be targeted for the study of F2L action in mouse models...
  45. pmc Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans
    David H McDermott
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIH, Building 10, 9000 Rockville Pike, Bethesda, MD 20892 1886, USA
    J Clin Invest 111:1241-50. 2003
    ..Moreover, they suggest that CX3CR1-M280 is a genetic risk factor for CVD...
  46. doi request reprint SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing
    Bing Mei Zhu
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Invest Dermatol 128:1821-9. 2008
    ..These results demonstrate that wound healing is controlled in keratinocytes by the gp130-SOCS3-STAT3 pathway and an imbalance of this pathway results in delayed wound healing...
  47. ncbi request reprint Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C
    Kittichai Promrat
    The Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 124:352-60. 2003
    ..The roles of other disease-associated chemokine system polymorphisms have not been evaluated in hepatitis C virus infection...
  48. ncbi request reprint Reduced cell surface expression of CCR5 in CCR5Delta 32 heterozygotes is mediated by gene dosage, rather than by receptor sequestration
    Sundararajan Venkatesan
    Laboratory of Molecular Microbiology and Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:2287-301. 2002
    ....
  49. pmc Reduced fear memory and anxiety-like behavior in mice lacking formylpeptide receptor 1
    Ji Liang Gao
    Molecular Signalling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N107, NIH, Bethesda, MD 20892, USA
    Behav Genet 41:724-33. 2011
    ..The data implicate Fpr1 in modulation of anxiety-like behavior and fear memory by regulating glucocorticoid production...
  50. ncbi request reprint IL-15 and IL-2 oppositely regulate expression of the chemokine receptor CX3CR1
    Jana Barlic
    molecualr Signalling Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:3494-503. 2003
    ..Finally, our results provide additional evidence for differential signaling by IL-2 and IL-15, despite usage of common beta gamma c receptor chains...
  51. ncbi request reprint Chemokine regulation of inflammation during acute viral infection
    William G Glass
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Allergy Clin Immunol 3:467-73. 2003
    ..This article will discuss scientific papers published primarily since June 2002 that have introduced new concepts in how chemokines regulate the inflammatory response to specific viruses...
  52. ncbi request reprint Chemokine regulation of atherosclerosis
    Jana Barlic
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 82:226-36. 2007
    ..The results suggest a coordinated mechanism for inflammatory cell accumulation in plaque and identify novel targets, such as CCR2 and CX3CR1, for potential drug development in coronary artery disease...
  53. ncbi request reprint Simian cytomegalovirus encodes five rapidly evolving chemokine receptor homologues
    Alfredo Sahagun-Ruiz
    Molecular Signaling Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virus Genes 28:71-83. 2004
    ..The rate of divergence appears to be very rapid compared to other known SCMV genes, suggesting strong positive selection...
  54. doi request reprint Regulation of atherogenesis by chemokines and chemokine receptors
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Immunol Ther Exp (Warsz) 61:1-14. 2013
    ..This study will review key discoveries in basic and translational research in this area...
  55. pmc Regulation of atherogenesis by chemokine receptor CCR6
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cardiovasc Med 21:140-4. 2011
    ....
  56. pmc The leukocyte chemotactic receptor FPR1 is functionally expressed on human lens epithelial cells
    Erich H Schneider
    Molecular Signaling Section, Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 287:40779-92. 2012
    ..Lens degeneration in Fpr1(-/-) mice prompted us to search for functional FPR1 expression directly on lens epithelial cells...
  57. ncbi request reprint CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study
    David H McDermott
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
    Circulation 112:1113-20. 2005
    ..Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory...
  58. ncbi request reprint Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways
    Christophe Cataisson
    Laboratories of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    J Immunol 171:2703-13. 2003
    ....
  59. pmc Autosomal dominant epidermodysplasia verruciformis lacking a known EVER1 or EVER2 mutation
    David F McDermott
    Molecular Signaling Section, NIAID, NIH, Bethesda, Maryland, USA
    Pediatr Dermatol 26:306-10. 2009
    ..This is the first report of autosomal dominant transmission of epidermodysplasia verruciformis, providing further evidence of the genetic heterogeneity of epidermodysplasia verruciformis...
  60. ncbi request reprint The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils
    Mark C Lavigne
    Laboratory of Host Defenses, NIAID, NIH, Bethesda, MD 20892, USA
    Cell Immunol 218:7-12. 2002
    ..This less sensitive second pathway may permit continued oxidant generation in response to formyl peptides when FPR is desensitized in high concentrations of the chemotactic gradient...
  61. pmc Antimicrobial chemokines
    Sunny C Yung
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD, USA
    Front Immunol 3:276. 2012
    ..More research will be needed to determine whether chemokines with direct antimicrobial activity may be translated into a novel class of antibiotics...
  62. pmc Distinct mechanisms of agonist-induced endocytosis for human chemokine receptors CCR5 and CXCR4
    Sundararajan Venkatesan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Biol Cell 14:3305-24. 2003
    ..This novel feature of CCR5 may modulate its signaling potential and could explain its preferential use by HIV for person-to-person transmission of disease...
  63. pmc Host chemokines bind to Staphylococcus aureus and stimulate protein A release
    Sunny C Yung
    Molecular Signaling Section, Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:5069-77. 2011
    ..Our data identify a potential new mode of immune evasion, in which the pathogen exploits a host defense factor to release a virulence factor; moreover, chemokine binding may serve a scavenging function in immune evasion by S. aureus...
  64. ncbi request reprint Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice
    Christophe Combadiere
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circulation 107:1009-16. 2003
    ..A polymorphism in the CX3CR1 gene is associated with low CX3CR1 expression and reduced risk of acute coronary disease in humans...
  65. ncbi request reprint Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2
    Michael H Kershaw
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 13:1971-80. 2002
    ..This study demonstrates the feasibility of redirecting the migration properties of T cells toward chemokines secreted by tumors...
  66. ncbi request reprint Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction
    Vaclav Eis
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 15:337-47. 2004
    ..Therefore, CCR1 is a promising target for therapeutic intervention in leukocyte-mediated fibrotic tissue injury, e.g. progressive renal fibrosis...
  67. ncbi request reprint Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production
    Koichi Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Immunol 34:3553-61. 2004
    ..These results indicate that CCR1, CCR5, and CCL3 cooperatively contribute to the cutaneous Arthus reaction, and also suggest that enhanced expression of CCL3 and CCL5 compensates for the loss of CCR1, CCR5, and CCL3 in the reaction...
  68. pmc Role for CCR5Delta32 protein in resistance to R5, R5X4, and X4 human immunodeficiency virus type 1 in primary CD4+ cells
    Lokesh Agrawal
    Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Virol 78:2277-87. 2004
    ....
  69. ncbi request reprint Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation
    Reza Abdi
    Renal Division, Brigham and Women s Hospital, Boston, Massachesetts, USA
    J Am Soc Nephrol 13:754-8. 2002
    ..20; P = 0.032) and homozygosity for the 59029-A allele (OR, 0.26; P = 0.027). It was concluded that the risk of acute rejection in renal transplantation is associated with genetic variation in the chemokine receptors CCR2 and CCR5...
  70. ncbi request reprint The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner
    Ian Sabroe
    Leukocyte Biology Section, Biomedical Sciences Division, Imperial College London, UK
    Eur J Immunol 35:1301-10. 2005
    ..Thus, the CCR3 C terminus contains distinct domains responsible for the regulation of receptor desensitization and for coupling to chemotactic responses...
  71. ncbi request reprint Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, University of Munich, Germany
    J Am Soc Nephrol 16:977-85. 2005
    ..These data identify CCR1 as a potential therapeutic target for Alport disease or other progressive nephropathies associated with interstitial macrophage infiltrates...
  72. ncbi request reprint Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines
    Cécile E Duchesnes
    Leukocyte Biology and Section, Biomedical Sciences Division, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK
    Mol Immunol 43:1221-31. 2006
    ..Determining how these chemokines interact with their receptor at the molecular level should increase our understanding of the process of chemokine receptor activation...
  73. ncbi request reprint Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10
    Alma Zernecke
    Department of Cardiology, Rheinisch Westfälische Technische Hochschule Aachen University, Germany
    Blood 107:4240-3. 2006
    ..This harbors important implications for targeting chemokine receptors in vascular remodeling...
  74. ncbi request reprint Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression
    Xiaoqin Yang
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Int J Cancer 118:1869-76. 2006
    ..These observations suggest the contribution of the CCR1-CCL3 axis to HCC progression...
  75. ncbi request reprint The chemokine receptor CCR1 is strongly up-regulated after skin injury but dispensable for wound healing
    Susanne Kaesler
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    Wound Repair Regen 12:193-204. 2004
    ..These results show that CCR1 is dispensable for wound healing, most likely due to redundancy in chemokine/chemokine receptor signaling...
  76. ncbi request reprint Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding
    Dennis Verzijl
    Leiden Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 281:35327-35. 2006
    ..Thus, Hx8 appears to exert a key role in receptor stabilization through the conserved residue R7.61, directing the ligand binding profile of ORF74 and likely also that of other class A G-protein-coupled receptors...
  77. ncbi request reprint Roles of chemokines in renal ischemia/reperfusion injury
    Kengo Furuichi
    Department of Gastroenterology and Nephrology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Front Biosci 13:4021-8. 2008
    ..A number of challenges of chemokine targeted therapy is trying to prevent the ischemic injury, and will give some beneficial effect on the injury...
  78. pmc Intra-neural administration of fractalkine attenuates neuropathic pain-related behaviour
    Fiona E Holmes
    Departments of Physiology and Pharmacology and Clinical Sciences South Bristol, University of Bristol, Bristol, UK
    J Neurochem 106:640-9. 2008
    ..Taken together, these results suggest an anti-allodynic role for fractalkine and its receptor in the mouse...