Elizabeth Murphy

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc S-nitrosylation: a radical way to protect the heart
    Elizabeth Murphy
    Cardiac Physiology Section, Systems Biology Center, NHLBI, NIH, Bethesda, MD 20892, USA
    J Mol Cell Cardiol 52:568-77. 2012
  2. pmc What makes the mitochondria a killer? Can we condition them to be less destructive?
    Elizabeth Murphy
    Translational Medicine Branch, NHLBI, NIH, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1813:1302-8. 2011
  3. pmc Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females
    Claudia J Lagranha
    Translational Medicine Branch, NHLBI NIH 10 Center Bethesda, MD 20892, USA
    Circ Res 106:1681-91. 2010
  4. pmc Disruption of caveolae blocks ischemic preconditioning-mediated S-nitrosylation of mitochondrial proteins
    Junhui Sun
    Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Antioxid Redox Signal 16:45-56. 2012
  5. pmc CypD(-/-) hearts have altered levels of proteins involved in Krebs cycle, branch chain amino acid degradation and pyruvate metabolism
    Sara Menazza
    Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Mol Cell Cardiol 56:81-90. 2013
  6. pmc Measurement of S-nitrosylation occupancy in the myocardium with cysteine-reactive tandem mass tags: short communication
    Mark J Kohr
    Laboratory of Cardiac Physiology, Systems Biology Center, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    Circ Res 111:1308-12. 2012
  7. ncbi request reprint Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport
    Junhui Sun
    NHLBI, NIH, Vascular Medicine Branch, Bethesda, MD 20892, USA
    Circ Res 101:1155-63. 2007
  8. pmc Acute inhibition of GSK causes mitochondrial remodeling
    Tiffany Nguyen
    Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Heart Circ Physiol 302:H2439-45. 2012
  9. pmc Mechanism of cardioprotection: what can we learn from females?
    Elizabeth Murphy
    NHLBI, NIH, Room 8N202, Building 10, 10 Center Drive, Bethesda, MD, USA
    Pediatr Cardiol 32:354-9. 2011
  10. pmc Cardioprotection leads to novel changes in the mitochondrial proteome
    Renee Wong
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 298:H75-91. 2010

Collaborators

Detail Information

Publications44

  1. pmc S-nitrosylation: a radical way to protect the heart
    Elizabeth Murphy
    Cardiac Physiology Section, Systems Biology Center, NHLBI, NIH, Bethesda, MD 20892, USA
    J Mol Cell Cardiol 52:568-77. 2012
    ..The role of nitric oxide synthase uncoupling in cardioprotection will also be addressed. This article is part of a Special Section entitled "Post-translational Modification."..
  2. pmc What makes the mitochondria a killer? Can we condition them to be less destructive?
    Elizabeth Murphy
    Translational Medicine Branch, NHLBI, NIH, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1813:1302-8. 2011
    ..This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
  3. pmc Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females
    Claudia J Lagranha
    Translational Medicine Branch, NHLBI NIH 10 Center Bethesda, MD 20892, USA
    Circ Res 106:1681-91. 2010
    ..Although premenopausal females have a lower risk for cardiovascular disease, the mechanism(s) are poorly understood...
  4. pmc Disruption of caveolae blocks ischemic preconditioning-mediated S-nitrosylation of mitochondrial proteins
    Junhui Sun
    Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Antioxid Redox Signal 16:45-56. 2012
    ..Mitochondria are key regulators of preconditioning, and most proteins showing an increase in SNO with IPC are mitochondrial. The aim of this study was to address how IPC transduces NO/SNO signaling to mitochondria in the heart...
  5. pmc CypD(-/-) hearts have altered levels of proteins involved in Krebs cycle, branch chain amino acid degradation and pyruvate metabolism
    Sara Menazza
    Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Mol Cell Cardiol 56:81-90. 2013
    ..In summary, CypD(-/-) hearts exhibit changes in many metabolic pathways and caution should be used when interpreting results from these mice as due solely to inhibition of the MPTP...
  6. pmc Measurement of S-nitrosylation occupancy in the myocardium with cysteine-reactive tandem mass tags: short communication
    Mark J Kohr
    Laboratory of Cardiac Physiology, Systems Biology Center, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    Circ Res 111:1308-12. 2012
    ..However, little is known with regard to the percentage of a given protein that is modified by SNO (ie, SNO occupancy). Current methods allow for the relative quantification of SNO levels, but not for the determination of SNO occupancy...
  7. ncbi request reprint Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport
    Junhui Sun
    NHLBI, NIH, Vascular Medicine Branch, Bethesda, MD 20892, USA
    Circ Res 101:1155-63. 2007
    ..IPC and GSNO produced a similar pattern of S-nitrosylation modification and cardiac protection against ischemia/reperfusion injury, suggesting that protein S-nitrosylation may play an important cardioprotective role in heart...
  8. pmc Acute inhibition of GSK causes mitochondrial remodeling
    Tiffany Nguyen
    Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Heart Circ Physiol 302:H2439-45. 2012
    ..Taken together, these data show that SB leads to a remodeling of the mitochondrial proteome that is partially GD sensitive...
  9. pmc Mechanism of cardioprotection: what can we learn from females?
    Elizabeth Murphy
    NHLBI, NIH, Room 8N202, Building 10, 10 Center Drive, Bethesda, MD, USA
    Pediatr Cardiol 32:354-9. 2011
    ..It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed...
  10. pmc Cardioprotection leads to novel changes in the mitochondrial proteome
    Renee Wong
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 298:H75-91. 2010
    ..Thus the ability of PC and GSK inhibition to alter the expression levels of electron transport complexes will have important implications for mitochondrial function...
  11. pmc Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats
    Anne M Deschamps
    National Institutes of Health, National Heart, Lung, and Blood Institute, Translational Medicine Branch, Laboratory of Cardiac Physiology, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 297:H1806-13. 2009
    ..Taken together, the data show that G-1 activation of GPER improves functional recovery and reduces infarct size in isolated rat hearts following I/R through a PI3K-dependent, gender-independent mechanism...
  12. pmc Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation versus sGC/cGMP/PKG signaling?
    Junhui Sun
    Systems Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 54:105-12. 2013
    ..In conclusion, these results suggest that the protective effect of NO is not related primarily to activation of the sGC/cGMP/PKG signaling pathway, but rather through SNO signaling in IPC-induced acute cardioprotection...
  13. pmc Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore
    Tiffany T Nguyen
    Systems Biology Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:40184-92. 2011
    ..Our results indicate that the Cys-203 residue of CypD is necessary for redox stress-induced activation of mPTP...
  14. pmc Calcium-sensing receptor: a sensor and mediator of ischemic preconditioning in the heart
    Junhui Sun
    Translational Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bldg 10 Rm 8N206, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 299:H1309-17. 2010
    ..Taken together, the distribution of CaSR in caveolae along with NPS2143-blockade of IPC-induced cardioprotective signaling suggest that the activation of CaSR during IPC is cardioprotective by a process involving caveolae...
  15. pmc Estrogen receptor activation and cardioprotection in ischemia reperfusion injury
    Anne M Deschamps
    National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cardiovasc Med 20:73-8. 2010
    ..In this review, we will focus on the signaling pathways leading to cardioprotection in ischemia reperfusion injury after ER activation and discuss the possibility and promise of specific ER modulators to treat ischemic heart diseases...
  16. pmc Optical spectroscopy in turbid media using an integrating sphere: mitochondrial chromophore analysis during metabolic transitions
    David J Chess
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Anal Biochem 439:161-72. 2013
    ..Surprisingly, I/R resulted in an inhibition of all measured MOPC conductances, suggesting a coordinated down-regulation of mitochondrial activity with this well-established cardiac perturbation...
  17. pmc Protein S-nitrosylation and cardioprotection
    Junhui Sun
    Translational Medicine Branch, NHLBI, NIH, 10 Center Dr, Room 7N112, Bethesda, MD 20892, USA
    Circ Res 106:285-96. 2010
    ..A better understanding of the mechanism regulating protein S-nitrosylation and its role in cardioprotection will provide us new therapeutic opportunities and targets for interventions in cardiovascular diseases...
  18. pmc Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury
    Elizabeth Murphy
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Physiol Rev 88:581-609. 2008
    ..Preconditioning activates a number of signaling pathways that reduce Ca(2+) overload and reduce activation of the mitochondrial permeability transition pore. The mitochondrial targets of cardioprotective signals are discussed in detail...
  19. pmc Myristoylated methionine sulfoxide reductase A protects the heart from ischemia-reperfusion injury
    Hang Zhao
    Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    Am J Physiol Heart Circ Physiol 301:H1513-8. 2011
    ..We conclude that cytosolic MsrA protects the heart from ischemia-reperfusion damage. The requirement for myristoylation suggests that MsrA must interact with a hydrophobic domain to provide protection...
  20. ncbi request reprint Cardioprotection in females: a role for nitric oxide and altered gene expression
    Elizabeth Murphy
    Head Cardiac Physiology Section, Vascular Medicine Branch, National Heart, Lung, and Blood Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Heart Fail Rev 12:293-300. 2007
    ..Taken together, estrogen by genomic and non-genomic pathways can result in the initiation of a number of signaling pathways that enhance cardioprotection...
  21. pmc miR-222 contributes to sex-dimorphic cardiac eNOS expression via ets-1
    Alicia M Evangelista
    Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Physiol Genomics 45:493-8. 2013
    ..Our findings indicate that sex-dependent miR-222 regulation alters the expression of the cardiac regulatory protein eNOS...
  22. doi request reprint The NAD-dependent deacetylase SIRT2 is required for programmed necrosis
    Nisha Narayan
    Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Nature 492:199-204. 2012
    ....
  23. pmc What can we learn about cardioprotection from the cardiac mitochondrial proteome?
    Marjan Gucek
    NHLBI Proteomics Core, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Cardiovasc Res 88:211-8. 2010
    ..We focus on the cardiac mitochondrial proteome with emphasis on changes associated with cell death and protection, and we summarize how proteomic data have contributed to addressing the role of mitochondria in cardioprotection...
  24. pmc Mitochondrial permeability transition pore and calcium handling
    Renee Wong
    Cardiac Physiology Section, Systems Biology Center, NHLBI, NIH, Bethesda, MD 20892, USA
    Methods Mol Biol 810:235-42. 2012
    ..This chapter focuses on key issues in the study of the MPT and provides some methods for measuring MPT opening in isolated mitochondria...
  25. pmc Does inhibition of glycogen synthase kinase protect in mice?
    Elizabeth Murphy
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Circ Res 103:226-8. 2008
  26. pmc The role of comorbidities in cardioprotection
    Michael N Sack
    Center for Molecular Medicine, NHLBI, NIH, Bethesda, MD, USA
    J Cardiovasc Pharmacol Ther 16:267-72. 2011
    ..It is important to understand at a mechanistic level the reasons for these differences. The effects of sex and diseases need to be considered in design of cardioprotective interventions in animal studies and clinical trials...
  27. pmc S-nitrosylation: NO-related redox signaling to protect against oxidative stress
    Junhui Sun
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Antioxid Redox Signal 8:1693-705. 2006
    ..However, oxidative stress and the resultant dysfunction of NO signaling have been implicated in the pathogenesis of cardiovascular diseases...
  28. ncbi request reprint Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and caffeine
    Abraham Nyska
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 83:388-96. 2005
    ..Our work shows the direct relationship between combined ephedrine and caffeine exposure and cardiac pathology...
  29. ncbi request reprint Bcl-2 regulation of mitochondrial energetics
    Elizabeth Murphy
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Trends Cardiovasc Med 15:283-90. 2005
    ..Understanding the physiologic processes controlled by Bcl-2 will be important in understanding cell regulation, and it may also provide new insights into the regulation of apoptosis...
  30. pmc Inhibit GSK-3beta or there's heartbreak dead ahead
    Elizabeth Murphy
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 113:1526-8. 2004
    ..The phosphorylation and inhibition of GSK-3beta lead to inhibition or delayed activation of the mitochondrial permeability transition, a key regulator of apoptosis...
  31. ncbi request reprint Primary and secondary signaling pathways in early preconditioning that converge on the mitochondria to produce cardioprotection
    Elizabeth Murphy
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, USA
    Circ Res 94:7-16. 2004
    ..Alterations in these mitochondrial proteins results in altered metabolism and inhibition of cell death, thus resulting in cardioprotection...
  32. ncbi request reprint Is Na/Ca exchange during ischemia and reperfusion beneficial or detrimental?
    Elizabeth Murphy
    Laboratory of Signal Transduction, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 976:421-30. 2002
    ..These studies suggest that overexpression of the Na/Ca exchanger enhances injury in males, but females are protected by a gender-related mechanism...
  33. ncbi request reprint Preconditioning: the mitochondrial connection
    Elizabeth Murphy
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Annu Rev Physiol 69:51-67. 2007
    ..This review focuses on mechanisms by which cardioprotection alters mitochondrial proteins and channels that regulate cell death and survival...
  34. pmc S-nitrosylation of TRIM72 at cysteine 144 is critical for protection against oxidation-induced protein degradation and cell death
    Mark J Kohr
    Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA Division of Cardiovascular Pathology, Department of Pathology, 720 Rutland Avenue, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Electronic address
    J Mol Cell Cardiol 69:67-74. 2014
    ....
  35. pmc Does the voltage dependent anion channel modulate cardiac ischemia-reperfusion injury?
    Samarjit Das
    Department of Pathology, Johns Hopkins Medical Institute and Systems Biology Center, NHLBI, NIH, Bethesda, MD, USA
    Biochim Biophys Acta 1818:1451-6. 2012
    ..This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism...
  36. ncbi request reprint Treatment with an estrogen receptor-beta-selective agonist is cardioprotective
    Ivana Nikolic
    Laboratory of Signal Transduction, NIEHS, NIH, DHHS, Durham, NC, USA
    J Mol Cell Cardiol 42:769-80. 2007
    ..Gene profiling showed that treatment with DPN resulted in upregulation of a number of protective genes such as heat shock protein 70, the antiapoptotic protein, growth arrest and DNA damage 45 beta, and cyclooxygenase 2...
  37. pmc Estrogen signaling and cardiovascular disease
    Elizabeth Murphy
    Cardiac Physiology Section, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 109:687-96. 2011
    ..This article reviews the different estrogen receptors and their signaling mechanisms, discusses mechanisms that regulate estrogen receptor levels and locations, and considers the cardiovascular effects of estrogen signaling...
  38. pmc Ion transport and energetics during cell death and protection
    Elizabeth Murphy
    National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Physiology (Bethesda) 23:115-23. 2008
    ..This review will discuss mechanisms involved in alterations in ions and high energy phosphate metabolites in perfused or intact heart during ischemia and reperfusion...
  39. ncbi request reprint Unresolved questions from the analysis of mice lacking MCU expression
    Elizabeth Murphy
    Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Biochem Biophys Res Commun 449:384-5. 2014
    ..Here, we discuss our findings as well as potential explanations for some of the more unexpected results. ..
  40. ncbi request reprint Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury
    Elizabeth Murphy
    Vascular Medicine Branch, NHLBI, NIH, DHHS, Bethesda, MD 20892, USA
    Cardiovasc Res 75:478-86. 2007
    ..This review will summarize the data showing protection in females in animal studies and will summarize the data on possible mechanisms of cardioprotection in females...
  41. ncbi request reprint Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration
    Sruti Shiva
    Vascular Medicine Branch, Clinical Center National Institutes of Health, Bethesda, MD 20892 1662, USA
    Circ Res 100:654-61. 2007
    ....
  42. ncbi request reprint Inhibition of GSK-3beta as a target for cardioprotection: the importance of timing, location, duration and degree of inhibition
    Elizabeth Murphy
    National Institute of Environmental Health Sciences, Laboratory of Signal Transduction, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Expert Opin Ther Targets 9:447-56. 2005
    ..Therapies for inhibiting GSK are feasible as there are a number of newly developed specific inhibitors of GSK available, although most of these drugs have not been tested in long-term animal studies...
  43. pmc Regulation of intracellular and mitochondrial sodium in health and disease
    Elizabeth Murphy
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Circ Res 104:292-303. 2009
    ..Although much has been learned about sodium regulation in the heart, there are still many unanswered questions, particularly concerning mitochondrial Na regulation...
  44. pmc Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1
    Edward G Lynn
    Translational Medicine Branch, NHLBI, NIH, Bethesda, MD 20892 1454, USA
    J Mol Cell Cardiol 49:693-8. 2010
    ..These adverse phenotypes appear to be mediated, in part, by PGC-1alpha induced upregulation of ANT1...