Dennis Murphy

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies
    Renee F Ren-Patterson
    Laboratory of Clinical Science, NIMH, Bethesda, MD 20892 1264, USA
    Cell Mol Neurobiol 26:755-80. 2006
  2. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
  3. ncbi request reprint The developing use of heterozygous mutant mouse models in brain monoamine transporter research
    Allan V Kalueff
    Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Drive, 1264 Bethesda, MD 20892 1264, USA
    Trends Pharmacol Sci 28:122-7. 2007
  4. pmc Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Eur J Pharmacol 589:225-7. 2008
  5. pmc How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
  6. pmc 5HTTLPR: White Knight or Dark Blight?
    Dennis L Murphy
    Laboratory of Clinical Science, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States
    ACS Chem Neurosci 4:13-5. 2013
  7. pmc Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice
    Pablo R Moya
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    BMC Pharmacol 11:3. 2011
  8. pmc Characterizing the hoarding phenotype in individuals with OCD: associations with comorbidity, severity and gender
    Michael Wheaton
    Laboratory of Clinical Science, National Institute of Mental Health, USA
    J Anxiety Disord 22:243-52. 2008
  9. doi request reprint Targeting the murine serotonin transporter: insights into human neurobiology
    Dennis L Murphy
    Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 9:85-96. 2008
  10. ncbi request reprint Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression
    Andrew Holmes
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 1375, USA
    Biol Psychiatry 54:953-9. 2003

Detail Information

Publications83

  1. ncbi request reprint Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies
    Renee F Ren-Patterson
    Laboratory of Clinical Science, NIMH, Bethesda, MD 20892 1264, USA
    Cell Mol Neurobiol 26:755-80. 2006
    ....
  2. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  3. ncbi request reprint The developing use of heterozygous mutant mouse models in brain monoamine transporter research
    Allan V Kalueff
    Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Drive, 1264 Bethesda, MD 20892 1264, USA
    Trends Pharmacol Sci 28:122-7. 2007
    ..Here, we discuss why heterozygous mouse models, in addition to knockout mice, might be useful for brain monoamine transporter research...
  4. pmc Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
    Eur J Pharmacol 589:225-7. 2008
    ..Moreover, blood pressure elevated similarly (~50 mm Hg) in all strains given DOCA and salt. Thus, the lack of functional SERT did not prevent development of DOCA-salt induced hypertension or modify basal blood pressure significantly...
  5. pmc How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
    ..We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin's many important homeostatic functions in humans, non-human primates, mice and other species...
  6. pmc 5HTTLPR: White Knight or Dark Blight?
    Dennis L Murphy
    Laboratory of Clinical Science, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States
    ACS Chem Neurosci 4:13-5. 2013
    ..This field thus seems stultified. Improved science for the present and future will be better served by attention to more complete methods for genotyping and subject sample reporting...
  7. pmc Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice
    Pablo R Moya
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    BMC Pharmacol 11:3. 2011
    ..In this study, we determined the responsiveness of 5-HT2CR in serotonin transporter (SERT) knockout (-/-) mice, a model characterized by increased anxiety-like and stress-responsive behaviors...
  8. pmc Characterizing the hoarding phenotype in individuals with OCD: associations with comorbidity, severity and gender
    Michael Wheaton
    Laboratory of Clinical Science, National Institute of Mental Health, USA
    J Anxiety Disord 22:243-52. 2008
    ..Male hoarders had an increased prevalence of social phobia compared to non-hoarding males. These results suggest that there are gender-specific differences in the hoarding sub-phenotype of OCD...
  9. doi request reprint Targeting the murine serotonin transporter: insights into human neurobiology
    Dennis L Murphy
    Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 9:85-96. 2008
    ..Nevertheless, SERT-function-modifying gene variants in humans apparently produce many phenotypes that are similar to those that manifest themselves in mice...
  10. ncbi request reprint Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression
    Andrew Holmes
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 1375, USA
    Biol Psychiatry 54:953-9. 2003
    ..Serotonin transporter null mutant mice provide a model system to study how genetic variation in serotonin transporter function affects risk for neuropsychiatric disease...
  11. ncbi request reprint Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter
    Dong Kyu Kim
    Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropharmacology 49:798-810. 2005
    ....
  12. pmc Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions
    Maria T G Perona
    Molecular Neurobiology Branch, NIDA IRP, NIH, Baltimore, Maryland 21224, USA
    Behav Pharmacol 19:566-74. 2008
    ....
  13. ncbi request reprint Ethanol-related behaviors in serotonin transporter knockout mice
    Janel M Boyce-Rustay
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
    Alcohol Clin Exp Res 30:1957-65. 2006
    ..Increasing evidence supports a role for 5-hydroxytryptamine (5-HT) and the 5-HT transporter (5-HTT) in modulating the neural and behavioral actions of ethanol (EtOH) and other drugs of abuse...
  14. ncbi request reprint Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity
    Gregor Hasler
    Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 15K North Drive, Room 200, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychiatry Res 135:121-32. 2005
    ....
  15. pmc Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice
    Takanori Esaki
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:5582-7. 2005
    ..These findings have implications for understanding the potential long-term consequences of genetic and pharmacological disruption of 5-HT neurotransmission on cerebral functions during critical periods of postnatal development...
  16. ncbi request reprint Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice
    Jenna C Carroll
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Behav Genet 37:214-22. 2007
    ..Data provide further evidence of emotional abnormalities following genetic disruption of the 5-HTT...
  17. ncbi request reprint Induction of antioxidative and antiapoptotic thioredoxin supports neuroprotective hypothesis of estrogen
    Chuang Chiueh
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Endocrine 21:27-31. 2003
    ....
  18. ncbi request reprint Locomotory patterns, spatiotemporal organization of exploration and spatial memory in serotonin transporter knockout mice
    Allan V Kalueff
    Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health, 10 Center Dr MSC 1264, Bethesda, MD 20892 1264, USA
    Brain Res 1169:87-97. 2007
    ..Given the relevance of exploratory strategies to human personality traits and brain disorders, our data may be useful for developing further neurobehavioral models using these mice...
  19. ncbi request reprint A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 32:2543-51. 2007
    ....
  20. ncbi request reprint A pharmacological analysis of mice with a targeted disruption of the serotonin transporter
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Building 10, Room 3D41, Bethesda, MD 20892, USA
    Psychopharmacology (Berl) 195:147-66. 2007
    ..Partial or complete ablation of serotonin transporter (SERT) expression in mice leads to altered responses to serotonin receptor agonists and other classes of drugs...
  21. pmc A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:408-16. 2009
    ..Recent evidence from linkage analyses and follow-up candidate gene studies supports the involvement of SLC1A1, which encodes the neuronal glutamate transporter, in the development of obsessive-compulsive disorder (OCD)...
  22. pmc Obsessive-compulsive disorder and its related disorders: a reappraisal of obsessive-compulsive spectrum concepts
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, Maryland 20892, USA
    Dialogues Clin Neurosci 12:131-48. 2010
    ..Considering the status of current research, the concept of OCD and OCD-related spectrum conditions seems fluid in 2010, and in need of ongoing reappraisal...
  23. ncbi request reprint Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study
    Gregor Hasler
    Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Biol Psychiatry 61:617-25. 2007
    ..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions...
  24. ncbi request reprint Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropharmacology 53:643-56. 2007
    ..These studies also show that the exaggerated behavioral responses observed in SERT +/- and -/- mice are mediated by postsynaptic Htr1a receptors, and suggest intact postsynaptic Htr1a function in SERT -/- mice...
  25. ncbi request reprint Perspectives on genetic animal models of serotonin toxicity
    Allan V Kalueff
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892 1264, USA
    Neurochem Int 52:649-58. 2008
    ..Here we discuss current problems and perspectives regarding genetic animal models of serotonin-related syndromes, and outline the potential utility of these models in experimental neurochemistry and clinical research...
  26. ncbi request reprint Analyzing grooming microstructure in neurobehavioral experiments
    Allan V Kalueff
    Laboratory of Clinical Science, National Institute of Mental Health, NIMH NIH, Bethesda, Maryland 20892, USA
    Nat Protoc 2:2538-44. 2007
    ..Owing to the ever-increasing number of rodent models that have strong grooming phenotypes, this high-throughput in-depth analysis is becoming crucial for biomedical research...
  27. pmc Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Int J Neuropsychopharmacol 12:1055-65. 2009
    ..These findings suggest that it is conceivable that there might be increased vulnerability in individuals with SERT polymorphisms that may reduce SERT by more than 50%, the level in SERT+/- mice...
  28. pmc Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Neuropsychopharmacology 34:1695-709. 2009
    ..Increased baseline AA signaling in humans having polymorphisms with reduced 5-HTT function might be identified using positron emission tomography...
  29. doi request reprint The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Psychopharmacology (Berl) 212:13-23. 2010
    ..There are few reports on the high-affinity 5-HT(2A) agonist (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide (TCB-2)...
  30. pmc Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice
    Meredith A Fox
    Laboratory of Clinical Science LCS, National Institute of Mental Health NIMH, National Institutes of Health NIH, 10 Center Drive, Building 10 3D41, MSC 1264, Bethesda, MD 20892 1264, USA
    Psychopharmacology (Berl) 201:203-18. 2008
    ..Serotonin transporter (SERT) knockout (-/-) mice have an altered phenotype in adulthood, including high baseline anxiety and depressive-like behaviors, associated with increased baseline extracellular serotonin levels throughout life...
  31. pmc Refining psychiatric genetics: from 'mouse psychiatry' to understanding complex human disorders
    Justin L LaPorte
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892 1264, USA
    Behav Pharmacol 19:377-84. 2008
    ..Here, we outline recent concepts and approaches that can help refine the field and enable more precise dissection of the genetic mechanisms contributing to psychiatric disorders...
  32. pmc Involvement of insula and cingulate cortices in control and suppression of natural urges
    Alicja Lerner
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Cereb Cortex 19:218-23. 2009
    ..These results suggest a central role for the insula possibly together with ACC in suppression of blinking...
  33. pmc The importance of cognitive phenotypes in experimental modeling of animal anxiety and depression
    Allan V Kalueff
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892 1264, USA
    Neural Plast 2007:52087. 2007
    ....
  34. pmc Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice
    Jonathan L Brigman
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, MD 20852 9411, USA
    Cereb Cortex 20:1955-63. 2010
    ..These findings could have important implications for understanding and treating cognitive inflexibility in neuropsychiatric disease...
  35. doi request reprint Hybridizing behavioral models: a possible solution to some problems in neurophenotyping research?
    Allan V Kalueff
    Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 1264, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1172-8. 2008
    ....
  36. pmc Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT)
    Meredith A Fox
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1264, USA
    Br J Pharmacol 159:879-87. 2010
    ..Our findings strongly support the correlation of WAY 100635 induced head twitches with increased 5-HT availability, induced genetically or pharmacologically...
  37. doi request reprint Domain interplay concept in animal models of neuropsychiatric disorders: a new strategy for high-throughput neurophenotyping research
    Allan V Kalueff
    Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892 1264, USA
    Behav Brain Res 188:243-9. 2008
    ..Here we develop a new concept based on targeting the complex interplay between different behavioral domains, meant to foster high-throughput phenotyping and integrative modeling of psychiatric disorders...
  38. ncbi request reprint A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 17:717-23. 2008
    ..Our results contribute to a better understanding of SLC6A4 expression genetics and provide a functional haplotype framework for future serotonin-related studies...
  39. ncbi request reprint Are serotonin transporter knockout mice 'depressed'?: hypoactivity but no anhedonia
    Allan V Kalueff
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892 1264, USA
    Neuroreport 17:1347-51. 2006
    ..These results demonstrate that depression-like behavior (unlike hypoactivity) is not a baseline phenotypic feature of serotonin transporter knockout mice, suggesting anew that these mice do not represent a genetic model of depression...
  40. ncbi request reprint Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice
    Renee F Ren-Patterson
    Laboratory of Clinical Science, NIMH, NIH, Bethesda, MD 20892 1264, USA
    J Neurosci Res 79:756-71. 2005
    ....
  41. ncbi request reprint Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress
    Olga A Tjurmina
    Laboratory of Clinical Science, NIMH, NIH, Bldg 10, Rm 3D41, 10 Center Dr, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:99-104. 2004
    ..Our results indicate that SERT function not only restrains stress-induced EPI release but also is required for the increase in adrenal catecholamine synthesis and AT(2) receptor expression...
  42. ncbi request reprint Effects of metergoline on symptoms in women with premenstrual dysphoric disorder
    Catherine A Roca
    National Institute of Mental Health, Bethesda, MD 20892 1277, USA
    Am J Psychiatry 159:1876-81. 2002
    ..The authors investigated the role of acute serotonergic modulation in the efficacy of selective serotonin reuptake inhibitors (SSRIs) in women with premenstrual dysphoric disorder...
  43. ncbi request reprint Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice
    Qian Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1264, USA
    J Neurochem 84:1256-65. 2003
    ..These changes may not be mediated by alterations in their gene expression or in the level of Gq/11 proteins. The alterations in these receptors may be related to the altered behaviors of 5-HTT knockout mice...
  44. ncbi request reprint Diagnostic interview assessed neuropsychiatric disorder comorbidity in 334 individuals with obsessive-compulsive disorder
    V Holland LaSalle
    Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, 20892, USA
    Depress Anxiety 19:163-73. 2004
    ..These data have implications for genetic studies of OCD and disorders related to OCD, as well as for specific psychotherapeutic and psychopharmacologic interventions...
  45. ncbi request reprint Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters
    Subroto Ghose
    Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland 20892, USA
    Synapse 56:100-4. 2005
    ..3H]MeNER displayed much higher affinity for NET than for SERT or DAT in homogenate binding studies. Each of these features supports the binding specificity of this candidate in vivo NET ligand...
  46. ncbi request reprint Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter
    Andrew Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, NIH, Bethesda, MD 20892 1375, USA
    Neuropsychopharmacology 27:914-23. 2002
    ..5-HTT knockout mice provide a valuable tool for delineating the neuropsychopharmacological actions of antidepressants...
  47. ncbi request reprint 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter
    Ying Qu
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Building 9, Room 1S128, Bethesda, MD, 20892, USA
    Psychopharmacology (Berl) 180:12-20. 2005
    ..To further understand SERT function, we measured a marker of regional brain phospholipase A2 (PLA2) activation in SERT knockout mice (SERT-/-) and their littermate controls (SERT+/+)...
  48. ncbi request reprint Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene
    Olga A Tjurmina
    Laboratory of Clinical Science, National Institute of Mental Health, and Clinical Neurocardiology Section, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 143:4520-6. 2002
    ..Exaggerated adrenomedullary responses seem to be an autonomic correlate of the anxiety-like behaviors in 5-HTT knockout mice...
  49. ncbi request reprint The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and men
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1276, USA
    Neuropsychopharmacology 27:800-12. 2002
    ....
  50. ncbi request reprint Serotonergic-like progenitor cells propagated from neural stem cells in vitro: survival with SERT protein expression following implantation into brains of mice lacking SERT
    Renee F Ren-Patterson
    Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD 20892 1264, USA
    FASEB J 19:1537-9. 2005
    ..These findings suggest that this serotonergic-like NSC model will be a useful contribution to the development of cell biotechnology in regard to the expression of missing genes such as SERT in the adult brain...
  51. pmc Predicting genetic loading from symptom patterns in obsessive- compulsive disorder: a latent variable analysis
    Carmi Schooler
    Section on Socio Environmental Studies, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland 20892 8408, USA
    Depress Anxiety 25:680-8. 2008
    ..However, these symptom dimensions are all from exploratory factor analyses of Yale-Brown Obsessive-Compulsive Scale Symptom Checklist ratings based on non-empirically derived symptom categories, rather than individual symptoms...
  52. ncbi request reprint Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB)
    Qian Li
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    J Pharmacol Exp Ther 308:481-6. 2004
    ..In addition, fenfluramine showed a low capability to compete with [(3)H]AFM. The present results suggest that both AFM and DASB are highly selective SERT ligands potentially suitable for use in human PET studies of SERT...
  53. ncbi request reprint Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior
    Andrew Holmes
    Laboratory of Behavioral Neuroscience, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 28:2077-88. 2003
    ..5-HTT null mutant mice provide a model to investigate the role of the 5-HTT in mood and anxiety disorders...
  54. ncbi request reprint Reduced aggression in mice lacking the serotonin transporter
    Andrew Holmes
    Section on Behavioral Genomics, National Institute of Mental Health, Building 10 Room 4D11, Bethesda, MD 20892 1375, USA
    Psychopharmacology (Berl) 161:160-7. 2002
    ..As a key regulator of central serotonergic activity, dysfunction of the serotonin transporter (5-HTT) represents a potential mechanism mediating pathological aggression...
  55. ncbi request reprint Serotonin transporter: gene, genetic disorders, and pharmacogenetics
    Dennis L Murphy
    Laboratory of Clinical Science, Building 10, Room 3D41, 10 Center Drive, MSC 1264, NIMH, NIH, Bethesda, MD 20892, USA
    Mol Interv 4:109-23. 2004
    ....
  56. doi request reprint SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, Mood and Anxiety Disorders Program, NIMH, NIH, Bethesda, Maryland 20892 1264, USA
    Psychiatr Genet 18:31-9. 2008
    ....
  57. doi request reprint Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoarding
    Kung Yee Liang
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1000-2. 2008
    ....
  58. ncbi request reprint The hoarding dimension of OCD: psychological comorbidity and the five-factor personality model
    V Holland LaSalle-Ricci
    The Catholic University of America, Adult OCD Unit, NIMH, 10 Center Drive MSC 1264, 10 3D41, Bethesda, MD 20892, USA
    Behav Res Ther 44:1503-12. 2006
    ..Recommendations are made for clinicians and for future research...
  59. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  60. ncbi request reprint Absence of thermal hyperalgesia in serotonin transporter-deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 23:708-15. 2003
    ..In contrast, bilateral mechanical allodynia, a centrally mediated phenomenon, was associated with decreased spinal 5-HT concentrations in 5-HTT-/- mice and may possibly be caused by a lack of spinal inhibition...
  61. pmc Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 160:83-93. 2008
    ..The results support investigation of this multidimensional model in OCD genetic linkage studies...
  62. ncbi request reprint Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res 942:109-19. 2002
    ..This study also demonstrates that DA neurons can store 5-HT for possible "false neurotransmitter" or other usage...
  63. ncbi request reprint Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter
    Min Tsai Liu
    Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1398-411. 2002
    ..Adaptive changes thus occur in the subunit composition of enteric 5-HT(3) receptors of SERT -/- mice that are reflected in 5-HT(3) receptor affinity and desensitization...
  64. ncbi request reprint Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice
    Sylvia MontaƱez
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, USA
    J Neurochem 86:210-9. 2003
    ..These data highlight the potential of the heterozygote 5-HTT mutant mice to model the dynamic in vivo consequences of the human 5-HTT polymorphism...
  65. ncbi request reprint 2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine]
    Erica L Unger
    152 Davey Laboratory, Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA
    J Pharmacol Exp Ther 303:527-33. 2002
    ..Moreover, this study clearly shows that 2'-NH(2)-MPTP can be utilized in rats as a tool to study the serotonergic and noradrenergic neurotransmitter systems...
  66. pmc The OCD collaborative genetics study: methods and sample description
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7228, USA
    Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006
    ....
  67. ncbi request reprint A human serotonin transporter mutation causes constitutive activation of transport activity
    Fusun Kilic
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, P O Box 208066, New Haven, CT 06520 8066, USA
    Mol Pharmacol 64:440-6. 2003
    ..This stimulation was prevented by the presence of oxyhemoglobin, which quenches nitric oxide, and by an inhibitor of guanylyl cyclase...
  68. pmc Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans
    Ana Marin D Carneiro
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8548, USA
    J Clin Invest 118:1544-52. 2008
    ....
  69. ncbi request reprint BDNF in anxiety and depression
    Allan V Kalueff
    Science 312:1598-9; author reply 1598-9. 2006
  70. ncbi request reprint Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Behav Res Ther 45:673-86. 2007
    ..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families...
  71. pmc Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder
    Xian Zhang Hu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA
    Am J Hum Genet 78:815-26. 2006
    ..The L(A) allele was twofold overtransmitted to the patients with OCD. The HTTLPR L(A)L(A) genotype exerts a moderate (1.8-fold) effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD...
  72. ncbi request reprint Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism
    Gregor Hasler
    Department of Psychiatry, University Hospital, 8091 Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:403-8. 2006
    ..This study may contribute to understanding of molecular genetic features underlying the appearance of symptom clusters in OCD...
  73. ncbi request reprint An investigation of traumatic life events and obsessive-compulsive disorder
    Kiara R Cromer
    Department of Psychology, Florida State University, Tallahassee, FL 32306 1270, USA
    Behav Res Ther 45:1683-91. 2007
    ....
  74. ncbi request reprint (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter
    Wei Ni
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, 48824 1317, USA
    J Pharmacol Exp Ther 314:953-60. 2005
    ..Understanding of the mechanism by which (+)-norfenfluramine induces vasoconstriction is important to characterize and understand the function of the serotonergic system in peripheral arterial vasculature...
  75. ncbi request reprint Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Depress Anxiety 25:218-24. 2008
    ..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner...
  76. ncbi request reprint Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression
    Tiffany A Mathews
    Department of Chemistry, The Pennsylvania State University, 104 Chemistry Building, University Park, PA 16802 6300, USA
    J Neurosci Methods 140:169-81. 2004
    ..Furthermore, use of zero net flux microdialysis appears warranted in investigations of serotonergic synaptic function where modest changes in extracellular 5-HT are thought to occur in response to altered uptake...
  77. ncbi request reprint Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences
    Qian Li
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0431, USA
    J Neurosci 24:10868-77. 2004
    ..Thus, the present results demonstrate that medial hypothalamic 5-HT1A receptors regulate stress responses and locomotor activity but may not regulate exploratory anxiety-like behaviors...
  78. ncbi request reprint Reduced programmed cell death in brains of serotonin transporter knockout mice
    Antonio M Persico
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Italy
    Neuroreport 14:341-4. 2003
    ....
  79. doi request reprint The regular and light-dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodents
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Nat Protoc 3:129-36. 2008
    ....
  80. ncbi request reprint Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters
    Hao wei Shen
    Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Neuropsychopharmacology 29:1790-9. 2004
    ..Cocaine-induced alterations in CPu DA levels in DAT-, SERT-, and DAT/SERT double-KO mice appear to provide better correlations with cocaine CPP than cocaine-induced DA level alterations in NAc or PFc...
  81. ncbi request reprint Neuronal and astroglial responses to the serotonin and norepinephrine neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine
    Beth A Luellen
    The Pennsylvania State University, 152 Davey Laboratory, University Park, PA 16802, USA
    J Pharmacol Exp Ther 307:923-31. 2003
    ....
  82. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  83. ncbi request reprint Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism
    Lynette C Daws
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurosci 26:6431-8. 2006
    ..The present findings provide new insights into the actions of ethanol on brain function and behavior...