Sachiko Murase

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint A new model for developmental neuronal death and excitatory/inhibitory balance in hippocampus
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorder and Stroke, National Institutes of Health, 35 Lincoln Dr, Bethesda, MD, 20892, USA
    Mol Neurobiol 49:316-25. 2014
  2. pmc Signal transducer and activator of transcription 3 (STAT3) degradation by proteasome controls a developmental switch in neurotrophin dependence
    Sachiko Murase
    Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 288:20151-61. 2013
  3. pmc Loss of signal transducer and activator of transcription 3 (STAT3) signaling during elevated activity causes vulnerability in hippocampal neurons
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 32:15511-20. 2012
  4. pmc Matrix metalloproteinase-9 regulates survival of neurons in newborn hippocampus
    Sachiko Murase
    Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:12184-94. 2012
  5. pmc In the newborn hippocampus, neurotrophin-dependent survival requires spontaneous activity and integrin signaling
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:7791-800. 2011
  6. doi request reprint p53 controls neuronal death in the CA3 region of the newborn mouse hippocampus
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Eur J Neurosci 34:374-81. 2011
  7. doi request reprint Generating neurons from stem cells
    Andreas Androutsellis-Theotokis
    Porter Neuroscience Research Center, Bethesda, MD, USA
    Methods Mol Biol 438:31-8. 2008
  8. doi request reprint Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD, USA
    Eur J Neurosci 39:557-65. 2014
  9. ncbi request reprint A specific survival response in dopamine neurons at most risk in Parkinson's disease
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:9750-60. 2006

Detail Information

Publications9

  1. doi request reprint A new model for developmental neuronal death and excitatory/inhibitory balance in hippocampus
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorder and Stroke, National Institutes of Health, 35 Lincoln Dr, Bethesda, MD, 20892, USA
    Mol Neurobiol 49:316-25. 2014
    ..Here, I discuss the molecular mechanisms for survival in neonatal neurons, how these mechanisms change during development, and how they may be linked to degenerative diseases. ..
  2. pmc Signal transducer and activator of transcription 3 (STAT3) degradation by proteasome controls a developmental switch in neurotrophin dependence
    Sachiko Murase
    Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 288:20151-61. 2013
    ..Thus, these results show that the ubiquitin-proteasome pathway controls the critical developmental switch of neurotrophin dependence in the newborn hippocampus. ..
  3. pmc Loss of signal transducer and activator of transcription 3 (STAT3) signaling during elevated activity causes vulnerability in hippocampal neurons
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 32:15511-20. 2012
    ..Thus, this study provides new insight into a mechanism by which chronic elevation of activity may cause neurodegeneration...
  4. pmc Matrix metalloproteinase-9 regulates survival of neurons in newborn hippocampus
    Sachiko Murase
    Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:12184-94. 2012
    ..This work is the first to report a role for MMP9 in regulating neuronal survival through the developmental process that establishes the functional brain...
  5. pmc In the newborn hippocampus, neurotrophin-dependent survival requires spontaneous activity and integrin signaling
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:7791-800. 2011
    ..These data are the first to link the early excitatory action of GABA to the developmental death period and to assign an essential role for activity in neurotrophin-mediated survival that establishes appropriate networks...
  6. doi request reprint p53 controls neuronal death in the CA3 region of the newborn mouse hippocampus
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Eur J Neurosci 34:374-81. 2011
    ..These results suggest that p53 is the key downstream regulator of the novel survival-signaling pathway that regulates the number of CA3 neurons in the first 10 days of postnatal life...
  7. doi request reprint Generating neurons from stem cells
    Andreas Androutsellis-Theotokis
    Porter Neuroscience Research Center, Bethesda, MD, USA
    Methods Mol Biol 438:31-8. 2008
    ..Ultimate validation of such a system comes from accurate prediction of in vivo effects, and the methods we present for CNS SC culture have also successfully predicted regenerative responses in the injured adult nervous system...
  8. doi request reprint Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD, USA
    Eur J Neurosci 39:557-65. 2014
    ..These results suggest that phasic and chronic neuronal activation induce distinct molecular pathways, resulting in opposing regulation of STAT3 signal. ..
  9. ncbi request reprint A specific survival response in dopamine neurons at most risk in Parkinson's disease
    Sachiko Murase
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:9750-60. 2006
    ..These data show that FGF signals to elevate DA levels and protect the specific midbrain neuron type at most risk in Parkinson's patients...