P A Muraro

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Decreased integrin gene expression in patients with MS responding to interferon-beta treatment
    P A Muraro
    Neuroimmunology Unit, Department of Oncology and Neuroscience, Medical School, University G D Annunzio, Via dei Vestini, Chieti 66013, Italy
    J Neuroimmunol 150:123-31. 2004
  2. ncbi Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:805-16. 2005
  3. ncbi Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, MD 20892 1400, USA
    Brain 126:20-31. 2003
  4. ncbi T cell response to 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in multiple sclerosis patients
    P A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bldg 10, Room 5B 16, National Institutes of Health, 10 Center Drive MSC1400, 20892, Bethesda, MD, USA
    J Neuroimmunol 130:233-42. 2002
  5. ncbi Clonotypic analysis of cerebrospinal fluid T cells during disease exacerbation and remission in a patient with multiple sclerosis
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10, Room 5B16, 10 Center Dr MSC1400 Bethesda, MD 20892 1400, USA
    J Neuroimmunol 171:177-83. 2006
  6. ncbi Renewing the T cell repertoire to arrest autoimmune aggression
    Paolo A Muraro
    Neuroimmunology Branch, NINDS NIH, Bldg 10, Room 5B16, 10 Center Drive, MSC1400, Bethesda, MD 20892 1400, USA
    Trends Immunol 27:61-7. 2006
  7. ncbi VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis
    P A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC1400, 20892 1400, Bethesda, MD, USA
    J Neuroimmunol 111:186-94. 2000
  8. ncbi Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire
    P A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1400, USA
    J Clin Invest 100:339-49. 1997
  9. ncbi Differential effects of phosphodiesterase type 4-specific inhibition on human autoreactive myelin-specific T cell clones
    M Pette
    Neuroimmunology Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Neuroimmunol 98:147-56. 1999
  10. ncbi In vitro modulation of human, autoreactive MBP-specific CD4 + T-cell clones by cyclosporin A
    M Pette
    Neuroimmunology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1400, USA
    J Neuroimmunol 76:91-9. 1997

Collaborators

Detail Information

Publications31

  1. ncbi Decreased integrin gene expression in patients with MS responding to interferon-beta treatment
    P A Muraro
    Neuroimmunology Unit, Department of Oncology and Neuroscience, Medical School, University G D Annunzio, Via dei Vestini, Chieti 66013, Italy
    J Neuroimmunol 150:123-31. 2004
    ..In vitro treatment of PBMC with IFN-beta indicated a direct effect on transcription of the integrins' genes. Transcriptional downmodulation of adhesion molecules during IFN-beta treatment may contribute to its mode of action in MS...
  2. ncbi Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:805-16. 2005
    ....
  3. ncbi Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, MD 20892 1400, USA
    Brain 126:20-31. 2003
    ....
  4. ncbi T cell response to 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in multiple sclerosis patients
    P A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bldg 10, Room 5B 16, National Institutes of Health, 10 Center Drive MSC1400, 20892, Bethesda, MD, USA
    J Neuroimmunol 130:233-42. 2002
    ..These data provide the immunological basis for further investigation of CNPase as a potential target self-antigen in MS...
  5. ncbi Clonotypic analysis of cerebrospinal fluid T cells during disease exacerbation and remission in a patient with multiple sclerosis
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10, Room 5B16, 10 Center Dr MSC1400 Bethesda, MD 20892 1400, USA
    J Neuroimmunol 171:177-83. 2006
    ..CDR3 spectratyping is a valuable approach to identify disease-associated T cells in the CNS...
  6. ncbi Renewing the T cell repertoire to arrest autoimmune aggression
    Paolo A Muraro
    Neuroimmunology Branch, NINDS NIH, Bldg 10, Room 5B16, 10 Center Drive, MSC1400, Bethesda, MD 20892 1400, USA
    Trends Immunol 27:61-7. 2006
    ..We propose a model envisioning a coordinated sequence of events, rebuilding an immune system that is competent against infection but that is substantially reconfigured in a way that is less likely to redevelop autoimmunity...
  7. ncbi VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis
    P A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC1400, 20892 1400, Bethesda, MD, USA
    J Neuroimmunol 111:186-94. 2000
    ..These effects may play an important role in the reduction of central nervous system cell trafficking and inflammation in MS...
  8. ncbi Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire
    P A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1400, USA
    J Clin Invest 100:339-49. 1997
    ..This study provides new insight about MBP recognition and proposes an alternative mechanism for immunodominance of self-antigen T cell epitopes in humans...
  9. ncbi Differential effects of phosphodiesterase type 4-specific inhibition on human autoreactive myelin-specific T cell clones
    M Pette
    Neuroimmunology Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Neuroimmunol 98:147-56. 1999
    ..This profile suggest that rolipram differs from other currently used immunomodulatory drugs...
  10. ncbi In vitro modulation of human, autoreactive MBP-specific CD4 + T-cell clones by cyclosporin A
    M Pette
    Neuroimmunology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1400, USA
    J Neuroimmunol 76:91-9. 1997
    ..Our observations are in line with results obtained in different experimental systems. The discrepancy between the profound inhibition of T-cells and the modest therapeutic effects on MS is discussed...
  11. ncbi T-cell clones persisting in the circulation after autologous hematopoietic SCT are undetectable in the peripheral CD34+ selected graft
    A N Dubinsky
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Bone Marrow Transplant 45:325-31. 2010
    ....
  12. ncbi Low-dose oral methotrexate treatment in chronic progressive multiple sclerosis
    A Lugaresi
    Department of Oncology and Neuroscience, Gabriele D'Annunzio University, Chieti, Italy
    Neurol Sci 22:209-10. 2001
    ..MTX is inexpensive and, given its anti-inflammatory and immunomodulatory properties, may be used as add-on therapy in non-responders to interferon beta, although hepatic toxicity may be a problem in long-term treatment...
  13. ncbi Immunological questions on hematopoietic stem cell transplantation for multiple sclerosis
    P A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 10, Room 5B16, 10 Center Dr MSC1400 Bethesda, MD 20892-1400, USA
    Bone Marrow Transplant 32:S41-4. 2003
    ..Here, we will summarize key immunopathological aspects of MS and discuss important questions that need to be addressed to clarify the therapeutic role and mechanism of action of HSCT in this disorder...
  14. ncbi Using stem cells in multiple sclerosis therapies
    P A Muraro
    Neuroimmunology Branch NINDS, NIH, Bethesda, Maryland 20892-1400, USA
    Cytotherapy 6:615-20. 2004
    ..Here we discuss key observations and questions emerging from clinical trials of hematopoietic stem cell transplantation for MS and from studies of myelin/neural repair in experimental models of demyelinating disorders...
  15. ncbi Interferon-beta-1b effects on re-enhancing lesions in patients with multiple sclerosis
    S Gupta
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
    Mult Scler 11:658-68. 2005
    ..Thus, IFNbeta appears to be effective in reducing the degree of severity of inflammation among Re-CELs, as reflected by their reduced maximal lesion sizes and durations of enhancement...
  16. ncbi Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing-remitting MS
    P A Muraro
    Neurological Clinic, Department of Oncology and Neuroscience, Nuovo Ospedale Clinicizzato, G D Annunzio University, Via dei Vestini, 66013 Chieti, Italy
    J Neuroimmunol 127:149-59. 2002
    ..05). Autoreactive T cell responses against myelin antigens may be implicated in perturbations of TCR repertoire in untreated MS patients, detectable even in the absence of clinically evident manifestations...
  17. ncbi Optimized clonotypic analysis of T-cell receptor repertoire in immune reconstitution
    Amy N Packer
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Exp Hematol 35:516-21. 2007
    ..The primary aim of this study was to optimize a procedure for clonotypic analysis of the TCR repertoire in patients undergoing autologous HSCT...
  18. ncbi Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity
    Mireia Sospedra
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 1:e41. 2005
    ..Our data suggest that repeated infections with common pathogenic and even nonpathogenic viruses could expand T cells specific for conserved protein domains that are able to cross-react with tissue-derived and ubiquitous autoantigens...
  19. ncbi Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response
    Riccardo Cassiani-Ingoni
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    J Neuropathol Exp Neurol 66:637-49. 2007
    ..Our data indicate that reactivation of a local inflammatory process after BMT is sustained predominantly by endogenous microglia/macrophages...
  20. ncbi Rapid identification of local T cell expansion in inflammatory organ diseases by flow cytometric T cell receptor Vbeta analysis
    P A Muraro
    Neuroimmunology Branch, NINDS, National Institutes of Health, Bethesda, MD, USA
    J Immunol Methods 246:131-43. 2000
    ....
  21. ncbi Different development of myelin basic protein agonist- and antagonist-specific human TCR transgenic T cells in the thymus and periphery
    Kazuyuki Kawamura
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    J Immunol 181:5462-72. 2008
    ..These results suggest that thymic and peripheral development of MBP-specific T cells are different; however, dual TCR expression can facilitate their development...
  22. ncbi Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis
    Jan D Lunemann
    Neuroimmunology Branch, Cellular Immunology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Brain 129:1493-506. 2006
    ..We suggest that the accumulation of highly antigen-sensitive EBNA1-specific Th1 cells in multiple sclerosis is capable of sustaining autoimmunity by cross-recognition of autoantigens or by TCR-independent bystander mechanisms...
  23. ncbi Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype
    Mireia Sospedra
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 176:1951-61. 2006
    ..A T cell signaling machinery tuned for efficient responses to weak ligands together with structural features of the TCR-HLA/peptide complex result in this promiscuous HLA class II restriction...
  24. ncbi Feasibility of allogeneic hematopoietic stem cell transplantation for autoimmune disease: position statement from a National Institute of Allergy and Infectious Diseases and National Cancer Institute-Sponsored International Workshop, Bethesda, MD, March 1
    Linda M Griffith
    Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Biol Blood Marrow Transplant 11:862-70. 2005
  25. ncbi Limited repertoire of HLA-DRB1*0401-restricted MBP111-129-specific T cells in HLA-DRB1*0401 Tg mice and their pathogenic potential
    Jaebong Huh
    Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, 10-5B16, 10 Center Drive, Bethesda, MD 20892, USA
    J Neuroimmunol 151:94-102. 2004
    ..In the spinal cord, the inflammation was observed in the peripheral nerve roots as well as in the CNS. These data suggest the pathogenic potential of HLA-DRB1*0401-restricted MBP111-129-specific T cells in humans...
  26. ncbi Hematopoietic stem cell transplantation for multiple sclerosis: current status and future challenges
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, MSC1400 Bethesda, MD 20892-1400, USA
    Curr Opin Neurol 16:299-305. 2003
    ..Recent advances on the migratory potential and on the differentiation plasticity of hematopoietic stem cells have opened new opportunities for remyelination and axonal repair strategies for multiple sclerosis...
  27. ncbi Granulocytic invasion of the central nervous system after hematopoietic stem cell transplantation for systemic lupus erythematosus
    Paolo A Muraro
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Haematologica 91:ECR21. 2006
    ..Granulocytic invasion of the central nervous system represents a novel and possibly preventable cause of neurological complications during haematologic reconstitution...
  28. ncbi Unique clinical and pathological features in HLA-DRB1*0401-restricted MBP 111-129-specific humanized TCR transgenic mice
    Jacqueline A Quandt
    Department of Neurology, Robert Wood Johnson Medical School, UMDNJ, 683 Hoes Ln, Piscataway, NJ 08854, USA
    J Exp Med 200:223-34. 2004
    ..This notion may help to explain the clinical and pathological heterogeneity of MS...
  29. ncbi Emerging therapies for multiple sclerosis
    Paolo A Muraro
    Department of Cellular and Molecular Neuroscience, Imperial College London, London SW7 2AZ, United Kingdom
    Neurotherapeutics 4:676-92. 2007
    ..The evidence supporting the potential of these emerging immunotherapies suggests that strong progress is being made in the development of effective cures for multiple sclerosis...
  30. ncbi Autologous HSCT for advanced MS: is the glass half-empty or really half-full?
    Richard A Nash
    Brain 131:e89; author reply e90. 2008
  31. ncbi Hematopoietic stem cell transplantation for multiple sclerosis
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 62:860-4. 2005