Yunhua L Muller

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes
    Yunhua L Muller
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85004, USA
    Hum Genet 132:697-707. 2013
  2. pmc Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes 62:2984-91. 2013
  3. pmc MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation
    Li Bian
    Diabetes Molecular Genetics Section and Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85004, USA
    Hum Mol Genet 22:4438-49. 2013
  4. pmc A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ
    Diabetes 63:369-76. 2014
  5. pmc Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish
    Yunhua L Muller
    Diabetes Molecular Genetics Section and, Diabetes Epidemiology, the National Institute of Diabetes and Digestive andKidney Disease, The National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2080-5. 2010
  6. pmc Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure
    Yunhua L Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 445 North 5th Street, Phoenix, AZ, 85004, USA
    Diabetologia 57:1382-90. 2014
  7. pmc Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians
    Marie S Thearle
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 61:250-7. 2012
  8. pmc Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians
    Li Bian
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA
    Diabetes 59:1276-82. 2010
  9. pmc Evaluation of A2BP1 as an obesity gene
    Lijun Ma
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2837-45. 2010

Collaborators

Detail Information

Publications9

  1. pmc Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes
    Yunhua L Muller
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85004, USA
    Hum Genet 132:697-707. 2013
    ..Alternatively, TREH variants may be tagging a nearby T2D locus...
  2. pmc Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes 62:2984-91. 2013
    ..In Pima Indians, the effect of maternally derived KCNQ1 variants appears to be mediated through decreased insulin secretion and is particularly strong, accounting for 4% of the variance in liability to diabetes. ..
  3. pmc MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation
    Li Bian
    Diabetes Molecular Genetics Section and Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85004, USA
    Hum Mol Genet 22:4438-49. 2013
    ..We conclude that MAP2K3 is a reproducible obesity locus that may affect body weight via complex mechanisms involving appetite regulation and hypothalamic inflammation. ..
  4. pmc A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ
    Diabetes 63:369-76. 2014
    ..Transfection studies in murine pancreatic β-cells suggested that DNER regulates expression of notch signaling pathway genes. These studies implicate DNER as a susceptibility gene for T2DM in American Indians. ..
  5. pmc Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish
    Yunhua L Muller
    Diabetes Molecular Genetics Section and, Diabetes Epidemiology, the National Institute of Diabetes and Digestive andKidney Disease, The National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2080-5. 2010
    ..To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the Pima Indian population, which has a high prevalence of type 2 diabetes...
  6. pmc Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure
    Yunhua L Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 445 North 5th Street, Phoenix, AZ, 85004, USA
    Diabetologia 57:1382-90. 2014
    ..Rare mutations in GCK cause MODY. We investigated whether common variation (minor allele frequency ≥0.01) in GCK is associated with metabolic traits and type 2 diabetes...
  7. pmc Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians
    Marie S Thearle
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 61:250-7. 2012
    ..The greater rates of body mass accumulation and risk of type 2 diabetes before the age of 20 years in individuals with MC4R deficiency indicate that the effects of these mutations are more apparent during the active growth of childhood...
  8. pmc Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians
    Li Bian
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA
    Diabetes 59:1276-82. 2010
    ..Genetic variants in or near ASK1 were analyzed to assess the role of this gene in insulin action and type 2 diabetes...
  9. pmc Evaluation of A2BP1 as an obesity gene
    Lijun Ma
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2837-45. 2010
    ..On the basis of this association and the obese phenotype of ataxin-2 knockout mice, A2BP1 was genetically and functionally analyzed to assess its potential role in human obesity...